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Search results 1 to 100 out of 115 for Tob1

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Type Details Score
Protein Domain
IPR015677 | Tob1
Type: Family
Description: Tob1 (transducer of ErbB2) is a member of the BTG/Tob family. Studies in mice carrying a targeted deletion of the Tob1 gene indicate that Tob1 is a negative regulator of osteogenesis and Tob1 has been shown to inhibit bone morphogenetic protein (BMP) signalling by interacting with receptor-regulated Smads in osteoblasts []. In addition, Tob1 null mice are prone to spontaneous tumour formation []and Tob1 expression is decreased in lung cancers []. These findings suggest that Tob1 acts as a tumour suppressor protein, and it has been shown that the Tob protein can inhibit cell cycle progression from the G0/G1 to S phases. This cell cycle regulatory function may occur in part, through their interaction with CAF1 [].The BTG/Tob family members contain an conserved N-terminal domain, known as APRO domain (AntiPROliferative) or BTG domain. In mammals, six family members have been identified: BTG1, BTG2/PC3/Tis21, BTG3/ANA, BTG4/PC3B, Tob1/Tob and Tob2. They interact with CAF1, a subunit of the CCR4-NOT complex. They display antiproliferative properties as their ectopic expression in a variety of cell lines reduced cell proliferation [].
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Gene
10140 | TOB1
Type: gene
Organism: human
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Gene
768016 | TOB1
Type: gene
Organism: cattle
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Gene
395225 | TOB1
Type: gene
Organism: chicken
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Gene
706873 | TOB1
Type: gene
Organism: macaque, rhesus
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Gene
549365 | tob1
Type: gene
Organism: frog, western clawed
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Gene
119873289 | TOB1
Type: gene
Organism: dog, domestic
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Gene
170842 | Tob1
Type: gene
Organism: rat
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Gene
468406 | TOB1
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:1349721 | Tob1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
12756225 | J:83357
First Author: Yoshida Y
Year: 2003
Journal: Genes Dev
Title: Mice lacking a transcriptional corepressor Tob are predisposed to cancer.
Volume: 17
Issue: 10
Pages: 1201-6
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Protein
Q61471
Organism: Mus musculus/domesticus
Length: 362  
Fragment?: false
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Publication
12782279 | -
First Author: Yoshida Y
Year: 2003
Journal: Mech Dev
Title: Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling.
Volume: 120
Issue: 5
Pages: 629-37
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Publication
14643028 | -
First Author: Iwanaga K
Year: 2003
Journal: Cancer Lett
Title: Alteration of expression or phosphorylation status of tob, a novel tumor suppressor gene product, is an early event in lung cancer.
Volume: 202
Issue: 1
Pages: 71-9
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Publication
10602502 | -
First Author: Ikematsu N
Year: 1999
Journal: Oncogene
Title: Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases.
Volume: 18
Issue: 52
Pages: 7432-41
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Gene
400604 | TOB1-AS1
Type: gene
Organism: human
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Protein
Q3UQ91
Organism: Mus musculus/domesticus
Length: 363  
Fragment?: false
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Publication
9210596 | J:41178
First Author: Yoshida Y
Year: 1997
Journal: Gene
Title: Cloning and characterization of the mouse tob gene.
Volume: 191
Issue: 1
Pages: 109-13
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Publication
20513747 | J:163417
First Author: Ho KJ
Year: 2010
Journal: J Exp Med
Title: Tob1 is a constitutively expressed repressor of liver regeneration.
Volume: 207
Issue: 6
Pages: 1197-208
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Publication
19746446 | -
First Author: Winkler GS
Year: 2010
Journal: J Cell Physiol
Title: The mammalian anti-proliferative BTG/Tob protein family.
Volume: 222
Issue: 1
Pages: 66-72
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Publication
36085336 | J:329012
First Author: Yu Z
Year: 2022
Journal: Commun Biol
Title: TOB1 attenuates IRF3-directed antiviral responses by recruiting HDAC8 to specifically suppress IFN-β expression.
Volume: 5
Issue: 1
Pages: 943
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Publication
23797093 | J:259339
First Author: Schulze-Topphoff U
Year: 2013
Journal: J Exp Med
Title: Tob1 plays a critical role in the activation of encephalitogenic T cells in CNS autoimmunity.
Volume: 210
Issue: 7
Pages: 1301-9
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Publication
27546286 | J:259307
 
