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Search results 1 to 100 out of 363 for Tmc1

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0.039s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
GXD Expression
Probe: MGI:6723841
Assay Type: Immunohistochemistry
Annotation Date: 2021-07-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1906128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6723934
Age: postnatal day 12
Image: 6 TMC1 tm1a/tm1a
Note: No difference expression from heterozygous control.
Specimen Label: 6 TMC1 tm1a/tm1a
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:6723841
Assay Type: Immunohistochemistry
Annotation Date: 2021-07-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1906128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6723934
Age: postnatal day 12
Image: 6 TMC1 tm1a/+
Specimen Label: 6 TMC1 tm1a/+
Detected: true
Specimen Num: 1
Publication
First Author: Beurg M
Year: 2021
Journal: J Neurosci
Title: New Tmc1 Deafness Mutations Impact Mechanotransduction in Auditory Hair Cells.
Volume: 41
Issue: 20
Pages: 4378-4391
Publication
First Author: Maeda R
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Tip-link protein protocadherin 15 interacts with transmembrane channel-like proteins TMC1 and TMC2.
Volume: 111
Issue: 35
Pages: 12907-12
Publication    
First Author: Ballesteros A
Year: 2018
Journal: Elife
Title: Structural relationship between the putative hair cell mechanotransduction channel TMC1 and TMEM16 proteins.
Volume: 7
Publication
First Author: Ballesteros A
Year: 2022
Journal: Sci Adv
Title: Regulation of membrane homeostasis by TMC1 mechanoelectrical transduction channels is essential for hearing.
Volume: 8
Issue: 31
Pages: eabm5550
Publication
First Author: Akyuz N
Year: 2022
Journal: Sci Adv
Title: Mechanical gating of the auditory transduction channel TMC1 involves the fourth and sixth transmembrane helices.
Volume: 8
Issue: 28
Pages: eabo1126
Publication
First Author: Kurima K
Year: 2015
Journal: Cell Rep
Title: TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia.
Volume: 12
Issue: 10
Pages: 1606-17
Publication
First Author: Pan B
Year: 2018
Journal: Neuron
Title: TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells.
Volume: 99
Issue: 4
Pages: 736-753.e6
Publication  
First Author: Marcovich I
Year: 2022
Journal: Biomolecules
Title: Optimized AAV Vectors for TMC1 Gene Therapy in a Humanized Mouse Model of DFNB7/11.
Volume: 12
Issue: 7
Publication
First Author: Manji SS
Year: 2012
Journal: Am J Pathol
Title: Identification of three novel hearing loss mouse strains with mutations in the Tmc1 gene.
Volume: 180
Issue: 4
Pages: 1560-9
Publication
First Author: Goldring AC
Year: 2019
Journal: J Physiol
Title: The contribution of TMC1 to adaptation of mechanoelectrical transduction channels in cochlear outer hair cells.
Volume: 597
Issue: 24
Pages: 5949-5961
Publication
First Author: Li X
Year: 2019
Journal: FASEB J
Title: Localization of TMC1 and LHFPL5 in auditory hair cells in neonatal and adult mice.
Volume: 33
Issue: 6
Pages: 6838-6851
Publication
First Author: Pan B
Year: 2013
Journal: Neuron
Title: TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear.
Volume: 79
Issue: 3
Pages: 504-15
Publication
First Author: Marcotti W
Year: 2006
Journal: J Physiol
Title: Tmc1 is necessary for normal functional maturation and survival of inner and outer hair cells in the mouse cochlea.
Volume: 574
Issue: Pt 3
Pages: 677-98
Publication
First Author: Soler DC
Year: 2019
Journal: Sci Rep
Title: An uncharacterized region within the N-terminus of mouse TMC1 precludes trafficking to plasma membrane in a heterologous cell line.
Volume: 9
Issue: 1
Pages: 15263
Publication    
First Author: Liu S
Year: 2019
Journal: Elife
Title: TMC1 is an essential component of a leak channel that modulates tonotopy and excitability of auditory hair cells in mice.
Volume: 8
Publication
First Author: Giese APJ
Year: 2017
Journal: Nat Commun
Title: CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.
