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Search results 1 to 100 out of 101 for Tigit

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Categories

Hits by Strain

Hits by Category

Type Details Score
Gene
201633 | TIGIT
Type: gene
Organism: human
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Gene
363784 | Tigit
Type: gene
Organism: rat
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Gene
470887 | TIGIT
Type: gene
Organism: chimpanzee
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Gene
487986 | TIGIT
Type: gene
Organism: dog, domestic
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Gene
100140801 | TIGIT
Type: gene
Organism: cattle
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Gene
710941 | TIGIT
Type: gene
Organism: macaque, rhesus
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Gene
101734270 | tigit
Type: gene
Organism: frog, western clawed
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Protein Domain
IPR042948 | TIGIT
Type: Family
Description: T-cell immunoglobulin and ITIM domain receptor (TIGIT) is a surface protein and an inhibitory receptor that suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells []. It contains an immunoglobulin tail tyrosine (ITT)-like phosphorylation motif and an ITIM (immunoreceptor tyrosine-based inhibition motif) in its cytoplasmic tail. The identified ligands of TIGIT include the poliovirus receptor (PVR or CD155) and PVRL2 (Nectin2 or CD112). The TIGIT/PVR signaling has been shown to suppresses granule polarization and NK cell cytotoxicity [].
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Protein Coding Gene
MGI:3642260 | Tigit
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
19011627 | J:150317
First Author: Yu X
Year: 2009
Journal: Nat Immunol
Title: The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Volume: 10
Issue: 1
Pages: 48-57
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Publication
36930687 | J:334638
First Author: Gao Y
Year: 2023
Journal: PLoS Pathog
Title: Inhibition of hepatic natural killer cell function via the TIGIT receptor in schistosomiasis-induced liver fibrosis.
Volume: 19
Issue: 3
Pages: e1011242
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Publication
32152316 | J:287078
First Author: Schorer M
Year: 2020
Journal: Nat Commun
Title: TIGIT limits immune pathology during viral infections.
Volume: 11
Issue: 1
Pages: 1288
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Publication
21199897 | J:168902
First Author: Joller N
Year: 2011
Journal: J Immunol
Title: Cutting edge: TIGIT has T cell-intrinsic inhibitory functions.
Volume: 186
Issue: 3
Pages: 1338-42
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Publication
23677581 | J:201012
First Author: Stanietsky N
Year: 2013
Journal: Eur J Immunol
Title: Mouse TIGIT inhibits NK-cell cytotoxicity upon interaction with PVR.
Volume: 43
Issue: 8
Pages: 2138-50
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Publication
26413872 | J:227490
First Author: Kurtulus S
Year: 2015
Journal: J Clin Invest
Title: TIGIT predominantly regulates the immune response via regulatory T cells.
Volume: 125
Issue: 11
Pages: 4053-62
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Publication
37036426 | J:335476
 
First Author: Yamada T
Year: 2023
Journal: J Exp Med
Title: TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy.
Volume: 220
Issue: 7
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Publication
24912841 | J:295465
First Author: Bi J
Year: 2014
Journal: Hepatology
Title: TIGIT safeguards liver regeneration through regulating natural killer cell-hepatocyte crosstalk.
Volume: 60
Issue: 4
Pages: 1389-98
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Publication
29986909 | J:273406
First Author: Guillerey C
Year: 2018
Journal: Blood
Title: TIGIT immune checkpoint blockade restores CD8+ T-cell immunity against multiple myeloma.
Volume: 132
Issue: 16
Pages: 1689-1694
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Publication
28108989 | J:246724
First Author: Mao L
Year: 2017
Journal: Immunology
Title: TIGIT signalling pathway negatively regulates CD4+ T-cell responses in systemic lupus erythematosus.
Volume: 151
Issue: 3
Pages: 280-290
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Publication
25465800 | J:217453
First Author: Johnston RJ
Year: 2014
Journal: Cancer Cell
Title: The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function.
Volume: 26
Issue: 6
Pages: 923-937
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Publication
31919790 | J:295726
First Author: Wang N
Year: 2019
Journal: Immunol Res
Title: CD226 attenuates Treg suppressive capacity via CTLA-4 and TIGIT during EAE.
Volume: 67
Issue: 6
Pages: 486-496
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Publication
32668241 | J:301616
First Author: Xiao S
Year: 2020
Journal: Cell Rep
Title: Checkpoint Receptor TIGIT Expressed on Tim-1+ B Cells Regulates Tissue Inflammation.
Volume: 32
Issue: 2
Pages: 107892
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Publication
34011606 | J:316956
 
First Author: Sato K
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: DNAM-1 regulates Foxp3 expression in regulatory T cells by interfering with TIGIT under inflammatory conditions.
Volume: 118
Issue: 21
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Publication
33117369 | J:314544
 
