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Search results 1 to 100 out of 189 for Tradd

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Type Details Score
Protein Domain
Type: Family
Description: This entry represents TRADD (or tumour necrosis factor receptor type 1-associated DEATH domain protein). TRADD interacts with the cytoplasmic domain of activated TNFRSF1A/TNFR1, which in turn enables it to interact with FADD. Overexpression of TRADD results in apoptosis and activation of NF-kappa-B []. TRADD shuttles from the cytoplasm into the nucleus. The nuclear form of TRADD is a tumour suppressor, which by interacting with TRIP12 disrupts its complex with isoform p19ARF/ARF of CDKN2A, preventing ubiquitination and degradation [].
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Publication
First Author: Chio II
Year: 2012
Journal: Nat Cell Biol
Title: TRADD contributes to tumour suppression by regulating ULF-dependent p19Arf ubiquitylation.
Volume: 14
Issue: 6
Pages: 625-33
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Hsu H
Year: 1995
Journal: Cell
Title: The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation.
Volume: 81
Issue: 4
Pages: 495-504
Protein
Organism: Mus musculus/domesticus
Length: 58  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 64  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 310  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 310  
Fragment?: false
Publication
First Author: Xu D
Year: 2020
Journal: Nature
Title: Modulating TRADD to restore cellular homeostasis and inhibit apoptosis.
Volume: 587
Issue: 7832
Pages: 133-138
Publication
First Author: Wesemann DR
Year: 2004
Journal: Nat Immunol
Title: TRADD interacts with STAT1-alpha and influences interferon-gamma signaling.
Volume: 5
Issue: 2
Pages: 199-207
Publication
First Author: Cao X
Year: 2011
Journal: FASEB J
Title: The role of TRADD in TRAIL-induced apoptosis and signaling.
Volume: 25
Issue: 4
Pages: 1353-8
Publication
First Author: Chen NJ
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors.
Volume: 105
Issue: 34
Pages: 12429-34
Publication
First Author: Kim JY
Year: 2011
Journal: FEBS Lett
Title: TRADD is critical for resistance to TRAIL-induced cell death through NF-κB activation.
Volume: 585
Issue: 14
Pages: 2144-50
Publication
First Author: Michallet MC
Year: 2008
Journal: Immunity
Title: TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
Volume: 28
Issue: 5
Pages: 651-61
Publication  
First Author: Pan MG
Journal: J Inflamm
Title: Sequence, genomic organization, and chromosome localization of the mouse TRADD gene.
Volume: 46
Issue: 3
Pages: 168-75
Publication
First Author: Pobezinskaya YL
Year: 2008
Journal: Nat Immunol
Title: The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors.
Volume: 9
Issue: 9
Pages: 1047-54
Publication
First Author: Pobezinskaya YL
Year: 2011
Journal: J Immunol
Title: The adaptor protein TRADD is essential for TNF-like ligand 1A/death receptor 3 signaling.
Volume: 186
Issue: 9
Pages: 5212-6
Publication
First Author: Ermolaeva MA
Year: 2008
Journal: Nat Immunol
Title: Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses.
Volume: 9
Issue: 9
Pages: 1037-46
Publication
First Author: Dowling JP
Year: 2019
Journal: Nat Commun
Title: TRADD regulates perinatal development and adulthood survival in mice lacking RIPK1 and RIPK3.
Volume: 10
Issue: 1
Pages: 705
Publication
First Author: Wu L
Year: 2017
Journal: Biochem Biophys Res Commun
Title: Loss of TRADD attenuates pressure overload-induced cardiac hypertrophy through regulating TAK1/P38 MAPK signalling in mice.
Volume: 483
Issue: 2
Pages: 810-815
Publication
First Author: Hsu H
Year: 1996
Journal: Cell
Title: TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways.
Volume: 84
Issue: 2
Pages: 299-308
Publication    
First Author: Kumari S
Year: 2014
Journal: Elife
Title: Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis.
Volume: 3
Publication
First Author: Kaklamanos A
Year: 2017
Journal: Sci Rep
Title: Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression.
Volume: 7
Issue: 1
Pages: 2397
Publication
First Author: Adam-Klages S
Year: 1998
Journal: J Leukoc Biol
Title: Distinct adapter proteins mediate acid versus neutral sphingomyelinase activation through the p55 receptor for tumor necrosis factor.
Volume: 63
Issue: 6
Pages: 678-82
Publication
First Author: Anderton H
Year: 2019
Journal: Cell Death Differ
Title: RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development.
Volume: 26
Issue: 5
Pages: 877-889
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Feng Q
Year: 2020
Journal: Am J Pathol
Title: miR-149* Suppresses Liver Cancer Progression by Down-Regulating Tumor Necrosis Factor Receptor 1-Associated Death Domain Protein Expression.
Volume: 190
Issue: 2
Pages: 469-483
GXD Expression      
Probe: MGI:3528461
Assay Type: RT-PCR
Annotation Date: 2005-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3528462
Age: postnatal
Specimen Label: liver
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3528461
Assay Type: RT-PCR
Annotation Date: 2005-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3528462
Age: postnatal
Specimen Label: spleen
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3528461
Assay Type: RT-PCR
Annotation Date: 2005-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3528462
Age: postnatal
Specimen Label: lung
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3528461
Assay Type: RT-PCR
Annotation Date: 2005-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3528462
Age: postnatal
Specimen Label: kidney
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3528461
Assay Type: RT-PCR
Annotation Date: 2005-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1738328
Stage: TS28
Assay Id: MGI:3528462
Age: postnatal
Specimen Label: gonad
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3528461
Assay Type: RT-PCR
Annotation Date: 2005-03-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3528462
Age: postnatal
Specimen Label: brain
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:3528461
Assay Type: RT-PCR
Annotation Date: 2005-03-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3557728
Stage: TS28
Assay Id: MGI:3528462
Age: postnatal
Specimen Label: muscle
Detected: false
Specimen Num: 7
GXD Expression      
Probe: MGI:3528461
Assay Type: RT-PCR
Annotation Date: 2005-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:3528462
Age: postnatal week 3
Specimen Label: 3wk adr
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3528461
Assay Type: RT-PCR
Annotation Date: 2005-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:3528462
Age: postnatal adult
Specimen Label: adult adr
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:3528461
Assay Type: RT-PCR
Annotation Date: 2005-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1842627
Stage: TS27
Assay Id: MGI:3528462
Age: postnatal newborn
Specimen Label: P1 adr
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:7523910
Assay Type: Western blot
Annotation Date: 2023-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684620
Stage: TS20
Assay Id: MGI:7523908
Age: embryonic day 12.5
Specimen Label: 12
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7523910
Assay Type: Western blot
Annotation Date: 2023-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684621
Stage: TS21
Assay Id: MGI:7523908
Age: embryonic day 13.5
Specimen Label: 13
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7523910
Assay Type: Western blot
Annotation Date: 2023-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:7523908
Age: embryonic day 14.5
Specimen Label: 14
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:7523910
Assay Type: Western blot
Annotation Date: 2023-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684623
Stage: TS23
Assay Id: MGI:7523908
Age: embryonic day 15.5
Specimen Label: 15
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:7523910
Assay Type: Western blot
Annotation Date: 2023-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:7523908
Age: embryonic day 16.5
Specimen Label: 16
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:7523910
Assay Type: Western blot
Annotation Date: 2023-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:7523908
Age: embryonic day 17.5
Specimen Label: 17
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:7523910
Assay Type: Western blot
Annotation Date: 2023-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684626
Stage: TS26
Assay Id: MGI:7523908
Age: embryonic day 18.5
Specimen Label: 18
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:7523910
Assay Type: Western blot
Annotation Date: 2023-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684626
Stage: TS26
Assay Id: MGI:7523908
Age: embryonic day 19.5
Specimen Label: 19
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:7523910
Assay Type: Western blot
Annotation Date: 2023-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684620
Stage: TS20
Assay Id: MGI:7523916
Age: embryonic day 12.5
Specimen Label: Wildtype 12
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7523910
Assay Type: Western blot
Annotation Date: 2023-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684621
Stage: TS21
Assay Id: MGI:7523916
Age: embryonic day 13.5
Specimen Label: Wildtype 13
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7523910
Assay Type: Western blot
Annotation Date: 2023-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:7523916
Age: embryonic day 14.5
Specimen Label: Wildtype 14
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:7523910
Assay Type: Western blot
Annotation Date: 2023-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684620
Stage: TS20
Assay Id: MGI:7523916
