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Search results 1 to 100 out of 741 for Traf2

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Protein Domain
Type: Family
Description: TNF receptor-associated factor 2 (TRAF2) regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis [, ].TRAF2 is heavily regulated by ubiquitin signals. It has E3 ubiquitin-protein ligase activity and promotes K63-linked ubiquitination of target proteins. Alternatively, TRAF2 may be required for recruiting other E3 ligases, such as A20, to help processing and turnover. Furthermore, TRAF2 is regulated by both K63 and K48 type ubiquitin chains. K63 linkage may be mediated by TRAF2 auto-ubiquitination, and is required for TRAF2 activation. c-IAPl and Siah2 are known E3 ligases that can K48-ubiquitinate TRAF2 to target it for proteasome-dependent degradation [, , ]. TRAF2 contains a RING finger domain, five zinc finger domains, and a TRAF domain.
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication  
First Author: Au PY
Year: 2007
Journal: Adv Exp Med Biol
Title: Physiological roles and mechanisms of signaling by TRAF2 and TRAF5.
Volume: 597
Pages: 32-47
Publication
First Author: Blackwell K
Year: 2009
Journal: Mol Cell Biol
Title: TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis.
Volume: 29
Issue: 2
Pages: 303-14
Protein
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
Publication
First Author: Baud V
Year: 1999
Journal: Genes Dev
Title: Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain.
Volume: 13
Issue: 10
Pages: 1297-308
Publication
First Author: Petersen SL
Year: 2015
Journal: Cell Death Differ
Title: TRAF2 is a biologically important necroptosis suppressor.
Volume: 22
Issue: 11
Pages: 1846-57
Publication
First Author: Kanazawa K
Year: 2005
Journal: J Bone Miner Res
Title: TRAF2 is essential for TNF-alpha-induced osteoclastogenesis.
Volume: 20
Issue: 5
Pages: 840-7
Publication
First Author: Lee SY
Year: 1997
Journal: Immunity
Title: TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survival.
Volume: 7
Issue: 5
Pages: 703-13
Publication
First Author: Alvarez SE
Year: 2010
Journal: Nature
Title: Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2.
Volume: 465
Issue: 7301
Pages: 1084-8
Publication
First Author: Chen Z
Year: 2012
Journal: Diabetes
Title: Hepatic TRAF2 regulates glucose metabolism through enhancing glucagon responses.
Volume: 61
Issue: 3
Pages: 566-73
Publication
First Author: Li J
Year: 2019
Journal: Cell Death Dis
Title: TRAF2 protects against cerebral ischemia-induced brain injury by suppressing necroptosis.
Volume: 10
Issue: 5
Pages: 328
Publication
First Author: Lamkanfi M
Year: 2005
Journal: J Biol Chem
Title: A novel caspase-2 complex containing TRAF2 and RIP1.
Volume: 280
Issue: 8
Pages: 6923-32
Publication
First Author: Li S
Year: 2009
Journal: Mol Cell
Title: PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination.
Volume: 33
Issue: 1
Pages: 30-42
Publication
First Author: Wertz IE
Year: 2004
Journal: Nature
Title: De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling.
Volume: 430
Issue: 7000
Pages: 694-9
Publication
First Author: Villanueva JE
Year: 2017
Journal: Diabetologia
Title: Targeted deletion of Traf2 allows immunosuppression-free islet allograft survival in mice.
Volume: 60
Issue: 4
Pages: 679-689
Publication
First Author: Jabara HH
Year: 2009
Journal: Int Immunol
Title: TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40.
Volume: 21
Issue: 4
Pages: 477-88
Publication
First Author: Grech AP
Year: 2004
Journal: Immunity
Title: TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells.
Volume: 21
Issue: 5
Pages: 629-42
Publication
First Author: Wang B
Year: 2017
Journal: Nature
Title: TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling.
Volume: 545
Issue: 7654
Pages: 365-369
Publication
First Author: Kanamori M
Year: 2002
Journal: Biochem Biophys Res Commun
Title: T2BP, a novel TRAF2 binding protein, can activate NF-kappaB and AP-1 without TNF stimulation.
Volume: 290
Issue: 3
Pages: 1108-13
Publication
First Author: Hu M
Year: 2017
Journal: Mol Cell
Title: Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy.
Volume: 66
Issue: 1
Pages: 141-153.e6
Publication
First Author: Carpentier I
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and TNF-R2-induced JNK activation.
Volume: 374
Issue: 4
Pages: 752-7
Publication
First Author: Gonzalvez F
Year: 2012
Journal: Mol Cell
Title: TRAF2 Sets a threshold for extrinsic apoptosis by tagging caspase-8 with a ubiquitin shutoff timer.
