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Search results 1 to 100 out of 2112 for Tlr2

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
7097 | TLR2
Type: gene
Organism: human
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Gene
100485771 | tlr2
Type: gene
Organism: frog, western clawed
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Gene
key_42872 | TLR2
Type: gene
Organism: hamster, Chinese
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Gene
310553 | Tlr2
Type: gene
Organism: rat
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Gene
448807 | TLR2
Type: gene
Organism: dog, domestic
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Gene
471325 | TLR2
Type: gene
Organism: chimpanzee
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Gene
281534 | TLR2
Type: gene
Organism: cattle
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Gene
769014 | TLR2
Type: gene
Organism: chicken
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Gene
403125 | tlr2
Type: gene
Organism: zebrafish
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Gene
574290 | TLR2
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR027185 | TLR2
Type: Family
Description: Toll-like receptor 2 (TLR2) is a member of the Toll-like receptor (TLR) family, which plays a role in activation of innate immunity and pathogen recognition []. It helps mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components, acting via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response [, , , ]. TLR2 in association with TLR1 or TLR6 is essential for recognising bacterial lipoproteins and lipopeptides [, ]. It also promotes apoptosis in response to lipoproteins [].Genetic variations in TLR2 are associated with susceptibility to leprosy, a chronic disease associated with depressed cellular (but not humoral) immunity [, ].
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Protein Coding Gene
MGI:1346060 | Tlr2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
11431423 | J:70578
First Author: Takeuchi O
Year: 2001
Journal: Int Immunol
Title: Discrimination of bacterial lipoproteins by Toll-like receptor 6.
Volume: 13
Issue: 7
Pages: 933-40
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Publication
12077222 | J:103395
First Author: Takeuchi O
Year: 2002
Journal: J Immunol
Title: Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins.
Volume: 169
Issue: 1
Pages: 10-4
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Publication
17449723 | -
First Author: Sheedy FJ
Year: 2007
Journal: J Leukoc Biol
Title: The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling.
Volume: 82
Issue: 2
Pages: 196-203
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Publication
12610729 | -
First Author: Droemann D
Year: 2003
Journal: Histochem Cell Biol
Title: Toll-like receptor 2 is expressed by alveolar epithelial cells type II and macrophages in the human lung.
Volume: 119
Issue: 2
Pages: 103-8
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Publication
18177245 | -
First Author: Bochud PY
Year: 2008
Journal: J Infect Dis
Title: Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy.
Volume: 197
Issue: 2
Pages: 253-61
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Publication
10426996 | -
First Author: Aliprantis AO
Year: 1999
Journal: Science
Title: Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2.
Volume: 285
Issue: 5428
Pages: 736-9
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Publication
12646604 | -
First Author: Bochud PY
Year: 2003
Journal: J Immunol
Title: Cutting edge: a Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling.
Volume: 170
Issue: 7
Pages: 3451-4
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Publication
12594207 | -
First Author: Schröder NW
Year: 2003
Journal: J Biol Chem
Title: Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved.
Volume: 278
Issue: 18
Pages: 15587-94
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Publication
11680785 | -
First Author: Kirschning CJ
Year: 2001
Journal: Int J Med Microbiol
Title: Toll-like receptors: cellular signal transducers for exogenous molecular patterns causing immune responses.
Volume: 291
Issue: 4
Pages: 251-60
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Publication
10426995 | -
First Author: Brightbill HD
Year: 1999
Journal: Science
Title: Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.
Volume: 285
Issue: 5428
Pages: 732-6
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Protein
Q9QUN7
Organism: Mus musculus/domesticus
Length: 784  
Fragment?: false
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Protein
Q811T5
Organism: Mus musculus/domesticus
Length: 784  
Fragment?: false
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Protein
Q8K3D9
Organism: Mus musculus/domesticus
Length: 784  
Fragment?: false
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Protein
G3X8Y8
Organism: Mus musculus/domesticus
Length: 784  
Fragment?: false
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Publication
17475877 | J:146111
First Author: Hoffmann O
Year: 2007
Journal: J Immunol
Title: TLR2 mediates neuroinflammation and neuronal damage.
Volume: 178
Issue: 10
Pages: 6476-81
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Publication
21998452 | J:179628
First Author: Kim DH
Year: 2011
Journal: J Immunol
Title: Inhibition of autoimmune diabetes by TLR2 tolerance.
Volume: 187
Issue: 10
Pages: 5211-20
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Publication
22110384 | J:287964
First Author: Reyes JL
Year: 2011
Journal: Int J Biol Sci
Title: TLR2 mediates immunity to experimental cysticercosis.
Volume: 7
Issue: 9
Pages: 1323-33
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Publication
22442665 | J:187039
First Author: Do KN
Year: 2012
Journal: PLoS One
Title: TLR2 controls intestinal carcinogen detoxication by CYP1A1.
Volume: 7
Issue: 3
Pages: e32309
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Publication
17513716 | J:147852
First Author: Imanishi T
Year: 2007
Journal: J Immunol
Title: Cutting edge: TLR2 directly triggers Th1 effector functions.
Volume: 178
Issue: 11
Pages: 6715-9
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GXD Expression
GXD Expression
     
