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Search results 1 to 100 out of 139 for Tob1

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Type Details Score
Protein Domain
Type: Family
Description: Tob1 (transducer of ErbB2) is a member of the BTG/Tob family. Studies in mice carrying a targeted deletion of the Tob1 gene indicate that Tob1 is a negative regulator of osteogenesis and Tob1 has been shown to inhibit bone morphogenetic protein (BMP) signalling by interacting with receptor-regulated Smads in osteoblasts []. In addition, Tob1 null mice are prone to spontaneous tumour formation []and Tob1 expression is decreased in lung cancers []. These findings suggest that Tob1 acts as a tumour suppressor protein, and it has been shown that the Tob protein can inhibit cell cycle progression from the G0/G1 to S phases. This cell cycle regulatory function may occur in part, through their interaction with CAF1 [].The BTG/Tob family members contain an conserved N-terminal domain, known as APRO domain (AntiPROliferative) or BTG domain. In mammals, six family members have been identified: BTG1, BTG2/PC3/Tis21, BTG3/ANA, BTG4/PC3B, Tob1/Tob and Tob2. They interact with CAF1, a subunit of the CCR4-NOT complex. They display antiproliferative properties as their ectopic expression in a variety of cell lines reduced cell proliferation [].
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Yoshida Y
Year: 2003
Journal: Genes Dev
Title: Mice lacking a transcriptional corepressor Tob are predisposed to cancer.
Volume: 17
Issue: 10
Pages: 1201-6
Protein
Organism: Mus musculus/domesticus
Length: 362  
Fragment?: false
Publication
First Author: Yoshida Y
Year: 2003
Journal: Mech Dev
Title: Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling.
Volume: 120
Issue: 5
Pages: 629-37
Publication
First Author: Iwanaga K
Year: 2003
Journal: Cancer Lett
Title: Alteration of expression or phosphorylation status of tob, a novel tumor suppressor gene product, is an early event in lung cancer.
Volume: 202
Issue: 1
Pages: 71-9
Publication
First Author: Ikematsu N
Year: 1999
Journal: Oncogene
Title: Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases.
Volume: 18
Issue: 52
Pages: 7432-41
Gene
Type: gene
Organism: human
Protein
Organism: Mus musculus/domesticus
Length: 363  
Fragment?: false
Publication
First Author: Yoshida Y
Year: 1997
Journal: Gene
Title: Cloning and characterization of the mouse tob gene.
Volume: 191
Issue: 1
Pages: 109-13
Publication
First Author: Ho KJ
Year: 2010
Journal: J Exp Med
Title: Tob1 is a constitutively expressed repressor of liver regeneration.
Volume: 207
Issue: 6
Pages: 1197-208
Publication
First Author: Winkler GS
Year: 2010
Journal: J Cell Physiol
Title: The mammalian anti-proliferative BTG/Tob protein family.
Volume: 222
Issue: 1
Pages: 66-72
Publication
First Author: Yu Z
Year: 2022
Journal: Commun Biol
Title: TOB1 attenuates IRF3-directed antiviral responses by recruiting HDAC8 to specifically suppress IFN-β expression.
Volume: 5
Issue: 1
Pages: 943
Publication  
First Author: Kitajima Y
Year: 2024
Journal: J Cell Sci
Title: Loss of Tob1 promotes muscle regeneration through muscle stem cell expansion.
Volume: 137
Issue: 15
Publication  
First Author: Didonna A
Year: 2016
Journal: Sci Rep
Title: Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitis.
Volume: 6
Pages: 31603
Publication
First Author: Schulze-Topphoff U
Year: 2013
Journal: J Exp Med
Title: Tob1 plays a critical role in the activation of encephalitogenic T cells in CNS autoimmunity.
Volume: 210
Issue: 7
Pages: 1301-9
Publication
First Author: May SL
Year: 2014
Journal: PLoS One
Title: Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis.
Volume: 9
Issue: 6
Pages: e100629
Publication
First Author: Perez RC
Year: 2024
Journal: J Mol Histol
Title: TOB1 and TOB2 mark distinct RNA processing granules in differentiating lens fiber cells.
Volume: 55
Issue: 1
Pages: 121-138
Publication
First Author: Chen Y
Year: 2015
Journal: Biochem Biophys Res Commun
Title: BTG/Tob family members Tob1 and Tob2 inhibit proliferation of mouse embryonic stem cells via Id3 mRNA degradation.
