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Search results 1 to 100 out of 608 for Timp2

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0.044s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: TIMP-2 is a serine protease inhibitor that inhibits MMPs. It is known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19 []. As opposed to other TIMPs, TIMP-2 abrogates angiogenic factor-induced endothelial cell proliferation in vitro and angiogenesis in vivo independent of MMP inhibition. These effects require alpha 3 beta 1 integrin-mediated binding of TIMP-2 to endothelial cells. Further, TIMP-2 induces a decrease in total protein tyrosine phosphatase (PTP) activity associated with beta1 integrin subunits as well as dissociation of the phosphatase SHP-1 from beta1. TIMP-2 treatment also results in a concomitant increase in PTP activity associated with tyrosine kinase receptors FGFR-1 and KDR [].Tissue inhibitors of metalloproteinases (TIMPs) are natural inhibitors of matrix metalloproteinases (MMPs) found in most tissues and body fluids. By inhibiting MMPs activities, they participate in tissue remodeling of the extracellular matrix (ECM). The balance between MMPs and TIMPs activities is involved in both normal and pathological events such as wound healing, tissue remodeling, angiogenesis, invasion, tumourigenesis and metastasis []. TIMPs also exhibit functions that appear to be independent of their metalloproteinase inhibitory capacity []. There are four mammalian TIMPs (TIMP-1 to -4), and each TIMP has its own profile of metalloproteinase inhibition.
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication      
First Author: Ferreira AC
Year: 2023
Journal: Mol Psychiatry
Title: Neuronal TIMP2 regulates hippocampus-dependent plasticity and extracellular matrix complexity.
Publication
First Author: Jiang N
Year: 2022
Journal: FASEB J
Title: TIMP2 mediates endoplasmic reticulum stress contributing to sepsis-induced acute kidney injury.
Volume: 36
Issue: 4
Pages: e22228
Publication
First Author: Wang Z
Year: 2014
Journal: Kidney Int
Title: TIMP2 and TIMP3 have divergent roles in early renal tubulointerstitial injury.
Volume: 85
Issue: 1
Pages: 82-93
Publication
First Author: Mi M
Year: 2012
Journal: Biochem Biophys Res Commun
Title: TIMP2 deficient mice develop accelerated osteoarthritis via promotion of angiogenesis upon destabilization of the medial meniscus.
Volume: 423
Issue: 2
Pages: 366-72
Publication
First Author: Fan D
Year: 2014
Journal: Cardiovasc Res
Title: Differential role of TIMP2 and TIMP3 in cardiac hypertrophy, fibrosis, and diastolic dysfunction.
Volume: 103
Issue: 2
Pages: 268-80
Publication
First Author: Kandalam V
Year: 2010
Journal: Circ Res
Title: TIMP2 deficiency accelerates adverse post-myocardial infarction remodeling because of enhanced MT1-MMP activity despite lack of MMP2 activation.
Volume: 106
Issue: 4
Pages: 796-808
Protein
Organism: Mus musculus/domesticus
Length: 220  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 220  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 95  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 143  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 220  
Fragment?: false
Publication
First Author: Lambert E
Year: 2004
Journal: Crit Rev Oncol Hematol
Title: TIMPs as multifacial proteins.
Volume: 49
Issue: 3
Pages: 187-98
Publication
First Author: Seo DW
Year: 2003
Journal: Cell
Title: TIMP-2 mediated inhibition of angiogenesis: an MMP-independent mechanism.
Volume: 114
Issue: 2
Pages: 171-80
Publication
First Author: Chattopadhyay N
Year: 2001
Journal: J Cancer Res Clin Oncol
Title: Human cervical tumor cell (SiHa) surface alphavbeta3 integrin receptor has associated matrix metalloproteinase (MMP-2) activity.
Volume: 127
Issue: 11
Pages: 653-8
Publication
First Author: Pushpakumar S
Year: 2013
Journal: J Hypertens
Title: Angiotensin-II induced hypertension and renovascular remodelling in tissue inhibitor of metalloproteinase 2 knockout mice.
Volume: 31
Issue: 11
Pages: 2270-81; discussion 2281
Publication
First Author: Li SH
Year: 2013
Journal: FASEB J
Title: miR-17 targets tissue inhibitor of metalloproteinase 1 and 2 to modulate cardiac matrix remodeling.
Volume: 27
Issue: 10
Pages: 4254-65
Publication
First Author: Castellano JM
Year: 2017
Journal: Nature
Title: Human umbilical cord plasma proteins revitalize hippocampal function in aged mice.
Volume: 544
Issue: 7651
Pages: 488-492
Publication
First Author: Guan Y
Year: 2010
Journal: PLoS Comput Biol
Title: Functional genomics complements quantitative genetics in identifying disease-gene associations.
