Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
TNF receptor-associated factor 2 (TRAF2) regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis [, ].TRAF2 is heavily regulated by ubiquitin signals. It has E3 ubiquitin-protein ligase activity and promotes K63-linked ubiquitination of target proteins. Alternatively, TRAF2 may be required for recruiting other E3 ligases, such as A20, to help processing and turnover. Furthermore, TRAF2 is regulated by both K63 and K48 type ubiquitin chains. K63 linkage may be mediated by TRAF2 auto-ubiquitination, and is required for TRAF2 activation. c-IAPl and Siah2 are known E3 ligases that can K48-ubiquitinate TRAF2 to target it for proteasome-dependent degradation [, , ]. TRAF2 contains a RING finger domain, five zinc finger domains, and a TRAF domain. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Au PY |
Year: |
2007 |
Journal: |
Adv Exp Med Biol |
Title: |
Physiological roles and mechanisms of signaling by TRAF2 and TRAF5. |
Volume: |
597 |
|
Pages: |
32-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Blackwell K |
Year: |
2009 |
Journal: |
Mol Cell Biol |
Title: |
TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis. |
Volume: |
29 |
Issue: |
2 |
Pages: |
303-14 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
501
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Baud V |
Year: |
1999 |
Journal: |
Genes Dev |
Title: |
Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. |
Volume: |
13 |
Issue: |
10 |
Pages: |
1297-308 |
|
•
•
•
•
•
|
Publication |
First Author: |
Petersen SL |
Year: |
2015 |
Journal: |
Cell Death Differ |
Title: |
TRAF2 is a biologically important necroptosis suppressor. |
Volume: |
22 |
Issue: |
11 |
Pages: |
1846-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kanazawa K |
Year: |
2005 |
Journal: |
J Bone Miner Res |
Title: |
TRAF2 is essential for TNF-alpha-induced osteoclastogenesis. |
Volume: |
20 |
Issue: |
5 |
Pages: |
840-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee SY |
Year: |
1997 |
Journal: |
Immunity |
Title: |
TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survival. |
Volume: |
7 |
Issue: |
5 |
Pages: |
703-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alvarez SE |
Year: |
2010 |
Journal: |
Nature |
Title: |
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. |
Volume: |
465 |
Issue: |
7301 |
Pages: |
1084-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Z |
Year: |
2012 |
Journal: |
Diabetes |
Title: |
Hepatic TRAF2 regulates glucose metabolism through enhancing glucagon responses. |
Volume: |
61 |
Issue: |
3 |
Pages: |
566-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li J |
Year: |
2019 |
Journal: |
Cell Death Dis |
Title: |
TRAF2 protects against cerebral ischemia-induced brain injury by suppressing necroptosis. |
Volume: |
10 |
Issue: |
5 |
Pages: |
328 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lamkanfi M |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
A novel caspase-2 complex containing TRAF2 and RIP1. |
Volume: |
280 |
Issue: |
8 |
Pages: |
6923-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li S |
Year: |
2009 |
Journal: |
Mol Cell |
Title: |
PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination. |
Volume: |
33 |
Issue: |
1 |
Pages: |
30-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wertz IE |
Year: |
2004 |
Journal: |
Nature |
Title: |
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. |
Volume: |
430 |
Issue: |
7000 |
Pages: |
694-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Villanueva JE |
Year: |
2017 |
Journal: |
Diabetologia |
Title: |
Targeted deletion of Traf2 allows immunosuppression-free islet allograft survival in mice. |
Volume: |
60 |
Issue: |
4 |
Pages: |
679-689 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jabara HH |
Year: |
2009 |
Journal: |
Int Immunol |
Title: |
TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40. |
Volume: |
21 |
Issue: |
4 |
Pages: |
477-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang B |
Year: |
2017 |
Journal: |
Nature |
Title: |
TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling. |
Volume: |
545 |
Issue: |
7654 |
Pages: |
365-369 |
|
•
•
•
•
•
|
Publication |
First Author: |
Grech AP |
Year: |
2004 |
Journal: |
Immunity |
Title: |
TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells. |
Volume: |
21 |
Issue: |
5 |
Pages: |
629-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kanamori M |
Year: |
2002 |
Journal: |
Biochem Biophys Res Commun |
Title: |
T2BP, a novel TRAF2 binding protein, can activate NF-kappaB and AP-1 without TNF stimulation. |
Volume: |
290 |
Issue: |
3 |
Pages: |
1108-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hu M |
Year: |
2017 |
Journal: |
Mol Cell |
Title: |
Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy. |
Volume: |
66 |
Issue: |
1 |
Pages: |
141-153.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carpentier I |
Year: |
2008 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and TNF-R2-induced JNK activation. |
Volume: |
374 |
Issue: |
4 |
Pages: |
752-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gonzalvez F |
Year: |
2012 |
Journal: |
Mol Cell |
Title: |
TRAF2 Sets a threshold for extrinsic apoptosis by tagging caspase-8 with a ubiquitin shutoff timer. |
Volume: |
48 |
Issue: |
6 |
Pages: |
888-99 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li L |
Year: |
2009 |
Journal: |
Biochim Biophys Acta |
Title: |
The zinc finger protein A20 targets TRAF2 to the lysosomes for degradation. |
Volume: |
1793 |
Issue: |
2 |
Pages: |
346-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tada K |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death. |
Volume: |
276 |
Issue: |
39 |
Pages: |
36530-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shen HM |
Year: |
2004 |
Journal: |
Mol Cell Biol |
Title: |
Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death. |
Volume: |
24 |
Issue: |
13 |
Pages: |
5914-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shimada K |
Year: |
2009 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Traf2 interacts with Smad4 and regulates BMP signaling pathway in MC3T3-E1 osteoblasts. |
Volume: |
390 |
Issue: |
3 |
Pages: |
775-9 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
501
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
501
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
501
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
501
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Villanueva JE |
Year: |
2015 |
Journal: |
Eur J Immunol |
Title: |
TRAF2 regulates peripheral CD8(+) T-cell and NKT-cell homeostasis by modulating sensitivity to IL-15. |
Volume: |
45 |
Issue: |
6 |
Pages: |
1820-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang L |
Year: |
2011 |
Journal: |
Mol Biol Cell |
Title: |
TRAF2 phosphorylation promotes NF-κB-dependent gene expression and inhibits oxidative stress-induced cell death. |
Volume: |
22 |
Issue: |
1 |
Pages: |
128-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Etemadi N |
Year: |
2015 |
Journal: |
Elife |
Title: |
TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1. |
Volume: |
4 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Vallabhapurapu S |
Year: |
2008 |
Journal: |
Nat Immunol |
Title: |
Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. |
Volume: |
9 |
Issue: |
12 |
Pages: |
1364-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xie X |
Year: |
2021 |
Journal: |
Cell Mol Immunol |
Title: |
TRAF2 regulates T cell immunity by maintaining a Tpl2-ERK survival signaling axis in effector and memory CD8 T cells. |
Volume: |
18 |
Issue: |
9 |
Pages: |
2262-2274 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jabara H |
Year: |
2002 |
Journal: |
Immunity |
Title: |
The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching. |
Volume: |
17 |
Issue: |
3 |
Pages: |
265-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chuang HC |
Year: |
2014 |
Journal: |
Nat Commun |
Title: |
HGK/MAP4K4 deficiency induces TRAF2 stabilization and Th17 differentiation leading to insulin resistance. |
Volume: |
5 |
|
Pages: |
4602 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hostager BS |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling. |
Volume: |
278 |
Issue: |
46 |
Pages: |
45382-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang L |
Year: |
2016 |
Journal: |
J Cell Sci |
Title: |
TRAF2 exerts opposing effects on basal and TNFα-induced activation of the classic IKK complex in hematopoietic cells in mice. |
Volume: |
129 |
Issue: |
7 |
Pages: |
1455-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Woolaver RA |
Year: |
2018 |
Journal: |