Probe: MGI:6185206
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6191486
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Tlr2
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6185206
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6191486
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Tlr2
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6185206
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:6191486
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Tlr2
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:6185206
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6191486
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Tlr2
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:6185206
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6191486
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Tlr2
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:6185206
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6191486
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Tlr2
Detected: false
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:6185206
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6191486
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Tlr2
Detected: false
Specimen Num: 7
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Publication
21454454 | J:174725
First Author: Beaulieu LM
Year: 2011
Journal: Blood
Title: Regulatory effects of TLR2 on megakaryocytic cell function.
Volume: 117
Issue: 22
Pages: 5963-74
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Publication
12825894 | J:119038
First Author: Sugawara I
Year: 2003
Journal: Microbiol Immunol
Title: Mycobacterial infection in TLR2 and TLR6 knockout mice.
Volume: 47
Issue: 5
Pages: 327-36
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Publication
26884587 | J:231520
First Author: Shmuel-Galia L
Year: 2016
Journal: EMBO J
Title: Neutralization of pro-inflammatory monocytes by targeting TLR2 dimerization ameliorates colitis.
Volume: 35
Issue: 6
Pages: 685-98
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Publication
16785538 | J:134400
First Author: Pecora ND
Year: 2006
Journal: J Immunol
Title: Mycobacterium tuberculosis LprA is a lipoprotein agonist of TLR2 that regulates innate immunity and APC function.
Volume: 177
Issue: 1
Pages: 422-9
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Publication
16825490 | J:140459
First Author: Yadav M
Year: 2006
Journal: Blood
Title: The beta-glucan receptor dectin-1 functions together with TLR2 to mediate macrophage activation by mycobacteria.
Volume: 108
Issue: 9
Pages: 3168-75
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Publication
15843573 | J:98456
First Author: Chu HW
Year: 2005
Journal: J Immunol
Title: TLR2 signaling is critical for Mycoplasma pneumoniae-induced airway mucin expression.
Volume: 174
Issue: 9
Pages: 5713-9
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Publication
16167081 | J:101532
First Author: Leemans JC
Year: 2005
Journal: J Clin Invest
Title: Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney.
Volume: 115
Issue: 10
Pages: 2894-903
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Publication
25596131 | J:220342
First Author: Maruyama A
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Pam2 lipopeptides systemically increase myeloid-derived suppressor cells through TLR2 signaling.
Volume: 457
Issue: 3
Pages: 445-50
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Publication
24892697 | J:218134
First Author: Mariano VS
Year: 2014
Journal: PLoS One
Title: Recognition of TLR2 N-glycans: critical role in ArtinM immunomodulatory activity.
Volume: 9
Issue: 6
Pages: e98512
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Publication
25539820 | J:331031
First Author: Pope MR
Year: 2015
Journal: J Immunol
Title: TLR2 modulates antibodies required for intestinal ischemia/reperfusion-induced damage and inflammation.
Volume: 194
Issue: 3
Pages: 1190-8
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Publication
20456021 | J:162497
First Author: Okun E
Year: 2010
Journal: J Neurochem
Title: TLR2 activation inhibits embryonic neural progenitor cell proliferation.
Volume: 114
Issue: 2
Pages: 462-74
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Publication
24780563 | J:214006
 
First Author: Bai Y
Year: 2014
Journal: Neurosci Lett
Title: TLR2 signaling directs NO-dependent MMP-9 induction in mouse microglia.
Volume: 571
Pages: 5-10
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Publication
23261454 | J:193847
First Author: Park DW
Year: 2013
Journal: Biochem Biophys Res Commun
Title: TLR2 stimulates ABCA1 expression via PKC-η and PLD2 pathway.
Volume: 430
Issue: 3
Pages: 933-7
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Publication
24058595 | J:207544
First Author: Sun X
Year: 2013
Journal: PLoS One
Title: TLR2 mediates Helicobacter pylori-induced tolerogenic immune response in mice.
Volume: 8
Issue: 9
Pages: e74595
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Publication
35362478 | J:327264
 