Volume: 6
Issue: 11
Pages: e1000991
Publication
First Author: Kandalam V
Year: 2011
Journal: Circulation
Title: Lack of tissue inhibitor of metalloproteinases 2 leads to exacerbated left ventricular dysfunction and adverse extracellular matrix remodeling in response to biomechanical stress.
Volume: 124
Issue: 19
Pages: 2094-105
Publication  
First Author: Flood HM
Year: 2019
Journal: Biol Open
Title: The Forkhead box F1 transcription factor inhibits collagen deposition and accumulation of myofibroblasts during liver fibrosis.
Volume: 8
Issue: 2
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Shimizu S
Year: 1992
Journal: Gene
Title: Cloning and sequencing of the cDNA encoding a mouse tissue inhibitor of metalloproteinase-2.
Volume: 114
Issue: 2
Pages: 291-2
Publication
First Author: Leco KJ
Year: 1992
Journal: Gene
Title: Differential regulation of TIMP-1 and TIMP-2 mRNA expression in normal and Ha-ras-transformed murine fibroblasts.
Volume: 117
Issue: 2
Pages: 209-17
Publication
First Author: Williamson RA
Year: 1994
Journal: Biochemistry
Title: Solution structure of the active domain of tissue inhibitor of metalloproteinases-2. A new member of the OB fold protein family.
Volume: 33
Issue: 39
Pages: 11745-59
Publication
First Author: Caterina JJ
Year: 2000
Journal: J Biol Chem
Title: Inactivating mutation of the mouse tissue inhibitor of metalloproteinases-2(Timp-2) gene alters proMMP-2 activation.
Volume: 275
Issue: 34
Pages: 26416-22
Publication
First Author: Jaworski DM
Year: 2005
Journal: Brain Res
Title: Prepulse inhibition and fear-potentiated startle are altered in tissue inhibitor of metalloproteinase-2 (TIMP-2) knockout mice.
Volume: 1051
Issue: 1-2
Pages: 81-9
Publication
First Author: Wang Z
Year: 2000
Journal: J Biol Chem
Title: TIMP-2 is required for efficient activation of proMMP-2 in vivo.
Volume: 275
Issue: 34
Pages: 26411-5
Publication
First Author: Jaworski DM
Year: 2011
Journal: Endocrinology
Title: Sexually dimorphic diet-induced insulin resistance in obese tissue inhibitor of metalloproteinase-2 (TIMP-2)-deficient mice.
Volume: 152
Issue: 4
Pages: 1300-13
Publication
First Author: De Clerck Y
Year: 1992
Journal: Genomics
Title: The gene for tissue inhibitor of metalloproteinases-2 is localized on human chromosome arm 17q25.
Volume: 14
Issue: 3
Pages: 782-4
Publication
First Author: Fujimoto N
Year: 1995
Journal: J Immunol Methods
Title: Determination of tissue inhibitor of metalloproteinases-2 (TIMP-2) in experimental animals using monoclonal antibodies against TIMP-2-specific oligopeptides.
Volume: 187
Issue: 1
Pages: 33-9
Publication
First Author: Imren S
Year: 1996
Journal: Cancer Res
Title: Overexpression of tissue inhibitor of metalloproteinases-2 retroviral-mediated gene transfer in vivo inhibits tumor growth and invasion.
Volume: 56
Issue: 13
Pages: 2891-5
Publication
First Author: Zhang J
Year: 2003
Journal: Dev Genes Evol
Title: The expression of tissue inhibitor of metalloproteinase 2 (TIMP-2) is required for normal development of zebrafish embryos.