J Immunol |
Title: |
TRAF2 Deficiency in B Cells Impairs CD40-Induced Isotype Switching That Can Be Rescued by Restoring NF-κB1 Activation. |
Volume: |
201 |
Issue: |
11 |
Pages: |
3421-3430 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nguyen LT |
Year: |
1999 |
Journal: |
Immunity |
Title: |
TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses. |
Volume: |
11 |
Issue: |
3 |
Pages: |
379-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brink R |
Year: |
1998 |
Journal: |
J Biol Chem |
Title: |
Tumor necrosis factor receptor (TNFR)-associated factor 2A (TRAF2A), a TRAF2 splice variant with an extended RING finger domain that inhibits TNFR2-mediated NF-kappaB activation. |
Volume: |
273 |
Issue: |
7 |
Pages: |
4129-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zarnegar BJ |
Year: |
2008 |
Journal: |
Nat Immunol |
Title: |
Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. |
Volume: |
9 |
Issue: |
12 |
Pages: |
1371-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gardam S |
Year: |
2008 |
Journal: |
Immunity |
Title: |
TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor. |
Volume: |
28 |
Issue: |
3 |
Pages: |
391-401 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vaitaitis GM |
Year: |
2008 |
Journal: |
PLoS One |
Title: |
High distribution of CD40 and TRAF2 in Th40 T cell rafts leads to preferential survival of this auto-aggressive population in autoimmunity. |
Volume: |
3 |
Issue: |
4 |
Pages: |
e2076 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Kimura M |
Year: |
2018 |
Journal: |
Int Immunol |
Title: |
TRAF2 and TRAF5 associated with the signal transducing receptor gp130 limit IL-6-driven transphosphorylation of JAK1 through the inhibition of proximal JAK-JAK interaction. |
Volume: |
30 |
Issue: |
7 |
Pages: |
291-299 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vince JE |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis. |
Volume: |
284 |
Issue: |
51 |
Pages: |
35906-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mikkelsen SS |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1. |
Volume: |
284 |
Issue: |
16 |
Pages: |
10774-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pérez-Chacón G |
Year: |
2012 |
Journal: |
J Immunol |
Title: |
TNFR-associated factor 2 deficiency in B lymphocytes predisposes to chronic lymphocytic leukemia/small lymphocytic lymphoma in mice. |
Volume: |
189 |
Issue: |
2 |
Pages: |
1053-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ye H |
Year: |
1999 |
Journal: |
Mol Cell |
Title: |
The structural basis for the recognition of diverse receptor sequences by TRAF2. |
Volume: |
4 |
Issue: |
3 |
Pages: |
321-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rothe M |
Year: |
1994 |
Journal: |
Cell |
Title: |
A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. |
Volume: |
78 |
Issue: |
4 |
Pages: |
681-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tesio M |
Year: |
2015 |
Journal: |
J Exp Med |
Title: |
Hematopoietic stem cell quiescence and function are controlled by the CYLD-TRAF2-p38MAPK pathway. |
Volume: |
212 |
Issue: |
4 |
Pages: |
525-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zapata JM |
Year: |
2004 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
TNF receptor-associated factor (TRAF) domain and Bcl-2 cooperate to induce small B cell lymphoma/chronic lymphocytic leukemia in transgenic mice. |
Volume: |
101 |
Issue: |
47 |
Pages: |
16600-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawamata S |
Year: |
1998 |
Journal: |
J Biol Chem |
Title: |
Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation. |
Volume: |
273 |
Issue: |
10 |
Pages: |
5808-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rothe M |
Year: |
1996 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. |
Volume: |
93 |
Issue: |
16 |
Pages: |
8241-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cannons JL |
Year: |
2002 |
Journal: |
J Immunol |
Title: |
Cutting edge: profound defect in T cell responses in TNF receptor-associated factor 2 dominant negative mice. |
Volume: |
169 |
Issue: |
6 |
Pages: |
2828-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yeung AT |
Year: |
2015 |
Journal: |
Sci Rep |
Title: |
Conditional-ready mouse embryonic stem cell derived macrophages enable the study of essential genes in macrophage function. |