Volume: 48
Issue: 6
Pages: 888-99
Publication
First Author: Li L
Year: 2009
Journal: Biochim Biophys Acta
Title: The zinc finger protein A20 targets TRAF2 to the lysosomes for degradation.
Volume: 1793
Issue: 2
Pages: 346-53
Publication
First Author: Tada K
Year: 2001
Journal: J Biol Chem
Title: Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death.
Volume: 276
Issue: 39
Pages: 36530-4
Publication
First Author: Shen HM
Year: 2004
Journal: Mol Cell Biol
Title: Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death.
Volume: 24
Issue: 13
Pages: 5914-22
Publication
First Author: Shimada K
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Traf2 interacts with Smad4 and regulates BMP signaling pathway in MC3T3-E1 osteoblasts.
Volume: 390
Issue: 3
Pages: 775-9
Protein
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
Publication
First Author: Villanueva JE
Year: 2015
Journal: Eur J Immunol
Title: TRAF2 regulates peripheral CD8(+) T-cell and NKT-cell homeostasis by modulating sensitivity to IL-15.
Volume: 45
Issue: 6
Pages: 1820-31
Publication
First Author: Zhang L
Year: 2011
Journal: Mol Biol Cell
Title: TRAF2 phosphorylation promotes NF-κB-dependent gene expression and inhibits oxidative stress-induced cell death.
Volume: 22
Issue: 1
Pages: 128-40
Publication
First Author: Vallabhapurapu S
Year: 2008
Journal: Nat Immunol
Title: Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling.
Volume: 9
Issue: 12
Pages: 1364-70
Publication    
First Author: Etemadi N
Year: 2015
Journal: Elife
Title: TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1.
Volume: 4
Publication
First Author: Xie X
Year: 2021
Journal: Cell Mol Immunol
Title: TRAF2 regulates T cell immunity by maintaining a Tpl2-ERK survival signaling axis in effector and memory CD8 T cells.
Volume: 18
Issue: 9
Pages: 2262-2274
Publication
First Author: Jabara H
Year: 2002
Journal: Immunity
Title: The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching.
Volume: 17
Issue: 3
Pages: 265-76
Publication  
First Author: Chuang HC
Year: 2014
Journal: Nat Commun
Title: HGK/MAP4K4 deficiency induces TRAF2 stabilization and Th17 differentiation leading to insulin resistance.
Volume: 5
Pages: 4602
Publication
First Author: Hostager BS
Year: 2003
Journal: J Biol Chem
Title: Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling.
Volume: 278
Issue: 46
Pages: 45382-90
Publication
First Author: Zhang L
Year: 2016
Journal: J Cell Sci
Title: TRAF2 exerts opposing effects on basal and TNFα-induced activation of the classic IKK complex in hematopoietic cells in mice.
Volume: 129
Issue: 7
Pages: 1455-67
Publication
First Author: Woolaver RA
Year: 2018
Journal: J Immunol
Title: TRAF2 Deficiency in B Cells Impairs CD40-Induced Isotype Switching That Can Be Rescued by Restoring NF-κB1 Activation.
Volume: 201
Issue: 11
Pages: 3421-3430
Publication
First Author: Nguyen LT
Year: 1999
Journal: Immunity
Title: TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses.
Volume: 11
Issue: 3
Pages: 379-89
Publication
First Author: Brink R
Year: 1998
Journal: J Biol Chem
Title: Tumor necrosis factor receptor (TNFR)-associated factor 2A (TRAF2A), a TRAF2 splice variant with an extended RING finger domain that inhibits TNFR2-mediated NF-kappaB activation.
Volume: 273
Issue: 7
Pages: 4129-34
Publication
First Author: Zarnegar BJ
Year: 2008
Journal: Nat Immunol
Title: Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.
Volume: 9
Issue: 12
Pages: 1371-8
Publication
First Author: Gardam S
Year: 2008
Journal: Immunity
Title: TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor.
Volume: 28
Issue: 3
Pages: 391-401
Publication
First Author: Vaitaitis GM
Year: 2008
Journal: PLoS One
Title: High distribution of CD40 and TRAF2 in Th40 T cell rafts leads to preferential survival of this auto-aggressive population in autoimmunity.
Volume: 3
Issue: 4
Pages: e2076
Gene
Type: gene
Organism: human
Publication
First Author: Kimura M
Year: 2018
Journal: Int Immunol
Title: TRAF2 and TRAF5 associated with the signal transducing receptor gp130 limit IL-6-driven transphosphorylation of JAK1 through the inhibition of proximal JAK-JAK interaction.
