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Search results 1 to 100 out of 11124 for Tnf

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
7124 | TNF
Type: gene
Organism: human
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Gene
100134991 | tnf
Type: gene
Organism: frog, western clawed
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Gene
key_36452 | TNF
Type: gene
Organism: cat, domestic
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Gene
key_27534 | TNF
Type: gene
Organism: rabbit, European
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Gene
key_36453 | TNF
Type: gene
Organism: sheep
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Gene
24835 | Tnf
Type: gene
Organism: rat
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Gene
494186 | TNF
Type: gene
Organism: chimpanzee
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Gene
403922 | TNF
Type: gene
Organism: dog, domestic
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Gene
280943 | TNF
Type: gene
Organism: cattle
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Gene
715467 | TNF
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR006053 | TNF
Type: Family
Description: Cytokines can be grouped into a family on the basis of sequence, functional and structural similarities [, , ]. Tumor necrosis factor (TNF) (also known as TNF-alpha or cachectin) is a monocyte-derived cytotoxin that has been implicated in tumour regression, septic shock and cachexia [, ]. The protein is synthesised as a prohormone with an unusually long and atypical signal sequence, which is absent from the mature secreted cytokine []. A short hydrophobic stretch of amino acids serves to anchor the prohormone in lipid bilayers []. Both the mature protein and a partially-processed form of the hormone are secreted after cleavage of the propeptide [].There are a number of different families of TNF, but all these cytokines seem to form homotrimeric (or heterotrimeric in the case of LT-alpha/beta) complexes that are recognised by their specific receptors.
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Protein Coding Gene
MGI:104798 | Tnf
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
2989794 | J:20071
First Author: Fransen L
Year: 1985
Journal: Nucleic Acids Res
Title: Molecular cloning of mouse tumour necrosis factor cDNA and its eukaryotic expression.
Volume: 13
Issue: 12
Pages: 4417-29
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Protein
Q5UBV8
Organism: Mus musculus/domesticus
Length: 252  
Fragment?: false
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Publication
11672546 | J:72327
First Author: Tsitsikov EN
Year: 2001
Journal: Immunity
Title: TRAF1 is a negative regulator of TNF signaling. enhanced TNF signaling in TRAF1-deficient mice.
Volume: 15
Issue: 4
Pages: 647-57
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Protein
Q9QYH9
Organism: Mus musculus/domesticus
Length: 239  
Fragment?: false
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Protein
P41155
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: false
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Publication
8934568 | J:37065
First Author: Xu Y
Year: 1996
Journal: Immunity
Title: Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses.
Volume: 5
Issue: 5
Pages: 407-15
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Protein
P09225
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: false
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Gene
7132 | TNFRSF1A
Type: gene
Organism: human
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Protein
P06804
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: false
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GXD Expression
GXD Expression
   
Probe: MGI:3056622
Assay Type: RT-PCR
Annotation Date: 2004-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893928
Stage: TS28
Assay Id: MGI:3505774
Age: postnatal month 9
Image: 4
Specimen Label: Th1 Tnf 9M WT
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:3056622
Assay Type: RT-PCR
Annotation Date: 2004-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893928
Stage: TS28
Assay Id: MGI:3505774
Age: postnatal week 9.5
Image: 4
Specimen Label: Th1 Tnf 9.5W WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3056622
Assay Type: RT-PCR
Annotation Date: 2004-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893928
Stage: TS28
Assay Id: MGI:3505774
Age: postnatal week 9.5
Image: 4
Specimen Label: Th1 Tnf 9.5W KO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3056622
Assay Type: RT-PCR
Annotation Date: 2004-12-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893928
Stage: TS28
Assay Id: MGI:3505774
Age: postnatal month 9
Image: 4
Specimen Label: Th1 Tnf 9M KO
Detected: true
Specimen Num: 4
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Publication
10934170 | J:74252
First Author: Shiels H
Year: 2000
Journal: Am J Pathol
Title: TRAF4 deficiency leads to tracheal malformation with resulting alterations in air flow to the lungs.
Volume: 157
Issue: 2
Pages: 679-88
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Gene
84957 | RELT
Type: gene
Organism: human
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Publication
10215628 | J:54467
First Author: Lomaga MA
Year: 1999
Journal: Genes Dev
Title: TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.
