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Search results 1 to 92 out of 92 for Tnfsf18

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
8995 | TNFSF18
Type: gene
Organism: human
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Gene
768081 | TNFSF18
Type: gene
Organism: cattle
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Gene
100855912 | TNFSF18
Type: gene
Organism: dog, domestic
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Gene
100148577 | tnfsf18
Type: gene
Organism: zebrafish
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Gene
678654 | TNFSF18
Type: gene
Organism: macaque, rhesus
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Gene
364031 | Tnfsf18
Type: gene
Organism: rat
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Gene
738190 | TNFSF18
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:2673064 | Tnfsf18
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR042380 | TNFSF18
Type: Family
Description: TNFSF18, also known as GITRL (glucocorticoid-induced TNF receptor ligand), binds to its receptor GITR on both effector and regulatory T cells and generates positive costimulatory signals []. GITR is also activated by a GITR ligand called SECTM1A []. The costimulatory effect of GITR activation in T cells has been shown to increase T cell expansion and cytokine production, exacerbate autoimmune/inflammatory diseases, favour tumour rejection, perform viral and parasite clearance, and potentiate immune/inflammatory responses [, ].
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Protein
Q7TS55
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: false
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Protein
A0A0U5J3Y4
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: false
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Publication
24039998 | J:318846
First Author: Howie D
Year: 2013
Journal: PLoS One
Title: Secreted and transmembrane 1A is a novel co-stimulatory ligand.
Volume: 8
Issue: 9
Pages: e73610
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Publication
18040044 | -
First Author: Chattopadhyay K
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function.
Volume: 104
Issue: 49
Pages: 19452-7
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Publication
21175417 | -
First Author: Azuma M
Year: 2010
Journal: Crit Rev Immunol
Title: Role of the glucocorticoid-induced TNFR-related protein (GITR)-GITR ligand pathway in innate and adaptive immunity.
Volume: 30
Issue: 6
Pages: 547-57
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Publication
25961057 | -
 