First Author: Han JH
Year: 2020
Journal: Front Immunol
Title: Effective Anti-tumor Response by TIGIT Blockade Associated With FcγR Engagement and Myeloid Cell Activation.
Volume: 11
Pages: 573405
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Publication
31022697 | J:289231
First Author: Negishi N
Year: 2018
Journal: Immunohorizons
Title: CD155-Transducing Signaling through TIGIT Plays an Important Role in Transmission of Tolerant State and Suppression Capacity.
Volume: 2
Issue: 10
Pages: 338-348
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Publication
24745333 | J:209951
First Author: Joller N
Year: 2014
Journal: Immunity
Title: Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses.
Volume: 40
Issue: 4
Pages: 569-81
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Publication
29915296 | J:274576
First Author: Zhang Q
Year: 2018
Journal: Nat Immunol
Title: Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity.
Volume: 19
Issue: 7
Pages: 723-732
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Publication
24817116 | -
First Author: Li M
Year: 2014
Journal: J Biol Chem
Title: T-cell immunoglobulin and ITIM domain (TIGIT) receptor/poliovirus receptor (PVR) ligand engagement suppresses interferon-γ production of natural killer cells via β-arrestin 2-mediated negative signaling.
Volume: 289
Issue: 25
Pages: 17647-57
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Protein
P86176
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: false
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Protein
A0A0B4J1G6
Organism: Mus musculus/domesticus
Length: 241  
Fragment?: false
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Publication
30644386 | J:270552
First Author: Zong L
Year: 2019
Journal: Nat Commun
Title: Breakdown of adaptive immunotolerance induces hepatocellular carcinoma in HBsAg-tg mice.
Volume: 10
Issue: 1
Pages: 221
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Publication
24658051 | J:209990
First Author: Chan CJ
Year: 2014
Journal: Nat Immunol
Title: The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions.
Volume: 15
Issue: 5
Pages: 431-8
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Publication
24376654 | J:211124
First Author: Foks AC
Year: 2013
Journal: PLoS One
Title: Agonistic anti-TIGIT treatment inhibits T cell responses in LDLr deficient mice without affecting atherosclerotic lesion development.
Volume: 8
Issue: 12
Pages: e83134
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Publication
21416464 | J:175415
First Author: Levin SD
Year: 2011
Journal: Eur J Immunol
Title: Vstm3 is a member of the CD28 family and an important modulator of T-cell function.
Volume: 41
Issue: 4
Pages: 902-15
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Protein Coding Gene
MGP_CAROLIEiJ_G0020756 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0022828 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0022793 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0022765 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0022794 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0022558 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_3642260 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0023241 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0022084 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0022529 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0022661 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0022636 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0022729 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0022655 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0023256 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0021824 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0022128 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0016456 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0021655 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
24319005 | J:295466
First Author: Bi J
Year: 2014
Journal: Hepatology
Title: T-cell Ig and ITIM domain regulates natural killer cell activation in murine acute viral hepatitis.
Volume: 59
Issue: 5
Pages: 1715-25
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Publication
25818301 | J:228168
First Author: Martinet L
Year: 2015
Journal: Cell Rep
Title: DNAM-1 expression marks an alternative program of NK cell maturation.
Volume: 11
Issue: 1
Pages: 85-97
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Publication
30894377 | J:274776
First Author: Mittal D
Year: 2019
Journal: Cancer Immunol Res
Title: CD96 Is an Immune Checkpoint That Regulates CD8+ T-cell Antitumor Function.
Volume: 7
Issue: 4
Pages: 559-571
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Publication
26787820 | J:236840
First Author: Blake SJ
Year: 2016
Journal: Cancer Discov
Title: Suppression of Metastases Using a New Lymphocyte Checkpoint Target for Cancer Immunotherapy.
Volume: 6
Issue: 4
Pages: 446-59
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Publication
27760760 | J:238745
First Author: Nishikii H
Year: 2016
Journal: Blood
Title: DR3 signaling modulates the function of Foxp3+ regulatory T cells and the severity of acute graft-versus-host disease.
Volume: 128
Issue: 24
Pages: 2846-2858
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Publication
- | J:147112
     
First Author: Taconic
Year: 2006
Journal: MGI Direct Data Submission
Title: Information obtained from Taconic website.
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Publication
- | J:193309
       
First Author: Mouse Genome Informatics Scientfic Curators
Year: 2013
Title: Curated associations of genes in MGI and UniProt sequence records
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:82809
     
First Author: European Mouse Mutant Archive
Year: 2003
Journal: Unpublished
Title: Information obtained from the European Mouse Mutant Archive (EMMA)
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
31108170 | J:294439
 
First Author: Rudak PT
Year: 2019
Journal: Brain Behav Immun
Title: Stress-elicited glucocorticoid receptor signaling upregulates TIGIT in innate-like invariant T lymphocytes.
Volume: 80
Pages: 793-804
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Allele
Tigit<em1(cre/ERT2)Tebi> | MGI:7484293
Name: T cell immunoreceptor with Ig and ITIM domains; endonuclease-mediated mutation 1, Takashi Ebihara
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase
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Allele
Tigit<em4Smoc> | MGI:7292791
Name: T cell immunoreceptor with Ig and ITIM domains; endonuclease-mediated mutation 4, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Tigit<em1Smoc> | MGI:7292789
Name: T cell immunoreceptor with Ig and ITIM domains; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Tigit<tm3(TIGIT)Smoc> | MGI:7292792
Name: T cell immunoreceptor with Ig and ITIM domains; targeted mutation 3, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:6355257 | C57BL/6J-Tigit<em4Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Tigit<em2(TIGIT)Smoc> | MGI:7292790
Name: T cell immunoreceptor with Ig and ITIM domains; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:6476465 | C57BL/6J-Tigit<tm3(TIGIT)Smoc>/Smoc
Attribute String: coisogenic, targeted mutation, mutant strain
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tigit/Tigit<+>
Background: involves: 129S6/SvEvTac * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
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Publication
26755705 | J:243463
First Author: Zhu Y
Year: 2016
Journal: J Exp Med
Title: Identification of CD112R as a novel checkpoint for human T cells.
Volume: 213
Issue: 2
Pages: 167-76
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Publication
26975663 | J:232395
 
First Author: Serr I
Year: 2016
Journal: Nat Commun
Title: Type 1 diabetes vaccine candidates promote human Foxp3(+)Treg induction in humanized mice.
Volume: 7
Pages: 10991
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Publication
37330549 | J:347041
First Author: Zhu F
Year: 2023
Journal: Nat Commun
Title: Spatiotemporal resolution of germinal center Tfh cell differentiation and divergence from central memory CD4(+) T cell fate.
Volume: 14
Issue: 1
Pages: 3611
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Publication
28290453 | J:244924
 
First Author: Downs-Canner S
Year: 2017
Journal: Nat Commun
Title: Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells.
Volume: 8
Pages: 14649
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Publication
37730678 | J:340766
First Author: Botta C
Year: 2023
Journal: Nat Commun
Title: Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance.
Volume: 14
Issue: 1
Pages: 5825
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Publication
32040157 | J:289912
 
First Author: Okumura G
Year: 2020
Journal: J Exp Med
Title: Tumor-derived soluble CD155 inhibits DNAM-1-mediated antitumor activity of natural killer cells.
Volume: 217
Issue: 4
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Publication
33687987 | J:305679
First Author: Alteber Z
Year: 2021
Journal: Cancer Discov
Title: Therapeutic Targeting of Checkpoint Receptors within the DNAM1 Axis.
Volume: 11
Issue: 5
Pages: 1040-1051
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Publication
27503073 | J:236730
First Author: Lenac Rovis T
Year: 2016
Journal: J Exp Med
Title: Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection.
Volume: 213
Issue: 9
Pages: 1835-50
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Publication
33831432 | J:312410
First Author: Luci C
Year: 2021
Journal: J Invest Dermatol
Title: Cutaneous Squamous Cell Carcinoma Development Is Associated with a Temporal Infiltration of ILC1 and NK Cells with Immune Dysfunctions.
Volume: 141
Issue: 10
Pages: 2369-2379
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Publication
30833348 | J:291417
First Author: Lahmann A
Year: 2019
Journal: J Immunol
Title: Bach2 Controls T Follicular Helper Cells by Direct Repression of Bcl-6.
Volume: 202
Issue: 8
Pages: 2229-2239
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Publication
31883911 | J:293695
 
First Author: O'Donnell JS
Year: 2020
Journal: Semin Cancer Biol
Title: Tumor intrinsic and extrinsic immune functions of CD155.
Volume: 65
Pages: 189-196
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Publication
32043568 | J:299864
First Author: Chiang EY
Year: 2020
Journal: Eur J Immunol
Title: CD96 functions as a co-stimulatory receptor to enhance CD8+ T cell activation and effector responses.
Volume: 50
Issue: 6
Pages: 891-902
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Publication
37344597 | J:340081
First Author: Bod L
Year: 2023
Journal: Nature
Title: B-cell-specific checkpoint molecules that regulate anti-tumour immunity.
Volume: 619
Issue: 7969
Pages: 348-356
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Publication
26735971 | J:252023
First Author: Yasuma K
Year: 2016
Journal: PLoS Pathog
Title: HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T Cell Immunoglobulin and ITIM Domain (TIGIT).
Volume: 12
Issue: 1
Pages: e1005372
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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