Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Akagi T |
Year: |
2022 |
Journal: |
Front Immunol |
Title: |
TRAPS mutations in Tnfrsf1a decrease the responsiveness to TNFα via reduced cell surface expression of TNFR1. |
Volume: |
13 |
|
Pages: |
926175 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
143
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Publication |
First Author: |
Steeland S |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
TNFR1 inhibition with a Nanobody protects against EAE development in mice. |
Volume: |
7 |
Issue: |
1 |
Pages: |
13646 |
|
•
•
•
•
•
|
Publication |
First Author: |
Puimège L |
Year: |
2015 |
Journal: |
EMBO Mol Med |
Title: |
Glucocorticoid-induced microRNA-511 protects against TNF by down-regulating TNFR1. |
Volume: |
7 |
Issue: |
8 |
Pages: |
1004-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Van Hauwermeiren F |
Year: |
2013 |
Journal: |
J Clin Invest |
Title: |
Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium. |
Volume: |
123 |
Issue: |
6 |
Pages: |
2590-603 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mohammed FF |
Year: |
2004 |
Journal: |
Nat Genet |
Title: |
Abnormal TNF activity in Timp3-/- mice leads to chronic hepatic inflammation and failure of liver regeneration. |
Volume: |
36 |
Issue: |
9 |
Pages: |
969-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pryhuber GS |
Year: |
2008 |
Journal: |
J Immunol |
Title: |
Parenchymal cell TNF receptors contribute to inflammatory cell recruitment and respiratory failure in Pneumocystis carinii-induced pneumonia. |
Volume: |
181 |
Issue: |
2 |
Pages: |
1409-19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Burrack AL |
Year: |
2021 |
Journal: |
J Immunol |
Title: |
CD40 Agonist Overcomes T Cell Exhaustion Induced by Chronic Myeloid Cell IL-27 Production in a Pancreatic Cancer Preclinical Model. |
Volume: |
206 |
Issue: |
6 |
Pages: |
1372-1384 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lou Y |
Year: |
2023 |
Journal: |
J Immunol |
Title: |
Epithelial TIPE1 Protein Guards against Colitis by Inhibiting TNF-α-Mediated Inflammation. |
Volume: |
211 |
Issue: |
5 |
Pages: |
874-884 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hu M |
Year: |
2011 |
Journal: |
J Immunol |
Title: |
Activated invariant NKT cells regulate osteoclast development and function. |
Volume: |
186 |
Issue: |
5 |
Pages: |
2910-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li C |
Year: |
2000 |
Journal: |
Infect Immun |
Title: |
Tumor necrosis factor alpha p55 receptor is important for development of memory responses to blood-stage malaria infection. |
Volume: |
68 |
Issue: |
10 |
Pages: |
5724-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Taoufik E |
Year: |
2008 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
TNF receptor I sensitizes neurons to erythropoietin- and VEGF-mediated neuroprotection after ischemic and excitotoxic injury. |
Volume: |
105 |
Issue: |
16 |
Pages: |
6185-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mori R |
Year: |
2002 |
Journal: |
FASEB J |
Title: |
Accelerated wound healing in tumor necrosis factor receptor p55-deficient mice with reduced leukocyte infiltration. |
Volume: |
16 |
Issue: |
9 |
Pages: |
963-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Llovera M |
Year: |
1998 |
Journal: |
Mol Cell Endocrinol |
Title: |
Role of TNF receptor 1 in protein turnover during cancer cachexia using gene knockout mice. |
Volume: |
142 |
Issue: |
1-2 |
Pages: |
183-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rocha AC |
Year: |
2006 |
Journal: |
Br J Pharmacol |
Title: |
Relevance of tumour necrosis factor-alpha for the inflammatory and nociceptive responses evoked by carrageenan in the mouse paw. |
Volume: |
148 |
Issue: |
5 |
Pages: |
688-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Balga R |
Year: |
2006 |
Journal: |
Bone |
Title: |
Tumor necrosis factor-alpha: alternative role as an inhibitor of osteoclast formation in vitro. |
Volume: |
39 |
Issue: |
2 |
Pages: |
325-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Street M |
Year: |
1999 |
Journal: |
J Immunol |
Title: |
TNF is essential for the cell-mediated protective immunity induced by the radiation-attenuated schistosome vaccine. |
