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Search results 1 to 100 out of 140 for Top1

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
7150 | TOP1
Type: gene
Organism: human
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Gene
100496521 | top1
Type: gene
Organism: frog, western clawed
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Gene
key_78778 | TOP1
Type: gene
Organism: hamster, Chinese
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Gene
64550 | Top1
Type: gene
Organism: rat
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Gene
477229 | TOP1
Type: gene
Organism: dog, domestic
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Gene
458252 | TOP1
Type: gene
Organism: chimpanzee
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Gene
534799 | TOP1
Type: gene
Organism: cattle
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Gene
396004 | TOP1
Type: gene
Organism: chicken
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Gene
697300 | TOP1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:98788 | Top1
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
   
Probe: MGI:4354565
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3270422
Stage: TS22
Assay Id: MGI:4354861
Age: embryonic day 14.5
Image: 3D & Table S5 - Top1
Specimen Label: 3D & Table S5 - Top1
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:4354565
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:4354861
Age: embryonic day 14.5
Image: 3D & Table S5 - Top1
Note: Expression is present in the upper, but not the lower, cortical plate.
Specimen Label: 3D & Table S5 - Top1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4354565
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4354861
Age: embryonic day 14.5
Image: 3D & Table S5 - Top1
Specimen Label: 3D & Table S5 - Top1
Detected: true
Specimen Num: 1
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Publication
35140396 | J:325942
First Author: Reijns MAM
Year: 2022
Journal: Nature
Title: Signatures of TOP1 transcription-associated mutagenesis in cancer and germline.
Volume: 602
Issue: 7898
Pages: 623-631
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GXD Expression
GXD Expression
   
Probe: MGI:6185659
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191495
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Top1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6185659
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191495
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Top1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6185659
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191495
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Top1
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6185659
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191495
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Top1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6185659
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191495
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Top1
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6185659
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191495
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Top1
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6185659
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191495
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Top1
Detected: true
Specimen Num: 7
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Gene
10210 | TOPORS
Type: gene
Organism: human
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Gene
107080552 | LOC107080552
Type: gene
Organism: human
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Publication
27231886 | J:236045
First Author: Mabb AM
Year: 2016
Journal: PLoS One
Title: Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms.
Volume: 11
Issue: 5
Pages: e0156439
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Publication
11255022 | J:68405
First Author: Smith SF
Year: 2001
Journal: Gene
Title: Characterisation of two topoisomerase 1 genes in the pufferfish (Fugu rubripes).
Volume: 265
Issue: 1-2
Pages: 195-204
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Publication
25404338 | J:216729
First Author: Mabb AM
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Topoisomerase 1 inhibition reversibly impairs synaptic function.
Volume: 111
Issue: 48
Pages: 17290-5
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Publication
22080610 | J:303117
First Author: Kobayashi M
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation.
Volume: 108
Issue: 48
Pages: 19305-10
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Publication
24798329 | J:216625
First Author: Dalla Rosa I
Year: 2014
Journal: J Biol Chem
Title: Mapping topoisomerase sites in mitochondrial DNA with a poisonous mitochondrial topoisomerase I (Top1mt).
Volume: 289
Issue: 26
Pages: 18595-602
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Publication
- | J:14878
 