Volume: 30
Issue: 7
Pages: 291-299
Publication
First Author: Vince JE
Year: 2009
Journal: J Biol Chem
Title: TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis.
Volume: 284
Issue: 51
Pages: 35906-15
Publication
First Author: Mikkelsen SS
Year: 2009
Journal: J Biol Chem
Title: RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
Volume: 284
Issue: 16
Pages: 10774-82
Publication
First Author: Pérez-Chacón G
Year: 2012
Journal: J Immunol
Title: TNFR-associated factor 2 deficiency in B lymphocytes predisposes to chronic lymphocytic leukemia/small lymphocytic lymphoma in mice.
Volume: 189
Issue: 2
Pages: 1053-61
Publication
First Author: Ye H
Year: 1999
Journal: Mol Cell
Title: The structural basis for the recognition of diverse receptor sequences by TRAF2.
Volume: 4
Issue: 3
Pages: 321-30
Publication
First Author: Rothe M
Year: 1994
Journal: Cell
Title: A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor.
Volume: 78
Issue: 4
Pages: 681-92
Publication
First Author: Tesio M
Year: 2015
Journal: J Exp Med
Title: Hematopoietic stem cell quiescence and function are controlled by the CYLD-TRAF2-p38MAPK pathway.
Volume: 212
Issue: 4
Pages: 525-38
Publication
First Author: Zapata JM
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: TNF receptor-associated factor (TRAF) domain and Bcl-2 cooperate to induce small B cell lymphoma/chronic lymphocytic leukemia in transgenic mice.
Volume: 101
Issue: 47
Pages: 16600-5
Publication
First Author: Kawamata S
Year: 1998
Journal: J Biol Chem
Title: Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation.
Volume: 273
Issue: 10
Pages: 5808-14
Publication
First Author: Rothe M
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.
Volume: 93
Issue: 16
Pages: 8241-6
Publication
First Author: Cannons JL
Year: 2002
Journal: J Immunol
Title: Cutting edge: profound defect in T cell responses in TNF receptor-associated factor 2 dominant negative mice.
Volume: 169
Issue: 6
Pages: 2828-31
Publication  
First Author: Yeung AT
Year: 2015
Journal: Sci Rep
Title: Conditional-ready mouse embryonic stem cell derived macrophages enable the study of essential genes in macrophage function.
Volume: 5
Pages: 8908
Publication
First Author: Hsu H
Year: 1996
Journal: Cell
Title: TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways.
Volume: 84
Issue: 2
Pages: 299-308
Publication
First Author: Lee SY
Year: 1996
Journal: J Exp Med
Title: T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors.
Volume: 183
Issue: 2
Pages: 669-74
Publication
First Author: Park KJ
Year: 2002
Journal: J Biol Chem
Title: Nonstructural 5A protein of hepatitis C virus modulates tumor necrosis factor alpha-stimulated nuclear factor kappa B activation.
Volume: 277
Issue: 15
Pages: 13122-8
Publication
First Author: Ko R
Year: 2019
Journal: J Immunol
Title: Glycogen Synthase Kinase 3β Regulates Antiviral Responses of TLR3 via TRAF2-Src Axis.
Volume: 203
Issue: 11
Pages: 2990-2999
Publication
First Author: Chung YM
Year: 2001
Journal: Biochem Biophys Res Commun
Title: Hepatitis C virus core protein potentiates TNF-alpha-induced NF-kappaB activation through TRAF2-IKKbeta-dependent pathway.
Volume: 284
Issue: 1
Pages: 15-9
Publication
First Author: Liu J
Year: 2007
Journal: FEBS Lett
Title: Suppressive effect of reactive oxygen species on CD40-induced B cell activation.
Volume: 581
Issue: 26
Pages: 5043-9
Publication
First Author: Kumar A
Year: 2001
Journal: J Biol Chem
Title: The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A.
Volume: 276
Issue: 4
Pages: 2668-77
Publication
First Author: Choi JW
Year: 2009
Journal: J Cell Sci
Title: AIMP2 promotes TNFalpha-dependent apoptosis via ubiquitin-mediated degradation of TRAF2.
Volume: 122
Issue: Pt 15
Pages: 2710-5
Publication
First Author: Liang Y
Year: 2011
Journal: PLoS One
Title: SHARPIN negatively associates with TRAF2-mediated NFκB activation.
Volume: 6
Issue: 7
Pages: e21696
Publication
First Author: Harit K
Year: 2023
Journal: Cell Death Dis
Title: The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2.
Volume: 14
Issue: 7
Pages: 480
Publication
First Author: Yeh WC
Year: 1997
Journal: Immunity
Title: Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice.