First Author: Matsumoto Y
Year: 2022
Journal: J Clin Invest
Title: Tankyrase represses autoinflammation through the attenuation of TLR2 signaling.
Volume: 132
Issue: 7
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Publication
19889726 | J:157121
First Author: Cole LE
Year: 2010
Journal: J Leukoc Biol
Title: Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signaling.
Volume: 87
Issue: 2
Pages: 275-81
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Publication
23446149 | J:200794
First Author: Huang QQ
Year: 2013
Journal: J Leukoc Biol
Title: TLR2 deletion promotes arthritis through reduction of IL-10.
Volume: 93
Issue: 5
Pages: 751-9
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Publication
25600646 | J:317002
First Author: Li S
Year: 2015
Journal: Cancer Res
Title: TLR2 limits development of hepatocellular carcinoma by reducing IL18-mediated immunosuppression.
Volume: 75
Issue: 6
Pages: 986-95
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Publication
33963333 | J:308903
First Author: Zheng M
Year: 2021
Journal: Nat Immunol
Title: TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines.
Volume: 22
Issue: 7
Pages: 829-838
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Publication
23264656 | J:192608
First Author: Papadopoulos G
Year: 2013
Journal: J Immunol
Title: Macrophage-specific TLR2 signaling mediates pathogen-induced TNF-dependent inflammatory oral bone loss.
Volume: 190
Issue: 3
Pages: 1148-57
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Publication
24227629 | J:208990
First Author: Teixeira-Coelho M
Year: 2014
Journal: Eur J Immunol
Title: Differential post-transcriptional regulation of IL-10 by TLR2 and TLR4-activated macrophages.
Volume: 44
Issue: 3
Pages: 856-66
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Publication
19122641 | J:143870
First Author: Kim S
Year: 2009
Journal: Nature
Title: Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis.
Volume: 457
Issue: 7225
Pages: 102-6
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Publication
38015955 | J:343261
First Author: Wyczanska M
Year: 2023
Journal: PLoS One
Title: TLR2 mediates renal apoptosis in neonatal mice subjected experimentally to obstructive nephropathy.
Volume: 18
Issue: 11
Pages: e0294142
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Publication
21611194 | J:172733
First Author: Lugade AA
Year: 2011
Journal: PLoS One
Title: Lipid motif of a bacterial antigen mediates immune responses via TLR2 signaling.
Volume: 6
Issue: 5
Pages: e19781
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Publication
20421349 | J:176095
First Author: Ha T
Year: 2010
Journal: Cardiovasc Res
Title: TLR2 ligands induce cardioprotection against ischaemia/reperfusion injury through a PI3K/Akt-dependent mechanism.
Volume: 87
Issue: 4
Pages: 694-703
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Publication
21282508 | J:169379
First Author: Henn A
Year: 2011
Journal: J Immunol
Title: TLR2 hypersensitivity of astrocytes as functional consequence of previous inflammatory episodes.
Volume: 186
Issue: 5
Pages: 3237-47
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Publication
31954829 | J:291794
 
First Author: Wang TT
Year: 2020
Journal: Neuroscience
Title: Activation of Different Heterodimers of TLR2 Distinctly Mediates Pain and Itch.
Volume: 429
Pages: 245-255
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Publication
19841034 | J:158035
First Author: Himes RW
Year: 2010
Journal: FASEB J
Title: Tlr2 is critical for diet-induced metabolic syndrome in a murine model.
Volume: 24
Issue: 3
Pages: 731-9
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Publication
16849506 | J:138399
First Author: Brown HJ
Year: 2006
Journal: J Immunol
Title: TLR2 stimulation of intrinsic renal cells in the induction of immune-mediated glomerulonephritis.
Volume: 177
Issue: 3
Pages: 1925-31
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Publication
20733560 | J:165445
First Author: Dasu MR
Year: 2010
Journal: Lab Invest
Title: TLR2 expression and signaling-dependent inflammation impair wound healing in diabetic mice.
Volume: 90
Issue: 11
Pages: 1628-36
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Publication
24098333 | J:209043
First Author: Lin H
Year: 2013
Journal: PLoS One
Title: Antioxidant N-acetylcysteine attenuates hepatocarcinogenesis by inhibiting ROS/ER stress in TLR2 deficient mouse.
Volume: 8
Issue: 10
Pages: e74130
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Publication
27463737 | J:318372
First Author: Huang Y
Year: 2016
Journal: Pediatr Res
Title: TLR2 promotes macrophage recruitment and Streptococcus pneumoniae clearance during mouse otitis media.
Volume: 80
Issue: 6
Pages: 886-893
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Publication
19574958 | J:150796
First Author: Santos-Sierra S
Year: 2009
Journal: EMBO J
Title: Mal connects TLR2 to PI3Kinase activation and phagocyte polarization.
Volume: 28
Issue: 14
Pages: 2018-27
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Publication
25870276 | J:221032
First Author: Mistry P
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain.
Volume: 112
Issue: 17
Pages: 5455-60
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Publication
27805901 | J:248448
   