Volume: 462
Issue: 3
Pages: 208-14
Publication
First Author: Li D
Year: 2018
Journal: Mol Cancer
Title: High expression of Tob1 indicates poor survival outcome and promotes tumour progression via a Wnt positive feedback loop in colon cancer.
Volume: 17
Issue: 1
Pages: 159
GXD Expression  
Probe: MGI:7662587
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716319
Pattern: Punctate
Stage: TS19
Assay Id: MGI:7662602
Age: embryonic day 11.5
Note: At E11.5, immunoreactivity was found throughout the lens vesicle as fine granular punctate staining, often in association with Dcp2. Larger cytoplasmic complexes of Tob1 and Dcp2 were observed in posterior vesicle cells.
Specimen Label: 2a
Detected: true
Specimen Num: 1
Publication
First Author: Wang M
Year: 2007
Journal: Cancer Res
Title: Fine mapping and candidate gene analyses of pulmonary adenoma resistance 1, a major genetic determinant of mouse lung adenoma resistance.
Volume: 67
Issue: 6
Pages: 2508-16
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Usui M
Year: 2002
Journal: J Bone Miner Res
Title: Enhancing effect of Tob deficiency on bone formation is specific to bone morphogenetic protein-induced osteogenesis.
Volume: 17
Issue: 6
Pages: 1026-33
Publication
First Author: Usui M
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Tob deficiency superenhances osteoblastic activity after ovariectomy to block estrogen deficiency-induced osteoporosis.
Volume: 101
Issue: 17
Pages: 6653-8
Publication
First Author: Youssef MMM
Year: 2022
Journal: Transl Psychiatry
Title: TOB is an effector of the hippocampus-mediated acute stress response.
Volume: 12
Issue: 1
Pages: 302
GXD Expression      
Probe: MGI:7662571
Assay Type: RT-PCR
Annotation Date: 2024-07-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783823
Stage: TS23
Assay Id: MGI:7662579
Age: embryonic day 15.5
Specimen Label: E15.5 +
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7662571
Assay Type: RT-PCR
Annotation Date: 2024-07-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783825
Stage: TS25
Assay Id: MGI:7662579
Age: embryonic day 17.5
Specimen Label: E17.5 +
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:7662571
Assay Type: RT-PCR
Annotation Date: 2024-07-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287127
Stage: TS27
Assay Id: MGI:7662579
Age: postnatal day 3
Specimen Label: P3-Epi +
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:7662571
Assay Type: RT-PCR
Annotation Date: 2024-07-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1784127
Stage: TS27
Assay Id: MGI:7662579
Age: postnatal day 3
Specimen Label: P3-Fib +
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:7779573
Assay Type: RT-PCR
Annotation Date: 2024-11-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1758921
Stage: TS21
Assay Id: MGI:7779584
Age: embryonic day 13.5
Specimen Label: Pinna 13.5 dpc
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7779573
Assay Type: RT-PCR
Annotation Date: 2024-11-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1758922
Stage: TS22
Assay Id: MGI:7779584
Age: embryonic day 14.5
Specimen Label: Pinna 14.5 dpc
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7779573
Assay Type: RT-PCR
Annotation Date: 2024-11-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3639221
Stage: TS21
Assay Id: MGI:7779584
Age: embryonic day 13.5
Specimen Label: Skin 13.5 dpc
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:7779573
Assay Type: RT-PCR
Annotation Date: 2024-11-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3639222
Stage: TS22
Assay Id: MGI:7779584
Age: embryonic day 14.5
Specimen Label: Skin 14.5 dpc
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4844797
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1611817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848641
Age: embryonic day 10.5
Note: Staining is present in the mandibular arch.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4844797
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1640517
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:4848641
Age: embryonic day 10.5
Note: Staining is present in the posterior limb.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3603811
Assay Type: RNA in situ
Annotation Date: 2005-11-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1721322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:3603815
Age: embryonic day 14.5
Note: Expression is in the periosteum of the bone collar.
Specimen Label: Not Shown
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4844797
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1738219
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:4848641
Age: embryonic day 11.5
Note: Staining is present in the external genitalia.
Specimen Label: Table S4 - E11.5
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4844797
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1680017
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848641
Age: embryonic day 10.5
Note: Staining is present in the olfactory placode.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:7662573
Assay Type: RNA in situ
Annotation Date: 2024-07-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783923
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7662581
Age: embryonic day 15.5
Note: The anterior epithelium signal was weaker than the fiber cells.
Specimen Label: 1b
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:7662587
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-03
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1783921
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:7662602
Age: embryonic day 13.5
Note: Weak granular immunoreactivity was observed.
Specimen Label: 2d
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7662587
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-03
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1783924
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:7662602
Age: embryonic day 16.5
Note: Little or no staining was detected.
Specimen Label: 2g
Specimen Num: 3
GXD Expression  
Probe: MGI:4844797
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3270519
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:4848641
Age: embryonic day 11.5
Note: Staining is present in the middle limb.
Specimen Label: Table S4 - E11.5
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4844797
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1636715
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:4848641
Age: embryonic day 9.5
Note: Staining is present in the external genitalia.
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4844797
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1636717
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:4848641
Age: embryonic day 10.5
Note: Staining is present in the external genitalia.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4844797
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848641
Age: embryonic day 10.5
Note: Staining is present in the otic pit.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:7662587
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1784124
Pattern: Punctate
Stage: TS24
Assay Id: MGI:7662602
Age: embryonic day 16.5
Note: In more differentiated fiber cells of the lens cortex, co-localization was associated with nuclei.
Specimen Label: 2g
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:7662587
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1784121
Pattern: Punctate
Stage: TS21
Assay Id: MGI:7662602
Age: embryonic day 13.5
Note: Distinct large punctate immunoreactivity was detected in the elongating fiber cells. Co-localization with Dcp2 was observed.
Specimen Label: 2d
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3603811
Assay Type: RNA in situ
Annotation Date: 2005-11-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3294026
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:3603815
Age: embryonic day 18.5
Specimen Label: 3A
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4844797
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1638817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848641
Age: embryonic day 10.5
Note: Staining is present in the maxillary process.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:7662573
Assay Type: RNA in situ
Annotation Date: 2024-07-03
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3827723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7662581
Age: embryonic day 15.5
Note: Weak expression was observed in cells just above the lens equator, which will become the germinative zone.
Specimen Label: 1b
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:7662587
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3827824
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:7662602
Age: embryonic day 16.5
Note: At E16.5 distinct granular cytoplasmic staining was detected in the germinative zone cells.
Specimen Label: 2g
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:7662573
Assay Type: RNA in situ
Annotation Date: 2024-07-03
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3827923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7662581
Age: embryonic day 15.5
Note: Expression was detected in fiber cells of the transitional zone. No signal was detected in differentiated fibers.
Specimen Label: 1b
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:7662587
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3827924
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:7662602
Age: embryonic day 16.5
Note: In transitional zone fiber cells, co-localization with DCP2 was found in large cytoplasmic complexes. Expression was also adjacent to DCP2 in large cytoplasmic complexes in fiber cells of the transitional zone.
Specimen Label: 2g
Detected: true
Specimen Num: 3
UniProt Feature
Begin: 1
Description: Protein Tob1
Type: chain
End: 362
Publication
First Author: Watanabe M
Year: 2011
Journal: FEBS Lett
Title: Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein Tob.
Volume: 585
Issue: 1
Pages: 65-70
Publication
First Author: Matsuda S
Year: 2001
Journal: FEBS Lett
Title: In search of a function for the TIS21/PC3/BTG1/TOB family.
Volume: 497
Issue: 2-3
Pages: 67-72
Publication
First Author: Lorda-Diez CI
Year: 2015
Journal: Aging (Albany NY)
Title: Apoptosis during embryonic tissue remodeling is accompanied by cell senescence.
Volume: 7
Issue: 11
Pages: 974-85
Publication
First Author: Yoshida Y
Year: 2000
Journal: Cell
Title: Negative regulation of BMP/Smad signaling by Tob in osteoblasts.
Volume: 103
Issue: 7
Pages: 1085-97
Publication
First Author: Torres L
Year: 2015
Journal: Int J Dev Biol
Title: External ear microRNA expression profiles during mouse development.
Volume: 59
Issue: 10-12
Pages: 497-503
Publication
First Author: Mohan RA
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system.
Volume: 117
Issue: 31
Pages: 18617-18626
Publication
First Author: Kannan K
Year: 2001
Journal: Oncogene
Title: DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1.
Volume: 20
Issue: 26
Pages: 3449-55
Publication
First Author: Desai J
Year: 2006
Journal: Hum Mol Genet
Title: Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.
Volume: 15
Issue: 8
Pages: 1329-41
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
Publication        
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use