First Author: Didonna A
Year: 2016
Journal: Sci Rep
Title: Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitis.
Volume: 6
Pages: 31603
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Publication
24945807 | J:218952
First Author: May SL
Year: 2014
Journal: PLoS One
Title: Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis.
Volume: 9
Issue: 6
Pages: e100629
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Publication
38165569 | J:346062
First Author: Perez RC
Year: 2024
Journal: J Mol Histol
Title: TOB1 and TOB2 mark distinct RNA processing granules in differentiating lens fiber cells.
Volume: 55
Issue: 1
Pages: 121-138
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Publication
25951976 | J:228465
First Author: Chen Y
Year: 2015
Journal: Biochem Biophys Res Commun
Title: BTG/Tob family members Tob1 and Tob2 inhibit proliferation of mouse embryonic stem cells via Id3 mRNA degradation.
Volume: 462
Issue: 3
Pages: 208-14
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Publication
30447686 | J:317022
First Author: Li D
Year: 2018
Journal: Mol Cancer
Title: High expression of Tob1 indicates poor survival outcome and promotes tumour progression via a Wnt positive feedback loop in colon cancer.
Volume: 17
Issue: 1
Pages: 159
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Publication
17363568 | J:120319
First Author: Wang M
Year: 2007
Journal: Cancer Res
Title: Fine mapping and candidate gene analyses of pulmonary adenoma resistance 1, a major genetic determinant of mouse lung adenoma resistance.
Volume: 67
Issue: 6
Pages: 2508-16
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Protein Coding Gene
MGP_CAROLIEiJ_G0016974 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0018950 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0018918 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0018888 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0018891 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0018705 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1349721 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0019343 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0018260 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0018676 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0018784 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0018773 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0018854 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0018800 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0019383 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0018030 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0018309 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0018105 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0017820 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
35906220 | J:327375
First Author: Youssef MMM
Year: 2022
Journal: Transl Psychiatry
Title: TOB is an effector of the hippocampus-mediated acute stress response.
Volume: 12
Issue: 1
Pages: 302
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Publication
15100414 | J:89577
First Author: Usui M
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Tob deficiency superenhances osteoblastic activity after ovariectomy to block estrogen deficiency-induced osteoporosis.
Volume: 101
Issue: 17
Pages: 6653-8
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Publication
12054157 | J:112398
First Author: Usui M
Year: 2002
Journal: J Bone Miner Res
Title: Enhancing effect of Tob deficiency on bone formation is specific to bone morphogenetic protein-induced osteogenesis.
Volume: 17
Issue: 6
Pages: 1026-33
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GXD Expression
GXD Expression
 
Probe: MGI:4844797
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1611817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848641
Age: embryonic day 10.5
Note: Staining is present in the mandibular arch.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4844797
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1640517
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:4848641
Age: embryonic day 10.5
Note: Staining is present in the posterior limb.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3603811
Assay Type: RNA in situ
Annotation Date: 2005-11-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1721322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:3603815
Age: embryonic day 14.5
Note: Expression is in the periosteum of the bone collar.
Specimen Label: Not Shown
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4844797
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1738219
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:4848641
Age: embryonic day 11.5
Note: Staining is present in the external genitalia.
Specimen Label: Table S4 - E11.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4844797
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1680017
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848641
Age: embryonic day 10.5
Note: Staining is present in the olfactory placode.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4844797
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3270519
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:4848641
Age: embryonic day 11.5
Note: Staining is present in the middle limb.
Specimen Label: Table S4 - E11.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4844797
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1636715
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:4848641
Age: embryonic day 9.5
Note: Staining is present in the external genitalia.
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4844797
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1636717
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:4848641
Age: embryonic day 10.5
Note: Staining is present in the external genitalia.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4844797
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848641
Age: embryonic day 10.5
Note: Staining is present in the otic pit.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3603811
Assay Type: RNA in situ
Annotation Date: 2005-11-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3294026
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:3603815
Age: embryonic day 18.5
Specimen Label: 3A
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4844797
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1638817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848641
Age: embryonic day 10.5
Note: Staining is present in the maxillary process.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
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Publication
21130766 | J:168702
First Author: Watanabe M
Year: 2011
Journal: FEBS Lett
Title: Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein Tob.
Volume: 585
Issue: 1
Pages: 65-70
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Publication
11377414 | J:69884
First Author: Matsuda S
Year: 2001
Journal: FEBS Lett
Title: In search of a function for the TIS21/PC3/BTG1/TOB family.
Volume: 497
Issue: 2-3
Pages: 67-72
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Publication
26568417 | J:317049
First Author: Lorda-Diez CI
Year: 2015
Journal: Aging (Albany NY)
Title: Apoptosis during embryonic tissue remodeling is accompanied by cell senescence.
Volume: 7
Issue: 11
Pages: 974-85
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UniProt Feature
UniProt Feature
Begin: 1
Description: Protein Tob1
Type: chain
End: 362
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Publication
11163184 | J:66504
First Author: Yoshida Y
Year: 2000
Journal: Cell
Title: Negative regulation of BMP/Smad signaling by Tob in osteoblasts.
Volume: 103
Issue: 7
Pages: 1085-97
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Publication
32675240 | J:295904
First Author: Mohan RA
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system.
Volume: 117
Issue: 31
Pages: 18617-18626
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Publication
11423996 | J:70201
First Author: Kannan K
Year: 2001
Journal: Oncogene
Title: DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1.
Volume: 20
Issue: 26
Pages: 3449-55
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
16537572 | J:108241
First Author: Desai J
Year: 2006
Journal: Hum Mol Genet
Title: Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.
Volume: 15
Issue: 8
Pages: 1329-41
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
- | J:346132
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
15235587 | -
First Author: Kawamura-Tsuzuku J
Year: 2004
Journal: Oncogene
Title: Nuclear localization of Tob is important for regulation of its antiproliferative activity.
Volume: 23
Issue: 39
Pages: 6630-8
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HT Experiment
E-GEOD-21836 | Tob1 is a Constitutively Expressed Repressor of Liver Regeneration
Series Id: GSE21836
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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