Age: embryonic day 12.5
Specimen Label: RelA-/- 12
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:7523910
Assay Type: Western blot
Annotation Date: 2023-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684621
Stage: TS21
Assay Id: MGI:7523916
Age: embryonic day 13.5
Specimen Label: RelA-/- 13
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:7523910
Assay Type: Western blot
Annotation Date: 2023-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:7523916
Age: embryonic day 14.5
Specimen Label: RelA-/- 14
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:7523910
Assay Type: Western blot
Annotation Date: 2023-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684620
Stage: TS20
Assay Id: MGI:7523916
Age: embryonic day 12.5
Specimen Label: TNFR-1-/- 12
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:7523910
Assay Type: Western blot
Annotation Date: 2023-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684621
Stage: TS21
Assay Id: MGI:7523916
Age: embryonic day 13.5
Specimen Label: TNFR-1-/- 13
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:7523910
Assay Type: Western blot
Annotation Date: 2023-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:7523916
Age: embryonic day 14.5
Specimen Label: TNFR-1-/- 14
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:7562235
Assay Type: RT-PCR
Annotation Date: 2023-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603914
Stage: TS14
Assay Id: MGI:7562279
Age: embryonic day 8.75
Specimen Label: E8.75 EM NC
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7562235
Assay Type: RT-PCR
Annotation Date: 2023-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616416
Stage: TS16
Assay Id: MGI:7562279
Age: embryonic day 10.0
Specimen Label: E10 NT NC
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:7562235
Assay Type: RT-PCR
Annotation Date: 2023-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616418
Stage: TS18
Assay Id: MGI:7562279
Age: embryonic day 11.0
Specimen Label: E11 NT NC
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:7562230
Assay Type: Western blot
Annotation Date: 2023-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616417
Stage: TS17
Assay Id: MGI:7562318
Age: embryonic day 10.0-11.0
Specimen Label: NC
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7562230
Assay Type: Western blot
Annotation Date: 2023-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603914
Stage: TS14
Assay Id: MGI:7562322
Age: embryonic day 8.75
Specimen Label: Nondiabetic
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7562235
Assay Type: RT-PCR
Annotation Date: 2023-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603914
Stage: TS14
Assay Id: MGI:7562324
Age: embryonic day 8.75
Specimen Label: Nondiabetic
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7562230
Assay Type: Western blot
Annotation Date: 2023-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603914
Stage: TS14
Assay Id: MGI:7562352
Age: embryonic day 8.75
Specimen Label: Nondiabetic
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7562235
Assay Type: RT-PCR
Annotation Date: 2023-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603914
Stage: TS14
Assay Id: MGI:7562353
Age: embryonic day 8.75
Specimen Label: Nondiabetic
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4417420
Assay Type: RNA in situ
Annotation Date: 2023-09-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7530798
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4417420
Assay Type: RNA in situ
Annotation Date: 2023-09-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7530798
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
Publication
First Author: Yazdanpanah B
Year: 2009
Journal: Nature
Title: Riboflavin kinase couples TNF receptor 1 to NADPH oxidase.
Volume: 460
Issue: 7259
Pages: 1159-63
Publication
First Author: Tong X
Year: 2006
Journal: Genes Dev
Title: Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion.
Volume: 20
Issue: 10
Pages: 1353-64
Publication
First Author: Zhu W
Year: 2019
Journal: EMBO J
Title: TRAF3IP3 mediates the recruitment of TRAF3 to MAVS for antiviral innate immunity.
Volume: 38
Issue: 18
Pages: e102075
Publication
First Author: Haas TL
Year: 2009
Journal: Mol Cell
Title: Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction.
Volume: 36
Issue: 5
Pages: 831-44
Publication
First Author: Kalkavan H
Year: 2018
Journal: Cell Death Differ
Title: MOMP, cell suicide as a BCL-2 family business.
Volume: 25
Issue: 1
Pages: 46-55
Publication
First Author: Baker SJ
Year: 1998
Journal: Oncogene
Title: Modulation of life and death by the TNF receptor superfamily.
Volume: 17
Issue: 25
Pages: 3261-70
Publication
First Author: Rosenfeld ME
Year: 2000
Journal: Am J Pathol
Title: Prevention of hepatic apoptosis and embryonic lethality in RelA/TNFR-1 double knockout mice.
Volume: 156
Issue: 3
Pages: 997-1007
Publication
First Author: Wertz IE
Year: 2015
Journal: Nature
Title: Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation.
Volume: 528
Issue: 7582
Pages: 370-5
Publication
First Author: Fujita H
Year: 2014
Journal: Mol Cell Biol
Title: Mechanism underlying IκB kinase activation mediated by the linear ubiquitin chain assembly complex.
Volume: 34
Issue: 7
Pages: 1322-35