Type |
Details |
Score |
Protein Domain |
Type: |
Family |
Description: |
Tob1 (transducer of ErbB2) is a member of the BTG/Tob family. Studies in mice carrying a targeted deletion of the Tob1 gene indicate that Tob1 is a negative regulator of osteogenesis and Tob1 has been shown to inhibit bone morphogenetic protein (BMP) signalling by interacting with receptor-regulated Smads in osteoblasts []. In addition, Tob1 null mice are prone to spontaneous tumour formation []and Tob1 expression is decreased in lung cancers []. These findings suggest that Tob1 acts as a tumour suppressor protein, and it has been shown that the Tob protein can inhibit cell cycle progression from the G0/G1 to S phases. This cell cycle regulatory function may occur in part, through their interaction with CAF1 [].The BTG/Tob family members contain an conserved N-terminal domain, known as APRO domain (AntiPROliferative) or BTG domain. In mammals, six family members have been identified: BTG1, BTG2/PC3/Tis21, BTG3/ANA, BTG4/PC3B, Tob1/Tob and Tob2. They interact with CAF1, a subunit of the CCR4-NOT complex. They display antiproliferative properties as their ectopic expression in a variety of cell lines reduced cell proliferation []. |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoshida Y |
Year: |
2003 |
Journal: |
Genes Dev |
Title: |
Mice lacking a transcriptional corepressor Tob are predisposed to cancer. |
Volume: |
17 |
Issue: |
10 |
Pages: |
1201-6 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
362
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoshida Y |
Year: |
2003 |
Journal: |
Mech Dev |
Title: |
Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling. |
Volume: |
120 |
Issue: |
5 |
Pages: |
629-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Iwanaga K |
Year: |
2003 |
Journal: |
Cancer Lett |
Title: |
Alteration of expression or phosphorylation status of tob, a novel tumor suppressor gene product, is an early event in lung cancer. |
Volume: |
202 |
Issue: |
1 |
Pages: |
71-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ikematsu N |
Year: |
1999 |
Journal: |
Oncogene |
Title: |
Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases. |
Volume: |
18 |
Issue: |
52 |
Pages: |
7432-41 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
363
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoshida Y |
Year: |
1997 |
Journal: |
Gene |
Title: |
Cloning and characterization of the mouse tob gene. |
Volume: |
191 |
Issue: |
1 |
Pages: |
109-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ho KJ |
Year: |
2010 |
Journal: |
J Exp Med |
Title: |
Tob1 is a constitutively expressed repressor of liver regeneration. |
Volume: |
207 |
Issue: |
6 |
Pages: |
1197-208 |
|
•
•
•
•
•
|
Publication |
First Author: |
Winkler GS |
Year: |
2010 |
Journal: |
J Cell Physiol |
Title: |
The mammalian anti-proliferative BTG/Tob protein family. |
Volume: |
222 |
Issue: |
1 |
Pages: |
66-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu Z |
Year: |
2022 |
Journal: |
Commun Biol |
Title: |
TOB1 attenuates IRF3-directed antiviral responses by recruiting HDAC8 to specifically suppress IFN-β expression. |
Volume: |
5 |
Issue: |
1 |
Pages: |
943 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kitajima Y |
Year: |
2024 |
Journal: |
J Cell Sci |
Title: |
Loss of Tob1 promotes muscle regeneration through muscle stem cell expansion. |
Volume: |
137 |
Issue: |
15 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Didonna A |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitis. |
Volume: |
6 |
|
Pages: |
31603 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schulze-Topphoff U |
Year: |
2013 |
Journal: |
J Exp Med |
Title: |
Tob1 plays a critical role in the activation of encephalitogenic T cells in CNS autoimmunity. |
Volume: |
210 |
Issue: |
7 |
Pages: |
1301-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
May SL |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis. |
Volume: |
9 |
Issue: |
6 |
Pages: |
e100629 |
|
•
•
•
•
•
|
Publication |
First Author: |
Perez RC |
Year: |
2024 |
Journal: |
J Mol Histol |
Title: |
TOB1 and TOB2 mark distinct RNA processing granules in differentiating lens fiber cells. |
Volume: |
55 |
Issue: |
1 |
Pages: |
121-138 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Y |
Year: |
2015 |
Journal: |
Biochem Biophys Res Commun |
Title: |
BTG/Tob family members Tob1 and Tob2 inhibit proliferation of mouse embryonic stem cells via Id3 mRNA degradation. |
Volume: |
462 |
Issue: |
3 |
Pages: |
208-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li D |
Year: |
2018 |
Journal: |
Mol Cancer |
Title: |
High expression of Tob1 indicates poor survival outcome and promotes tumour progression via a Wnt positive feedback loop in colon cancer. |
Volume: |
17 |
Issue: |
1 |
Pages: |
159 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7662587 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-07-03 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1716319 |
Pattern: |
Punctate |
Stage: |
TS19 |
Assay Id: |
MGI:7662602 |
Age: |
embryonic day 11.5 |
|
Note: |
At E11.5, immunoreactivity was found throughout the lens vesicle as fine granular punctate staining, often in association with Dcp2. Larger cytoplasmic complexes of Tob1 and Dcp2 were observed in posterior vesicle cells. |
Specimen Label: |
2a |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang M |
Year: |
2007 |
Journal: |
Cancer Res |
Title: |
Fine mapping and candidate gene analyses of pulmonary adenoma resistance 1, a major genetic determinant of mouse lung adenoma resistance. |
Volume: |
67 |
Issue: |
6 |
Pages: |
2508-16 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Usui M |
Year: |
2002 |
Journal: |
J Bone Miner Res |
Title: |
Enhancing effect of Tob deficiency on bone formation is specific to bone morphogenetic protein-induced osteogenesis. |
Volume: |
17 |
Issue: |
6 |
Pages: |
1026-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Usui M |
Year: |
2004 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Tob deficiency superenhances osteoblastic activity after ovariectomy to block estrogen deficiency-induced osteoporosis. |
Volume: |
101 |
Issue: |
17 |
Pages: |
