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Search results 1 to 100 out of 957 for Tlr3

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
7098 | TLR3
Type: gene
Organism: human
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Gene
100486223 | tlr3
Type: gene
Organism: frog, western clawed
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Gene
364594 | Tlr3
Type: gene
Organism: rat
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Gene
482905 | TLR3
Type: gene
Organism: dog, domestic
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Gene
471374 | TLR3
Type: gene
Organism: chimpanzee
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Gene
281535 | TLR3
Type: gene
Organism: cattle
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Gene
422720 | TLR3
Type: gene
Organism: chicken
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Gene
403126 | tlr3
Type: gene
Organism: zebrafish
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Gene
574378 | TLR3
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR027173 | TLR3
Type: Family
Description: Toll-like receptor 3 (TLR3) is a key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection [, , , , , ]. TLR3 assembles on dsRNA as stable dimers and the minimal signaling unit is one TLR3 dimer []. Most TLRs signal through the MyD88-dependent pathway. However, TLR3 utilises a MyD88-independent pathway. TLR3 induces type I interferon (IFN), inflammatory cytokine/chemokine production, and dendritic cell (DC) maturation via the adaptor protein TICAM-1 (also called TRIF) [].
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Protein Coding Gene
MGI:2156367 | Tlr3
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
14993594 | J:88906
First Author: Tabeta K
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection.
Volume: 101
Issue: 10
Pages: 3516-21
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Publication
18172197 | -
First Author: Leonard JN
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: The TLR3 signaling complex forms by cooperative receptor dimerization.
Volume: 105
Issue: 1
Pages: 258-63
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Publication
18420935 | -
First Author: Liu L
Year: 2008
Journal: Science
Title: Structural basis of toll-like receptor 3 signaling with double-stranded RNA.
Volume: 320
Issue: 5874
Pages: 379-81
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Publication
16144834 | -
First Author: de Bouteiller O
Year: 2005
Journal: J Biol Chem
Title: Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH.
Volume: 280
Issue: 46
Pages: 38133-45
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Publication
16858407 | -
First Author: Johnsen IB
Year: 2006
Journal: EMBO J
Title: Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling.
Volume: 25
Issue: 14
Pages: 3335-46
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Publication
16720699 | -
First Author: Bell JK
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: The dsRNA binding site of human Toll-like receptor 3.
Volume: 103
Issue: 23
Pages: 8792-7
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Publication
17178723 | -
First Author: Sarkar SN
Year: 2007
Journal: J Biol Chem
Title: Two tyrosine residues of Toll-like receptor 3 trigger different steps of NF-kappa B activation.
Volume: 282
Issue: 6
Pages: 3423-7
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Publication
18262679 | -
First Author: Matsumoto M
Year: 2008
Journal: Adv Drug Deliv Rev
Title: TLR3: interferon induction by double-stranded RNA including poly(I:C).
Volume: 60
Issue: 7
Pages: 805-12
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Publication
38499210 | J:348990
 
First Author: Dilly GA
Year: 2024
Journal: Brain Behav Immun
Title: Knockdown of Tlr3 in dorsal striatum reduces ethanol consumption and acute functional tolerance in male mice.
Volume: 118
Pages: 437-448
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Publication
19710451 | J:152308
First Author: Xiao X
Year: 2009
Journal: J Immunol
Title: Inflammatory regulation by TLR3 in acute hepatitis.
Volume: 183
Issue: 6
Pages: 3712-9
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Publication
22323545 | J:181853
First Author: Yamashita M
Year: 2012
Journal: J Immunol
Title: A TRIF-independent branch of TLR3 signaling.
Volume: 188
Issue: 6
Pages: 2825-33
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Publication
26385519 | J:239774
First Author: Tsai SY
Year: 2015
Journal: J Immunol
Title: Regulation of TLR3 Activation by S100A9.
Volume: 195
Issue: 9
Pages: 4426-37
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Publication
32539223 | J:304220
First Author: Stöß C
Year: 2020
Journal: FASEB J
Title: TLR3 promotes hepatocyte proliferation after partial hepatectomy by stimulating uPA expression and the release of tissue-bound HGF.
Volume: 34
Issue: 8
Pages: 10387-10397
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Protein
Q8C2X8
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: true
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Publication
16473828 | J:113319
First Author: Lee HK
Year: 2006
Journal: Immunity
Title: Double-stranded RNA-mediated TLR3 activation is enhanced by CD14.
Volume: 24
Issue: 2
Pages: 153-63
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Protein
Q99MB1
Organism: Mus musculus/domesticus
Length: 905  
Fragment?: false
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Protein
Q3TM31
Organism: Mus musculus/domesticus
Length: 905  
Fragment?: false
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Protein
Q499F3
Organism: Mus musculus/domesticus
Length: 905  
Fragment?: false
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Publication
30246036 | J:295262
 
