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Search results 1 to 84 out of 84 for Thoc6

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Hits by Strain

Type Details Score
Gene
79228 | THOC6
Type: gene
Organism: human
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Gene
100498236 | thoc6
Type: gene
Organism: frog, western clawed
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Gene
107968770 | THOC6
Type: gene
Organism: chimpanzee
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Gene
79227 | Thoc6
Type: gene
Organism: rat
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Gene
479871 | THOC6
Type: gene
Organism: dog, domestic
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Gene
100125940 | THOC6
Type: gene
Organism: cattle
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Gene
100004014 | thoc6
Type: gene
Organism: zebrafish
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Gene
700217 | THOC6
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR042626 | THOC6
Type: Family
Description: In humans, THOC6 is a component of the THO subcomplex of the TREX complex []. The THO complex is a conserved RNA binding complex that has been implicated in mRNA export of subsets of mRNAs.It plays an essential role in dopamine synaptogenesis []. Mutations in the THOC6 genes have been linked to intellectual disability []. In flies, THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress [].
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Protein Coding Gene
MGI:2677480 | Thoc6
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
38388531 | J:345604
First Author: Werren EA
Year: 2024
Journal: Nat Commun
Title: TREX tetramer disruption alters RNA processing necessary for corticogenesis in THOC6 Intellectual Disability Syndrome.
Volume: 15
Issue: 1
Pages: 1640
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Publication
23621916 | -
 
First Author: Beaulieu CL
Year: 2013
Journal: Orphanet J Rare Dis
Title: Intellectual disability associated with a homozygous missense mutation in THOC6.
Volume: 8
Pages: 62
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Publication
30146163 | J:272720
First Author: Maeder CI
Year: 2018
Journal: Cell
Title: The THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival.
Volume: 174
Issue: 6
Pages: 1436-1449.e20
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Publication
11979277 | -
First Author: Strässer K
Year: 2002
Journal: Nature
Title: TREX is a conserved complex coupling transcription with messenger RNA export.
Volume: 417
Issue: 6886
Pages: 304-8
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Publication
15133499 | -
First Author: Rehwinkel J
Year: 2004
Journal: Nat Struct Mol Biol
Title: Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster.
Volume: 11
Issue: 6
Pages: 558-66
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Protein
Q5U4D9
Organism: Mus musculus/domesticus
Length: 341  
Fragment?: false
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Protein
D3Z132
Organism: Mus musculus/domesticus
Length: 337  
Fragment?: false
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Protein Coding Gene
MGP_CAROLIEiJ_G0021150 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0023261 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0023221 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0023191 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0023226 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0022986 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2677480 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0023669 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0022492 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0022962 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0023094 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0023061 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0023168 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0023080 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0023708 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0022240 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0022555 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0023467 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0022060 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
24315442 | J:204143
First Author: Wang L
Year: 2013
Journal: Cell Stem Cell
Title: The THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogramming.
Volume: 13
Issue: 6
Pages: 676-90
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Publication
38331934 | J:345229
First Author: Bhattacharjee R
Year: 2024
Journal: Nat Commun
Title: Compromised transcription-mRNA export factor THOC2 causes R-loop accumulation, DNA damage and adverse neurodevelopment.
Volume: 15
Issue: 1
Pages: 1210
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Publication
19501082 | J:152865
First Author: Georgas K
Year: 2009
Journal: Dev Biol
Title: Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment.
Volume: 332
Issue: 2
Pages: 273-86
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Publication
- | J:165963
     
First Author: Centre for Modeling Human Disease
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Centre for Modeling Human Disease (Cmhd), Institute of Biomaterials & Biomedical Engineering, University of Toronto
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Publication
- | J:157064
     