6653-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Youssef MMM |
Year: |
2022 |
Journal: |
Transl Psychiatry |
Title: |
TOB is an effector of the hippocampus-mediated acute stress response. |
Volume: |
12 |
Issue: |
1 |
Pages: |
302 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7662571 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-07-03 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1783823 |
|
Stage: |
TS23 |
Assay Id: |
MGI:7662579 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
E15.5 + |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7662571 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-07-03 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1783825 |
|
Stage: |
TS25 |
Assay Id: |
MGI:7662579 |
Age: |
embryonic day 17.5 |
|
|
Specimen Label: |
E17.5 + |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7662571 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-07-03 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3287127 |
|
Stage: |
TS27 |
Assay Id: |
MGI:7662579 |
Age: |
postnatal day 3 |
|
|
Specimen Label: |
P3-Epi + |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7662571 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-07-03 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1784127 |
|
Stage: |
TS27 |
Assay Id: |
MGI:7662579 |
Age: |
postnatal day 3 |
|
|
Specimen Label: |
P3-Fib + |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7779573 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-11-12 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1758921 |
|
Stage: |
TS21 |
Assay Id: |
MGI:7779584 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Pinna 13.5 dpc |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7779573 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-11-12 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1758922 |
|
Stage: |
TS22 |
Assay Id: |
MGI:7779584 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
Pinna 14.5 dpc |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7779573 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-11-12 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3639221 |
|
Stage: |
TS21 |
Assay Id: |
MGI:7779584 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Skin 13.5 dpc |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7779573 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-11-12 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3639222 |
|
Stage: |
TS22 |
Assay Id: |
MGI:7779584 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
Skin 14.5 dpc |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4844797 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-12-22 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1611817 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:4848641 |
Age: |
embryonic day 10.5 |
|
Note: |
Staining is present in the mandibular arch. |
Specimen Label: |
Table S4 - E10.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4844797 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-12-22 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640517 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:4848641 |
Age: |
embryonic day 10.5 |
|
Note: |
Staining is present in the posterior limb. |
Specimen Label: |
Table S4 - E10.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3603811 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-11-07 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1721322 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:3603815 |
Age: |
embryonic day 14.5 |
|
Note: |
Expression is in the periosteum of the bone collar. |
Specimen Label: |
Not Shown |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4844797 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-12-22 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1738219 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:4848641 |
Age: |
embryonic day 11.5 |
|
Note: |
Staining is present in the external genitalia. |
Specimen Label: |
Table S4 - E11.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4844797 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-12-22 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1680017 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:4848641 |
Age: |
embryonic day 10.5 |
|
Note: |
Staining is present in the olfactory placode. |
Specimen Label: |
Table S4 - E10.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7662573 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-07-03 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1783923 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:7662581 |
Age: |
embryonic day 15.5 |
|
Note: |
The anterior epithelium signal was weaker than the fiber cells. |
Specimen Label: |
1b |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7662587 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-07-03 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1783921 |
Pattern: |
Regionally restricted |
Stage: |
TS21 |
Assay Id: |
MGI:7662602 |
Age: |
embryonic day 13.5 |
|
Note: |
Weak granular immunoreactivity was observed. |
Specimen Label: |
2d |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7662587 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-07-03 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1783924 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:7662602 |
Age: |
embryonic day 16.5 |
|
Note: |
Little or no staining was detected. |
Specimen Label: |
2g |
|
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4844797 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-12-22 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3270519 |
Pattern: |
Regionally restricted |
Stage: |
TS19 |
Assay Id: |
MGI:4848641 |
Age: |
embryonic day 11.5 |
|
Note: |
Staining is present in the middle limb. |
Specimen Label: |
Table S4 - E11.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4844797 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-12-22 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1636715 |
Pattern: |
Regionally restricted |
Stage: |
TS15 |
Assay Id: |
MGI:4848641 |
Age: |
embryonic day 9.5 |
|
Note: |
Staining is present in the external genitalia. |
Specimen Label: |
