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Search results 1 to 86 out of 86 for Thoc5

0.024s
Type Details Score
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Guria A
Year: 2011
Journal: RNA
Title: Identification of mRNAs that are spliced but not exported to the cytoplasm in the absence of THOC5 in mouse embryo fibroblasts.
Volume: 17
Issue: 6
Pages: 1048-56
Publication  
First Author: Saran S
Year: 2013
Journal: BMC Cell Biol
Title: THOC5, a member of the mRNA export complex, contributes to processing of a subset of wingless/integrated (Wnt) target mRNAs and integrity of the gut epithelial barrier.
Volume: 14
Pages: 51
Publication
First Author: Tamura T
Year: 1999
Journal: Oncogene
Title: FMIP, a novel Fms-interacting protein, affects granulocyte/macrophage differentiation.
Volume: 18
Issue: 47
Pages: 6488-95
Publication
First Author: Wang L
Year: 2013
Journal: Cell Stem Cell
Title: The THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogramming.
Volume: 13
Issue: 6
Pages: 676-90
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:5632358
Assay Type: RT-PCR
Annotation Date: 2015-04-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:5632375
Age: embryonic day 1.0
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5632358
Assay Type: RT-PCR
Annotation Date: 2015-04-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:5632375
Age: embryonic day 3.0
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5632358
Assay Type: RT-PCR
Annotation Date: 2015-04-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360411
Stage: TS01
Assay Id: MGI:5632375
Age: embryonic day 0.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5632358
Assay Type: RT-PCR
Annotation Date: 2015-04-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:5632375
Age: embryonic day 3.5
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5632358
Assay Type: RT-PCR
Annotation Date: 2015-04-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360633
Stage: TS03
Assay Id: MGI:5632375
Age: embryonic day 2.0-2.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:5632369
Assay Type: Immunohistochemistry
Annotation Date: 2015-04-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160414
Pattern: Not Specified
Stage: TS04
Assay Id: MGI:5632378
Age: embryonic day 3.5
Detected: true
Specimen Num: 1
Publication
First Author: Mancini A
Year: 2004
Journal: Oncogene
Title: The M-CSF receptor substrate and interacting protein FMIP is governed in its subcellular localization by protein kinase C-mediated phosphorylation, and thereby potentiates M-CSF-mediated differentiation.
Volume: 23
Issue: 39
Pages: 6581-9
Publication  
First Author: Mancini A
Year: 2010
Journal: BMC Biol
Title: THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo.
Volume: 8
Pages: 1
Publication
First Author: Maeder CI
Year: 2018
Journal: Cell
Title: The THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival.
Volume: 174
Issue: 6
Pages: 1436-1449.e20
Publication
First Author: Klein AD
Year: 2016
Journal: Cell Rep
Title: Identification of Modifier Genes in a Mouse Model of Gaucher Disease.
Volume: 16
Issue: 10
Pages: 2546-2553
Publication
First Author: Licatalosi DD
Year: 2012
Journal: Genes Dev
Title: Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain.
Volume: 26
Issue: 14
Pages: 1626-42
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
Publication
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication          
First Author: MGD Nomenclature Committee
Year: 1995
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication
First Author: Carney L
Year: 2009
Journal: Cell Signal
Title: THOC5 couples M-CSF receptor signaling to transcription factor expression.
Volume: 21
Issue: 2
Pages: 309-16
Interaction Experiment
Description: Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA.
Publication
First Author: Katahira J
Year: 2009
Journal: EMBO J
Title: Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA.
Volume: 28
Issue: 5
Pages: 556-67
Protein
Organism: Mus musculus
Length: 683  
Fragment?: false
Protein
Organism: Mus musculus
Length: 635  
Fragment?: false
Protein
Organism: Mus musculus
Length: 683  
Fragment?: false
Protein
Organism: Mus musculus
Length: 300  
Fragment?: true
Publication
First Author: Voynov V
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Genes with internal repeats require the THO complex for transcription.
Volume: 103
Issue: 39
Pages: 14423-8
Publication
First Author: Merz C
Year: 2007
Journal: RNA
Title: Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitment.
Volume: 13
Issue: 1
Pages: 116-28
Protein Domain
Type: Family
Description: This entry represents Thoc5 which is one of the subunits of the THO complex, which additionally contains: HPR1, Thoc2, Thoc6 and Thoc7. The evolutionarily conserved multisubunit THO complex, which is recruited to actively transcribed genes is required for the efficient expression of genes that have internal tandem repeats. It is suggested that the THO complex functions to rectify aberrant structures that arise during transcription [, ]and is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress []. This entry also identifies the crucial 144 N-terminal residues of the FMIP protein, which is essential for the binding of the protein to the cytoplasmic domain of activated Fms-molecules in M-CSF induced haematopoietic differentiation of macrophages. The C terminus contains a putative nuclear localisation sequence and a leucine zipper which suggest further, as yet unknown, nuclear functions. The level of FMIP expression might form a threshold that determines whether cells differentiate into macrophages or into granulocytes [].
Protein Domain
Type: Domain
Description: The THO/TREX complex is the transcription- and export-related complex associated with spliceosomes that preferentially deal with spliced mRNAs as opposed to unspliced mRNAs. Thoc2 plays a role in RNA polymerase II (RNA pol II)-dependent transcription and is required for the stability of DNA repeats []. In humans, the TRE complex is comprised of the exon-junction-associated proteins Aly/REF and UAP56 together with the THO proteins THOC1 (hHpr1/p84), Thoc2 (hRlr1), THOC3 (hTex1), THOC5 (fSAP79), THOC6 (fSAP35), and THOC7 (fSAP24). Although much evidence indicates that the function of the TREX complex as an adaptor between the mRNA and components of the export machinery is conserved among eukaryotes, in Drosophila the majority of mRNAs can be exported from the nucleus independently of the THO complex []. This entry represents a conserved domain found towards the N terminus of these proteins.
Protein
Organism: Mus musculus
Length: 1594  
Fragment?: false
Protein
Organism: Mus musculus
Length: 921  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1589  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1017  
Fragment?: true
Publication
First Author: Rehwinkel J
Year: 2004
Journal: Nat Struct Mol Biol
Title: Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster.
Volume: 11
Issue: 6
Pages: 558-66
Publication
First Author: Masuda S
Year: 2005
Journal: Genes Dev
Title: Recruitment of the human TREX complex to mRNA during splicing.
Volume: 19
Issue: 13
Pages: 1512-7
Publication
First Author: Piruat JI
Year: 1998
Journal: EMBO J
Title: A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination.
Volume: 17
Issue: 16
Pages: 4859-72