| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
204
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
111
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
125
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
45
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang H |
| Year: |
2020 |
| Journal: |
Cell Host Microbe |
| Title: |
TMEM173 Drives Lethal Coagulation in Sepsis. |
| Volume: |
27 |
| Issue: |
4 |
| Pages: |
556-570.e6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Patel S |
| Year: |
2017 |
| Journal: |
J Immunol |
| Title: |
The Common R71H-G230A-R293Q Human TMEM173 Is a Null Allele. |
| Volume: |
198 |
| Issue: |
2 |
| Pages: |
776-787 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
199
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
372
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
E-GEOD-68140 |
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Surpris G |
| Year: |
2016 |
| Journal: |
J Immunol |
| Title: |
Cutting Edge: Novel Tmem173 Allele Reveals Importance of STING N Terminus in Trafficking and Type I IFN Production. |
| Volume: |
196 |
| Issue: |
2 |
| Pages: |
547-52 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
378
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Allele |
| Name: |
stimulator of interferon response cGAMP interactor 1; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
stimulator of interferon response cGAMP interactor 1; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
stimulator of interferon response cGAMP interactor 1; targeted mutation 2, Shanghai Model Organisms Center |
| Allele Type: |
Targeted |
| Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Feng M |
| Year: |
2022 |
| Journal: |
Biochem Pharmacol |
| Title: |
Gelsevirine improves age-related and surgically induced osteoarthritis in mice by reducing STING availability and local inflammation. |
| Volume: |
198 |
|
| Pages: |
114975 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, targeted mutation, mutant strain |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, targeted mutation, mutant strain |
|
•
•
•
•
•
|
| Allele |
| Name: |
stimulator of interferon response cGAMP interactor 1; targeted mutation 3.1, Genoway |
| Allele Type: |
Targeted |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
stimulator of interferon response cGAMP interactor 1; endonuclease-mediated mutation 1, Jonathan Miner |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Humanized sequence |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
378
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
427
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
337
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Sting1/Sting1<+> |
| Background: |
involves: C57BL/6N |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Park SM |
| Year: |
2019 |
| Journal: |
Commun Biol |
| Title: |
T cell fate following Salmonella infection is determined by a STING-IRF1 signaling axis in mice. |
| Volume: |
2 |
|
| Pages: |
464 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cerboni S |
| Year: |
2017 |
| Journal: |
J Exp Med |
| Title: |
Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes. |
| Volume: |
214 |
| Issue: |
6 |
| Pages: |
1769-1785 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bertaux F |
| Year: |
2022 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Direct Data Submission for Knock-in Genoway Alleles. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ruiz-Moreno JS |
| Year: |
2018 |
| Journal: |
Infect Immun |
| Title: |
The cGAS/STING Pathway Detects Streptococcus pneumoniae but Appears Dispensable for Antipneumococcal Defense in Mice and Humans. |
| Volume: |
86 |
| Issue: |
3 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cai Y |
| Year: |
2024 |
| Journal: |
Theranostics |
| Title: |
Intestinal epithelial damage-derived mtDNA activates STING-IL12 axis in dendritic cells to promote colitis. |
| Volume: |
14 |
| Issue: |
11 |
| Pages: |
4393-4410 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hu Z |
| Year: |
2023 |
| Journal: |
J Clin Invest |
| Title: |
Glycolysis drives STING signaling to facilitate dendritic cell antitumor function. |
| Volume: |
133 |
| Issue: |
7 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shanghai Model Organisms Center |
| Year: |
2017 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|