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Search results 1 to 100 out of 260 for Tpx2

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: This family represents the eukaryotic targeting protein for Xklp2 (TPX2). TPX2 is a microtubule-associated protein that targets a plus end-directed motor (Xklp2) to the minus ends of microtubules in the mitotic spindle. In Xenopus, it has been shown that Xklp2 protein is required for centrosome separation and maintenance of spindle bi-polarity []. It is phosphorylated during mitosis in a microtubule-dependent way []. TPX2 activates Aurora A kinase by promoting its autophosphorylation and protects the phosphorylated residue against dephosphorylation [].
Publication
First Author: Bird AW
Year: 2008
Journal: J Cell Biol
Title: Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A.
Volume: 182
Issue: 2
Pages: 289-300
GXD Expression
Probe: MGI:7570100
Assay Type: RNA in situ
Annotation Date: 2024-01-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7570116
Age: embryonic day 14.5
Image: S4a Tpx2
Note: Strong expression in ventricular zone only.
Specimen Label: S4a Tpx2
Detected: true
Specimen Num: 1
Publication
First Author: Aguirre-Portolés C
Year: 2012
Journal: Cancer Res
Title: Tpx2 controls spindle integrity, genome stability, and tumor development.
Volume: 72
Issue: 6
Pages: 1518-28
Publication
First Author: Ma N
Year: 2011
Journal: J Cell Biol
Title: TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle.
Volume: 195
Issue: 1
Pages: 87-98
Publication
First Author: Wei JH
Year: 2015
Journal: Cell
Title: GM130 Regulates Golgi-Derived Spindle Assembly by Activating TPX2 and Capturing Microtubules.
Volume: 162
Issue: 2
Pages: 287-299
Publication
First Author: Lee SY
Year: 2016
Journal: Cell Cycle
Title: Bcl2l10, a new Tpx2 binding partner, is a master regulator of Aurora kinase A in mouse oocytes.
Volume: 15
Issue: 23
Pages: 3296-3305
Publication
First Author: Kosodo Y
Year: 2011
Journal: EMBO J
Title: Regulation of interkinetic nuclear migration by cell cycle-coupled active and passive mechanisms in the developing brain.
Volume: 30
Issue: 9
Pages: 1690-704
Publication
First Author: Mori D
Year: 2009
Journal: Nat Cell Biol
Title: An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics.
Volume: 11
Issue: 9
Pages: 1057-68
Publication
First Author: Treekitkarnmongkol W
Year: 2016
Journal: Carcinogenesis
Title: Aurora kinase-A overexpression in mouse mammary epithelium induces mammary adenocarcinomas harboring genetic alterations shared with human breast cancer.
Volume: 37
Issue: 12
Pages: 1180-1189
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression    
Probe: MGI:7525616
Assay Type: RT-PCR
Annotation Date: 2023-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283426
Stage: TS26
Assay Id: MGI:7526199
Age: embryonic day 18.5
Image: 6
Specimen Label: EpCAM+/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7525616
Assay Type: RT-PCR
Annotation Date: 2023-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283426
Stage: TS26
Assay Id: MGI:7526199
Age: embryonic day 18.5
Image: 6
Specimen Label: EpCAM-/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7525616
Assay Type: RT-PCR
Annotation Date: 2023-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1925226
Stage: TS26
Assay Id: MGI:7526200
Age: embryonic day 18.5
Image: S4
Specimen Label: EpCAM+/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7525616
Assay Type: RT-PCR
Annotation Date: 2023-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1925226
Stage: TS26
Assay Id: MGI:7526200
Age: embryonic day 18.5
Image: S4
Specimen Label: EpCAM-/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7525616
Assay Type: RT-PCR
Annotation Date: 2023-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283427
Stage: TS27
Assay Id: MGI:7526201
Age: postnatal day 0
Image: S5
Specimen Label: EpCAM+/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7525616
Assay Type: RT-PCR
Annotation Date: 2023-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283427
Stage: TS27
Assay Id: MGI:7526201
Age: postnatal day 0
Image: S5
Specimen Label: EpCAM-/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7525616
Assay Type: RT-PCR
Annotation Date: 2023-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1925227
Stage: TS27
Assay Id: MGI:7526202
Age: postnatal day 0
Image: S5
Specimen Label: EpCAM+/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7525616
Assay Type: RT-PCR
Annotation Date: 2023-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1925227
Stage: TS27
Assay Id: MGI:7526202
Age: postnatal day 0
Image: S5
Specimen Label: EpCAM-/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7525616
Assay Type: RT-PCR
Annotation Date: 2023-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283427
Stage: TS27
Assay Id: MGI:7526203
Age: postnatal day 3
Image: 6
Specimen Label: EpCAM+/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7525616
Assay Type: RT-PCR
Annotation Date: 2023-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283427
Stage: TS27
Assay Id: MGI:7526203
Age: postnatal day 3
Image: 6
Specimen Label: EpCAM-/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7525616
Assay Type: RT-PCR
Annotation Date: 2023-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1925227
Stage: TS27
Assay Id: MGI:7526204
Age: postnatal day 3
Image: S4
Specimen Label: EpCAM+/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7525616
Assay Type: RT-PCR
Annotation Date: 2023-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1925227
Stage: TS27
Assay Id: MGI:7526204
Age: postnatal day 3
Image: S4
Specimen Label: EpCAM-/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6696249
Assay Type: RNA in situ
Annotation Date: 2021-05-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2772122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:6711649
Age: embryonic day 14.5
Specimen Label: S6C-Tpx2
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1059344
Assay Type: RNA in situ
Annotation Date: 2023-08-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7516946
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
Publication
First Author: Zheng P
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis.
Volume: 106
Issue: 18
Pages: 7473-8
Publication
First Author: Bizzotto S
Year: 2017
Journal: Sci Rep
Title: Eml1 loss impairs apical progenitor spindle length and soma shape in the developing cerebral cortex.
Volume: 7
Issue: 1
Pages: 17308
Publication
First Author: Journiac N
Year: 2020
Journal: Cell Rep
Title: Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly.
Volume: 31
Issue: 2
Pages: 107506
Publication
First Author: Yeh ML
Year: 2014
Journal: J Neurosci
Title: Robo1 modulates proliferation and neurogenesis in the developing neocortex.
Volume: 34
Issue: 16
Pages: 5717-31
Publication
First Author: Rong Y
Year: 2019
Journal: Nucleic Acids Res
Title: ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.
Volume: 47
Issue: 21
Pages: 11387-11402
Publication  
First Author: Eguren M
Year: 2013
Journal: Nat Commun
Title: The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors.
Volume: 4
Pages: 2880
Publication
First Author: Li L
Year: 2023
Journal: Cell Rep
Title: Mettl14-mediated m(6)A modification ensures the cell-cycle progression of late-born retinal progenitor cells.
Volume: 42
Issue: 6
Pages: 112596
Publication  
First Author: Lei Z
Year: 2022
Journal: Front Immunol
Title: EpCAM Is Essential to Maintaining the Immune Homeostasis of Intestines via Keeping the Expression of pIgR in the Intestinal Epithelium of Mice.
Volume: 13
Pages: 843378
Publication
First Author: Naiman N
Year: 2017
Journal: Dev Cell
Title: Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development.
Volume: 41
Issue: 4
Pages: 349-365.e3
Publication
First Author: Cobellis G
Year: 2005
Journal: Nucleic Acids Res
Title: Tagging genes with cassette-exchange sites.
Volume: 33
Issue: 4
Pages: e44
Publication        
First Author: Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration
Year: 2001
Title: LocusLink Collaboration
Publication      
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication  
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication
First Author: Schatz CA
Year: 2003
Journal: EMBO J
Title: Importin alpha-regulated nucleation of microtubules by TPX2.
Volume: 22
Issue: 9
Pages: 2060-70
Protein Domain
Type: Domain
Description: This entry represents the central domain found in the eukaryotic targeting protein for Xklp2 (TPX2) protein. TPX2 is a microtubule-associated protein that targets a plus end-directed motor (Xklp2) to the minus ends of microtubules in the mitotic spindle. This domain is close to the C-terminal of TPX2. The protein importin alpha regulates the activity of TPX2 by binding to the nuclear localisation signal in this domain [].
Publication
First Author: Wittmann T
Year: 2000
Journal: J Cell Biol
Title: TPX2, A novel xenopus MAP involved in spindle pole organization.
Volume: 149
Issue: 7
Pages: 1405-18
Protein
Organism: Mus musculus/domesticus
Length: 745  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: true