Volume: 8
Issue: 1
Pages: 43
Publication
First Author: Corns LF
Year: 2016
Journal: J Neurosci
Title: Tmc1 Point Mutation Affects Ca2+ Sensitivity and Block by Dihydrostreptomycin of the Mechanoelectrical Transducer Current of Mouse Outer Hair Cells.
Volume: 36
Issue: 2
Pages: 336-49
Publication
First Author: Nakanishi H
Year: 2018
Journal: Sci Rep
Title: Tmc2 expression partially restores auditory function in a mouse model of DFNB7/B11 deafness caused by loss of Tmc1 function.
Volume: 8
Issue: 1
Pages: 12125
Publication
First Author: Beurg M
Year: 2015
Journal: J Gen Physiol
Title: The effects of Tmc1 Beethoven mutation on mechanotransducer channel function in cochlear hair cells.
Volume: 146
Issue: 3
Pages: 233-43
QTL
Type: QTL
Organism: mouse, laboratory
QTL
Type: QTL
Organism: mouse, laboratory
QTL
Type: QTL
Organism: mouse, laboratory
QTL
Type: QTL
Organism: mouse, laboratory
Publication
First Author: Noguchi Y
Year: 2006
Journal: Genetics
Title: Multiple quantitative trait loci modify cochlear hair cell degeneration in the Beethoven (Tmc1Bth) mouse model of progressive hearing loss DFNA36.
Volume: 173
Issue: 4
Pages: 2111-9
GXD Expression
Probe: MGI:6391205
Assay Type: Immunohistochemistry
Annotation Date: 2022-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7266314
Age: postnatal day 16
Image: 7B Tmc1 delta/delta Apical
Note: Expression along perimeter of outer hair cells .
Specimen Label: 7B Tmc1 delta/delta Apical
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:6391205
Assay Type: Immunohistochemistry
Annotation Date: 2022-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7266314
Age: postnatal day 16
Image: 7B Tmc1 delta/delta Middle
Note: Expression along perimeter of outer hair cells. Outer hair cells were degenerating.
Specimen Label: 7B Tmc1 delta/delta Middle
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:6391205
Assay Type: Immunohistochemistry
Annotation Date: 2022-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7266314
Age: postnatal day 16
Image: 7B Tmc1 delta/delta Basal
Note: Expression along perimeter of outer hair cells. Outer hair cells were degenerating.
Specimen Label: 7B Tmc1 delta/delta Basal
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:5308606
Assay Type: Immunohistochemistry
Annotation Date: 2022-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7266315
Age: postnatal day 16
Image: 7B Tmc1 delta/delta Apical
Specimen Label: 7B Tmc1 delta/delta Apical
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5308606
Assay Type: Immunohistochemistry
Annotation Date: 2022-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7266315
Age: postnatal day 16
Image: 7B Tmc1 delta/delta Apical
Specimen Label: 7B Tmc1 delta/delta Apical
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5308606
Assay Type: Immunohistochemistry
Annotation Date: 2022-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7266315
Age: postnatal day 16
Image: 7B Tmc1 delta/delta Middle
Specimen Label: 7B Tmc1 delta/delta Middle
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:5308606
Assay Type: Immunohistochemistry
Annotation Date: 2022-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7266315
Age: postnatal day 16
Image: 7B Tmc1 delta/delta Middle
Specimen Label: 7B Tmc1 delta/delta Middle
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:5308606
Assay Type: Immunohistochemistry
Annotation Date: 2022-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7266315
Age: postnatal day 16
Image: 7B Tmc1 delta/delta Basal
Specimen Label: 7B Tmc1 delta/delta Basal
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:5308606
Assay Type: Immunohistochemistry
Annotation Date: 2022-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7266315
Age: postnatal day 16
Image: 7B Tmc1 delta/delta Basal
Specimen Label: 7B Tmc1 delta/delta Basal
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:7266305
Assay Type: Immunohistochemistry
Annotation Date: 2022-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7266316
Age: postnatal day 25
Image: 8A Tmc1 +/+
Note: Expression around perimeter of outer hair cells in apical cohlear turn.