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
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Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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HT Experiment
GSE245121 | TREX tetramer disruption alters RNA processing necessary for corticogenesis in THOC6 Intellectual Disability Syndrome
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
10597251 | J:58748
First Author: Tamura T
Year: 1999
Journal: Oncogene
Title: FMIP, a novel Fms-interacting protein, affects granulocyte/macrophage differentiation.
Volume: 18
Issue: 47
Pages: 6488-95
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Protein
Q8BKT7
Organism: Mus musculus/domesticus
Length: 683  
Fragment?: false
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Protein
Q5SVF9
Organism: Mus musculus/domesticus
Length: 635  
Fragment?: false
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Protein
A0A0R4J0J6
Organism: Mus musculus/domesticus
Length: 683  
Fragment?: false
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Protein
Q5SVF8
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: true
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Publication
16983072 | -
First Author: Voynov V
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Genes with internal repeats require the THO complex for transcription.
Volume: 103
Issue: 39
Pages: 14423-8
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Publication
17095540 | -
First Author: Merz C
Year: 2007
Journal: RNA
Title: Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitment.
Volume: 13
Issue: 1
Pages: 116-28
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Protein Domain
IPR019163 | THO_Thoc5
Type: Family
Description: This entry represents Thoc5 which is one of the subunits of the THO complex, which additionally contains: HPR1, Thoc2, Thoc6 and Thoc7. The evolutionarily conserved multisubunit THO complex, which is recruited to actively transcribed genes is required for the efficient expression of genes that have internal tandem repeats. It is suggested that the THO complex functions to rectify aberrant structures that arise during transcription [, ]and is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress []. This entry also identifies the crucial 144 N-terminal residues of the FMIP protein, which is essential for the binding of the protein to the cytoplasmic domain of activated Fms-molecules in M-CSF induced haematopoietic differentiation of macrophages. The C terminus contains a putative nuclear localisation sequence and a leucine zipper which suggest further, as yet unknown, nuclear functions. The level of FMIP expression might form a threshold that determines whether cells differentiate into macrophages or into granulocytes [].
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Protein Domain
IPR021726 | THO_THOC2_N
Type: Domain
Description: The THO/TREX complex is the transcription- and export-related complex associated with spliceosomes that preferentially deal with spliced mRNAs as opposed to unspliced mRNAs. Thoc2 plays a role in RNA polymerase II (RNA pol II)-dependent transcription and is required for the stability of DNA repeats []. In humans, the TRE complex is comprised of the exon-junction-associated proteins Aly/REF and UAP56 together with the THO proteins THOC1 (hHpr1/p84), Thoc2 (hRlr1), THOC3 (hTex1), THOC5 (fSAP79), THOC6 (fSAP35), and THOC7 (fSAP24). Although much evidence indicates that the function of the TREX complex as an adaptor between the mRNA and components of the export machinery is conserved among eukaryotes, in Drosophila the majority of mRNAs can be exported from the nucleus independently of the THO complex []. This entry represents a conserved domain found towards the N terminus of these proteins.
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HT Experiment
GSE245539 | Compromised THOC2, a TREX mRNA export complex scaffold protein, leads to R-loop accumulation, DNA damage and adverse neurodevelopmental outcomes in mice and men
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein
B1AZI6
Organism: Mus musculus/domesticus
Length: 1594  
Fragment?: false
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Protein
E9Q5E2
Organism: Mus musculus/domesticus
Length: 1589  
Fragment?: false
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Protein
Q3UYT9
Organism: Mus musculus/domesticus
Length: 1017  
Fragment?: true
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Protein
Q3US09
Organism: Mus musculus/domesticus
Length: 921  
Fragment?: true
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Publication
15998806 | -
First Author: Masuda S
Year: 2005
Journal: Genes Dev
Title: Recruitment of the human TREX complex to mRNA during splicing.
Volume: 19
Issue: 13
Pages: 1512-7
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Publication
9707445 | -
First Author: Piruat JI
Year: 1998
Journal: EMBO J
Title: A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination.
Volume: 17
Issue: 16
Pages: 4859-72
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