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Search results 1 to 100 out of 10261 for Tnf

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: cat, domestic
Gene
Type: gene
Organism: sheep
Gene
Type: gene
Organism: rabbit, European
Gene
Type: gene
Organism: rat
Protein Domain
Type: Family
Description: Cytokines can be grouped into a family on the basis of sequence, functional and structural similarities [, , ]. Tumor necrosis factor (TNF) (also known as TNF-alpha or cachectin) is a monocyte-derived cytotoxin that has been implicated in tumour regression, septic shock and cachexia [, ]. The protein is synthesised as a prohormone with an unusually long and atypical signal sequence, which is absent from the mature secreted cytokine []. A short hydrophobic stretch of amino acids serves to anchor the prohormone in lipid bilayers []. Both the mature protein and a partially-processed form of the hormone are secreted after cleavage of the propeptide [].There are a number of different families of TNF, but all these cytokines seem to form homotrimeric (or heterotrimeric in the case of LT-alpha/beta) complexes that are recognised by their specific receptors.
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Fransen L
Year: 1985
Journal: Nucleic Acids Res
Title: Molecular cloning of mouse tumour necrosis factor cDNA and its eukaryotic expression.
Volume: 13
Issue: 12
Pages: 4417-29
Protein
Organism: Mus musculus/domesticus
Length: 252  
Fragment?: false
Publication
First Author: Tsitsikov EN
Year: 2001
Journal: Immunity
Title: TRAF1 is a negative regulator of TNF signaling. enhanced TNF signaling in TRAF1-deficient mice.
Volume: 15
Issue: 4
Pages: 647-57
Protein
Organism: Mus musculus/domesticus
Length: 239  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: false
Publication
First Author: Xu Y
Year: 1996
Journal: Immunity
Title: Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses.
Volume: 5
Issue: 5
Pages: 407-15
Protein
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: false
GXD Expression    
Probe: MGI:3056622
Assay Type: RT-PCR
Annotation Date: 2004-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893928
Stage: TS28
Assay Id: MGI:3505774
Age: postnatal week 9.5
Image: 4
Specimen Label: Th1 Tnf 9.5W WT
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3056622
Assay Type: RT-PCR
Annotation Date: 2004-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893928
Stage: TS28
Assay Id: MGI:3505774
Age: postnatal week 9.5
Image: 4
Specimen Label: Th1 Tnf 9.5W KO
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3056622
Assay Type: RT-PCR
Annotation Date: 2004-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893928
Stage: TS28
Assay Id: MGI:3505774
Age: postnatal month 9
Image: 4
Specimen Label: Th1 Tnf 9M WT
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3056622
Assay Type: RT-PCR
Annotation Date: 2004-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893928
Stage: TS28
Assay Id: MGI:3505774
Age: postnatal month 9
Image: 4
Specimen Label: Th1 Tnf 9M KO
Detected: true
Specimen Num: 4
Publication
First Author: Shiels H
Year: 2000
Journal: Am J Pathol
Title: TRAF4 deficiency leads to tracheal malformation with resulting alterations in air flow to the lungs.
Volume: 157
Issue: 2
Pages: 679-88
Publication
First Author: Lomaga MA
Year: 1999
Journal: Genes Dev
Title: TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.
Volume: 13
Issue: 8
Pages: 1015-24
Gene
Type: gene
Organism: human
Publication
First Author: Yeh WC
Year: 1997
Journal: Immunity
Title: Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice.
Volume: 7
Issue: 5
Pages: 715-25
Publication
First Author: Lin WJ
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Crucial role for TNF receptor-associated factor 2 (TRAF2) in regulating NFκB2 signaling that contributes to autoimmunity.
Volume: 108
Issue: 45
Pages: 18354-9
Protein
Organism: Mus musculus/domesticus
Length: 239  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 252  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 270  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 219  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 219  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 324  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 138  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 304  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 185  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: false
Publication
First Author: Bazan JF
Year: 1993
Journal: Curr Biol
Title: Emerging families of cytokines and receptors.
Volume: 3
Issue: 9
Pages: 603-6
Publication
First Author: Farrah T
Year: 1992
Journal: Nature
Title: Emerging cytokine family.
Volume: 358
Issue: 6381
Pages: 26
Publication
First Author: Peitsch MC
Year: 1993
Journal: Int Immunol
Title: A 3-D model for the CD40 ligand predicts that it is a compact trimer similar to the tumor necrosis factors.
Volume: 5
Issue: 2
Pages: 233-8
Publication
First Author: Cseh K
Year: 1989
Journal: J Biol Chem
Title: Alternative cleavage of the cachectin/tumor necrosis factor propeptide results in a larger, inactive form of secreted protein.
Volume: 264
Issue: 27
Pages: 16256-60
Publication
First Author: Sherry B
Year: 1990
Journal: Biochem Biophys Res Commun
Title: Characterization of high molecular weight glycosylated forms of murine tumor necrosis factor.
Volume: 173
Issue: 3
Pages: 1072-8
Publication
First Author: Kriegler M
Year: 1988
Journal: Cell
Title: A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF.
Volume: 53
Issue: 1
Pages: 45-53
Publication
First Author: Nguyen LT
Year: 1999
Journal: Immunity
Title: TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses.
Volume: 11
Issue: 3
Pages: 379-89
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication
First Author: Kato T Jr
Year: 2008
Journal: Genes Cells
Title: Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1.
Volume: 13
Issue: 5
Pages: 509-20
Publication
First Author: Zhao X
Year: 2012
Journal: J Clin Invest
Title: TNF signaling drives myeloid-derived suppressor cell accumulation.
Volume: 122
Issue: 11
Pages: 4094-104
Publication
First Author: Ware CF
Year: 2003
Journal: Cytokine Growth Factor Rev
Title: The TNF superfamily.
Volume: 14
Issue: 3-4
Pages: 181-4
Publication
First Author: Locksley RM
Year: 2001
Journal: Cell
Title: The TNF and TNF receptor superfamilies: integrating mammalian biology.
Volume: 104
Issue: 4
Pages: 487-501
Publication
First Author: Noti M
Year: 2010
Journal: J Exp Med
Title: TNF suppresses acute intestinal inflammation by inducing local glucocorticoid synthesis.
Volume: 207
Issue: 5
Pages: 1057-66
Publication
First Author: Wright HV
Year: 2006
Journal: J Immunol
Title: IL-3-mediated TNF production is necessary for mast cell development.
Volume: 176
Issue: 4
Pages: 2114-21
Publication
First Author: Kanazawa K
Year: 2005
Journal: J Bone Miner Res
Title: TRAF2 is essential for TNF-alpha-induced osteoclastogenesis.
Volume: 20
Issue: 5
Pages: 840-7
Publication
First Author: Suto H
Year: 2006
Journal: J Immunol
Title: Mast cell-associated TNF promotes dendritic cell migration.
Volume: 176
Issue: 7
Pages: 4102-12
Publication
First Author: Kontoyiannis D
Year: 1999
Journal: Immunity
Title: Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies.
Volume: 10
Issue: 3
Pages: 387-98
Publication
First Author: Jabara HH
Year: 2009
Journal: Int Immunol
Title: TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40.
Volume: 21
Issue: 4
Pages: 477-88
Publication
First Author: Andrade RM
Year: 2005
Journal: J Immunol
Title: TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alpha.
Volume: 175
Issue: 9
Pages: 6014-21
Publication
First Author: Soni S
Year: 2019
Journal: FASEB J
Title: ATP redirects cytokine trafficking and promotes novel membrane TNF signaling via microvesicles.
Volume: 33
Issue: 5
Pages: 6442-6455
Publication
First Author: Gardam S
Year: 2008
Journal: Immunity
Title: TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor.
Volume: 28
Issue: 3
Pages: 391-401
Publication  
First Author: Probert L
Year: 2015
Journal: Neuroscience
Title: TNF and its receptors in the CNS: The essential, the desirable and the deleterious effects.
Volume: 302
Pages: 2-22
Publication
First Author: Ichikawa D
Year: 2006
Journal: Biochem Biophys Res Commun
Title: TNF-receptor associated factor 6-deficient fibroblast is sensitive to the TNF-alpha-induced cell death: involvement of reactive oxygen species.
Volume: 351
Issue: 1
Pages: 93-8
Publication
First Author: Ilg RC
Year: 2005
Journal: Curr Eye Res
Title: Altered retinal neovascularization in TNF receptor-deficient mice.
Volume: 30
Issue: 11
Pages: 1003-13
Publication
First Author: Babaya N
Year: 2002
Journal: Autoimmunity
Title: Sequence analysis of Tnf as a candidate for Idd16.
Volume: 35
Issue: 1
Pages: 63-6
Publication
First Author: Peppel K
Year: 1993
Journal: J Immunol
Title: Expression of a TNF inhibitor in transgenic mice.
Volume: 151
Issue: 10
Pages: 5699-703
Publication
First Author: Wolf Y
Year: 2017
Journal: J Exp Med
Title: Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation.
Volume: 214
Issue: 4
Pages: 905-917
Publication
First Author: Deboer T
Year: 2002
Journal: J Neurophysiol
Title: Tumor necrosis factor (TNF) ligand and TNF receptor deficiency affects sleep and the sleep EEG.
Volume: 88
Issue: 2
Pages: 839-46
Publication
First Author: Alexopoulou L
Year: 1997
Journal: Eur J Immunol
Title: A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF receptor signaling.
Volume: 27
Issue: 10
Pages: 2588-92
Publication
First Author: Willemsen J
Year: 2021
Journal: Cell Rep
Title: TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis.
Volume: 37
Issue: 6
Pages: 109977
Publication
First Author: Shakhov AN
Year: 2000
Journal: J Leukoc Biol
Title: Gene profiling approach in the analysis of lymphotoxin and TNF deficiencies.
Volume: 68
Issue: 1
Pages: 151-7
Publication
First Author: Makarenkova V
Year: 2005
Journal: J Leukoc Biol
Title: Dendritic cells and natural killer cells interact via multiple TNF family molecules.
Volume: 77
Issue: 3
Pages: 408-13
Publication
First Author: Speiser DE
Year: 1997
Journal: J Immunol
Title: TNF receptor p55 controls early acute graft-versus-host disease.
Volume: 158
Issue: 11
Pages: 5185-90
Publication
First Author: Kontoyiannis D
Year: 2001
Journal: EMBO J
Title: Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology.
Volume: 20
Issue: 14
Pages: 3760-70
Publication
First Author: Nie S
Year: 2009
Journal: J Immunol
Title: Resistance to vaccinia virus is less dependent on TNF under conditions of heterologous immunity.
Volume: 183
Issue: 10
Pages: 6554-60
Publication
First Author: Hojilla CV
Year: 2011
Journal: PLoS One
Title: TIMP3 regulates mammary epithelial apoptosis with immune cell recruitment through differential TNF dependence.
Volume: 6
Issue: 10
Pages: e26718
Publication
First Author: Kobayashi T
Year: 2003
Journal: Immunity
Title: TRAF6 is a critical factor for dendritic cell maturation and development.
Volume: 19
Issue: 3
Pages: 353-63
Publication
First Author: Fontaine V
Year: 2002
Journal: J Neurosci
Title: Neurodegenerative and neuroprotective effects of tumor Necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2.
Volume: 22
Issue: 7
Pages: RC216
Publication
First Author: Ledgerwood EC
Year: 1999
Journal: Lab Invest
Title: Recent advances in the molecular basis of TNF signal transduction.
Volume: 79
Issue: 9
Pages: 1041-50
Publication  
First Author: Karamita M
Year: 2017
Journal: JCI Insight
Title: Therapeutic inhibition of soluble brain TNF promotes remyelination by increasing myelin phagocytosis by microglia.
Volume: 2
Issue: 8
Publication
First Author: Clayer E
Year: 2020
Journal: iScience
Title: Severe Impairment of TNF Post-transcriptional Regulation Leads to Embryonic Death.
Volume: 23
Issue: 11
Pages: 101726
Publication      
First Author: Heaton WL
Year: 2018
Journal: Leukemia
Title: Autocrine Tnf signaling favors malignant cells in myelofibrosis in a Tnfr2-dependent fashion.
Publication
First Author: Liu J
Year: 1998
Journal: Nat Med
Title: TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination.
Volume: 4
Issue: 1
Pages: 78-83
Publication
First Author: Togbe D
Year: 2007
Journal: Eur J Immunol
Title: T cell-derived TNF down-regulates acute airway response to endotoxin.
Volume: 37
Issue: 3
Pages: 768-79
Publication
First Author: Li S
Year: 2009
Journal: Mol Cell
Title: PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination.
Volume: 33
Issue: 1
Pages: 30-42
Publication
First Author: Iqbal J
Year: 2006
Journal: Biochem Biophys Res Commun
Title: TNF regulates cellular NAD+ metabolism in primary macrophages.
Volume: 342
Issue: 4
Pages: 1312-8