Volume: |
5 |
|
Pages: |
8908 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hsu H |
Year: |
1996 |
Journal: |
Cell |
Title: |
TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. |
Volume: |
84 |
Issue: |
2 |
Pages: |
299-308 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee SY |
Year: |
1996 |
Journal: |
J Exp Med |
Title: |
T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors. |
Volume: |
183 |
Issue: |
2 |
Pages: |
669-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Park KJ |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Nonstructural 5A protein of hepatitis C virus modulates tumor necrosis factor alpha-stimulated nuclear factor kappa B activation. |
Volume: |
277 |
Issue: |
15 |
Pages: |
13122-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ko R |
Year: |
2019 |
Journal: |
J Immunol |
Title: |
Glycogen Synthase Kinase 3β Regulates Antiviral Responses of TLR3 via TRAF2-Src Axis. |
Volume: |
203 |
Issue: |
11 |
Pages: |
2990-2999 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chung YM |
Year: |
2001 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Hepatitis C virus core protein potentiates TNF-alpha-induced NF-kappaB activation through TRAF2-IKKbeta-dependent pathway. |
Volume: |
284 |
Issue: |
1 |
Pages: |
15-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu J |
Year: |
2007 |
Journal: |
FEBS Lett |
Title: |
Suppressive effect of reactive oxygen species on CD40-induced B cell activation. |
Volume: |
581 |
Issue: |
26 |
Pages: |
5043-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kumar A |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A. |
Volume: |
276 |
Issue: |
4 |
Pages: |
2668-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Choi JW |
Year: |
2009 |
Journal: |
J Cell Sci |
Title: |
AIMP2 promotes TNFalpha-dependent apoptosis via ubiquitin-mediated degradation of TRAF2. |
Volume: |
122 |
Issue: |
Pt 15 |
Pages: |
2710-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liang Y |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
SHARPIN negatively associates with TRAF2-mediated NFκB activation. |
Volume: |
6 |
Issue: |
7 |
Pages: |
e21696 |
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First Author: |
Harit K |
Year: |
2023 |
Journal: |
Cell Death Dis |
Title: |
The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2. |
Volume: |
14 |
Issue: |
7 |
Pages: |
480 |
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First Author: |
Yeh WC |
Year: |
1997 |
Journal: |
Immunity |
Title: |
Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice. |
Volume: |
7 |
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5 |
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715-25 |
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Publication |
First Author: |
Jin J |
Year: |
2015 |
Journal: |
Nat Commun |
Title: |
Proinflammatory TLR signalling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages. |
Volume: |
6 |
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Pages: |
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Publication |
First Author: |
Ohazama A |
Year: |
2003 |
Journal: |
Gene Expr Patterns |
Title: |
Expression of TNF-receptor-associated factor genes in murine tooth development. |
Volume: |
3 |
Issue: |
2 |
Pages: |
127-9 |
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Publication |
First Author: |
Kim JY |
Year: |
2011 |
Journal: |
J Cell Sci |
Title: |
TNFα induced noncanonical NF-κB activation is attenuated by RIP1 through stabilization of TRAF2. |
Volume: |
124 |
Issue: |
Pt 4 |
Pages: |
647-56 |
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Publication |
First Author: |
Moore CR |
Year: |
2005 |
Journal: |
J Immunol |
Title: |
Differential regulation of CD40-mediated TNF receptor-associated factor degradation in B lymphocytes. |
Volume: |
175 |
Issue: |
6 |
Pages: |
3780-9 |
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Publication |
First Author: |
Evans S |
Year: |
2018 |
Journal: |
JCI Insight |
Title: |
TNF receptor-activated factor 2 mediates cardiac protection through noncanonical NF-κB signaling. |
Volume: |
3 |
Issue: |
3 |
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Publication |
First Author: |
Grech A |
Year: |
2000 |
Journal: |
Mol Immunol |
Title: |