Volume: |
163 |
Issue: |
8 |
Pages: |
4489-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ishida Y |
Year: |
2004 |
Journal: |
J Leukoc Biol |
Title: |
The pathogenic roles of tumor necrosis factor receptor p55 in acetaminophen-induced liver injury in mice. |
Volume: |
75 |
Issue: |
1 |
Pages: |
59-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mori L |
Year: |
1996 |
Journal: |
J Immunol |
Title: |
Attenuation of collagen-induced arthritis in 55-kDa TNF receptor type 1 (TNFR1)-IgG1-treated and TNFR1-deficient mice. |
Volume: |
157 |
Issue: |
7 |
Pages: |
3178-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hoefer IE |
Year: |
2002 |
Journal: |
Circulation |
Title: |
Direct evidence for tumor necrosis factor-alpha signaling in arteriogenesis. |
Volume: |
105 |
Issue: |
14 |
Pages: |
1639-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chee J |
Year: |
2011 |
Journal: |
J Immunol |
Title: |
TNF receptor 1 deficiency increases regulatory T cell function in nonobese diabetic mice. |
Volume: |
187 |
Issue: |
4 |
Pages: |
1702-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Roumelioti F |
Year: |
2024 |
Journal: |
Elife |
Title: |
Mir221/222 drive synovial hyperplasia and arthritis by targeting cell cycle inhibitors and chromatin remodeling components. |
Volume: |
13 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Chee J |
Year: |
2014 |
Journal: |
J Immunol |
Title: |
Effector-memory T cells develop in islets and report islet pathology in type 1 diabetes. |
Volume: |
192 |
Issue: |
2 |
Pages: |
572-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Steeland S |
Year: |
2018 |
Journal: |
EMBO Mol Med |
Title: |
Counteracting the effects of TNF receptor-1 has therapeutic potential in Alzheimer's disease. |
Volume: |
10 |
Issue: |
4 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Brewer JM |
Year: |
1998 |
Journal: |
Immunology |
Title: |
Neither interleukin-6 nor signalling via tumour necrosis factor receptor-1 contribute to the adjuvant activity of Alum and Freund's adjuvant. |
Volume: |
93 |
Issue: |
1 |
Pages: |
41-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fang J |
Year: |
1997 |
Journal: |
J Neurosci |
Title: |
Mice lacking the TNF 55 kDa receptor fail to sleep more after TNFalpha treatment. |
Volume: |
17 |
Issue: |
15 |
Pages: |
5949-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kaster MP |
Year: |
2012 |
Journal: |
Neuropharmacology |
Title: |
Depressive-like behavior induced by tumor necrosis factor-α in mice. |
Volume: |
62 |
Issue: |
1 |
Pages: |
419-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
López-Soriano J |
Year: |
1997 |
Journal: |
Mol Cell Endocrinol |
Title: |
Lipid metabolism in tumour-bearing mice: studies with knockout mice for tumour necrosis factor receptor 1 protein. |
Volume: |
132 |
Issue: |
1-2 |
Pages: |
93-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Karrer U |
Year: |
2000 |
Journal: |
J Immunol |
Title: |
Antiviral B cell memory in the absence of mature follicular dendritic cell networks and classical germinal centers in TNFR1-/- mice. |
Volume: |
164 |
Issue: |
2 |
Pages: |
768-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ye P |
Year: |
2007 |
Journal: |
J Neurosci Res |
Title: |
Insulin-like growth factor-I ameliorates demyelination induced by tumor necrosis factor-alpha in transgenic mice. |
Volume: |
85 |
Issue: |
4 |
Pages: |
712-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Svandova EB |
Year: |
2017 |
Journal: |
Histochem Cell Biol |
Title: |
Expression of Fas, FasL, caspase-8 and other factors of the extrinsic apoptotic pathway during the onset of interdigital tissue elimination. |
Volume: |
147 |
Issue: |
4 |
Pages: |
497-510 |
|
•
•
•
•
•
|
Publication |
First Author: |
Victoratos P |
Year: |
2009 |
Journal: |
Immunity |
Title: |
Induction of autoantibody-mediated spontaneous arthritis critically depends on follicular dendritic cells. |
Volume: |
30 |
Issue: |
1 |
Pages: |
130-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kalb A |
Year: |
1996 |
Journal: |
J Biol Chem |
Title: |
Tumor necrosis factor receptors (Tnfr) in mouse fibroblasts deficient in Tnfr1 or Tnfr2 are signaling competent and activate the mitogen-activated protein kinase pathway with differential kinetics. |