Specimen Label: 8A Tmc1 +/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7266305
Assay Type: Immunohistochemistry
Annotation Date: 2022-05-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:7266316
Age: postnatal day 25
Image: 8A Tmc1 delta/delta
Specimen Label: 8A Tmc1 delta/delta
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:7266307
Assay Type: Immunohistochemistry
Annotation Date: 2022-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7266317
Age: postnatal day 25
Image: 8A Tmc1 +/+
Specimen Label: 8A Tmc1 +/+
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:7266307
Assay Type: Immunohistochemistry
Annotation Date: 2022-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7266317
Age: postnatal day 25
Image: 8A Tmc1 delta/delta
Specimen Label: 8A Tmc1 delta/delta
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:7266307
Assay Type: Immunohistochemistry
Annotation Date: 2022-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7266317
Age: postnatal day 16
Image: 8B P16 Tmc1 +/+
Specimen Label: 8B P16 Tmc1 +/+
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:7266307
Assay Type: Immunohistochemistry
Annotation Date: 2022-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7266317
Age: postnatal day 16
Image: 8B P16 Tmc1 delta/delta
Specimen Label: 8B P16 Tmc1 delta/delta
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:7266307
Assay Type: Immunohistochemistry
Annotation Date: 2022-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7266317
Age: postnatal day 25
Image: 8B P25 Tmc1 +/+
Specimen Label: 8B P25 Tmc1 +/+
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:7266307
Assay Type: Immunohistochemistry
Annotation Date: 2022-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7266317
Age: postnatal day 25
Image: 8B P25 Tmc1 delta/delta
Specimen Label: 8B P25 Tmc1 delta/delta
Detected: true
Specimen Num: 6
GXD Expression
Probe: MGI:7266308
Assay Type: Immunohistochemistry
Annotation Date: 2022-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Pattern: Punctate
Stage: TS28
Assay Id: MGI:7266321
Age: postnatal day 16
Image: 8B P16 Tmc1 +/+
Note: Punctate expression at neck of inner hair cells in apical cochlear turn.
Specimen Label: 8B P16 Tmc1 +/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7266308
Assay Type: Immunohistochemistry
Annotation Date: 2022-05-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:7266321
Age: postnatal day 16
Image: 8B P16 Tmc1 delta/delta
Specimen Label: 8B P16 Tmc1 delta/delta
Detected: false
Specimen Num: 2
GXD Expression
Probe: MGI:7266308
Assay Type: Immunohistochemistry
Annotation Date: 2022-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Pattern: Punctate
Stage: TS28
Assay Id: MGI:7266321
Age: postnatal day 25
Image: 8B P25 Tmc1 +/+
Note: Punctate expression at neck of inner hair cells in apical cochlear turn.
Specimen Label: 8B P25 Tmc1 +/+
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:7266308
Assay Type: Immunohistochemistry
Annotation Date: 2022-05-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:7266321
Age: postnatal day 25
Image: 8B P25 Tmc1 delta/delta
Specimen Label: 8B P25 Tmc1 delta/delta
Detected: false
Specimen Num: 4
Publication
First Author: Beurg M
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: A Tmc1 mutation reduces calcium permeability and expression of mechanoelectrical transduction channels in cochlear hair cells.
Volume: 116
Issue: 41
Pages: 20743-20749
Publication
First Author: Vreugde S
Year: 2002
Journal: Nat Genet
Title: Beethoven, a mouse model for dominant, progressive hearing loss DFNA36.
Volume: 30
Issue: 3
Pages: 257-8
Publication    
First Author: Erickson T
Year: 2017
Journal: Elife
Title: Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt).
Volume: 6
Publication
First Author: Kurima K
Year: 2002
Journal: Nat Genet
Title: Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function.
Volume: 30
Issue: 3
Pages: 277-84
Publication
First Author: Beurg M
Year: 2018
Journal: Nat Commun
Title: Variable number of TMC1-dependent mechanotransducer channels underlie tonotopic conductance gradients in the cochlea.
Volume: 9
Issue: 1
Pages: 2185
Publication
First Author: Shibata SB
Year: 2016
Journal: Am J Hum Genet
Title: RNA Interference Prevents Autosomal-Dominant Hearing Loss.
