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Search results 1 to 100 out of 166 for Tlr8

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Type Details Score
Gene
51311 | TLR8
Type: gene
Organism: human
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Gene
684440 | Tlr8
Type: gene
Organism: rat
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Gene
532262 | TLR8
Type: gene
Organism: cattle
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Gene
100684828 | TLR8
Type: gene
Organism: dog, domestic
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Gene
574292 | TLR8
Type: gene
Organism: macaque, rhesus
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Gene
100496108 | tlr8
Type: gene
Organism: frog, western clawed
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Gene
473522 | TLR8
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:2176887 | Tlr8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR027175 | TLR8
Type: Family
Description: Toll-like receptor 8 (TLR8) is a key component of innate and adaptive immunity [, , ]. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. It acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response []. TLR8 has been shown to recognise different types of ligands such as viral or bacterial ssRNA, as well as small synthetic molecules. Activation by ligands is species-specific, varying among non-rodents and rodents [, ].
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Publication
12032557 | J:114769
First Author: Jurk M
Year: 2002
Journal: Nat Immunol
Title: Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848.
Volume: 3
Issue: 6
Pages: 499
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Publication
14976262 | J:90025
First Author: Heil F
Year: 2004
Journal: Science
Title: Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8.
Volume: 303
Issue: 5663
Pages: 1526-9
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Gene
349408 | TLR8-AS1
Type: gene
Organism: human
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Publication
20811154 | J:165267
First Author: Demaria O
Year: 2010
Journal: J Clin Invest
Title: TLR8 deficiency leads to autoimmunity in mice.
Volume: 120
Issue: 10
Pages: 3651-62
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Publication
16188996 | -
First Author: Melchjorsen J
Year: 2005
Journal: J Virol
Title: Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner.
Volume: 79
Issue: 20
Pages: 12944-51
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Publication
17082568 | J:140503
First Author: Gorden KK
Year: 2006
Journal: J Immunol
Title: Cutting edge: activation of murine TLR8 by a combination of imidazoquinoline immune response modifiers and polyT oligodeoxynucleotides.
Volume: 177
Issue: 10
Pages: 6584-7
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Publication
30455267 | J:269886
First Author: Zhang ZJ
Year: 2018
Journal: J Exp Med
Title: TLR8 and its endogenous ligand miR-21 contribute to neuropathic pain in murine DRG.
Volume: 215
Issue: 12
Pages: 3019-3037
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Publication
29777026 | J:264619
First Author: Hung YF
Year: 2018
Journal: J Cell Biol
Title: Endosomal TLR3, TLR7, and TLR8 control neuronal morphology through different transcriptional programs.
Volume: 217
Issue: 8
Pages: 2727-2742
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Publication
24474776 | J:206649
First Author: Desnues B
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: TLR8 on dendritic cells and TLR9 on B cells restrain TLR7-mediated spontaneous autoimmunity in C57BL/6 mice.
Volume: 111
Issue: 4
Pages: 1497-502
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Publication
21949866 | -
First Author: Govindaraj RG
Year: 2011
Journal: PLoS One
Title: Comparative analysis of species-specific ligand recognition in Toll-like receptor 8 signaling: a hypothesis.
Volume: 6
Issue: 9
Pages: e25118
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Publication
16123302 | -
First Author: Peng G
Year: 2005
Journal: Science
Title: Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function.
Volume: 309
Issue: 5739
Pages: 1380-4
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Publication
17932028 | -
First Author: Doyle SL
Year: 2007
Journal: J Biol Chem
Title: Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase.
Volume: 282
Issue: 51
Pages: 36953-60
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Protein
A2AHI8
Organism: Mus musculus/domesticus
Length: 100  
Fragment?: true
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Protein
P58682
Organism: Mus musculus/domesticus
Length: 1032  
Fragment?: false
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Publication
17060494 | J:114983
First Author: Ma Y
Year: 2006
Journal: J Cell Biol
Title: Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis.
Volume: 175
Issue: 2
Pages: 209-15
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Publication
25468389 | J:269052
 
First Author: Kimura J
Year: 2014
Journal: Sci Rep
Title: Overexpression of Toll-like receptor 8 correlates with the progression of podocyte injury in murine autoimmune glomerulonephritis.
Volume: 4
Pages: 7290
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Publication
25229618 | J:220640
First Author: Snyder JM
Year: 2014
Journal: PLoS One
Title: Humanized TLR7/8 expression drives proliferative multisystemic histiocytosis in C57BL/6 mice.
Volume: 9
Issue: 9
Pages: e107257
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Publication
18322178 | J:132906
First Author: Forsbach A
Year: 2008
Journal: J Immunol
Title: Identification of RNA sequence motifs stimulating sequence-specific TLR8-dependent immune responses.
Volume: 180
Issue: 6
Pages: 3729-38
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Publication
25424423 | J:247270
First Author: Tran NL
Year: 2015
Journal: Immunology
Title: Toll-like receptor 8 deletion accelerates autoimmunity in a mouse model of lupus through a Toll-like receptor 7-dependent mechanism.
Volume: 145
Issue: 1
Pages: 60-70
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Publication
31408454 | J:278976
First Author: Umehara T
Year: 2019
Journal: PLoS Biol
Title: Activation of Toll-like receptor 7/8 encoded by the X chromosome alters sperm motility and provides a novel simple technology for sexing sperm.
Volume: 17
Issue: 8
Pages: e3000398
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Publication
33317145 | J:304336
 
First Author: Campolo M
Year: 2020
Journal: Int J Mol Sci
Title: TLR7/8 in the Pathogenesis of Parkinson's Disease.
Volume: 21
Issue: 24
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Publication
17040905 | J:117607
First Author: Wang J
Year: 2006
Journal: J Biol Chem
Title: The functional effects of physical interactions among Toll-like receptors 7, 8, and 9.
Volume: 281
Issue: 49
Pages: 37427-34
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Publication
20308556 | J:159319
First Author: Martinez J
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA.
Volume: 107
Issue: 14
Pages: 6442-7
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Publication
19850743 | J:155700
First Author: Vanderwerf SM
Year: 2009
Journal: Blood
Title: TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells.
Volume: 114
Issue: 26
Pages: 5290-8
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Publication
24500834 | J:225247
First Author: Umiker BR
Year: 2014
Journal: Eur J Immunol
Title: Dosage of X-linked Toll-like receptor 8 determines gender differences in the development of systemic lupus erythematosus.
Volume: 44
Issue: 5
Pages: 1503-16
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Publication
23843519 | J:199815
First Author: Liu HY
Year: 2013
Journal: J Neurosci
Title: TLR7 negatively regulates dendrite outgrowth through the Myd88-c-Fos-IL-6 pathway.
Volume: 33
Issue: 28
Pages: 11479-93
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Protein Coding Gene
MGP_CAROLIEiJ_G0033577 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0036270 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0036239 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0036169 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0036234 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0035941 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2176887 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0036757 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0035228 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0035915 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0036081 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0036013 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0036166 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0036045 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0036796 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0034927 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0035364 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0032116 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0034746 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:5609313
Assay Type: RT-PCR
Annotation Date: 2015-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689425
Stage: TS25
Assay Id: MGI:5609327
Age: embryonic day 17.5
Image: 2
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5609313
Assay Type: RT-PCR
Annotation Date: 2015-01-09
Strength: Present
Sex: Female
Emaps: EMAPS:1689425
Stage: TS25
Assay Id: MGI:5609327
Age: embryonic day 17.5
Image: 2
Specimen Label: TLR7 KO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5609313
Assay Type: RT-PCR
Annotation Date: 2015-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:5609328
Age: embryonic day 17.5
Image: 2
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5609313
Assay Type: RT-PCR
Annotation Date: 2015-01-09
Strength: Present
Sex: Female
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:5609328
Age: embryonic day 17.5
Image: 2
Specimen Label: TLR7 KO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7334816
Assay Type: RT-PCR
Annotation Date: 2022-09-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:7334825
Age: embryonic day 13.0
Image: 1
Specimen Label: E13
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7334816
Assay Type: RT-PCR
Annotation Date: 2022-09-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689422
Stage: TS22
Assay Id: MGI:7334825
Age: embryonic day 14.0
Image: 1
Specimen Label: E14
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7334816
Assay Type: RT-PCR
Annotation Date: 2022-09-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:7334825
Age: embryonic day 15.0
Image: 1
Specimen Label: E15
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7334816
Assay Type: RT-PCR
Annotation Date: 2022-09-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:7334825
Age: embryonic day 16.0
Image: 1
Specimen Label: E16
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7334816
Assay Type: RT-PCR
Annotation Date: 2022-09-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689425
Stage: TS25
Assay Id: MGI:7334825
Age: embryonic day 17.0
Image: 1
Specimen Label: E17
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:7334816
Assay Type: RT-PCR
Annotation Date: 2022-09-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:7334825
Age: embryonic day 18.0
Image: 1
Specimen Label: E18
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:7334816
Assay Type: RT-PCR
Annotation Date: 2022-09-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:7334825
Age: embryonic day 19.0
Image: 1
Specimen Label: E19
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:7334816
Assay Type: RT-PCR
Annotation Date: 2022-09-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:7334825
Age: postnatal day 0
Image: 1
Specimen Label: P0
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:7334816
Assay Type: RT-PCR
Annotation Date: 2022-09-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7334825
Age: postnatal day 4
Image: 1
Specimen Label: P4
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
   
Probe: MGI:7334816
Assay Type: RT-PCR
Annotation Date: 2022-09-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7334825
Age: postnatal day 8
Image: 1
Specimen Label: P8
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
   
Probe: MGI:7334816
Assay Type: RT-PCR
Annotation Date: 2022-09-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7334825
Age: postnatal day 12
Image: 1
Specimen Label: P12
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
   
Probe: MGI:7334816
Assay Type: RT-PCR
Annotation Date: 2022-09-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7334825
Age: postnatal month 5
Image: 1
Specimen Label: P5m
Detected: true
Specimen Num: 12
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Publication
- | J:75515
   
First Author: Heil FJ
Year: 2001
Journal: GenBank Submission
Title: Mus musculus toll-like receptor 8 (Tlr8) mRNA, complete cds
Pages: AY035890
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Publication
31552019 | J:283144
 
First Author: Hanna Kazazian N
Year: 2019
Journal: Front Immunol
Title: Lupus Autoimmunity and Metabolic Parameters Are Exacerbated Upon High Fat Diet-Induced Obesity Due to TLR7 Signaling.
Volume: 10
Pages: 2015
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Publication
34108972 | J:312592
 
First Author: Wang Y
Year: 2021
Journal: Front Immunol
Title: TLR7 Signaling Drives the Development of Sjögren's Syndrome.
Volume: 12
Pages: 676010
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Publication
24227841 | J:205285
First Author: Sarvestani ST
Year: 2014
Journal: J Virol
Title: Inosine-mediated modulation of RNA sensing by Toll-like receptor 7 (TLR7) and TLR8.
Volume: 88
Issue: 2
Pages: 799-810
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Publication
27600904 | J:246481
First Author: Desnues B
Year: 2016
Journal: Eur J Immunol
Title: The transcriptional repressor Gfi1 prevents lupus autoimmunity by restraining TLR7 signaling.
Volume: 46
Issue: 12
Pages: 2801-2811
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Publication
23370539 | J:198006
First Author: Jiang W
Year: 2013
Journal: J Invest Dermatol
Title: A Toll-like receptor 7, 8, and 9 antagonist inhibits Th1 and Th17 responses and inflammasome activation in a model of IL-23-induced psoriasis.
Volume: 133
Issue: 7
Pages: 1777-84
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Publication
20368279 | J:160439
First Author: Bessa J
Year: 2010
Journal: J Immunol
Title: Cutting edge: IL-21 and TLR signaling regulate germinal center responses in a B cell-intrinsic manner.
Volume: 184
Issue: 9
Pages: 4615-9
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Publication
20451253 | J:160699
First Author: Mitchell D
Year: 2010
Journal: Mol Immunol
Title: Regulation of Toll-like receptor-induced chemokine production in murine dendritic cells by mitogen-activated protein kinases.
Volume: 47
Issue: 11-12
Pages: 2065-73
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Publication
21515789 | J:173203
First Author: Qi J
Year: 2011
Journal: J Immunol
Title: Painful pathways induced by TLR stimulation of dorsal root ganglion neurons.
Volume: 186
Issue: 11
Pages: 6417-26
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Publication
26095358 | J:224870
First Author: Heinz LX
Year: 2015
Journal: Cell Rep
Title: The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity.
Volume: 11
Issue: 12
Pages: 1919-28
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Publication
22659029 | J:184829
First Author: Cunningham MA
Year: 2012
Journal: Clin Immunol
Title: Estrogen receptor alpha modulates Toll-like receptor signaling in murine lupus.
Volume: 144
Issue: 1
Pages: 1-12
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Publication