Volume: 213
Issue: 8
Pages: 382-9
GXD Expression    
Probe: MGI:1329135
Assay Type: RT-PCR
Annotation Date: 1999-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360411
Stage: TS01
Assay Id: MGI:1335407
Age: embryonic day 1.0
Image: 1
Specimen Label: 2
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:1329135
Assay Type: RT-PCR
Annotation Date: 1999-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:1335407
Age: embryonic day 2.0
Image: 1
Specimen Label: 3
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:1329135
Assay Type: RT-PCR
Annotation Date: 1999-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:1335407
Age: embryonic day 3.0
Image: 1
Specimen Label: 4
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:1329135
Assay Type: RT-PCR
Annotation Date: 1999-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:1335407
Age: embryonic day 4.0
Image: 1
Specimen Label: 5
Detected: true
Specimen Num: 6
GXD Expression        
Probe: MGI:2651530
Assay Type: Northern blot
Annotation Date: 2003-03-17
Strength: Not Specified
Sex: Female
Emaps: EMAPS:3278228
Stage: TS28
Assay Id: MGI:2651534
Age: postnatal adult
Specimen Label: bone
Specimen Num: 1
GXD Expression      
Probe: MGI:2651530
Assay Type: Northern blot
Annotation Date: 2003-03-17
Strength: Present
Sex: Female
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2651534
Age: postnatal adult
Specimen Label: brain
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2651530
Assay Type: Northern blot
Annotation Date: 2003-03-17
Strength: Present
Sex: Female
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2651534
Age: postnatal adult
Specimen Label: heart
Detected: true
Specimen Num: 3
GXD Expression        
Probe: MGI:2651530
Assay Type: Northern blot
Annotation Date: 2003-03-17
Strength: Not Specified
Sex: Female
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2651534
Age: postnatal adult
Specimen Label: kidney
Specimen Num: 4
GXD Expression        
Probe: MGI:2651530
Assay Type: Northern blot
Annotation Date: 2003-03-17
Strength: Not Specified
Sex: Female
Emaps: EMAPS:1925228
Stage: TS28
Assay Id: MGI:2651534
Age: postnatal adult
Specimen Label: lg int
Specimen Num: 5
GXD Expression        
Probe: MGI:2651530
Assay Type: Northern blot
Annotation Date: 2003-03-17
Strength: Not Specified
Sex: Female
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2651534
Age: postnatal adult
Specimen Label: liver
Specimen Num: 6
GXD Expression      
Probe: MGI:2651530
Assay Type: Northern blot
Annotation Date: 2003-03-17
Strength: Present
Sex: Female
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2651534
Age: postnatal adult
Specimen Label: lung
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:2651530
Assay Type: Northern blot
Annotation Date: 2003-03-17
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:2651534
Age: postnatal adult
Specimen Label: ovary
Detected: true
Specimen Num: 8
GXD Expression        
Probe: MGI:2651530
Assay Type: Northern blot
Annotation Date: 2003-03-17
Strength: Not Specified
Sex: Female
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2651534
Age: postnatal adult
Specimen Label: sk muscle
Specimen Num: 9
GXD Expression        
Probe: MGI:2651530
Assay Type: Northern blot
Annotation Date: 2003-03-17
Strength: Not Specified
Sex: Female
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:2651534
Age: postnatal adult
Specimen Label: skin
Specimen Num: 10
GXD Expression      
Probe: MGI:2651530
Assay Type: Northern blot
Annotation Date: 2003-03-17
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:2651534
Age: postnatal month 9
Specimen Label: testis
Detected: true
Specimen Num: 11
GXD Expression        
Probe: MGI:2651530
Assay Type: Northern blot
Annotation Date: 2003-03-17
Strength: Not Specified
Sex: Female
Emaps: EMAPS:2991528
Stage: TS28
Assay Id: MGI:2651534
Age: postnatal adult
Specimen Label: uterus
Specimen Num: 12
GXD Expression      
Probe: MGI:2669485
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Present
Sex: Pooled
Emaps: EMAPS:1736220
Stage: TS20
Assay Id: MGI:2669535
Age: embryonic day 12.5
Specimen Label: None
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2669485
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Present
Sex: Pooled
Emaps: EMAPS:1736221
Stage: TS21
Assay Id: MGI:2669535
Age: embryonic day 13.5
Specimen Label: None
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2669485
Assay Type: RT-PCR
Annotation Date: 2003-08-19
Strength: Present
Sex: Pooled
Emaps: EMAPS:1736222
Stage: TS22
Assay Id: MGI:2669535
Age: embryonic day 14.5
Specimen Label: None
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:2687313
Assay Type: RT-PCR
Annotation Date: 2004-02-03
Strength: Present
Sex: Male
Emaps: EMAPS:1674419
Stage: TS19
Assay Id: MGI:2687431
Age: embryonic day 11.5
Specimen Label: 11.5 dpc male gonad
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2687313
Assay Type: RT-PCR
Annotation Date: 2004-02-03
Strength: Present
Sex: Male