Volume: 98
Issue: 6
Pages: 1101-1113
Publication
First Author: Mahendrasingam S
Year: 2019
Journal: Sci Rep
Title: Ultrastructural localization of the likely mechanoelectrical transduction channel protein, transmembrane-like channel 1 (TMC1) during development of cochlear hair cells.
Volume: 9
Issue: 1
Pages: 1274
Publication  
First Author: Yamaguchi S
Year: 2020
Journal: Int J Mol Sci
Title: A Mechanosensitive Channel, Mouse Transmembrane Channel-Like Protein 1 (Mtmc1) Is Translated from a Splice Variant mTmc1ex1 but Not from the Other Variant mTmc1ex2.
Volume: 21
Issue: 18
Publication
First Author: Cunningham CL
Year: 2020
Journal: Neuron
Title: TMIE Defines Pore and Gating Properties of the Mechanotransduction Channel of Mammalian Cochlear Hair Cells.
Volume: 107
Issue: 1
Pages: 126-143.e8
Publication    
First Author: Lee J
Year: 2021
Journal: Elife
Title: Sensory transduction is required for normal development and maturation of cochlear inner hair cell synapses.
Volume: 10
Publication  
First Author: Beurg M
Year: 2021
Journal: J Gen Physiol
Title: The speed of the hair cell mechanotransducer channel revealed by fluctuation analysis.
Volume: 153
Issue: 10
Publication
First Author: Kim KX
Year: 2013
Journal: J Gen Physiol
Title: The role of transmembrane channel-like proteins in the operation of hair cell mechanotransducer channels.
Volume: 142
Issue: 5
Pages: 493-505
Publication
First Author: Askew C
Year: 2015
Journal: Sci Transl Med
Title: Tmc gene therapy restores auditory function in deaf mice.
Volume: 7
Issue: 295
Pages: 295ra108
Publication
First Author: Gao X
Year: 2018
Journal: Nature
Title: Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents.
Volume: 553
Issue: 7687
Pages: 217-221
Publication
First Author: Kurima K
Year: 2003
Journal: Genomics
Title: Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis.
Volume: 82
Issue: 3
Pages: 300-8
Publication
First Author: Wu Z
Year: 2017
Journal: Nat Neurosci
Title: Mechanosensory hair cells express two molecularly distinct mechanotransduction channels.
Volume: 20
Issue: 1
Pages: 24-33
Publication
First Author: Liang X
Year: 2021
Journal: Neuron
Title: CIB2 and CIB3 are auxiliary subunits of the mechanotransduction channel of hair cells.
Volume: 109
Issue: 13
Pages: 2131-2149.e15
Publication
First Author: Beurg M
Year: 2024
Journal: Proc Natl Acad Sci U S A
Title: LHFPL5 is a key element in force transmission from the tip link to the hair cell mechanotransducer channel.
Volume: 121
Issue: 3
Pages: e2318270121
Publication
First Author: Kim KX
Year: 2013
Journal: J Gen Physiol
Title: Developmental changes in the cochlear hair cell mechanotransducer channel and their regulation by transmembrane channel-like proteins.
Volume: 141
Issue: 1
Pages: 141-8
Publication
First Author: Fettiplace R
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: The conductance and organization of the TMC1-containing mechanotransducer channel complex in auditory hair cells.
Volume: 119
Issue: 41
Pages: e2210849119
Publication
First Author: Beurg M
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Subunit determination of the conductance of hair-cell mechanotransducer channels.
Volume: 112
Issue: 5
Pages: 1589-94
Publication
First Author: Beurg M
Year: 2014
Journal: J Gen Physiol
Title: Conductance and block of hair-cell mechanotransducer channels in transmembrane channel-like protein mutants.
Volume: 144
Issue: 1
Pages: 55-69
Publication
First Author: Kawashima Y
Year: 2011
Journal: J Clin Invest
Title: Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes.
Volume: 121
Issue: 12
Pages: 4796-809
Publication
First Author: Asai Y
Year: 2018
Journal: Sci Rep
Title: Transgenic Tmc2 expression preserves inner ear hair cells and vestibular function in mice lacking Tmc1.
Volume: 8
Issue: 1
Pages: 12124
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus