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Search results 1 to 100 out of 180 for Tom1

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Hits by Strain

Type Details Score
Gene
10043 | TOM1
Type: gene
Organism: human
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Gene
549524 | tom1
Type: gene
Organism: frog, western clawed
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Gene
361370 | Tom1
Type: gene
Organism: rat
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Gene
739845 | TOM1
Type: gene
Organism: chimpanzee
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Gene
608746 | TOM1
Type: gene
Organism: dog, domestic
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Gene
504912 | TOM1
Type: gene
Organism: cattle
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Gene
396049 | TOM1
Type: gene
Organism: chicken
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Gene
553244 | tom1
Type: gene
Organism: zebrafish
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Gene
717499 | TOM1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1338026 | Tom1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR014645 | TOM1
Type: Family
Description: Tom1 (target of Myb 1) and its related proteins (Tom1L1 and Tom1L2) constitute a protein family and share an N-terminal VHS (Vps27p/Hrs/Stam) domain followed by a GAT (GGA and Tom1) domain.VHS domains are found at the N termini of select proteins involved in intracellular membrane trafficking and are often localized to membranes. The three dimensional structure of human TOM1 VHS domain reveals eight helices arranged in a superhelix. The surface of the domain has two main features: (1) a basic patch on one side due to several conserved positively charged residues on helix 3 and (2) a negatively charged ridge on the opposite side, formed by residues on helix 2 []. The basic patch is thought to mediate membrane binding.It was demonstrated that the GAT domain of both Tom1 and Tom1L1 binds ubiquitin, suggesting that these proteins might participate in the sorting of ubiquitinated proteins into multivesicular bodies (MVB) []. Moreover, Tom1L1 interacts with members of the MVB sorting machinery. Specifically, the VHS domain of Tom1L1 interacts with Hrs (hepatocyte growth factor-regulated tyrosine kinase substrate), whereas a PTAP motif, located between the VHS and GAT domains of Tom1L1, is responsible for binding to TSG101 (tumour susceptibility gene 101). Myc epitope-tagged Tom1L1 is recruited to endosomes following Hrs expression. In addition, Tom1L1 possesses several tyrosine motifs at the C-terminal region that mediate interactions with members of the Src family kinases and other signalling proteins such as Grb2 and p85. Expression of a constitutively active form of Fyn kinase promotes the recruitment of Tom1L1 to enlarged endosomes. It is proposed that Tom1L1 could act as an intermediary between the signalling and degradative pathways [].Over expression of Tom1 suppresses activation of the transcription factors NF-kappaB and AP-1, induced by either IL-1beta or tumour necrosis factor (TNF)-alpha, and the VHS domain of Tom1 is indispensable for this suppressive activity. This suggests that Tom1 is a common negative regulator of signalling pathways induced by IL-1beta and TNF-alpha [].
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Publication
14563850 | J:148073
First Author: Yamakami M
Year: 2003
Journal: J Biol Chem
Title: Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin.
Volume: 278
Issue: 52
Pages: 52865-72
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Publication
30185465 | J:266518
First Author: Gwon Y
Year: 2018
Journal: J Neurosci
Title: TOM1 Regulates Neuronal Accumulation of Amyloid-β Oligomers by FcγRIIb2 Variant in Alzheimer's Disease.
Volume: 38
Issue: 42
Pages: 9001-9018
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Publication
15056867 | -
First Author: Yamakami M
Year: 2004
Journal: Biol Pharm Bull
Title: Tom1 (target of Myb 1) is a novel negative regulator of interleukin-1- and tumor necrosis factor-induced signaling pathways.
Volume: 27
Issue: 4
Pages: 564-6
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Publication
10329004 | J:54916
First Author: Seroussi E
Year: 1999
Journal: Genomics
Title: TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM.
Volume: 57
Issue: 3
Pages: 380-8
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Publication
10985773 | -
First Author: Misra S
Year: 2000
Journal: Biochemistry
Title: Structure of the VHS domain of human Tom1 (target of myb 1): insights into interactions with proteins and membranes.
Volume: 39
Issue: 37
Pages: 11282-90
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Publication
15611048 | -
First Author: Puertollano R
Year: 2005
Journal: J Biol Chem
Title: Interactions of TOM1L1 with the multivesicular body sorting machinery.
Volume: 280
Issue: 10
Pages: 9258-64
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Protein
Q923U0
Organism: Mus musculus/domesticus
Length: 474  
Fragment?: false
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Protein
O88746
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: false
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Protein
Q5SRX1
Organism: Mus musculus/domesticus
Length: 507  
Fragment?: false
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Protein
Q7TNI6
Organism: Mus musculus/domesticus
Length: 474  
Fragment?: false
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Protein
Q8BZR6
Organism: Mus musculus/domesticus
Length: 397  
Fragment?: false
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Protein
Q3UDC3
Organism: Mus musculus/domesticus
Length: 516  
Fragment?: false
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Protein
Q5SXA4
Organism: Mus musculus/domesticus
Length: 462  
Fragment?: false
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Protein
Q5SXA5
Organism: Mus musculus/domesticus
Length: 457  
Fragment?: false
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Protein
Q561M4
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: false
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Protein Coding Gene
MGP_CAROLIEiJ_G0031231 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0033794 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0033776 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0033703 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0033770 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0033479 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1338026 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0034290 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0032808 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0033458 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0033612 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0033557 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0033701 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0033600 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0034307 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0032514 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0032923 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0021696 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0032352 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
 
Probe: MGI:3795945
Assay Type: RNA in situ
Annotation Date: 2008-07-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3267828
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3795946
Age: postnatal adult
Note: Expression is in the medial lemniscus.
Specimen Label: 3C
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3795945
Assay Type: RNA in situ
Annotation Date: 2008-07-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3795946
Age: postnatal adult
Specimen Label: 3C
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3795945
Assay Type: RNA in situ
Annotation Date: 2008-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Pattern: Ubiquitous
Stage: TS25
Assay Id: MGI:3795946
Age: embryonic day 17.5
Specimen Label: 3A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3795945
Assay Type: RNA in situ
Annotation Date: 2008-07-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3522328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3795946
Age: postnatal adult
Specimen Label: 3C
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3795945
Assay Type: RNA in situ
Annotation Date: 2008-07-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3287425
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:3795946
Age: embryonic day 17.5
Specimen Label: 3A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3795945
Assay Type: RNA in situ
Annotation Date: 2008-07-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3795946
Age: postnatal adult
Specimen Label: 3C
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3795945
Assay Type: RNA in situ
Annotation Date: 2008-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689425
Pattern: Ubiquitous
Stage: TS25
Assay Id: MGI:3795946
Age: embryonic day 17.5
Specimen Label: 3A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3795945
Assay Type: RNA in situ
Annotation Date: 2008-07-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3521728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3795946
Age: postnatal adult
Specimen Label: 3C
Detected: true
Specimen Num: 2
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Publication
37019113 | J:345544
First Author: Shinde SR
Year: 2023
Journal: Dev Cell
Title: The ancestral ESCRT protein TOM1L2 selects ubiquitinated cargoes for retrieval from cilia.
Volume: 58
Issue: 8
Pages: 677-693.e9
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Publication
- | J:72400
       
First Author: Mouse Genome Sequence and Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Mouse Genome Sequence Project Annotation
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
19054384 | -
First Author: Blanc C
Year: 2009
Journal: Traffic
Title: Dictyostelium Tom1 participates to an ancestral ESCRT-0 complex.
Volume: 10
Issue: 2
Pages: 161-71
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Publication
16847136 | -
First Author: Fujisaki K
Year: 2006
Journal: J Gen Virol
Title: Involvement of THH1, an Arabidopsis thaliana homologue of the TOM1 gene, in tobamovirus multiplication.
Volume: 87
Issue: Pt 8
Pages: 2397-401
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Protein Domain
IPR009457 | THH1/TOM1/TOM3_dom
Type: Domain
Description: This domain is found in plant proteins including THH1/TOM1/TOM3 from Arabidopsis. TOM1 and TOM3 are transmembrane proteins necessary for the efficient multiplication of tobamoviruses []. THH1 supports tobamovirus multiplication, but to a lesser extent than TOM1 and TOM3 []. Members containing this domain are part of the GPCR superfamily and involved in stress tolerance [, ].
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Protein Domain
IPR040226 | THH1/TOM1/TOM3
Type: Family
Description: This entry represents a group of plant proteins, including THH1/TOM1/TOM3 from Arabidopsis. TOM1 and TOM3 are transmembrane proteins necessary for the efficient multiplication of tobamoviruses []. THH1 supports tobamovirus multiplication, but to a lesser extent than TOM1 and TOM3 []. Proteins in this family belong to the GCPR superfamily and are also involved in stress tolerance [, ].
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Publication
11836427 | -
First Author: Yamanaka T
Year: 2002
Journal: J Virol
Title: Complete inhibition of tobamovirus multiplication by simultaneous mutations in two homologous host genes.
Volume: 76
Issue: 5
Pages: 2491-7
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Publication
31412764 | -
First Author: Lu P
Year: 2019
Journal: BMC Genomics
Title: Genome-wide analysis of the cotton G-coupled receptor proteins (GPCR) and functional analysis of GTOM1, a novel cotton GPCR gene under drought and cold stress.
Volume: 20
Issue: 1
Pages: 651
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Publication
29649144 | -
 
First Author: Lu P
Year: 2018
Journal: Genes (Basel)
Title: A Novel G-Protein-Coupled Receptors Gene from Upland Cotton Enhances Salt Stress Tolerance in Transgenic Arabidopsis.
Volume: 9
Issue: 4
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Publication
31570577 | J:280407
First Author: Martini AC
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Amyloid-beta impairs TOM1-mediated IL-1R1 signaling.
Volume: 116
Issue: 42
Pages: 21198-21206
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Publication
18343975 | J:133892
First Author: Girirajan S
Year: 2008
Journal: Mamm Genome
Title: Tom1l2 hypomorphic mice exhibit increased incidence of infections and tumors and abnormal immunologic response.
Volume: 19
Issue: 4
Pages: 246-62
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Publication
23023224 | J:193935
First Author: Tumbarello DA
Year: 2012
Journal: Nat Cell Biol
Title: Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome.
Volume: 14
Issue: 10
Pages: 1024-35
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Publication
25764436 | -
First Author: Moulinier-Anzola J
Year: 2014
Journal: Plant Signal Behav
Title: Expression of Arabidopsis TOL genes.
Volume: 9
Issue: 4
Pages: e28667
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Publication
24316203 | -
First Author: Korbei B
Year: 2013
Journal: Curr Biol
Title: Arabidopsis TOL proteins act as gatekeepers for vacuolar sorting of PIN2 plasma membrane protein.
Volume: 23
Issue: 24
Pages: 2500-5
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Protein Domain
IPR044836 | TOL_plant
Type: Family
Description: This entry includes TOM1-like protein 1-9 (TOL1-9) from Arabidopsis [, ]. In general, they contain the VHS and GAT domains that bind to phospholipids and ubiquitin []. They may be part of the ESCRT (Endosomal Sorting Complex Required for Transport) complex contributing to the sorting of ubiquinated proteins to the MVB (multivesicular body) formation machinery. In plants they play a role in the control of plant morphogenesis []. This entry also includes TOM1 from Dictyostelium discoideum [].
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Publication
10854325 | J:64697
First Author: Burns K
Year: 2000
Journal: Nat Cell Biol
Title: Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor.
Volume: 2
Issue: 6
Pages: 346-51
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Protein Domain
IPR041799 | TOLIP_CUE
Type: Domain
Description: Tollip (Toll-interacting protein) is a component of the IL-1RI pathway which contains an N-terminal C2 domain and a C-terminal CUE domain. Tollip binds to the cytoplasmic TIR domain of IL-1Rs after IL-1 stimulation. It is sufficient for recruitment of IRAK to IL-1Rs and negatively regulates IL-1-induced signaling by inhibiting IRAK phosphorylation. In addition, Tollip directly interacts with toll-like receptors TLR2 and TLR4, and plays an inhibitory role in TLR-mediated cell activation through suppressing phosphorylation and kinase activity of IRAK. Moreover, Tollip can associate with GAT domains of Tom1 and its related proteins Tom1L1 and Tom1L2, and facilitate the recruitment of clathrin onto endosomes [, ].
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Publication
16479011 | J:106907
First Author: Franco M
Year: 2006
Journal: Mol Cell Biol
Title: The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors.
Volume: 26
Issue: 5
Pages: 1932-47
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Publication
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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