First Author: McKelvey AC
Year: 2016
Journal: Elife
Title: RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity.
Volume: 5
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Publication
16611887 | J:144127
First Author: Szomolanyi-Tsuda E
Year: 2006
Journal: J Virol
Title: Role for TLR2 in NK cell-mediated control of murine cytomegalovirus in vivo.
Volume: 80
Issue: 9
Pages: 4286-91
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Publication
22529298 | J:188745
First Author: Rodriguez AR
Year: 2012
Journal: J Immunol
Title: Mast cell TLR2 signaling is crucial for effective killing of Francisella tularensis.
Volume: 188
Issue: 11
Pages: 5604-11
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Publication
19454709 | J:148854
First Author: Nichols JR
Year: 2009
Journal: J Immunol
Title: TLR2 deficiency leads to increased Th17 infiltrates in experimental brain abscesses.
Volume: 182
Issue: 11
Pages: 7119-30
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Publication
19050280 | J:142056
First Author: Sørensen LN
Year: 2008
Journal: J Immunol
Title: TLR2 and TLR9 synergistically control herpes simplex virus infection in the brain.
Volume: 181
Issue: 12
Pages: 8604-12
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Publication
21632710 | J:175931
First Author: Myneni SR
Year: 2011
Journal: J Immunol
Title: TLR2 signaling and Th2 responses drive Tannerella forsythia-induced periodontal bone loss.
Volume: 187
Issue: 1
Pages: 501-9
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Publication
24376539 | J:209851
First Author: Gao Y
Year: 2013
Journal: PLoS One
Title: TLR2 directing PD-L2 expression inhibit T cells response in Schistosoma japonicum infection.
Volume: 8
Issue: 12
Pages: e82480
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Publication
17173973 | J:117805
First Author: Xu WY
Year: 2007
Journal: Mol Immunol
Title: TLR2 and TLR4 agonists synergistically up-regulate SR-A in RAW264.7 through p38.
Volume: 44
Issue: 9
Pages: 2315-23
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Publication
21695078 | J:174293
First Author: He X
Year: 2011
Journal: PLoS One
Title: Enhanced virulence of Chlamydia muridarum respiratory infections in the absence of TLR2 activation.
Volume: 6
Issue: 6
Pages: e20846
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Publication
17548055 | J:122281
First Author: Ziegler G
Year: 2007
Journal: Biochem Biophys Res Commun
Title: TLR2 has a detrimental role in mouse transient focal cerebral ischemia.
Volume: 359
Issue: 3
Pages: 574-9
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Publication
30029916 | J:317331
 
First Author: Li F
Year: 2018
Journal: Tuberculosis (Edinb)
Title: LpqT improves mycobacteria survival in macrophages by inhibiting TLR2 mediated inflammatory cytokine expression and cell apoptosis.
Volume: 111
Pages: 57-66
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Publication
23079657 | J:192030
First Author: Tye H
Year: 2012
Journal: Cancer Cell
Title: STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation.
Volume: 22
Issue: 4
Pages: 466-78
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Publication
21998707 | J:179623
First Author: Liu G
Year: 2011
Journal: PLoS One
Title: The receptor for urokinase regulates TLR2 mediated inflammatory responses in neutrophils.
Volume: 6
Issue: 10
Pages: e25843
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Publication
21698237 | J:174784
First Author: Jones CL
Year: 2011
Journal: PLoS One
Title: TLR2 signaling contributes to rapid inflammasome activation during F. novicida infection.
Volume: 6
Issue: 6
Pages: e20609
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Publication
28432147 | J:247661
First Author: Gutjahr A
Year: 2017
Journal: J Immunol
Title: Cutting Edge: A Dual TLR2 and TLR7 Ligand Induces Highly Potent Humoral and Cell-Mediated Immune Responses.
Volume: 198
Issue: 11
Pages: 4205-4209
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Publication
17617606 | J:149395
First Author: Debierre-Grockiego F
Year: 2007
Journal: J Immunol
Title: Activation of TLR2 and TLR4 by glycosylphosphatidylinositols derived from Toxoplasma gondii.
Volume: 179
Issue: 2
Pages: 1129-37
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Publication
17947688 | J:152996
First Author: Lehnardt S
Year: 2007
Journal: J Immunol
Title: TLR2 and caspase-8 are essential for group B Streptococcus-induced apoptosis in microglia.
Volume: 179
Issue: 9
Pages: 6134-43
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Publication
19191335 | J:156204
First Author: So EY
Year: 2009
Journal: Glia
Title: Theiler's virus infection induces TLR3-dependent upregulation of TLR2 critical for proinflammatory cytokine production.
Volume: 57
Issue: 11
Pages: 1216-26
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Publication
20927103 | J:165559
First Author: West XZ
Year: 2010
Journal: Nature
Title: Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands.
Volume: 467
Issue: 7318
Pages: 972-6
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Publication
31383741 | J:279270
First Author: Eyking A
Year: 2019
Journal: J Immunol
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