Table S4 - E9.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4844797 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-12-22 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1636717 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:4848641 |
Age: |
embryonic day 10.5 |
|
Note: |
Staining is present in the external genitalia. |
Specimen Label: |
Table S4 - E10.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4844797 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-12-22 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1666917 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:4848641 |
Age: |
embryonic day 10.5 |
|
Note: |
Staining is present in the otic pit. |
Specimen Label: |
Table S4 - E10.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7662587 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-07-03 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1784124 |
Pattern: |
Punctate |
Stage: |
TS24 |
Assay Id: |
MGI:7662602 |
Age: |
embryonic day 16.5 |
|
Note: |
In more differentiated fiber cells of the lens cortex, co-localization was associated with nuclei. |
Specimen Label: |
2g |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7662587 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-07-03 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1784121 |
Pattern: |
Punctate |
Stage: |
TS21 |
Assay Id: |
MGI:7662602 |
Age: |
embryonic day 13.5 |
|
Note: |
Distinct large punctate immunoreactivity was detected in the elongating fiber cells. Co-localization with Dcp2 was observed. |
Specimen Label: |
2d |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3603811 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-11-07 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3294026 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:3603815 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
3A |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4844797 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-12-22 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1638817 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:4848641 |
Age: |
embryonic day 10.5 |
|
Note: |
Staining is present in the maxillary process. |
Specimen Label: |
Table S4 - E10.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7662573 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-07-03 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:3827723 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:7662581 |
Age: |
embryonic day 15.5 |
|
Note: |
Weak expression was observed in cells just above the lens equator, which will become the germinative zone. |
Specimen Label: |
1b |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7662587 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-07-03 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3827824 |
Pattern: |
Regionally restricted |
Stage: |
TS24 |
Assay Id: |
MGI:7662602 |
Age: |
embryonic day 16.5 |
|
Note: |
At E16.5 distinct granular cytoplasmic staining was detected in the germinative zone cells. |
Specimen Label: |
2g |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7662573 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-07-03 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3827923 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:7662581 |
Age: |
embryonic day 15.5 |
|
Note: |
Expression was detected in fiber cells of the transitional zone. No signal was detected in differentiated fibers. |
Specimen Label: |
1b |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7662587 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-07-03 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3827924 |
Pattern: |
Regionally restricted |
Stage: |
TS24 |
Assay Id: |
MGI:7662602 |
Age: |
embryonic day 16.5 |
|
Note: |
In transitional zone fiber cells, co-localization with DCP2 was found in large cytoplasmic complexes. Expression was also adjacent to DCP2 in large cytoplasmic complexes in fiber cells of the transitional zone. |
Specimen Label: |
2g |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
1 |
Description: |
Protein Tob1 |
Type: |
chain |
End: |
362 |
|
•
•
•
•
•
|
Publication |
First Author: |
Watanabe M |
Year: |
2011 |
Journal: |
FEBS Lett |
Title: |
Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein Tob. |
Volume: |
585 |
Issue: |
1 |
Pages: |
65-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsuda S |
Year: |
2001 |
Journal: |
FEBS Lett |
Title: |
In search of a function for the TIS21/PC3/BTG1/TOB family. |
Volume: |
497 |
Issue: |
2-3 |
Pages: |
67-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lorda-Diez CI |
Year: |
2015 |
Journal: |
Aging (Albany NY) |
Title: |
Apoptosis during embryonic tissue remodeling is accompanied by cell senescence. |
Volume: |
7 |
Issue: |
11 |
Pages: |
974-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoshida Y |
Year: |
2000 |
Journal: |
Cell |
Title: |
Negative regulation of BMP/Smad signaling by Tob in osteoblasts. |
Volume: |
103 |
Issue: |
7 |
Pages: |
1085-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Torres L |
Year: |
2015 |
Journal: |
Int J Dev Biol |
Title: |
External ear microRNA expression profiles during mouse development. |
Volume: |
59 |
Issue: |
10-12 |
Pages: |
497-503 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mohan RA |
Year: |
2020 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system. |
Volume: |
117 |
Issue: |
31 |
Pages: |
18617-18626 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kannan K |
Year: |
2001 |
Journal: |
Oncogene |
Title: |
DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1. |
Volume: |
20 |
Issue: |
26 |
Pages: |
3449-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Desai J |
Year: |
2006 |
Journal: |
Hum Mol Genet |
Title: |
Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. |
Volume: |
15 |
Issue: |
8 |
Pages: |
1329-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Yokoyama S |
Year: |
2009 |
Journal: |
Dev Cell |
Title: |
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. |
Volume: |
17 |
Issue: |
6 |
Pages: |
836-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2016 |
|
Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|