First Author: Rettenberger G
Year: 1991
Journal: Cytogenet Cell Genet
Title: Localization of the type I DNA topoisomerase gene in man and mouse
Volume: 58
Pages: 2032 (Abstr.)
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Publication
32327659 | J:292445
First Author: Fragola G
Year: 2020
Journal: Nat Commun
Title: Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration.
Volume: 11
Issue: 1
Pages: 1962
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Publication
18515798 | J:137993
First Author: Lin CP
Year: 2008
Journal: J Biol Chem
Title: A ubiquitin-proteasome pathway for the repair of topoisomerase I-DNA covalent complexes.
Volume: 283
Issue: 30
Pages: 21074-83
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Publication
24793032 | J:212924
First Author: Katyal S
Year: 2014
Journal: Nat Neurosci
Title: Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes.
Volume: 17
Issue: 6
Pages: 813-21
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Protein Coding Gene
MGP_CAROLIEiJ_G0024599 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0026805 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0026771 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0026742 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0026780 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026522 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_98788 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0027229 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0025984 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0026499 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026637 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0026604 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0026740 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026625 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0027285 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0025718 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0026054 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0026043 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025521 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
8111124 | J:16405
First Author: Baumgärtner B
Year: 1994
Journal: Mamm Genome
Title: Mouse genes encoding DNA topoisomerase I.
Volume: 5
Issue: 1
Pages: 19-25
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Publication
8193161 | J:18344
First Author: Baumgärtner B
Year: 1994
Journal: Biochim Biophys Acta
Title: Conserved regulatory elements in the type I DNA topoisomerase gene promoters of mouse and man.
Volume: 1218
Issue: 1
Pages: 123-7
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Publication
8943335 | J:36546
First Author: Morham SG
Year: 1996
Journal: Mol Cell Biol
Title: Targeted disruption of the mouse topoisomerase I gene by camptothecin selection.
Volume: 16
Issue: 12
Pages: 6804-9
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Publication
16261531 | J:104607
First Author: Plaschkes I
Year: 2005
Journal: J Comp Neurol
Title: DNA topoisomerase I in the mouse central nervous system: Age and sex dependence.
Volume: 493
Issue: 3
Pages: 357-69
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Publication
11016921 | J:66711
First Author: Mo YY
Year: 2000
Journal: J Biol Chem
Title: A novel nuclear localization signal in human DNA topoisomerase I.
Volume: 275
Issue: 52
Pages: 41107-13
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GXD Expression
GXD Expression
     