Volume: |
271 |
Issue: |
45 |
Pages: |
28097-104 |
|
•
•
•
•
•
|
Publication |
First Author: |
Steinshamn S |
Year: |
1996 |
Journal: |
J Immunol |
Title: |
TNF receptors in murine Candida albicans infection: evidence for an important role of TNF receptor p55 in antifungal defense. |
Volume: |
157 |
Issue: |
5 |
Pages: |
2155-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Naude PJ |
Year: |
2014 |
Journal: |
Behav Brain Res |
Title: |
Analysis of cognition, motor performance and anxiety in young and aged tumor necrosis factor alpha receptor 1 and 2 deficient mice. |
Volume: |
258 |
|
Pages: |
43-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Williams SK |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Antibody-mediated inhibition of TNFR1 attenuates disease in a mouse model of multiple sclerosis. |
Volume: |
9 |
Issue: |
2 |
Pages: |
e90117 |
|
•
•
•
•
•
|
Publication |
First Author: |
Abu-Amer Y |
Year: |
1997 |
Journal: |
J Clin Invest |
Title: |
Lipopolysaccharide-stimulated osteoclastogenesis is mediated by tumor necrosis factor via its P55 receptor. |
Volume: |
100 |
Issue: |
6 |
Pages: |
1557-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miao K |
Year: |
2020 |
Journal: |
PLoS Biol |
Title: |
Transmembrane tumor necrosis factor alpha attenuates pressure-overload cardiac hypertrophy via tumor necrosis factor receptor 2. |
Volume: |
18 |
Issue: |
12 |
Pages: |
e3000967 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lucas R |
Year: |
1997 |
Journal: |
Eur J Immunol |
Title: |
Crucial role of tumor necrosis factor (TNF) receptor 2 and membrane-bound TNF in experimental cerebral malaria. |
Volume: |
27 |
Issue: |
7 |
Pages: |
1719-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Funk JO |
Year: |
2000 |
Journal: |
J Immunol |
Title: |
Cutting edge: resistance to apoptosis and continuous proliferation of dendritic cells deficient for TNF receptor-1. |
Volume: |
165 |
Issue: |
9 |
Pages: |
4792-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vandewalle J |
Year: |
2019 |
Journal: |
Front Immunol |
Title: |
A Study of Cecal Ligation and Puncture-Induced Sepsis in Tissue-Specific Tumor Necrosis Factor Receptor 1-Deficient Mice. |
Volume: |
10 |
|
Pages: |
2574 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao X |
Year: |
2007 |
Journal: |
Cancer Res |
Title: |
Tumor necrosis factor receptor 2-mediated tumor suppression is nitric oxide dependent and involves angiostasis. |
Volume: |
67 |
Issue: |
9 |
Pages: |
4443-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim GM |
Year: |
2001 |
Journal: |
J Neurosci |
Title: |
Tumor necrosis factor receptor deletion reduces nuclear factor-kappaB activation, cellular inhibitor of apoptosis protein 2 expression, and functional recovery after traumatic spinal cord injury. |
Volume: |
21 |
Issue: |
17 |
Pages: |
6617-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yap GS |
Year: |
1998 |
Journal: |
J Immunol |
Title: |
Decreased resistance of TNF receptor p55- and p75-deficient mice to chronic toxoplasmosis despite normal activation of inducible nitric oxide synthase in vivo. |
Volume: |
160 |
Issue: |
3 |
Pages: |
1340-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ruef N |
Year: |
2017 |
Journal: |
Bone |
Title: |
Granulocyte-macrophage colony-stimulating factor-dependent CD11c-positive cells differentiate into active osteoclasts. |
Volume: |
97 |
|
Pages: |
267-277 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tacchini-Cottier F |
Year: |
1998 |
Journal: |
J Immunol |
Title: |
Role of TNFR1 and TNFR2 in TNF-induced platelet consumption in mice. |
Volume: |
160 |
Issue: |
12 |
Pages: |
6182-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ding X |
Year: |
2011 |
Journal: |
J Immunol |
Title: |
TNF receptor 1 mediates dendritic cell maturation and CD8 T cell response through two distinct mechanisms. |
Volume: |
187 |
Issue: |
3 |
Pages: |
1184-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Raymond CR |
Year: |
2007 |
Journal: |
J Neuroimmunol |
Title: |
Assessing the involvement of migratory dendritic cells in the transfer of the scrapie agent from the immune to peripheral nervous systems. |
Volume: |
187 |
Issue: |
1-2 |
Pages: |
114-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Leng A |
Year: |
2005 |
Journal: |
Neurosci Lett |
Title: |
Tumor necrosis factor-alpha receptor ablation in a chronic MPTP mouse model of Parkinson's disease. |
Volume: |
375 |
Issue: |
2 |
Pages: |
107-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tkachuk M |
Year: |
1998 |
Journal: |
J Exp Med |
Title: |
Crucial role of tumor necrosis factor receptor 1 expression on nonhematopoietic cells for B cell localization within the splenic white pulp. |
Volume: |
187 |
Issue: |
4 |
Pages: |
469-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wolf D |
Year: |
2001 |
Journal: |
J Immunol |
Title: |
TNF-alpha-induced expression of adhesion molecules in the liver is under the control of TNFR1--relevance for concanavalin A-induced hepatitis. |
Volume: |
166 |
Issue: |
2 |
Pages: |
1300-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Milićević NM |
Year: |
2011 |
Journal: |
J Immunol |
Title: |
TNF receptor-1 is required for the formation of splenic compartments during adult, but not embryonic life. |
Volume: |
186 |
Issue: |
3 |
Pages: |
1486-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wallaeys C |
Year: |
2024 |
Journal: |
Cell Host Microbe |
Title: |
Paneth cell TNF signaling induces gut bacterial translocation and sepsis. |
Volume: |
32 |
Issue: |
10 |
Pages: |
1725-1743.e7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Deckert-Schlüter M |
Year: |
1998 |
Journal: |
J Immunol |
Title: |
Crucial role of TNF receptor type 1 (p55), but not of TNF receptor type 2 (p75), in murine toxoplasmosis. |
Volume: |
160 |
Issue: |
7 |
Pages: |
3427-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schümann J |
Year: |
2000 |
Journal: |
Immunol Lett |
Title: |
Synergism of Pseudomonas aeruginosa exotoxin A with endotoxin, superantigen, or TNF results in TNFR1- and TNFR2-dependent liver toxicity in mice. |
Volume: |
74 |
Issue: |
2 |
Pages: |
165-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Piguet PF |
Year: |
2002 |
Journal: |
Lab Invest |
Title: |
Role of the tumor necrosis factor receptor 2 (TNFR2) in cerebral malaria in mice. |
Volume: |
82 |
Issue: |
9 |
Pages: |
1155-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Merkel KD |
Year: |
1999 |
Journal: |
Am J Pathol |
Title: |
Tumor necrosis factor-alpha mediates orthopedic implant osteolysis. |
Volume: |
154 |
Issue: |
1 |
Pages: |
203-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rousselet E |
Year: |
2002 |
Journal: |
Exp Neurol |
Title: |
Role of TNF-alpha receptors in mice intoxicated with the parkinsonian toxin MPTP. |
Volume: |
177 |
Issue: |
1 |
Pages: |
183-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Taoufik E |
Year: |
2007 |
Journal: |
J Neurosci |
Title: |
FLIP(L) protects neurons against in vivo ischemia and in vitro glucose deprivation-induced cell death. |
Volume: |
27 |
Issue: |
25 |
Pages: |
6633-46 |
|
•
•
•
•
•
|
Allele |
Name: |
tumor necrosis factor receptor superfamily, member 1a; endonuclease-mediated mutation 1, Tomoyuki Mukai |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Humanized sequence |
|
•
•
•
•
•
|
Allele |
Name: |
tumor necrosis factor receptor superfamily, member 1a; endonuclease-mediated mutation 2, Tomoyuki Mukai |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Humanized sequence |
|
•
•
•
•
•
|
Allele |
Name: |
tumor necrosis factor receptor superfamily, member 1a; endonuclease-mediated mutation 3, Tomoyuki Mukai |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Humanized sequence |
|
•
•
•
•
•
|
Publication |
First Author: |
Sacca R |
Year: |
1998 |
Journal: |
J Immunol |
Title: |
Differential activities of secreted lymphotoxin-alpha3 and membrane lymphotoxin-alpha1beta2 in lymphotoxin-induced inflammation: critical role of TNF receptor 1 signaling. |
Volume: |
160 |
Issue: |
1 |
Pages: |
485-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lawrence CE |
Year: |
1998 |
Journal: |
Eur J Immunol |
Title: |
IL-4-regulated enteropathy in an intestinal nematode infection. |
Volume: |
28 |
Issue: |
9 |
Pages: |
2672-84 |
|
•
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•
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