First Author: Qu J
Year: 2018
Journal: J Immunol Res
Title: TLR3 Modulates the Response of NK Cells against Schistosoma japonicum.
Volume: 2018
Pages: 7519856
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Publication
24486326 | J:208047
First Author: Mitchell WM
Year: 2014
Journal: Am J Pathol
Title: Discordant biological and toxicological species responses to TLR3 activation.
Volume: 184
Issue: 4
Pages: 1062-72
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Publication
27810922 | J:237520
First Author: Zinngrebe J
Year: 2016
Journal: J Exp Med
Title: --LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation.
Volume: 213
Issue: 12
Pages: 2671-2689
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Publication
17981792 | J:128904
First Author: Sugiyama T
Year: 2008
Journal: Int Immunol
Title: Immunoadjuvant effects of polyadenylic:polyuridylic acids through TLR3 and TLR7.
Volume: 20
Issue: 1
Pages: 1-9
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Publication
24637670 | J:210311
 
First Author: Takemura N
Year: 2014
Journal: Nat Commun
Title: Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome.
Volume: 5
Pages: 3492
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Publication
18097050 | J:130913
First Author: Hutchens M
Year: 2008
Journal: J Immunol
Title: TLR3 increases disease morbidity and mortality from vaccinia infection.
Volume: 180
Issue: 1
Pages: 483-91
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Publication
31619538 | J:282205
First Author: Ko R
Year: 2019
Journal: J Immunol
Title: Glycogen Synthase Kinase 3β Regulates Antiviral Responses of TLR3 via TRAF2-Src Axis.
Volume: 203
Issue: 11
Pages: 2990-2999
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Publication
31277274 | J:295307
 
First Author: Patel S
Year: 2019
Journal: Viruses
Title: Role of NS1 and TLR3 in Pathogenesis and Immunity of WNV.
Volume: 11
Issue: 7
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Publication
31801911 | J:285250
 
First Author: Suresh MV
Year: 2019
Journal: JCI Insight
Title: TLR3 absence confers increased survival with improved macrophage activity against pneumonia.
Volume: 4
Issue: 23
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Publication
22491246 | J:188684
First Author: Reuter S
Year: 2012
Journal: J Immunol
Title: TLR3 but not TLR7/8 ligand induces allergic sensitization to inhaled allergen.
Volume: 188
Issue: 10
Pages: 5123-31
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Publication
26253200 | J:315930
First Author: Nelson AM
Year: 2015
Journal: Cell Stem Cell
Title: dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration.
Volume: 17
Issue: 2
Pages: 139-51
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Publication
22570612 | J:195388
First Author: Pott J
Year: 2012
Journal: PLoS Pathog
Title: Age-dependent TLR3 expression of the intestinal epithelium contributes to rotavirus susceptibility.
Volume: 8
Issue: 5
Pages: e1002670
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Publication
17056560 | J:140514
First Author: Gowen BB
Year: 2006
Journal: J Immunol
Title: TLR3 deletion limits mortality and disease severity due to Phlebovirus infection.
Volume: 177
Issue: 9
Pages: 6301-7
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Publication
21092943 | J:168591
First Author: Bunting RA
Year: 2011
Journal: Cell Immunol
Title: Novel antagonist antibody to TLR3 blocks poly(I:C)-induced inflammation in vivo and in vitro.
Volume: 267
Issue: 1
Pages: 9-16
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Publication
38671318 | J:349457
First Author: Qiu L
Year: 2024
Journal: EMBO Mol Med
Title: TLR3 activation enhances abscopal effect of radiotherapy in HCC by promoting tumor ferroptosis.
Volume: 16
Issue: 5
Pages: 1193-1219
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Publication
31388100 | J:320925
First Author: Zhong X
Year: 2020
Journal: Cell Mol Immunol
Title: The zinc-finger protein ZFYVE1 modulates TLR3-mediated signaling by facilitating TLR3 ligand binding.
Volume: 17
Issue: 7
Pages: 741-752
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Publication
25452586 | J:232610
First Author: Her Z
Year: 2015
Journal: EMBO Mol Med
Title: Loss of TLR3 aggravates CHIKV replication and pathology due to an altered virus-specific neutralizing antibody response.
Volume: 7
Issue: 1
Pages: 24-41
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Publication
17372013 | J:145138
First Author: Zhou R
Year: 2007
Journal: J Immunol
Title: Recognition of double-stranded RNA by TLR3 induces severe small intestinal injury in mice.
Volume: 178
Issue: 7
Pages: 4548-56
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Publication
28198368 | J:274157
 
First Author: Ding X
Year: 2017
Journal: Sci Rep
Title: TLR4 signaling induces TLR3 up-regulation in alveolar macrophages during acute lung injury.
Volume: 7
Pages: 34278
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Publication
31076723 | J:315640
First Author: Song X
Year: 2020
Journal: Cell Mol Immunol
Title: E3 ubiquitin ligase RNF170 inhibits innate immune responses by targeting and degrading TLR3 in murine cells.
Volume: 17
Issue: 8
Pages: 865-874
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Publication
30625140 | J:269922
First Author: Kumar R
Year: 2019
Journal: PLoS One
Title: TLR3 deficiency exacerbates the loss of epithelial barrier function during genital tract Chlamydia muridarum infection.
Volume: 14
Issue: 1
Pages: e0207422
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Publication
30997942 | J:282010
First Author: Hong JY
Year: 2019
Journal: J Leukoc Biol
Title: Frontline Science: TLR3 activation inhibits food allergy in mice by inducing IFN-γ+ Foxp3+ regulatory T cells.
Volume: 106
Issue: 6
Pages: 1201-1209
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Publication
30248373 | J:318543
 
First Author: Huo C
Year: 2018
Journal: Virus Res
Title: Lethal influenza A virus preferentially activates TLR3 and triggers a severe inflammatory response.
Volume: 257
Pages: 102-112
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Publication
19239422 | J:164980
First Author: Koga K
Year: 2009
Journal: Am J Reprod Immunol
Title: Activation of TLR3 in the trophoblast is associated with preterm delivery.
Volume: 61
Issue: 3
Pages: 196-212
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Publication
28945004 | J:321321
First Author: Gao T
Year: 2018
Journal: J Cell Mol Med
Title: TLR3 contributes to persistent autophagy and heart failure in mice after myocardial infarction.
Volume: 22
Issue: 1
Pages: 395-408
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Publication
16424225 | J:126415
First Author: Rudd BD
Year: 2006
Journal: J Immunol
Title: Deletion of TLR3 alters the pulmonary immune environment and mucus production during respiratory syncytial virus infection.
Volume: 176
Issue: 3
Pages: 1937-42
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Publication
19009529 | J:141387
First Author: Joshi AD
Year: 2008
Journal: Eur J Immunol
Title: TLR3 modulates immunopathology during a Schistosoma mansoni egg-driven Th2 response in the lung.
Volume: 38
Issue: 12
Pages: 3436-49
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Publication
18838547 | J:141426
First Author: Cavassani KA
Year: 2008
Journal: J Exp Med
Title: TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events.
Volume: 205
Issue: 11
Pages: 2609-21
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Publication
19359485 | J:148335
First Author: Cho WG
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth.
Volume: 106
Issue: 17
Pages: 7137-42
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Publication
27505671 | J:234983
First Author: Liu Y
Year: 2016
Journal: Cancer Cell
Title: Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils.
Volume: 30
Issue: 2
Pages: 243-256
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Publication
27405980 | J:260301
First Author: Liu B
Year: 2016
Journal: Sci Signal
Title: Innate immune memory and homeostasis may be conferred through crosstalk between the TLR3 and TLR7 pathways.
Volume: 9
Issue: 436
Pages: ra70
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Publication
16105838 | J:102910
First Author: Nishiya T
Year: 2005
Journal: J Biol Chem
Title: TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements.
Volume: 280
Issue: 44
Pages: 37107-17
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Publication
21637773 | J:176090
First Author: Wang Q
Year: 2011
Journal: PLoS Pathog
Title: MDA5 and TLR3 initiate pro-inflammatory signaling pathways leading to rhinovirus-induced airways inflammation and hyperresponsiveness.
Volume: 7
Issue: 5
Pages: e1002070
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Publication
26508631 | J:227257
First Author: Hu W
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Differential outcome of TRIF-mediated signaling in TLR4 and TLR3 induced DC maturation.
Volume: 112
Issue: 45
Pages: 13994-9
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Publication
18471880 | J:136204
First Author: Dong LW
Year: 2008
Journal: Mol Immunol
Title: Signal regulatory protein alpha negatively regulates both TLR3 and cytoplasmic pathways in type I interferon induction.
Volume: 45
Issue: 11
Pages: 3025-35
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Publication
29358670 | J:268265
First Author: Wang X
Year: 2018
Journal: Cell Death Differ
Title: TLR3 Mediates Repair and Regeneration of Damaged Neonatal Heart through Glycolysis Dependent YAP1 Regulated miR-152 Expression.
Volume: 25
Issue: 5
Pages: 966-982
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Publication
19995959 | J:155673
First Author: McCartney S
Year: 2009
Journal: J Exp Med
Title: Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells.
Volume: 206
Issue: 13
Pages: 2967-76
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Publication
16751377 | J:132231
First Author: Zaks K
Year: 2006
Journal: J Immunol
Title: Efficient immunization and cross-priming by vaccine adjuvants containing TLR3 or TLR9 agonists complexed to cationic liposomes.
Volume: 176
Issue: 12
Pages: 7335-45
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Publication
22565312 | J:188291
First Author: Liu T
Year: 2012
Journal: J Clin Invest
Title: TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice.
Volume: 122
Issue: 6
Pages: 2195-207
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Publication
34211474 | J:309088
 
First Author: Chen CY
Year: 2021
Journal: Front Immunol
Title: Transcriptomic Analysis and C-Terminal Epitope Tagging Reveal Differential Processing and Signaling of Endogenous TLR3 and TLR7.
Volume: 12
Pages: 686060
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Publication
22147891 | J:181740
First Author: Carvalho A
Year: 2012
Journal: Blood
Title: TLR3 essentially promotes protective class I-restricted memory CD8⁺ T-cell responses to Aspergillus fumigatus in hematopoietic transplanted patients.
Volume: 119
Issue: 4
Pages: 967-77
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Publication
32878999 | J:296221
First Author: Li WW
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Ubiquitination of TLR3 by TRIM3 signals its ESCRT-mediated trafficking to the endolysosomes for innate antiviral response.
Volume: 117
Issue: 38
Pages: 23707-23716
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Publication
23271706 | J:198081
First Author: Jin JO
Year: 2013
Journal: J Leukoc Biol
Title: Systemic administration of TLR3 agonist induces IL-7 expression and IL-7-dependent CXCR3 ligand production in the lung.
Volume: 93
Issue: 3
Pages: 413-25
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Publication
25188232 | J:246035
First Author: Han YW
Year: 2014
Journal: PLoS Pathog
Title: Distinct dictation of Japanese encephalitis virus-induced neuroinflammation and lethality via triggering TLR3 and TLR4 signal pathways.
Volume: 10
Issue: 9
Pages: e1004319
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Publication
27979975 | J:239308
First Author: Chen CY
Year: 2017
Journal: EMBO Rep
Title: TLR3 downregulates expression of schizophrenia gene Disc1 via MYD88 to control neuronal morphology.
Volume: 18
Issue: 1
Pages: 169-183
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Publication
35011620 | J:345580
 
First Author: Rahman S
Year: 2021
Journal: Cells
Title: miR-511 Deficiency Protects Mice from Experimental Colitis by Reducing TLR3 and TLR4 Responses via WD Repeat and FYVE-Domain-Containing Protein 1.
Volume: 11
Issue: 1
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Publication
22426207 | J:184552
First Author: Reinert LS
Year: 2012
Journal: J Clin Invest
Title: TLR3 deficiency renders astrocytes permissive to herpes simplex virus infection and facilitates establishment of CNS infection in mice.
Volume: 122
Issue: 4
Pages: 1368-76
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Publication
20124105 | J:159648
First Author: Davey GM
Year: 2010
Journal: J Immunol
Title: Cutting edge: priming of CD8 T cell immunity to herpes simplex virus type 1 requires cognate TLR3 expression in vivo.
Volume: 184
Issue: 5
Pages: 2243-6
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Publication
22013485 | J:321338
 
First Author: Abston ED
Year: 2012
Journal: Clin Dev Immunol
Title: Th2 regulation of viral myocarditis in mice: different roles for TLR3 versus TRIF in progression to chronic disease.
Volume: 2012
Pages: 129486
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Publication
25564448 | J:230985
First Author: Chintala SK
Year: 2015
Journal: Invest Ophthalmol Vis Sci
Title: Activation of TLR3 promotes the degeneration of retinal ganglion cells by upregulating the protein levels of JNK3.
Volume: 56
Issue: 1
Pages: 505-14
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Publication
16369915 | J:113850
First Author: Flandin JF
Year: 2006
Journal: Eur J Immunol
Title: RNA interference reveals a role for TLR2 and TLR3 in the recognition of Leishmania donovani promastigotes by interferon-gamma-primed macrophages.
Volume: 36
Issue: 2
Pages: 411-20
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Publication
31827178 | J:297978
First Author: Ahmed D
Year: 2019
Journal: Sci Rep
Title: Differential remodeling of the electron transport chain is required to support TLR3 and TLR4 signaling and cytokine production in macrophages.
Volume: 9
Issue: 1
Pages: 18801
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Publication
23255589 | J:195232
First Author: Abston ED
Year: 2013
Journal: Am J Physiol Regul Integr Comp Physiol
Title: TLR3 deficiency induces chronic inflammatory cardiomyopathy in resistant mice following coxsackievirus B3 infection: role for IL-4.
Volume: 304
Issue: 4
Pages: R267-77
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Publication
20804821 | J:169724
First Author: Hyakkoku K
Year: 2010
Journal: Neuroscience
Title: Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia.
Volume: 171
Issue: 1
Pages: 258-67
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Publication
18650463 | J:138193
First Author: Cao O
Year: 2008
Journal: Blood
Title: TLR3 signaling does not affect organ-specific immune responses to factor IX in AAV gene therapy.
Volume: 112
Issue: 3
Pages: 910-1
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Publication
31067281 | J:275459
First Author: Veazey JM
Year: 2019
Journal: PLoS One
Title: Distinct roles for MDA5 and TLR3 in the acute response to inhaled double-stranded RNA.
Volume: 14
Issue: 5
Pages: e0216056
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Publication
17339421 | J:145420
First Author: Hervas-Stubbs S
Year: 2007
Journal: Blood
Title: TLR3 ligand stimulates fully functional memory CD8+ T cells in the absence of CD4+ T-cell help.
Volume: 109
Issue: 12
Pages: 5318-26
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Publication
21266579 | J:170947
First Author: Watanabe A
Year: 2011
Journal: J Biol Chem
Title: Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation.
Volume: 286
Issue: 12
Pages: 10702-11
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Publication
35584177 | J:338965
First Author: Gibson AR
Year: 2022
Journal: PLoS Pathog
Title: A genetic screen identifies a protective type III interferon response to Cryptosporidium that requires TLR3 dependent recognition.
Volume: 18
Issue: 5
Pages: e1010003
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Publication
22189096 | J:317934
 
First Author: Jin YH
Year: 2011
Journal: J Neuroinflammation
Title: TLR3 signaling is either protective or pathogenic for the development of Theiler's virus-induced demyelinating disease depending on the time of viral infection.
Volume: 8
Pages: 178
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Publication
24353176 | J:209068
First Author: Alkanani AK
Year: 2014
Journal: Diabetes
Title: Induction of diabetes in the RIP-B7.1 mouse model is critically dependent on TLR3 and MyD88 pathways and is associated with alterations in the intestinal microbiome.
Volume: 63
Issue: 2
Pages: 619-31
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Publication
15240691 | J:91934
First Author: Punturieri A
Year: 2004
Journal: J Immunol
Title: Specific engagement of TLR4 or TLR3 does not lead to IFN-beta-mediated innate signal amplification and STAT1 phosphorylation in resident murine alveolar macrophages.
Volume: 173
Issue: 2
Pages: 1033-42
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Publication
17404303 | J:145273
First Author: Gowen BB
Year: 2007
Journal: J Immunol
Title: TLR3 is essential for the induction of protective immunity against Punta Toro Virus infection by the double-stranded RNA (dsRNA), poly(I:C12U), but not Poly(I:C): differential recognition of synthetic dsRNA molecules.
Volume: 178
Issue: 8
Pages: 5200-8
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Publication
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