Emaps: EMAPS:1738319
Stage: TS19
Assay Id: MGI:2687431
Age: embryonic day 11.5
Specimen Label: 11.5 dpc male gonad
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2687313
Assay Type: RT-PCR
Annotation Date: 2004-02-03
Strength: Present
Sex: Female
Emaps: EMAPS:1674419
Stage: TS19
Assay Id: MGI:2687431
Age: embryonic day 11.5
Specimen Label: 11.5 dpc female gonad
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2687313
Assay Type: RT-PCR
Annotation Date: 2004-02-03
Strength: Present
Sex: Female
Emaps: EMAPS:1738319
Stage: TS19
Assay Id: MGI:2687431
Age: embryonic day 11.5
Specimen Label: 11.5 dpc female gonad
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2687313
Assay Type: RT-PCR
Annotation Date: 2004-02-03
Strength: Present
Sex: Male
Emaps: EMAPS:1797227
Stage: TS27
Assay Id: MGI:2687431
Age: postnatal day 1
Specimen Label: 1 dpp testes
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:2687345
Assay Type: Western blot
Annotation Date: 2004-02-04
Strength: Present
Sex: Male
Emaps: EMAPS:1674419
Stage: TS19
Assay Id: MGI:3026609
Age: embryonic day 11.5
Image: 2
Specimen Label: 11.5 M
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:2687345
Assay Type: Western blot
Annotation Date: 2004-02-04
Strength: Present
Sex: Male
Emaps: EMAPS:1738319
Stage: TS19
Assay Id: MGI:3026609
Age: embryonic day 11.5
Image: 2
Specimen Label: 11.5 M
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:2687345
Assay Type: Western blot
Annotation Date: 2004-02-04
Strength: Present
Sex: Female
Emaps: EMAPS:1674419
Stage: TS19
Assay Id: MGI:3026609
Age: embryonic day 11.5
Image: 2
Specimen Label: 11.5 F
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:2687345
Assay Type: Western blot
Annotation Date: 2004-02-04
Strength: Present
Sex: Female
Emaps: EMAPS:1738319
Stage: TS19
Assay Id: MGI:3026609
Age: embryonic day 11.5
Image: 2
Specimen Label: 11.5 F
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:2687345
Assay Type: Western blot
Annotation Date: 2004-02-04
Strength: Present
Sex: Male
Emaps: EMAPS:1674420
Stage: TS20
Assay Id: MGI:3026609
Age: embryonic day 12.5
Image: 2
Specimen Label: 12.5 M
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:2687345
Assay Type: Western blot
Annotation Date: 2004-02-04
Strength: Present
Sex: Male
Emaps: EMAPS:1797220
Stage: TS20
Assay Id: MGI:3026609
Age: embryonic day 12.5
Image: 2
Specimen Label: 12.5 M
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:2687345
Assay Type: Western blot
Annotation Date: 2004-02-04
Strength: Present
Sex: Female
Emaps: EMAPS:1674420
Stage: TS20
Assay Id: MGI:3026609
Age: embryonic day 12.5
Image: 2
Specimen Label: 12.5 F
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:2687345
Assay Type: Western blot
Annotation Date: 2004-02-04
Strength: Present
Sex: Female
Emaps: EMAPS:1796220
Stage: TS20
Assay Id: MGI:3026609
Age: embryonic day 12.5
Image: 2
Specimen Label: 12.5 F
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:2687345
Assay Type: Western blot
Annotation Date: 2004-02-04
Strength: Present
Sex: Male
Emaps: EMAPS:1674421
Stage: TS21
Assay Id: MGI:3026609
Age: embryonic day 13.5
Image: 2
Specimen Label: 13.5 M
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:2687345
Assay Type: Western blot
Annotation Date: 2004-02-04
Strength: Present
Sex: Male
Emaps: EMAPS:1797221
Stage: TS21
Assay Id: MGI:3026609
Age: embryonic day 13.5
Image: 2
Specimen Label: 13.5 M
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:2687345
Assay Type: Western blot
Annotation Date: 2004-02-04
Strength: Present
Sex: Female
Emaps: EMAPS:1674421
Stage: TS21
Assay Id: MGI:3026609
Age: embryonic day 13.5
Image: 2
Specimen Label: 13.5 F
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:2687345
Assay Type: Western blot
Annotation Date: 2004-02-04
Strength: Present
Sex: Female
Emaps: EMAPS:1796221
Stage: TS21
Assay Id: MGI:3026609
Age: embryonic day 13.5
Image: 2
Specimen Label: 13.5 F
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:2687345
Assay Type: Western blot
Annotation Date: 2004-02-04
Strength: Present
Sex: Male
Emaps: EMAPS:1674422
Stage: TS22
Assay Id: MGI:3026609
Age: embryonic day 14.5
Image: 2
Specimen Label: 14.5 M
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:2687345
Assay Type: Western blot
Annotation Date: 2004-02-04
Strength: Present
Sex: Male
Emaps: EMAPS:1797222
Stage: TS22
Assay Id: MGI:3026609
Age: embryonic day 14.5
Image: 2
Specimen Label: 14.5 M
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:2687345
Assay Type: Western blot
Annotation Date: 2004-02-04
Strength: Present
Sex: Female
Emaps: EMAPS:1674422
Stage: TS22
Assay Id: MGI:3026609
Age: embryonic day 14.5
Image: 2
Specimen Label: 14.5 F
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:2687345
Assay Type: Western blot
Annotation Date: 2004-02-04
Strength: Present
Sex: Female
Emaps: EMAPS:1796222
Stage: TS22
Assay Id: MGI:3026609
Age: embryonic day 14.5
Image: 2
Specimen Label: 14.5 F
Detected: true
Specimen Num: 8