Complete structural characterisation of the mammalian and Drosophila TRAF genes: implications for TRAF evolution and the role of RING finger splice variants. |
Volume: |
37 |
Issue: |
12-13 |
Pages: |
721-34 |
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First Author: |
Rothe M |
Year: |
1995 |
Journal: |
Cell |
Title: |
The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. |
Volume: |
83 |
Issue: |
7 |
Pages: |
1243-52 |
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Publication |
First Author: |
Schneider AT |
Year: |
2017 |
Journal: |
Cancer Cell |
Title: |
RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer. |
Volume: |
31 |
Issue: |
1 |
Pages: |
94-109 |
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Publication |
First Author: |
Sun D |
Year: |
2011 |
Journal: |
Nat Immunol |
Title: |
Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF). |
Volume: |
12 |
Issue: |
9 |
Pages: |
853-60 |
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Publication |
First Author: |
Gil J |
Year: |
2004 |
Journal: |
Mol Cell Biol |
Title: |
TRAF family proteins link PKR with NF-kappa B activation. |
Volume: |
24 |
Issue: |
10 |
Pages: |
4502-12 |
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Publication |
First Author: |
Lin WJ |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Crucial role for TNF receptor-associated factor 2 (TRAF2) in regulating NFκB2 signaling that contributes to autoimmunity. |
Volume: |
108 |
Issue: |
45 |
Pages: |
18354-9 |
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First Author: |
Piao JH |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
Tumor necrosis factor receptor-associated factor (TRAF) 2 controls homeostasis of the colon to prevent spontaneous development of murine inflammatory bowel disease. |
Volume: |
286 |
Issue: |
20 |
Pages: |
17879-88 |
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Publication |
First Author: |
Xie P |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
Cooperation between TNF receptor-associated factors 1 and 2 in CD40 signaling. |
Volume: |
176 |
Issue: |
9 |
Pages: |
5388-400 |
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Publication |
First Author: |
Piao JH |
Year: |
2007 |
Journal: |
J Immunol |
Title: |
TNF receptor-associated factor 2-dependent canonical pathway is crucial for the development of Peyer's patches. |
Volume: |
178 |
Issue: |
4 |
Pages: |
2272-7 |
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Publication |
First Author: |
So T |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Antigen-independent signalosome of CARMA1, PKCθ, and TNF receptor-associated factor 2 (TRAF2) determines NF-κB signaling in T cells. |
Volume: |
108 |
Issue: |
7 |
Pages: |
2903-8 |
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Publication |
First Author: |
Wu YT |
Year: |
2008 |
Journal: |
Cell Death Differ |
Title: |
Signaling pathways from membrane lipid rafts to JNK1 activation in reactive nitrogen species-induced non-apoptotic cell death. |
Volume: |
15 |
Issue: |
2 |
Pages: |
386-97 |
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Publication |
First Author: |
Arch RH |
Year: |
1998 |
Journal: |
Mol Cell Biol |
Title: |
4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB. |
Volume: |
18 |
Issue: |
1 |
Pages: |
558-65 |
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Publication |
First Author: |
Guo X |
Year: |
2017 |
Journal: |
Circulation |
Title: |
Cardioprotective Role of Tumor Necrosis Factor Receptor-Associated Factor 2 by Suppressing Apoptosis and Necroptosis. |
Volume: |
136 |
Issue: |
8 |
Pages: |
729-742 |
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Publication |
First Author: |
Gardam S |
Year: |
2011 |
Journal: |
Blood |
Title: |
Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response. |
Volume: |
117 |
Issue: |
15 |
Pages: |
4041-51 |
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Publication |
First Author: |
Blackwell K |
Year: |
2013 |
Journal: |
Mol Cell Biol |
Title: |
Two coordinated mechanisms underlie tumor necrosis factor alpha-induced immediate and delayed IκB kinase activation. |
Volume: |
33 |
Issue: |
10 |
Pages: |
1901-15 |
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
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•
•
•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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