Probe: MGI:5699734
Assay Type: Northern blot
Annotation Date: 2015-12-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691022
Stage: TS22
Assay Id: MGI:5699735
Age: embryonic day 14.5
Specimen Label: Embryonic
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5699734
Assay Type: Northern blot
Annotation Date: 2015-12-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691028
Stage: TS28
Assay Id: MGI:5699735
Age: postnatal adult
Specimen Label: Adult
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:4354565
Assay Type: RNA in situ
Annotation Date: 2023-10-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7540360
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4354565
Assay Type: RNA in situ
Annotation Date: 2023-10-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7540360
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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Publication
26305952 | J:226811
First Author: Khiati S
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration.
Volume: 112
Issue: 36
Pages: 11282-7
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Publication
22911747 | J:189886
First Author: Douarre C
Year: 2012
Journal: PLoS One
Title: Mitochondrial topoisomerase I is critical for mitochondrial integrity and cellular energy metabolism.
Volume: 7
Issue: 7
Pages: e41094
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Publication
9094096 | J:39389
First Author: Cobb J
Year: 1997
Journal: Mol Reprod Dev
Title: Analysis of expression and function of topoisomerase I and II during meiosis in male mice.
Volume: 46
Issue: 4
Pages: 489-98
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Publication
28199696 | J:246108
First Author: Maskey RS
Year: 2017
Journal: Nucleic Acids Res
Title: Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis.
Volume: 45
Issue: 8
Pages: 4564-4576
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Publication
- | J:20791
First Author: Liddell RA
Year: 1994
Journal: Mouse Genome
Title: Chromosomal localization and evolution of topoisomerase I sequences in the Mus genome
Volume: 92
Issue: 3
Pages: 520-22
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Publication
9144489 | J:40206
First Author: Grillot DA
Year: 1997
Journal: J Immunol
Title: Genomic organization, promoter region analysis, and chromosome localization of the mouse bcl-x gene.
Volume: 158
Issue: 10
Pages: 4750-7
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Publication
10334875 | J:55184
First Author: Nanda N
Year: 1999
Journal: Arch Biochem Biophys
Title: Organization and chromosomal mapping of mouse Gh/tissue transglutaminase gene (Tgm2).
Volume: 366
Issue: 1
Pages: 151-6
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Publication
34644582 | J:328271
First Author: Krupa O
Year: 2021
Journal: Cell Rep
Title: NuMorph: Tools for cortical cellular phenotyping in tissue-cleared whole-brain images.
Volume: 37
Issue: 2
Pages: 109802
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Publication
28007908 | J:241438
First Author: Shekhar S
Year: 2017
Journal: Hum Mol Genet
Title: Topoisomerase 1 inhibitor topotecan delays the disease progression in a mouse model of Huntington's disease.
Volume: 26
Issue: 2
Pages: 420-429
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Publication
7842491 | J:22850
First Author: Baloch Z
Year: 1995
Journal: Cell Immunol
Title: Modulation of topoisomerase activities by tumor necrosis factor.
Volume: 160
Issue: 1
Pages: 98-103
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Publication
1372074 | J:2278
First Author: Porteus MH
Year: 1992
Journal: Brain Res Mol Brain Res
Title: Isolation and characterization of a library of cDNA clones that are preferentially expressed in the embryonic telencephalon.
Volume: 12
Issue: 1-3
Pages: 7-22
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Publication
8096488 | J:4311
First Author: Koiwai O
Year: 1993
Journal: Gene
Title: Cloning of the mouse cDNA encoding DNA topoisomerase I and chromosomal location of the gene.
Volume: 125
Issue: 2
Pages: 211-6
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Publication
11756244 | J:73919
First Author: Lebel M
Year: 2002
Journal: Carcinogenesis
Title: Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue.
Volume: 23
Issue: 1
Pages: 213-6
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Publication
9291580 | J:42729
First Author: Leco KJ
Year: 1997
Journal: Dev Genet
Title: Matrix metalloproteinase-9 maps to the distal end of chromosome 2 in the mouse.
Volume: 21
Issue: 1
Pages: 55-60
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Publication
11322760 | J:71014
First Author: Verlaet M
Year: 2001
Journal: Biochem Biophys Res Commun
Title: Genetic imbalances in preleukemic thymuses.
Volume: 283
Issue: 1
Pages: 12-8
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Publication
7806233 | J:19680
First Author: Masaki S
Year: 1994
Journal: Genomics
Title: The gene Bfsp1 for the lens fiber cell beaded-filament structural protein CP94 maps to mouse chromosome 2.
Volume: 22
Issue: 2
Pages: 449-50
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Protein
Q569Q5
Organism: Mus musculus/domesticus
Length: 107  
Fragment?: true
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Publication
33836156 | J:308894
First Author: Ho JSY
Year: 2021
Journal: Cell
Title: TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation.
Volume: 184
Issue: 10
Pages: 2618-2632.e17
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Publication
22308494 | J:182019
First Author: Gowher H
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Vezf1 protein binding sites genome-wide are associated with pausing of elongating RNA polymerase II.
Volume: 109
Issue: 7
Pages: 2370-5
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Publication
8012118 | J:17621
First Author: Kingsmore SF
Year: 1994
Journal: Mamm Genome
Title: Genetic mapping of DNA topoisomerase I-related sequences to mouse chromosomes 2 and 14.
Volume: 5
Issue: 4
Pages: 247-8
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Publication
33524014 | J:305161
First Author: Dar AA
Year: 2021
Journal: PLoS Biol
Title: The E3 ubiquitin ligase Cul4b promotes CD4+ T cell expansion by aiding the repair of damaged DNA.
Volume: 19
Issue: 2
Pages: e3001041
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Publication
7752808 | J:25158
First Author: Giros B
Year: 1995
Journal: Life Sci
Title: Chromosomal localization of opioid peptide and receptor genes in the mouse.
Volume: 56
Issue: 18
Pages: PL369-75
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Publication
16107646 | J:100324
First Author: Bulfone A
Year: 2005
Journal: J Neurosci
Title: Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes.
Volume: 25
Issue: 33
Pages: 7586-600
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Publication
19521500 | J:149737
First Author: Sansom SN
Year: 2009
Journal: PLoS Genet
Title: The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.
Volume: 5
Issue: 6
Pages: e1000511
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Publication
15741177 | J:126097
First Author: Cobellis G
Year: 2005
Journal: Nucleic Acids Res
Title: Tagging genes with cassette-exchange sites.
Volume: 33
Issue: 4
Pages: e44
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Publication
- | J:15839
       
First Author: International Committee on Standardized Genetic Nomenclature for Mice
Year: 1993
Title: Nomenclature rule change to delete hyphens and parentheses from mouse locus symbols
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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