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Search results 1 to 82 out of 82 for Tm6sf2

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Hits by Pathway

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Hits by Category

Type Details Score
Gene
53345 | TM6SF2
Type: gene
Organism: human
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Gene
515889 | TM6SF2
Type: gene
Organism: cattle
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Gene
425719 | TM6SF2
Type: gene
Organism: chicken
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Gene
719756 | TM6SF2
Type: gene
Organism: macaque, rhesus
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Gene
100158592 | tm6sf2
Type: gene
Organism: frog, western clawed
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Gene
689029 | Tm6sf2
Type: gene
Organism: rat
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Gene
609715 | TM6SF2
Type: gene
Organism: dog, domestic
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Gene
736763 | TM6SF2
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:1933210 | Tm6sf2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
36139452 | J:332459
 
First Author: Zhu W
Year: 2022
Journal: Cells
Title: Myeloid TM6SF2 Deficiency Inhibits Atherosclerosis.
Volume: 11
Issue: 18
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Publication
33638902 | J:322313
First Author: Newberry EP
Year: 2021
Journal: Hepatology
Title: Liver-Specific Deletion of Mouse Tm6sf2 Promotes Steatosis, Fibrosis, and Hepatocellular Cancer.
Volume: 74
Issue: 3
Pages: 1203-1219
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Publication
34746691 | J:314590
First Author: Fan Y
Year: 2021
Journal: iScience
Title: Type 2 diabetes sex-specific effects associated with E167K coding variant in TM6SF2.
Volume: 24
Issue: 11
Pages: 103196
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Publication
11124529 | J:66727
First Author: Carim-Todd L
Year: 2000
Journal: Cytogenet Cell Genet
Title: Cloning of the novel gene TM6SF1 reveals conservation of clusters of paralogous genes between human chromosomes 15q24-->q26 and 19p13.3-->p12.
Volume: 90
Issue: 3-4
Pages: 255-60
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Publication
26774178 | J:235704
First Author: Fan Y
Year: 2016
Journal: Gastroenterology
Title: Hepatic Transmembrane 6 Superfamily Member 2 Regulates Cholesterol Metabolism in Mice.
Volume: 150
Issue: 5
Pages: 1208-1218
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Publication
32776921 | J:296036
First Author: Li BT
Year: 2020
Journal: PLoS Genet
Title: Disruption of the ERLIN-TM6SF2-APOB complex destabilizes APOB and contributes to non-alcoholic fatty liver disease.
Volume: 16
Issue: 8
Pages: e1008955
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Publication
27013658 | J:234195
First Author: Smagris E
Year: 2016
Journal: J Biol Chem
Title: Inactivation of Tm6sf2, a Gene Defective in Fatty Liver Disease, Impairs Lipidation but Not Secretion of Very Low Density Lipoproteins.
Volume: 291
Issue: 20
Pages: 10659-76
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Protein Coding Gene
MGP_CAROLIEiJ_G0031127 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0033687 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0033670 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0033595 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0033666 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0033376 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1933210 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0034183 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0032701 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0033354 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0033508 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0033449 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0033595 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0033493 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0034201 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0032409 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0032816 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0021592 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0032245 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3667028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692320
Age: postnatal adult
Image: MRC Harwell_1612458
Specimen Label: MRC Harwell_1612458
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692320
Age: postnatal adult
Image: MRC Harwell_1612457
Specimen Label: MRC Harwell_1612457
Detected: true
Specimen Num: 1
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Publication
- | J:90559
     
First Author: The Mammalian Genetics Unit at Harwell
Year: 2004
Journal: Unpublished
Title: Information obtained from the Mammalian Genetics Unit, Medical Research Council (MRC), Harwell, UK
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Publication
- | J:72400
       
First Author: Mouse Genome Sequence and Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Mouse Genome Sequence Project Annotation
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Tm6sf2<em1Yech> | MGI:5896993
Name: transmembrane 6 superfamily member 2; endonuclease-mediated mutation 1, Y Eugene Chen
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
34923175 | J:320935
First Author: Luo F
Year: 2022
Journal: Cell Mol Gastroenterol Hepatol
Title: Hepatic TM6SF2 Is Required for Lipidation of VLDL in a Pre-Golgi Compartment in Mice and Rats.
Volume: 13
Issue: 3
Pages: 879-899
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Allele
Tm6sf2<em1Smoc> | MGI:7292827
Name: transmembrane 6 superfamily member 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Strain
MGI:6429675 | C57BL/6J-Tm6sf2<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
25566323 | -
 
First Author: Sanchez-Pulido L
Year: 2014
Journal: Front Genet
Title: TM6SF2 and MAC30, new enzyme homologs in sterol metabolism and common metabolic disease.
Volume: 5
Pages: 439
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Publication
24531328 | -
First Author: Kozlitina J
Year: 2014
Journal: Nat Genet
Title: Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease.
Volume: 46
Issue: 4
Pages: 352-6
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Publication
24633158 | -
First Author: Holmen OL
Year: 2014
Journal: Nat Genet
Title: Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk.
Volume: 46
Issue: 4
Pages: 345-51
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Protein
P58749
Organism: Mus musculus/domesticus
Length: 370  
Fragment?: false
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Protein
Q8R1J1
Organism: Mus musculus/domesticus
Length: 378  
Fragment?: false
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Protein
A0A0R4J0J9
Organism: Mus musculus/domesticus
Length: 376  
Fragment?: false
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Protein
Q3TA24
Organism: Mus musculus/domesticus
Length: 370  
Fragment?: false
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Protein
D3YX52
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: false
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Protein
E9QM19
Organism: Mus musculus/domesticus
Length: 378  
Fragment?: false
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Protein
Q3TA39
Organism: Mus musculus/domesticus
Length: 370  
Fragment?: false
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Protein Domain
IPR033118 | EXPERA
Type: Domain
Description: The EXPERA (EXPanded EBP superfamilly) domain is conserved among the followingprotein families:Vertebrate TM6SF1 (Transmembrane 6 Superfamily Member 1).Vertebrate TM6SF2 (Transmembrane 6 Superfamily Member 2).Eukaryotic MAC30 (Meningioma-associated protein 30) also known as TMEM97(Transmembrane protein 97), mainly localized in the endoplasmic reticulum(ER).Eukaryotic EBP (Emopamil binding protein), an enzyme with a D8, D7 sterolisomerase activity that catalyzes the transposition of a double bond fromC8=C9 to C7=C8 in the sterol B-ring.The EXPERA domain contains four transmembrane regions and is likely to possessa sterol isomerase catalytic activity [].
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Protein
Q8VD00
Organism: Mus musculus/domesticus
Length: 176  
Fragment?: false
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Protein
P70245
Organism: Mus musculus/domesticus
Length: 230  
Fragment?: false
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Protein
Q9D0P0
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: false
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Protein
A2AC29
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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