21918198 | J:179303
First Author: Porter GW
Year: 2011
Journal: J Immunol
Title: TLR agonists downregulate H2-O in CD8alpha- dendritic cells.
Volume: 187
Issue: 8
Pages: 4151-60
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Publication
25416814 | J:220189
First Author: Chinnery HR
Year: 2015
Journal: J Leukoc Biol
Title: TLR9 and TLR7/8 activation induces formation of keratic precipitates and giant macrophages in the mouse cornea.
Volume: 97
Issue: 1
Pages: 103-10
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Publication
12730667 | J:102090
First Author: Valenzuela DM
Year: 2003
Journal: Nat Biotechnol
Title: High-throughput engineering of the mouse genome coupled with high-resolution expression analysis.
Volume: 21
Issue: 6
Pages: 652-9
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Publication
24740015 | J:215205
First Author: Festuccia WT
Year: 2014
Journal: PLoS One
Title: Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide.
Volume: 9
Issue: 4
Pages: e95432
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Publication
21239713 | J:169160
First Author: Enoksson M
Year: 2011
Journal: J Immunol
Title: Mast cells as sensors of cell injury through IL-33 recognition.
Volume: 186
Issue: 4
Pages: 2523-8
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Publication
34206257 | J:308973
 
First Author: Gao Y
Year: 2021
Journal: Int J Mol Sci
Title: YAP/TEAD1 Complex Is a Default Repressor of Cardiac Toll-Like Receptor Genes.
Volume: 22
Issue: 13
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Publication
22666391 | J:187296
First Author: Kaul D
Year: 2012
Journal: PLoS One
Title: Expression of Toll-like receptors in the developing brain.
Volume: 7
Issue: 5
Pages: e37767
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Publication
31729371 | J:281617
First Author: Balounová J
Year: 2019
Journal: Nat Commun
Title: Toll-like receptor 2 expression on c-kit+ cells tracks the emergence of embryonic definitive hematopoietic progenitors.
Volume: 10
Issue: 1
Pages: 5176
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Publication
15561968 | J:94605
First Author: Cheverud JM
Year: 2004
Journal: Diabetes
Title: Quantitative trait loci for obesity- and diabetes-related traits and their dietary responses to high-fat feeding in LGXSM recombinant inbred mouse strains.
Volume: 53
Issue: 12
Pages: 3328-36
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Publication
28400473 | J:242009
First Author: Choo MK
Year: 2017
Journal: J Exp Med
Title: TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects.
Volume: 214
Issue: 5
Pages: 1297-1311
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Publication
34395439 | J:310855
 
First Author: Yiu JHC
Year: 2021
Journal: Front Cell Dev Biol
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First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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First Author: Tang T
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Title: A mouse knockout library for secreted and transmembrane proteins.
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First Author: Lexicon Genetics, Inc
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Journal: Database Download
Title: MGI download of Lexicon knockout data
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First Author: GOA curators
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Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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First Author: UniProt-GOA
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Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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