Volume: 13
Issue: 8
Pages: 1015-24
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Publication
9390694 | J:44360
First Author: Yeh WC
Year: 1997
Journal: Immunity
Title: Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice.
Volume: 7
Issue: 5
Pages: 715-25
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Publication
22042853 | J:180231
First Author: Lin WJ
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Crucial role for TNF receptor-associated factor 2 (TRAF2) in regulating NFκB2 signaling that contributes to autoimmunity.
Volume: 108
Issue: 45
Pages: 18354-9
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Protein
A0A0U5JAA8
Organism: Mus musculus/domesticus
Length: 239  
Fragment?: false
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Protein
B2RR33
Organism: Mus musculus/domesticus
Length: 252  
Fragment?: false
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Protein
A0A0U5J7F3
Organism: Mus musculus/domesticus
Length: 270  
Fragment?: false
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Protein
P41047
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: false
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Protein
Q3U4I6
Organism: Mus musculus/domesticus
Length: 219  
Fragment?: false
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Protein
Q3U593
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: false
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Protein
A0A0R4J210
Organism: Mus musculus/domesticus
Length: 219  
Fragment?: false
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Protein
A0A0U5J4W4
Organism: Mus musculus/domesticus
Length: 324  
Fragment?: false
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Protein
Q0X0E6
Organism: Mus musculus/domesticus
Length: 138  
Fragment?: true
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Protein
Q544E9
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: false
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Protein
A0A0U5JAA2
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: false
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Protein
A4FUI4
Organism: Mus musculus/domesticus
Length: 304  
Fragment?: true
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Protein
G3V002
Organism: Mus musculus/domesticus
Length: 185  
Fragment?: false
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Protein
Q542S2
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: false
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Publication
15335677 | -
First Author: Bazan JF
Year: 1993
Journal: Curr Biol
Title: Emerging families of cytokines and receptors.
Volume: 3
Issue: 9
Pages: 603-6
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Publication
1377364 | -
First Author: Farrah T
Year: 1992
Journal: Nature
Title: Emerging cytokine family.
Volume: 358
Issue: 6381
Pages: 26
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Publication
8095800 | -
First Author: Peitsch MC
Year: 1993
Journal: Int Immunol
Title: A 3-D model for the CD40 ligand predicts that it is a compact trimer similar to the tumor necrosis factors.
Volume: 5
Issue: 2
Pages: 233-8
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Publication
2777790 | -
First Author: Cseh K
Year: 1989
Journal: J Biol Chem
Title: Alternative cleavage of the cachectin/tumor necrosis factor propeptide results in a larger, inactive form of secreted protein.
Volume: 264
Issue: 27
Pages: 16256-60
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Publication
2268312 | -
First Author: Sherry B
Year: 1990
Journal: Biochem Biophys Res Commun
Title: Characterization of high molecular weight glycosylated forms of murine tumor necrosis factor.
Volume: 173
Issue: 3
Pages: 1072-8
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Publication
3349526 | -
First Author: Kriegler M
Year: 1988
Journal: Cell
Title: A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF.
Volume: 53
Issue: 1
Pages: 45-53
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Publication
10514016 | J:57913
First Author: Nguyen LT
Year: 1999
Journal: Immunity
Title: TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses.
Volume: 11
Issue: 3
Pages: 379-89
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Gene
8743 | TNFSF10
Type: gene
Organism: human
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Gene
8741 | TNFSF13
Type: gene
Organism: human
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Gene
7292 | TNFSF4
Type: gene
Organism: human
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Gene
8600 | TNFSF11
Type: gene
Organism: human
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Gene
9516 | LITAF
Type: gene
Organism: human
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Gene
10673 | TNFSF13B
Type: gene
Organism: human
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Gene
8740 | TNFSF14
Type: gene
Organism: human
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Gene
8744 | TNFSF9
Type: gene
Organism: human
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Gene
944 | TNFSF8
Type: gene
Organism: human
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Gene
8742 | TNFSF12
Type: gene
Organism: human
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Gene
9966 | TNFSF15
Type: gene
Organism: human
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Gene
8995 | TNFSF18
Type: gene
Organism: human
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Publication
18429822 | J:141705
First Author: Kato T Jr
Year: 2008
Journal: Genes Cells
Title: Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1.
Volume: 13
Issue: 5
Pages: 509-20
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Publication
23064360 | J:193549
First Author: Zhao X
Year: 2012
Journal: J Clin Invest
Title: TNF signaling drives myeloid-derived suppressor cell accumulation.
Volume: 122
Issue: 11
Pages: 4094-104
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Publication
12787557 | J:85468
First Author: Ware CF
Year: 2003
Journal: Cytokine Growth Factor Rev
Title: The TNF superfamily.
Volume: 14
Issue: 3-4
Pages: 181-4
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Publication
11239407 | J:74923
First Author: Locksley RM
Year: 2001
Journal: Cell
Title: The TNF and TNF receptor superfamilies: integrating mammalian biology.
Volume: 104
Issue: 4
Pages: 487-501
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Publication
20439544 | J:160930
First Author: Noti M
Year: 2010
Journal: J Exp Med
Title: TNF suppresses acute intestinal inflammation by inducing local glucocorticoid synthesis.
Volume: 207
Issue: 5
Pages: 1057-66
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Publication
37634571 | J:358401
 
First Author: Kelagere Y
Year: 2023
Journal: Ocul Surf
Title: TNF is a critical cytokine in age-related dry eye disease.
Volume: 30
Pages: 119-128
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Publication
16455967 | J:129126
First Author: Wright HV
Year: 2006
Journal: J Immunol
Title: IL-3-mediated TNF production is necessary for mast cell development.
Volume: 176
Issue: 4
Pages: 2114-21
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Publication
10204494 | J:54056
First Author: Kontoyiannis D
Year: 1999
Journal: Immunity
Title: Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies.
Volume: 10
Issue: 3
Pages: 387-98
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Publication
15824857 | J:128108
First Author: Kanazawa K
Year: 2005
Journal: J Bone Miner Res
Title: TRAF2 is essential for TNF-alpha-induced osteoclastogenesis.
Volume: 20
Issue: 5
Pages: 840-7
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Publication
16547246 | J:129877
First Author: Suto H
Year: 2006
Journal: J Immunol
Title: Mast cell-associated TNF promotes dendritic cell migration.
Volume: 176
Issue: 7
Pages: 4102-12
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Publication
16237096 | J:119350
First Author: Andrade RM
Year: 2005
Journal: J Immunol
Title: TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alpha.
Volume: 175
Issue: 9
Pages: 6014-21
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Publication
37212045 | J:352492
First Author: Luecke S
Year: 2023
Journal: EMBO Rep
Title: Tonic TNF conditioning of macrophages safeguards stimulus-specific inflammatory responses.
Volume: 24
Issue: 7
Pages: e55986
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Publication
19228877 | J:147101
First Author: Jabara HH
Year: 2009
Journal: Int Immunol
Title: TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40.
Volume: 21
Issue: 4
Pages: 477-88
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Publication
26117714 | J:226284
 
First Author: Probert L
Year: 2015
Journal: Neuroscience
Title: TNF and its receptors in the CNS: The essential, the desirable and the deleterious effects.
Volume: 302
Pages: 2-22
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Publication
18313334 | J:132877
First Author: Gardam S
Year: 2008
Journal: Immunity
Title: TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor.
Volume: 28
Issue: 3
Pages: 391-401
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Publication
30776316 | J:291795
First Author: Soni S
Year: 2019
Journal: FASEB J
Title: ATP redirects cytokine trafficking and promotes novel membrane TNF signaling via microvesicles.
Volume: 33
Issue: 5
Pages: 6442-6455
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Publication
16282134 | J:104652
First Author: Ilg RC
Year: 2005
Journal: Curr Eye Res
Title: Altered retinal neovascularization in TNF receptor-deficient mice.
Volume: 30
Issue: 11
Pages: 1003-13
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Publication
28330904 | J:241862
First Author: Wolf Y
Year: 2017
Journal: J Exp Med
Title: Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation.
Volume: 214
Issue: 4
Pages: 905-917
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Publication
12163535 | J:103266
First Author: Deboer T
Year: 2002
Journal: J Neurophysiol
Title: Tumor necrosis factor (TNF) ligand and TNF receptor deficiency affects sleep and the sleep EEG.
Volume: 88
Issue: 2
Pages: 839-46
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Publication
9368614 | J:43603
First Author: Alexopoulou L
Year: 1997
Journal: Eur J Immunol
Title: A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF receptor signaling.
Volume: 27
Issue: 10
Pages: 2588-92
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Publication
17055451 | J:115275
First Author: Ichikawa D
Year: 2006
Journal: Biochem Biophys Res Commun
Title: TNF-receptor associated factor 6-deficient fibroblast is sensitive to the TNF-alpha-induced cell death: involvement of reactive oxygen species.
Volume: 351
Issue: 1
Pages: 93-8
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Publication
9164935 | J:40628
First Author: Speiser DE
Year: 1997
Journal: J Immunol
Title: TNF receptor p55 controls early acute graft-versus-host disease.
Volume: 158
Issue: 11
Pages: 5185-90
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Publication
11908709 | J:75405
First Author: Babaya N
Year: 2002
Journal: Autoimmunity
Title: Sequence analysis of Tnf as a candidate for Idd16.
Volume: 35
Issue: 1
Pages: 63-6
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Publication
7693816 | J:15526
First Author: Peppel K
Year: 1993
Journal: J Immunol
Title: Expression of a TNF inhibitor in transgenic mice.
Volume: 151
Issue: 10
Pages: 5699-703
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Publication
11917000 | J:75537
First Author: Fontaine V
Year: 2002
Journal: J Neurosci
Title: Neurodegenerative and neuroprotective effects of tumor Necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2.
Volume: 22
Issue: 7
Pages: RC216
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Publication
11447117 | J:108402
First Author: Kontoyiannis D
Year: 2001
Journal: EMBO J
Title: Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology.
Volume: 20
Issue: 14
Pages: 3760-70
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Protein Coding Gene
MGI:1314884 | Tnfrsf1a
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
34758308 | J:328220
First Author: Willemsen J
Year: 2021
Journal: Cell Rep
Title: TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis.
Volume: 37
Issue: 6
Pages: 109977
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Publication
10914503 | J:120421
First Author: Shakhov AN
Year: 2000
Journal: J Leukoc Biol
Title: Gene profiling approach in the analysis of lymphotoxin and TNF deficiencies.
Volume: 68
Issue: 1
Pages: 151-7
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Publication
15604121 | J:96428
First Author: Makarenkova V
Year: 2005
Journal: J Leukoc Biol
Title: Dendritic cells and natural killer cells interact via multiple TNF family molecules.
Volume: 77
Issue: 3
Pages: 408-13
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Publication
33210082 | J:306876
First Author: Clayer E
Year: 2020
Journal: iScience
Title: Severe Impairment of TNF Post-transcriptional Regulation Leads to Embryonic Death.
Volume: 23
Issue: 11
Pages: 101726
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Publication
14499111 | J:85808
First Author: Kobayashi T
Year: 2003
Journal: Immunity
Title: TRAF6 is a critical factor for dendritic cell maturation and development.
Volume: 19
Issue: 3
Pages: 353-63
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Publication
19150425 | J:146162
First Author: Li S
Year: 2009
Journal: Mol Cell
Title: PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination.
Volume: 33
Issue: 1
Pages: 30-42
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Publication
19846867 | J:157185
First Author: Nie S
Year: 2009
Journal: J Immunol
Title: Resistance to vaccinia virus is less dependent on TNF under conditions of heterologous immunity.
Volume: 183
Issue: 10
Pages: 6554-60
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Publication
22053204 | J:178068
First Author: Hojilla CV
Year: 2011
Journal: PLoS One
Title: TIMP3 regulates mammary epithelial apoptosis with immune cell recruitment through differential TNF dependence.
Volume: 6
Issue: 10
Pages: e26718
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Publication
38395613 | J:350701
 
First Author: Heir R
Year: 2024
Journal: J Neurosci
Title: Astrocytes Are the Source of TNF Mediating Homeostatic Synaptic Plasticity.
Volume: 44
Issue: 14
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Publication
10496522 | J:57641
First Author: Ledgerwood EC
Year: 1999
Journal: Lab Invest
Title: Recent advances in the molecular basis of TNF signal transduction.
Volume: 79
Issue: 9
Pages: 1041-50
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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