Volume: 7
Issue: 5
Pages: 715-25
Publication  
First Author: Jin J
Year: 2015
Journal: Nat Commun
Title: Proinflammatory TLR signalling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages.
Volume: 6
Pages: 5930
Publication
First Author: Ohazama A
Year: 2003
Journal: Gene Expr Patterns
Title: Expression of TNF-receptor-associated factor genes in murine tooth development.
Volume: 3
Issue: 2
Pages: 127-9
Publication
First Author: Kim JY
Year: 2011
Journal: J Cell Sci
Title: TNFα induced noncanonical NF-κB activation is attenuated by RIP1 through stabilization of TRAF2.
Volume: 124
Issue: Pt 4
Pages: 647-56
Publication
First Author: Moore CR
Year: 2005
Journal: J Immunol
Title: Differential regulation of CD40-mediated TNF receptor-associated factor degradation in B lymphocytes.
Volume: 175
Issue: 6
Pages: 3780-9
Publication  
First Author: Evans S
Year: 2018
Journal: JCI Insight
Title: TNF receptor-activated factor 2 mediates cardiac protection through noncanonical NF-κB signaling.
Volume: 3
Issue: 3
Publication
First Author: Grech A
Year: 2000
Journal: Mol Immunol
Title: Complete structural characterisation of the mammalian and Drosophila TRAF genes: implications for TRAF evolution and the role of RING finger splice variants.
Volume: 37
Issue: 12-13
Pages: 721-34
Publication
First Author: Rothe M
Year: 1995
Journal: Cell
Title: The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins.
Volume: 83
Issue: 7
Pages: 1243-52
Publication
First Author: Schneider AT
Year: 2017
Journal: Cancer Cell
Title: RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer.
Volume: 31
Issue: 1
Pages: 94-109
Publication
First Author: Sun D
Year: 2011
Journal: Nat Immunol
Title: Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF).
Volume: 12
Issue: 9
Pages: 853-60
Publication
First Author: Gil J
Year: 2004
Journal: Mol Cell Biol
Title: TRAF family proteins link PKR with NF-kappa B activation.
Volume: 24
Issue: 10
Pages: 4502-12
Publication
First Author: Lin WJ
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Crucial role for TNF receptor-associated factor 2 (TRAF2) in regulating NFκB2 signaling that contributes to autoimmunity.
Volume: 108
Issue: 45
Pages: 18354-9
Publication
First Author: Piao JH
Year: 2011
Journal: J Biol Chem
Title: Tumor necrosis factor receptor-associated factor (TRAF) 2 controls homeostasis of the colon to prevent spontaneous development of murine inflammatory bowel disease.
Volume: 286
Issue: 20
Pages: 17879-88
Publication
First Author: Xie P
Year: 2006
Journal: J Immunol
Title: Cooperation between TNF receptor-associated factors 1 and 2 in CD40 signaling.
Volume: 176
Issue: 9
Pages: 5388-400
Publication
First Author: So T
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Antigen-independent signalosome of CARMA1, PKCθ, and TNF receptor-associated factor 2 (TRAF2) determines NF-κB signaling in T cells.
Volume: 108
Issue: 7
Pages: 2903-8
Publication
First Author: Piao JH
Year: 2007
Journal: J Immunol
Title: TNF receptor-associated factor 2-dependent canonical pathway is crucial for the development of Peyer's patches.
Volume: 178
Issue: 4
Pages: 2272-7
Publication
First Author: Arch RH
Year: 1998
Journal: Mol Cell Biol
Title: 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB.
Volume: 18
Issue: 1
Pages: 558-65
Publication
First Author: Wu YT
Year: 2008
Journal: Cell Death Differ
Title: Signaling pathways from membrane lipid rafts to JNK1 activation in reactive nitrogen species-induced non-apoptotic cell death.
Volume: 15
Issue: 2
Pages: 386-97
Publication
First Author: Guo X
Year: 2017
Journal: Circulation
Title: Cardioprotective Role of Tumor Necrosis Factor Receptor-Associated Factor 2 by Suppressing Apoptosis and Necroptosis.
Volume: 136
Issue: 8
Pages: 729-742
Publication
First Author: Gardam S
Year: 2011
Journal: Blood
Title: Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response.
Volume: 117
Issue: 15
Pages: 4041-51
Publication
First Author: Blackwell K
Year: 2013
Journal: Mol Cell Biol
Title: Two coordinated mechanisms underlie tumor necrosis factor alpha-induced immediate and delayed IκB kinase activation.
Volume: 33
Issue: 10
Pages: 1901-15
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory