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Search results 1 to 100 out of 121 for Tob2

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0.085s
Type Details Score
Protein Domain
Type: Family
Description: Tob (transducer of ErbB2) is a member of the BTG/Tob family. Tob2 consists of 344 amino acids with high similarity to the Tob1 protein. Like the Tob1 protein, Tob2 can inhibit cell cycle progression from the G0/G1 to S phases. This cell cycle regulatory function may occur in part, through their interaction with CAF1 [].The BTG/Tob family members contain an conserved N-terminal domain, known as APRO domain (AntiPROliferative) or BTG domain. In mammals, six family members have been identified: BTG1, BTG2/PC3/Tis21, BTG3/ANA, BTG4/PC3B, Tob1/Tob and Tob2. They interact with CAF1, a subunit of the CCR4-NOT complex. They display antiproliferative properties as their ectopic expression in a variety of cell lines reduced cell proliferation [].
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 44  
Fragment?: true
Publication
First Author: Ajima R
Year: 2000
Journal: Gene
Title: Cloning and characterization of the mouse tob2 gene.
Volume: 253
Issue: 2
Pages: 215-20
Protein
Organism: Mus musculus/domesticus
Length: 345  
Fragment?: false
Publication
First Author: Ikematsu N
Year: 1999
Journal: Oncogene
Title: Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases.
Volume: 18
Issue: 52
Pages: 7432-41
Protein
Organism: Mus musculus/domesticus
Length: 124  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 348  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 345  
Fragment?: false
Publication
First Author: Winkler GS
Year: 2010
Journal: J Cell Physiol
Title: The mammalian anti-proliferative BTG/Tob protein family.
Volume: 222
Issue: 1
Pages: 66-72
Publication
First Author: Jiang G
Year: 2020
Journal: J Immunol
Title: Tob2 Inhibits TLR-Induced Inflammatory Responses by Association with TRAF6 and MyD88.
Volume: 205
Issue: 4
Pages: 981-986
Publication
First Author: Gámez B
Year: 2013
Journal: J Biol Chem
Title: MicroRNA-322 (miR-322) and its target protein Tob2 modulate Osterix (Osx) mRNA stability.
Volume: 288
Issue: 20
Pages: 14264-75
Publication
First Author: Ajima R
Year: 2008
Journal: FEBS Lett
Title: Osteoporotic bone formation in mice lacking tob2; involvement of Tob2 in RANK ligand expression and osteoclasts differentiation.
Volume: 582
Issue: 9
Pages: 1313-8
Publication
First Author: Takahashi A
Year: 2012
Journal: Mol Cell Biol
Title: Tob2 inhibits peroxisome proliferator-activated receptor γ2 expression by sequestering Smads and C/EBPα during adipocyte differentiation.
Volume: 32
Issue: 24
Pages: 5067-77
Publication
First Author: Perez RC
Year: 2024
Journal: J Mol Histol
Title: TOB1 and TOB2 mark distinct RNA processing granules in differentiating lens fiber cells.
Volume: 55
Issue: 1
Pages: 121-138
Publication
First Author: Chen Y
Year: 2015
Journal: Biochem Biophys Res Commun
Title: BTG/Tob family members Tob1 and Tob2 inhibit proliferation of mouse embryonic stem cells via Id3 mRNA degradation.
Volume: 462
Issue: 3
Pages: 208-14
Gene
Type: gene
Organism: zebrafish
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:3586331
Assay Type: Northern blot
Annotation Date: 2005-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3586333
Age: postnatal adult
Specimen Label: testis
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3586331
Assay Type: Northern blot
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3586333
Age: postnatal adult
Specimen Label: kidney
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3586331
Assay Type: Northern blot
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:3586333
Age: postnatal adult
Specimen Label: skeletal muscle
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3586331
Assay Type: Northern blot
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3586333
Age: postnatal adult
Specimen Label: liver
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3586331
Assay Type: Northern blot
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3586333
Age: postnatal adult
Specimen Label: lung
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3586331
Assay Type: Northern blot
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3586333
Age: postnatal adult
Specimen Label: spleen
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3586331
Assay Type: Northern blot
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3586333
Age: postnatal adult
Specimen Label: brain
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3586331
Assay Type: Northern blot
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3586333
Age: postnatal adult
Specimen Label: heart
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:213725
Assay Type: RNA in situ
Annotation Date: 2024-03-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7614580
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:213725
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828866
Age: embryonic day 14.5
Image: euxassay_002023_02
Specimen Label: euxassay_002023_02
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:213725
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828866
Age: embryonic day 14.5
Image: euxassay_002023_03
Specimen Label: euxassay_002023_03
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:213725
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828866
Age: embryonic day 14.5
Image: euxassay_002023_04
Specimen Label: euxassay_002023_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:213725
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828866
Age: embryonic day 14.5
Image: euxassay_002023_05
Specimen Label: euxassay_002023_05
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:213725
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828866
Age: embryonic day 14.5
Image: euxassay_002023_06
Specimen Label: euxassay_002023_06
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:213725
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828866
Age: embryonic day 14.5
Image: euxassay_002023_07
Specimen Label: euxassay_002023_07
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:213725
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828866
Age: embryonic day 14.5
Image: euxassay_002023_16
Specimen Label: euxassay_002023_16
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:213725
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828866
Age: embryonic day 14.5
Image: euxassay_002023_17
Specimen Label: euxassay_002023_17
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:213725
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828866
Age: embryonic day 14.5
Image: euxassay_002023_18
Specimen Label: euxassay_002023_18
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:213725
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828866
Age: embryonic day 14.5
Image: euxassay_002023_19
Specimen Label: euxassay_002023_19
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:213725
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828866
Age: embryonic day 14.5
Image: euxassay_002023_20
Specimen Label: euxassay_002023_20
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:213725
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828866
Age: embryonic day 14.5
Image: euxassay_002023_21
Specimen Label: euxassay_002023_21
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:3586331
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:3598826
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:3586334
Age: embryonic day 18.5
Specimen Label: 3B
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3586331
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603926
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:3586334
Age: embryonic day 18.5
Note: Ubiquitous expression.
Specimen Label: 3B
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:213725
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1871923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828866
Age: embryonic day 14.5
Image: euxassay_002023_01
Specimen Label: euxassay_002023_01
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:213725
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1871923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828866
Age: embryonic day 14.5
Image: euxassay_002023_02
Specimen Label: euxassay_002023_02
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:213725
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1871923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828866
Age: embryonic day 14.5
Image: euxassay_002023_03
Specimen Label: euxassay_002023_03
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:213725
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1871923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828866
Age: embryonic day 14.5
Image: euxassay_002023_19
Specimen Label: euxassay_002023_19
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:213725
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1871923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828866
Age: embryonic day 14.5
Image: euxassay_002023_20
Specimen Label: euxassay_002023_20
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:213725
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1871923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828866
Age: embryonic day 14.5
Image: euxassay_002023_21
Specimen Label: euxassay_002023_21
Detected: true
Specimen Num: 13
GXD Expression  
Probe: MGI:213725
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1871923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828866
Age: embryonic day 14.5
Image: euxassay_002023_22
Specimen Label: euxassay_002023_22
Detected: true
Specimen Num: 14
GXD Expression    
Probe: MGI:213725
Assay Type: RNA in situ
Annotation Date: 2024-03-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7614580
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
UniProt Feature
Begin: 1
Description: Protein Tob2
Type: chain
End: 345
Publication
First Author: Matsuda S
Year: 2001
Journal: FEBS Lett
Title: In search of a function for the TIS21/PC3/BTG1/TOB family.
Volume: 497
Issue: 2-3
Pages: 67-72
Publication
First Author: Lorda-Diez CI
Year: 2015
Journal: Aging (Albany NY)
Title: Apoptosis during embryonic tissue remodeling is accompanied by cell senescence.
Volume: 7
Issue: 11
Pages: 974-85
Publication
First Author: Lee YJ
Year: 2000
Journal: FEBS Lett
Title: Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1).
Volume: 472
Issue: 2-3
Pages: 230-4
Publication
First Author: Ye A
Year: 2016
Journal: Epigenetics
Title: PEG3 binds to H19-ICR as a transcriptional repressor.
Volume: 11
Issue: 12
Pages: 889-900
Publication
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 1
Pages: 35-48
Publication      
First Author: Mammalian Functional Genomics Centre
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
Publication      
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication  
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer