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Search results 1 to 100 out of 293 for Tmc1

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0.052s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Saccharomyces cerevisiae
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication    
First Author: Ballesteros A
Year: 2018
Journal: Elife
Title: Structural relationship between the putative hair cell mechanotransduction channel TMC1 and TMEM16 proteins.
Volume: 7
Publication
First Author: Maeda R
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Tip-link protein protocadherin 15 interacts with transmembrane channel-like proteins TMC1 and TMC2.
Volume: 111
Issue: 35
Pages: 12907-12
Publication
First Author: Kurima K
Year: 2015
Journal: Cell Rep
Title: TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia.
Volume: 12
Issue: 10
Pages: 1606-17
Publication
First Author: Pan B
Year: 2018
Journal: Neuron
Title: TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells.
Volume: 99
Issue: 4
Pages: 736-753.e6
Publication
First Author: Manji SS
Year: 2012
Journal: Am J Pathol
Title: Identification of three novel hearing loss mouse strains with mutations in the Tmc1 gene.
Volume: 180
Issue: 4
Pages: 1560-9
Publication
First Author: Pan B
Year: 2013
Journal: Neuron
Title: TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear.
Volume: 79
Issue: 3
Pages: 504-15
Publication
First Author: Marcotti W
Year: 2006
Journal: J Physiol
Title: Tmc1 is necessary for normal functional maturation and survival of inner and outer hair cells in the mouse cochlea.
Volume: 574
Issue: Pt 3
Pages: 677-98
Publication
First Author: Giese APJ
Year: 2017
Journal: Nat Commun
Title: CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.
Volume: 8
Issue: 1
Pages: 43
Publication
First Author: Corns LF
Year: 2016
Journal: J Neurosci
Title: Tmc1 Point Mutation Affects Ca2+ Sensitivity and Block by Dihydrostreptomycin of the Mechanoelectrical Transducer Current of Mouse Outer Hair Cells.
Volume: 36
Issue: 2
Pages: 336-49
Publication
First Author: Nakanishi H
Year: 2018
Journal: Sci Rep
Title: Tmc2 expression partially restores auditory function in a mouse model of DFNB7/B11 deafness caused by loss of Tmc1 function.
Volume: 8
Issue: 1
Pages: 12125
QTL
Type: QTL
Organism: Mus musculus
QTL
Type: QTL
Organism: Mus musculus
QTL
Type: QTL
Organism: Mus musculus
QTL
Type: QTL
Organism: Mus musculus
Publication
First Author: Noguchi Y
Year: 2006
Journal: Genetics
Title: Multiple quantitative trait loci modify cochlear hair cell degeneration in the Beethoven (Tmc1Bth) mouse model of progressive hearing loss DFNA36.
Volume: 173
Issue: 4
Pages: 2111-9
Publication
First Author: Vreugde S
Year: 2002
Journal: Nat Genet
Title: Beethoven, a mouse model for dominant, progressive hearing loss DFNA36.
Volume: 30
Issue: 3
Pages: 257-8
Publication
First Author: Kurima K
Year: 2002
Journal: Nat Genet
Title: Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function.
Volume: 30
Issue: 3
Pages: 277-84
Publication    
First Author: Erickson T
Year: 2017
Journal: Elife
Title: Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt).
Volume: 6
Publication
First Author: Shibata SB
Year: 2016
Journal: Am J Hum Genet
Title: RNA Interference Prevents Autosomal-Dominant Hearing Loss.
Volume: 98
Issue: 6
Pages: 1101-1113
Publication
First Author: Beurg M
Year: 2018
Journal: Nat Commun
Title: Variable number of TMC1-dependent mechanotransducer channels underlie tonotopic conductance gradients in the cochlea.
Volume: 9
Issue: 1
Pages: 2185
Publication
First Author: Mahendrasingam S
Year: 2019
Journal: Sci Rep
Title: Ultrastructural localization of the likely mechanoelectrical transduction channel protein, transmembrane-like channel 1 (TMC1) during development of cochlear hair cells.
Volume: 9
Issue: 1
Pages: 1274
Publication
First Author: Wu Z
Year: 2017
Journal: Nat Neurosci
Title: Mechanosensory hair cells express two molecularly distinct mechanotransduction channels.
Volume: 20
Issue: 1
Pages: 24-33
Publication
First Author: Askew C
Year: 2015
Journal: Sci Transl Med
Title: Tmc gene therapy restores auditory function in deaf mice.
Volume: 7
Issue: 295
Pages: 295ra108
Publication
First Author: Gao X
Year: 2018
Journal: Nature
Title: Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents.
Volume: 553
Issue: 7687
Pages: 217-221
Publication
First Author: Kurima K
Year: 2003
Journal: Genomics
Title: Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis.