First Author: Ronchetti S
Year: 2015
Journal: J Immunol Res
Title: Glucocorticoid-induced tumour necrosis factor receptor-related protein: a key marker of functional regulatory T cells.
Volume: 2015
Pages: 171520
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Protein Coding Gene
MGP_CAROLIEiJ_G0014765 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0016653 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0016634 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0016600 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0016595 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0016419 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2673064 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0017056 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0015999 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0016394 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0016500 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0016498 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0016571 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0016523 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0017092 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0015785 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0016061 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0028002 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0015572 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
17417651 | J:121754
First Author: Grohmann U
Year: 2007
Journal: Nat Med
Title: Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy.
Volume: 13
Issue: 5
Pages: 579-86
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Publication
19604302 | J:155988
First Author: Piao J
Year: 2009
Journal: Immunology
Title: Enhancement of T-cell-mediated anti-tumour immunity via the ectopically expressed glucocorticoid-induced tumour necrosis factor receptor-related receptor ligand (GITRL) on tumours.
Volume: 127
Issue: 4
Pages: 489-99
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1706828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692771
Age: postnatal adult
Image: JAX_1306034
Specimen Label: JAX_1306034
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1752528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692771
Age: postnatal adult
Image: JAX_1306035
Specimen Label: JAX_1306035
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1881228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692771
Age: postnatal adult
Image: JAX_1306033
Specimen Label: JAX_1306033
Detected: true
Specimen Num: 1
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Publication
14521928 | J:180483
First Author: Yu KY
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Identification of a ligand for glucocorticoid-induced tumor necrosis factor receptor constitutively expressed in dendritic cells.
Volume: 310
Issue: 2
Pages: 433-8
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Publication
14647196 | J:114773
First Author: Kim JD
Year: 2003
Journal: Genes Immun
Title: Cloning and characterization of GITR ligand.
Volume: 4
Issue: 8
Pages: 564-9
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Publication
15128759 | J:89870
First Author: Ji HB
Year: 2004
Journal: J Immunol
Title: Cutting edge: the natural ligand for glucocorticoid-induced TNF receptor-related protein abrogates regulatory T cell suppression.
Volume: 172
Issue: 10
Pages: 5823-7
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Publication
18182486 | J:131097
First Author: Chattopadhyay K
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Evolution of GITRL immune function: murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily.
Volume: 105
Issue: 2
Pages: 635-40
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Publication
18178614 | J:131029
First Author: Zhou Z
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Structural basis for ligand-mediated mouse GITR activation.
Volume: 105
Issue: 2
Pages: 641-5
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Publication
15470044 | J:93749
First Author: Stephens GL
Year: 2004
Journal: J Immunol
Title: Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells.
Volume: 173
Issue: 8
Pages: 5008-20
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Publication
25787078 | J:259399
First Author: Kobayashi Y
Year: 2015
Journal: J Biol Chem
Title: Macrophage-T cell interactions mediate neuropathic pain through the glucocorticoid-induced tumor necrosis factor ligand system.
Volume: 290
Issue: 20
Pages: 12603-13
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Publication
18346459 | J:134277
First Author: Igarashi H
Year: 2008
Journal: Biochem Biophys Res Commun
Title: GITR ligand-costimulation activates effector and regulatory functions of CD4+ T cells.
Volume: 369
Issue: 4
Pages: 1134-8
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Publication
19234165 | J:146259
First Author: Kamimura Y
Year: 2009
Journal: J Immunol
Title: The glucocorticoid-induced TNF receptor-related protein (GITR)-GITR ligand pathway acts as a mediator of cutaneous dendritic cell migration and promotes T cell-mediated acquired immunity.
Volume: 182
Issue: 5
Pages: 2708-16
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Publication
19936238 | J:155400
First Author: You S
Year: 2009
Journal: PLoS One
Title: Key role of the GITR/GITRLigand pathway in the development of murine autoimmune diabetes: a potential therapeutic target.
Volume: 4
Issue: 11
Pages: e7848
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Publication
19536139 | J:157134
First Author: Byrne AM
Year: 2009
Journal: J Invest Dermatol
Title: Identification of glucocorticoid-induced TNF receptor-related protein ligand on keratinocytes: ligation by GITR induces keratinocyte chemokine production and augments T-cell proliferation.
Volume: 129
Issue: 12
Pages: 2784-94
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Publication
21705620 | J:179112
First Author: van der Werf N
Year: 2011
Journal: J Immunol
Title: Th2 responses to helminth parasites can be therapeutically enhanced by, but are not dependent upon, GITR-GITR ligand costimulation in vivo.
Volume: 187
Issue: 3
Pages: 1411-20
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Publication
22214837 | J:181958
First Author: Wang S
Year: 2012
Journal: Am J Pathol
Title: Glucocorticoid-induced tumor necrosis factor receptor family-related protein exacerbates collagen-induced arthritis by enhancing the expansion of Th17 cells.
Volume: 180
Issue: 3
Pages: 1059-67
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Publication
29150240 | J:253563
First Author: Chang YH
Year: 2017
Journal: Immunity
Title: Dichotomous Expression of TNF Superfamily Ligands on Antigen-Presenting Cells Controls Post-priming Anti-viral CD4+ T Cell Immunity.
Volume: 47
Issue: 5
Pages: 943-958.e9
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Publication
30487647 | J:318837
First Author: Chu KL
Year: 2019
Journal: Mucosal Immunol
Title: GITRL on inflammatory antigen presenting cells in the lung parenchyma provides signal 4 for T-cell accumulation and tissue-resident memory T-cell formation.
Volume: 12
Issue: 2
Pages: 363-377
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Publication
38321001 | J:346395
First Author: Li L
Year: 2024
Journal: Cell Death Dis
Title: GITRL impairs hepatocyte repopulation by liver progenitor cells to aggravate inflammation and fibrosis by GITR(+)CD8(+) T lymphocytes in CDE Mice.
Volume: 15
Issue: 2
Pages: 114
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Publication
21636079 | J:176752
First Author: Tian J
Year: 2011
Journal: Cell Immunol
Title: Increased expression of mGITRL on D2SC/1 cells by particulate β-glucan impairs the suppressive effect of CD4+CD25+ regulatory T cells and enhances the effector T cell proliferation.
Volume: 270
Issue: 2
Pages: 183-7
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Publication
23892569 | J:220504
First Author: Lacal PM
Year: 2013
Journal: J Pharmacol Exp Ther
Title: Glucocorticoid-induced tumor necrosis factor receptor family-related ligand triggering upregulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 and promotes leukocyte adhesion.
Volume: 347
Issue: 1
Pages: 164-72
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Publication
24107315 | J:206613
First Author: Liao G
Year: 2014
Journal: FASEB J
Title: Glucocorticoid-induced TNF receptor family-related protein ligand regulates the migration of monocytes to the inflamed intestine.
Volume: 28
Issue: 1
Pages: 474-84
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Publication
19272591 | J:148548
First Author: Vecchiarelli A
Year: 2009
Journal: Cell Immunol
Title: The GITRL-GITR system alters TLR-4 expression on DC during fungal infection.
Volume: 257
Issue: 1-2
Pages: 13-22
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Publication
22368274 | J:183107
First Author: Ray A
Year: 2012
Journal: J Immunol
Title: A novel IL-10-independent regulatory role for B cells in suppressing autoimmunity by maintenance of regulatory T cells via GITR ligand.
Volume: 188
Issue: 7
Pages: 3188-98
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Publication
22678896 | J:187761
First Author: Carrier Y
Year: 2012
Journal: Eur J Immunol
Title: Enhanced GITR/GITRL interactions augment IL-27 expression and induce IL-10-producing Tr-1 like cells.
Volume: 42
Issue: 6
Pages: 1393-404
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Publication
14608036 | J:86980
First Author: Tone M
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells.
Volume: 100
Issue: 25
Pages: 15059-64
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Publication
30643147 | J:272027
First Author: Ray A
Year: 2019
Journal: Nat Commun
Title: Mature IgDlow/- B cells maintain tolerance by promoting regulatory T cell homeostasis.
Volume: 10
Issue: 1
Pages: 190
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:147112
     
First Author: Taconic
Year: 2006
Journal: MGI Direct Data Submission
Title: Information obtained from Taconic website.
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:72247
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Allele
Tnfsf18<tm1.2Etms> | MGI:6863893
Name: tumor necrosis factor (ligand) superfamily, member 18; targeted mutation 1.2, Ethan M Shevach
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Tnfsf18<em1Smoc> | MGI:7292907
Name: tumor necrosis factor (ligand) superfamily, member 18; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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HT Experiment
GSE226113 | gammadelta T cells control murine subcutaneous adipose wasting during chronic Trypanosoma brucei infection
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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