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Search results 1 to 87 out of 87 for Tnrc6c

0.034s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Domain
Type: Family
Description: This entry represents TNRC6C from vertebrates. Similar to TNRC6A/B, TNRC6C is essential for efficient miRNA repression [].Mammals have three GW182 paralogues, TNRC6A, TNRC6B and TNRC6C. They interact directly with Argonaute (Ago) proteins and function downstream as effectors mediating mRNA repression. They repress mRNAs by recruiting the CCR4-NOT complex to the mRNA. They contain the N-terminal effector domain (NED), the middle Q-rich region, and the C-terminal effector domain (CED) containing the poly(A) binding protein (PABP)-interacting motif 2 (PAM2) and the RNA-recognition motif (RRM) [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Zipprich JT
Year: 2009
Journal: RNA
Title: Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression.
Volume: 15
Issue: 5
Pages: 781-93
Protein
Organism: Mus musculus
Length: 1690  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1732  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1900  
Fragment?: false
Publication
First Author: Chekulaeva M
Year: 2011
Journal: Nat Struct Mol Biol
Title: miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs.
Volume: 18
Issue: 11
Pages: 1218-26
Publication
First Author: Chen CY
Year: 2009
Journal: Nat Struct Mol Biol
Title: Ago-TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps.
Volume: 16
Issue: 11
Pages: 1160-6
Publication
First Author: Guo H
Year: 2017
Journal: Dev Biol
Title: Trinucleotide repeat containing 6c (TNRC6c) is essential for microvascular maturation during distal airspace sacculation in the developing lung.
Volume: 430
Issue: 1
Pages: 214-223
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:3614673
Assay Type: RT-PCR
Annotation Date: 2006-03-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:3616491
Age: embryonic day 13.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3614673
Assay Type: RT-PCR
Annotation Date: 2006-03-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:3616491
Age: postnatal day 0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3615480
Assay Type: RNA in situ
Annotation Date: 2006-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1665821
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617765
Age: embryonic day 13.5
Image: E13.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3615480
Assay Type: RNA in situ
Annotation Date: 2006-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691621
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617765
Age: embryonic day 13.5
Image: E13.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3615480
Assay Type: RNA in situ
Annotation Date: 2006-03-27
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1691627
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617765
Age: postnatal day 0
Image: P0
Note: Authors indicate that there was either ubiquitous or background expression.
Specimen Num: 2
GXD Expression  
Probe: MGI:3615480
Assay Type: RNA in situ
Annotation Date: 2006-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1760621
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617765
Age: embryonic day 13.5
Image: E13.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3615480
Assay Type: RNA in situ
Annotation Date: 2006-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1760627
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617765
Age: postnatal day 0
Image: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3615480
Assay Type: RNA in situ
Annotation Date: 2006-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754921
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617765
Age: embryonic day 13.5
Image: E13.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3615480
Assay Type: RNA in situ
Annotation Date: 2006-03-27
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754927
Stage: TS27
Assay Id: MGI:3617765
Age: postnatal day 0
Image: P0
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:3615480
Assay Type: RNA in situ
Annotation Date: 2006-03-27
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1697427
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617765
Age: postnatal day 0
Image: P0
Note: Authors indicate that there was either ubiquitous or background expression.
Specimen Num: 2
GXD Expression  
Probe: MGI:3615480
Assay Type: RNA in situ
Annotation Date: 2006-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716821
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617765
Age: embryonic day 13.5
Image: E13.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3615480
Assay Type: RNA in situ
Annotation Date: 2006-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716827
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617765
Age: postnatal day 0
Image: P0
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3615480
Assay Type: RNA in situ
Annotation Date: 2006-03-27
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1753627
Stage: TS27
Assay Id: MGI:3617765
Age: postnatal day 0
Image: P0
Detected: false
Specimen Num: 2
GXD Expression
Probe: MGI:3615480
Assay Type: RNA in situ
Annotation Date: 2006-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617765
Age: embryonic day 13.5
Image: E13.5
Note: Expression was detected in precortical tissue.
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3615480
Assay Type: RNA in situ
Annotation Date: 2006-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754427
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617765
Age: postnatal day 0
Image: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3615480
Assay Type: RNA in situ
Annotation Date: 2006-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284527
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617765
Age: postnatal day 0
Image: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3615480
Assay Type: RNA in situ
Annotation Date: 2006-03-27
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1679727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617765
Age: postnatal day 0
Image: P0
Note: Authors indicate that there was either ubiquitous or background expression.
Specimen Num: 2
GXD Expression    
Probe: MGI:3615480
Assay Type: RNA in situ
Annotation Date: 2006-03-27
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754027
Stage: TS27
Assay Id: MGI:3617765
Age: postnatal day 0
Image: P0
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:3615480
Assay Type: RNA in situ
Annotation Date: 2006-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280927
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617765
Age: postnatal day 0
Image: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3615480
Assay Type: RNA in situ
Annotation Date: 2006-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267921
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617765
Age: embryonic day 13.5
Image: E13.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3615480
Assay Type: RNA in situ
Annotation Date: 2006-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757721
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617765
Age: embryonic day 13.5
Image: E13.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3615480
Assay Type: RNA in situ
Annotation Date: 2006-03-27
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757727
Stage: TS27
Assay Id: MGI:3617765
Age: postnatal day 0
Image: P0
Detected: false
Specimen Num: 2
Publication
First Author: Jiang Z
Year: 2012
Journal: J Biol Chem
Title: Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm.
Volume: 287
Issue: 8
Pages: 5979-87
Publication
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 1
Pages: 35-48
Publication  
First Author: McKee AE
Year: 2005
Journal: BMC Dev Biol
Title: A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.
Volume: 5
Pages: 14
Publication      
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
Publication
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication
First Author: Nakajima D
Year: 2002
Journal: DNA Res
Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
Volume: 9
Issue: 3
Pages: 99-106
Protein Domain
Type: Domain
Description: Trinucleotide repeat-containing gene 6C protein (TNRC6C) is one of three GW182 paralogs in mammalian genomes. It is enriched in P-bodies and important for efficient miRNA-mediated repression. TNRC6C is composed of an N-terminal glycine/tryptophan (G/W)-rich region containing an Ago hook responsible for Ago protein-binding; a ubiquitin-associated (UBA) domain and a glutamine (Q)-rich region in the middle region; a middle G/W-rich region, a RNA recognition motif (RRM), also called RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and a C-terminal G/W-rich region, at the C terminus. A bipartite C-terminal region including the middle and C-terminal G/W-rich regions is referred to as silencing domain, that triggers silencing of bound transcripts by inhibiting protein expression and promoting mRNA decay via deadenylation. The C-terminal half containing the RRM domain functions as a key effector domain mediating protein synthesis repression by TNRC6C [, ].