Volume: 82
Issue: 3
Pages: 300-8
Publication
First Author: Asai Y
Year: 2018
Journal: Sci Rep
Title: Transgenic Tmc2 expression preserves inner ear hair cells and vestibular function in mice lacking Tmc1.
Volume: 8
Issue: 1
Pages: 12124
Publication
First Author: Beurg M
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Subunit determination of the conductance of hair-cell mechanotransducer channels.
Volume: 112
Issue: 5
Pages: 1589-94
Publication
First Author: Beurg M
Year: 2014
Journal: J Gen Physiol
Title: Conductance and block of hair-cell mechanotransducer channels in transmembrane channel-like protein mutants.
Volume: 144
Issue: 1
Pages: 55-69
Publication
First Author: Kawashima Y
Year: 2011
Journal: J Clin Invest
Title: Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes.
Volume: 121
Issue: 12
Pages: 4796-809
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication  
First Author: Deol MS
Year: 1958
Journal: Heredity
Title: A new gene for deafness in the mouse.
Volume: 12
Pages: 463-6
Publication
First Author: Steel KP
Year: 1984
Journal: Hear Res
Title: Electrically-evoked responses in animals with progressive spiral ganglion degeneration.
Volume: 15
Issue: 1
Pages: 59-67
Publication
First Author: McKay SM
Year: 2007
Journal: Hear Res
Title: The role of spontaneous activity in development of the endbulb of Held synapse.
Volume: 230
Issue: 1-2
Pages: 53-63
Publication
First Author: Oleskevich S
Year: 2002
Journal: J Physiol
Title: Synaptic transmission in the auditory brainstem of normal and congenitally deaf mice.
Volume: 540
Issue: Pt 2
Pages: 447-55
Publication
First Author: Pujol R
Year: 1983
Journal: Hear Res
Title: Early degeneration of sensory and ganglion cells in the inner ear of mice with uncomplicated genetic deafness (dn): preliminary observations.
Volume: 12
Issue: 1
Pages: 57-63
Publication
First Author: Bock GR
Year: 1982
Journal: Brain Res
Title: Preservation of central auditory function in the deafness mouse.
Volume: 239
Issue: 2
Pages: 608-12
Publication
First Author: Leão RN
Year: 2006
Journal: Eur J Neurosci
Title: Altered sodium currents in auditory neurons of congenitally deaf mice.
Volume: 24
Issue: 4
Pages: 1137-46
Publication
First Author: Keats BJ
Year: 1995
Journal: Mamm Genome
Title: The deafness locus (dn) maps to mouse chromosome 19.
Volume: 6
Issue: 1
Pages: 8-10
Publication
First Author: Webster DB
Year: 1992
Journal: Exp Neurol
Title: Degeneration followed by partial regeneration of the organ of Corti in deafness (dn/dn) mice.
Volume: 115
Issue: 1
Pages: 27-31
Publication
First Author: Steel KP
Year: 1980
Journal: Nature
Title: The nature of inherited deafness in deafness mice.
Volume: 288
Issue: 5787
Pages: 159-61
Publication
First Author: Oleskevich S
Year: 2004
Journal: J Physiol
Title: Presynaptic plasticity at two giant auditory synapses in normal and deaf mice.
Volume: 560
Issue: Pt 3
Pages: 709-19
Publication
First Author: Kirsch JP
Year: 1993
Journal: Hear Res
Title: Mice heterozygous for the deafness gene have normal auditory thresholds.
Volume: 67
Issue: 1-2
Pages: 51-4
Publication
First Author: Leao RN
Year: 2005
Journal: Eur J Neurosci
Title: Hyperpolarization-activated (I) currents in auditory brainstem neurons of normal and congenitally deaf mice.
Volume: 22
Issue: 1
Pages: 147-57
Publication
First Author: Leao RN
Year: 2004
Journal: J Physiol
Title: Reduced low-voltage activated K+ conductances and enhanced central excitability in a congenitally deaf (dn/dn) mouse.
Volume: 559
Issue: Pt 1
Pages: 25-33
Publication
First Author: Youssoufian M
Year: 2005
Journal: J Neurophysiol
Title: Development of a robust central auditory synapse in congenital deafness.
Volume: 94
Issue: 5
Pages: 3168-80
Publication
First Author: Couchman K
Year: 2011
Journal: Hear Res
Title: Lateral superior olive function in congenital deafness.
Volume: 277
Issue: 1-2
Pages: 163-75
Publication
First Author: Martínez-Cué C
Year: 2005
Journal: Behav Brain Res
Title: Behavioral, cognitive and biochemical responses to different environmental conditions in male Ts65Dn mice, a model of Down syndrome.
Volume: 163
Issue: 2
Pages: 174-85
Publication
First Author: Viñas AM
Year: 1998
Journal: Biochim Biophys Acta
Title: The mouse deafness locus (dn) is associated with an inversion on chromosome 19.
Volume: 1407
Issue: 3
Pages: 257-62
GXD Expression    
Probe: MGI:5474482
Assay Type: RT-PCR
Annotation Date: 2013-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1729328
Stage: TS28
Assay Id: MGI:5474486
Age: postnatal day 21
Image: 1
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:5474482
Assay Type: RT-PCR
Annotation Date: 2013-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1729328
Stage: TS28
Assay Id: MGI:5474486
Age: postnatal day 7
Image: 1
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:5474482
Assay Type: RT-PCR
Annotation Date: 2013-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1729327
Stage: TS27
Assay Id: MGI:5474486
Age: postnatal day 3
Image: 1
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:5474482
Assay Type: RT-PCR
Annotation Date: 2013-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1729327
Stage: TS27
Assay Id: MGI:5474486
Age: postnatal day 1
Image: 1
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:5474482
Assay Type: RT-PCR
Annotation Date: 2013-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1729326
Stage: TS26
Assay Id: MGI:5474486
Age: embryonic day 18.0
Image: 1
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:5474482
Assay Type: RT-PCR
Annotation Date: 2013-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1729325
Stage: TS25
Assay Id: MGI:5474486
Age: embryonic day 17.0
Image: 1
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:5474482
Assay Type: RT-PCR
Annotation Date: 2013-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1729324
Stage: TS24
Assay Id: MGI:5474486
Age: embryonic day 16.0
Image: 1
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5474482
Assay Type: RT-PCR
Annotation Date: 2013-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1729323
Stage: TS23
Assay Id: MGI:5474486
Age: embryonic day 15.0
Image: 1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5474482
Assay Type: RT-PCR
Annotation Date: 2013-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:5474488
Age: postnatal day 22
Image: 1
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:5474482
Assay Type: RT-PCR
Annotation Date: 2013-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:5474488
Age: postnatal day 5
Image: 1
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:5474482
Assay Type: RT-PCR
Annotation Date: 2013-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:5474488
Age: postnatal day 4
Image: 1
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:5474482
Assay Type: RT-PCR
Annotation Date: 2013-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759727
Stage: TS27
Assay Id: MGI:5474488
Age: postnatal day 3
Image: 1
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:5474482
Assay Type: RT-PCR
Annotation Date: 2013-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759727
Stage: TS27
Assay Id: MGI:5474488
Age: postnatal day 2
Image: 1
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:5474482
Assay Type: RT-PCR
Annotation Date: 2013-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759727
Stage: TS27
Assay Id: MGI:5474488
Age: postnatal day 1
Image: 1
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5474482
Assay Type: RT-PCR
Annotation Date: 2013-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759727
Stage: TS27
Assay Id: MGI:5474488
Age: postnatal day 0
Image: 1
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4424106
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4828752
Age: embryonic day 14.5
Image: euxassay_011795_24
Detected: true
Specimen Num: 24
GXD Expression  
Probe: MGI:4424106
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4828752
Age: embryonic day 14.5
Image: euxassay_011795_23
Detected: true
Specimen Num: 23
GXD Expression  
Probe: MGI:4424106
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4828752
Age: embryonic day 14.5
Image: euxassay_011795_22
Detected: true
Specimen Num: 22
GXD Expression  
Probe: MGI:4424106
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4828752
Age: embryonic day 14.5
Image: euxassay_011795_21
Detected: true
Specimen Num: 21
GXD Expression  
Probe: MGI:4424106
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4828752
Age: embryonic day 14.5
Image: euxassay_011795_20
Detected: true
Specimen Num: 20
GXD Expression  
Probe: MGI:4424106
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4828752
Age: embryonic day 14.5
Image: euxassay_011795_19
Detected: true
Specimen Num: 19
GXD Expression  
Probe: MGI:4424106
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4828752
Age: embryonic day 14.5
Image: euxassay_011795_18
Detected: true
Specimen Num: 18
GXD Expression  
Probe: MGI:4424106
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4828752
Age: embryonic day 14.5
Image: euxassay_011795_17
Detected: true
Specimen Num: 17
GXD Expression  
Probe: MGI:4424106
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4828752
Age: embryonic day 14.5
Image: euxassay_011795_09
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:4424106
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4828752
Age: embryonic day 14.5
Image: euxassay_011795_07
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:4424106
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4828752
Age: embryonic day 14.5
Image: euxassay_011795_06
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:4424106
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4828752
Age: embryonic day 14.5
Image: euxassay_011795_05
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:4424106
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4828752
Age: embryonic day 14.5
Image: euxassay_011795_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4424106
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4828752
Age: embryonic day 14.5
Image: euxassay_011795_02
Detected: true
Specimen Num: 2