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Search results 1 to 100 out of 773 for Traf3

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Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
100498216 | traf3
Type: gene
Organism: frog, western clawed
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Gene
7187 | TRAF3
Type: gene
Organism: human
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Gene
362788 | Traf3
Type: gene
Organism: rat
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Gene
490867 | TRAF3
Type: gene
Organism: dog, domestic
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Gene
453178 | TRAF3
Type: gene
Organism: chimpanzee
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Gene
506182 | TRAF3
Type: gene
Organism: cattle
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Gene
423471 | TRAF3
Type: gene
Organism: chicken
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Gene
445119 | traf3
Type: gene
Organism: zebrafish
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Gene
693961 | TRAF3
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR027128 | TRAF3
Type: Family
Description: Tumor necrosis factor (TNF) receptor associated factor 3 (TRAF3) is a highly versatile regulator that positively controls type I interferon production, but negatively regulates mitogen-activated protein (MAP) kinase activation and non-canonical nuclear factor-kB signalling []. It is a critical regulator of both innate and adaptive immune responses []. TRAF3 plays a role in the regulation of B-cell survival [], in the regulation of antiviral responses [], and in T-cell dependent immune responses []. It is required for normal antibody isotype switching from IgM to IgG []. Differences in the ubiquitination of TRAF3 are the key to the selective production of type I interferons versus proinflammatory cytokines [].
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Protein Coding Gene
MGI:108041 | Traf3
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
8934568 | J:37065
First Author: Xu Y
Year: 1996
Journal: Immunity
Title: Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses.
Volume: 5
Issue: 5
Pages: 407-15
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Publication
18313334 | J:132877
First Author: Gardam S
Year: 2008
Journal: Immunity
Title: TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor.
Volume: 28
Issue: 3
Pages: 391-401
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Publication
19228877 | J:147101
First Author: Jabara HH
Year: 2009
Journal: Int Immunol
Title: TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40.
Volume: 21
Issue: 4
Pages: 477-88
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Publication
16306936 | J:245346
First Author: Oganesyan G
Year: 2006
Journal: Nature
Title: Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response.
Volume: 439
Issue: 7073
Pages: 208-11
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Publication
19898473 | J:157878
First Author: Tseng PH
Year: 2010
Journal: Nat Immunol
Title: Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines.
Volume: 11
Issue: 1
Pages: 70-5
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Publication
17633016 | -
 
First Author: He JQ
Year: 2007
Journal: Adv Exp Med Biol
Title: TRAF3 and its biological function.
Volume: 597
Pages: 48-59
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Publication
21660053 | -
First Author: Häcker H
Year: 2011
Journal: Nat Rev Immunol
Title: Expanding TRAF function: TRAF3 as a tri-faced immune regulator.
Volume: 11
Issue: 7
Pages: 457-68
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Gene
26146 | TRAF3IP1
Type: gene
Organism: human
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Gene
10758 | TRAF3IP2
Type: gene
Organism: human
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Gene
80342 | TRAF3IP3
Type: gene
Organism: human
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Protein
Q60803
Organism: Mus musculus/domesticus
Length: 567  
Fragment?: false
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Publication
29215030 | J:293226
First Author: Zhang R
Year: 2017
Journal: Sci Rep
Title: TRAF3 negatively regulates platelet activation and thrombosis.
Volume: 7
Issue: 1
Pages: 17112
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Publication
27752131 | J:251796
 
First Author: Mambetsariev N
Year: 2016
Journal: Sci Rep
Title: TRAF3 deficiency promotes metabolic reprogramming in B cells.
Volume: 6
Pages: 35349
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Publication
25010048 | J:218916
First Author: Yi Z
Year: 2014
Journal: PLoS One
Title: TRAF3 regulates homeostasis of CD8+ central memory T cells.
Volume: 9
Issue: 7
Pages: e102120
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Publication
23603814 | J:198506
First Author: Xiao Y
Year: 2013
Journal: Nat Med
Title: Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation.
Volume: 19
Issue: 5
Pages: 595-602
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Publication
32324863 | J:294929
 
First Author: Zhu Q
Year: 2020
Journal: J Exp Med
Title: TRIM24 facilitates antiviral immunity through mediating K63-linked TRAF3 ubiquitination.
Volume: 217
Issue: 7
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Publication
26882989 | J:234742
 
First Author: Wang PX
Year: 2016
Journal: Nat Commun
Title: Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling.
Volume: 7
Pages: 10592
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Publication
24316970 | J:207911
First Author: Xiu Y
Year: 2014
Journal: J Clin Invest
Title: Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation.
Volume: 124
Issue: 1
Pages: 297-310
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Publication
31243287 | J:279665
First Author: Li J
Year: 2019
Journal: Nat Commun
Title: TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis.
Volume: 10
Issue: 1
Pages: 2795
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Publication
28522807 | J:275297
First Author: Wallis AM
Year: 2017
Journal: Sci Rep
Title: TRAF3 enhances TCR signaling by regulating the inhibitors Csk and PTPN22.
Volume: 7
Issue: 1
Pages: 2081
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Publication
32275117 | J:316350
First Author: Shen Y
Year: 2020
Journal: FASEB J
Title: TRAF3 promotes ROS production and pyroptosis by targeting ULK1 ubiquitination in macrophages.
Volume: 34
Issue: 5
Pages: 7144-7159
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Publication
26474655 | J:233920
First Author: Panda S
Year: 2015
Journal: Immunity
Title: Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation of TRAF3 and TRAF6 Complexes.
Volume: 43
Issue: 4
Pages: 647-59
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Publication
29920190 | J:266602
First Author: Li F
Year: 2018
Journal: J Clin Invest
Title: HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection.
Volume: 128
Issue: 9
Pages: 4148-4162
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Publication
32562145 | J:303214
First Author: Sun N
Year: 2020
Journal: Protein Cell
Title: TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2.
Volume: 11
Issue: 12
Pages: 894-914
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Publication
17158868 | J:164781
First Author: He JQ
Year: 2007
Journal: J Biol Chem
Title: Specificity of TRAF3 in its negative regulation of the noncanonical NF-kappa B pathway.
Volume: 282
Issue: 6
Pages: 3688-94
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Publication
19074733 | J:148557
First Author: Zapata JM
Year: 2009
Journal: Blood
Title: Lymphocyte-specific TRAF3 transgenic mice have enhanced humoral responses and develop plasmacytosis, autoimmunity, inflammation, and cancer.
Volume: 113
Issue: 19
Pages: 4595-603
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Publication
16306937 | J:166021
First Author: Häcker H
Year: 2006
Journal: Nature
Title: Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6.
Volume: 439
Issue: 7073
Pages: 204-7
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Publication
25422508 | J:230694
First Author: Lalani AI
Year: 2015
Journal: J Immunol
Title: Myeloid cell TRAF3 regulates immune responses and inhibits inflammation and tumor development in mice.
Volume: 194
Issue: 1
Pages: 334-48
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Publication
37207205 | J:346309
 
First Author: Zhu S
Year: 2023
Journal: Front Immunol
Title: The adaptor protein TRAF3 is an immune checkpoint that inhibits myeloid-derived suppressor cell expansion.
Volume: 14
Pages: 1167924
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Publication
34145060 | J:308023
     
First Author: Arkee T
Year: 2021
Journal: J Immunol
Title: TRAF3 in T Cells Restrains Negative Regulators of LAT to Promote TCR/CD28 Signaling.
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Publication
16858409 | J:200433
First Author: Saha SK
Year: 2006
Journal: EMBO J
Title: Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif.
Volume: 25
Issue: 14
Pages: 3257-63
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Publication
28071724 | J:272190
 
First Author: Liu J
Year: 2017
Journal: Sci Rep
Title: Osteoclastic miR-214 targets TRAF3 to contribute to osteolytic bone metastasis of breast cancer.
Volume: 7
Pages: 40487
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Publication
24378539 | J:208351
First Author: Chang JH
Year: 2014
Journal: J Exp Med
Title: TRAF3 regulates the effector function of regulatory T cells and humoral immune responses.
Volume: 211
Issue: 1
Pages: 137-51
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Publication
25628422 | J:220716
First Author: Chen Z
Year: 2015
Journal: Am J Physiol Endocrinol Metab
Title: Myeloid cell TRAF3 promotes metabolic inflammation, insulin resistance, and hepatic steatosis in obesity.
Volume: 308
Issue: 6
Pages: E460-9
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Publication
31386800 | J:329344
First Author: Xie M
Year: 2020
Journal: FEBS J
Title: Scavenger receptor A impairs interferon response to HBV infection by limiting TRAF3 ubiquitination through recruiting OTUB1.
Volume: 287
Issue: 2
Pages: 310-324
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Publication
26909311 | J:341552
First Author: Chen Z
Year: 2015
Journal: Mol Metab
Title: Hepatocyte TRAF3 promotes insulin resistance and type 2 diabetes in mice with obesity.
Volume: 4
Issue: 12
Pages: 951-60
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Publication
22033491 | J:188983
First Author: Moore CR
Year: 2012
Journal: Leukemia
Title: Specific deletion of TRAF3 in B lymphocytes leads to B-lymphoma development in mice.
Volume: 26
Issue: 5
Pages: 1122-7
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Publication
26329582 | J:259486
First Author: Lin WW
Year: 2015
Journal: Sci Signal
Title: The adaptor protein TRAF3 inhibits interleukin-6 receptor signaling in B cells to limit plasma cell development.
Volume: 8
Issue: 392
Pages: ra88
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Publication
24324158 | J:206133
First Author: Jenkinson SR
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development.
Volume: 110
Issue: 52
Pages: 21107-12
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Publication
26755589 | J:229924
First Author: Mambetsariev N
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Nuclear TRAF3 is a negative regulator of CREB in B cells.
Volume: 113
Issue: 4
Pages: 1032-7
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Publication
18997792 | J:143169
First Author: Vallabhapurapu S
Year: 2008
Journal: Nat Immunol
Title: Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling.
Volume: 9
Issue: 12
Pages: 1364-70
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Publication
25029551 | J:259156
First Author: Yi Z
Year: 2014
Journal: Nat Immunol
Title: The adaptor TRAF3 restrains the lineage determination of thymic regulatory T cells by modulating signaling via the receptor for IL-2.
Volume: 15
Issue: 9
Pages: 866-74
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Publication
12354380 | J:113610
First Author: Jabara H
Year: 2002
Journal: Immunity
Title: The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching.
Volume: 17
Issue: 3
Pages: 265-76
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Publication
34745083 | J:313471
 
First Author: Liu Y
Year: 2021
Journal: Front Immunol
Title: Mitochondrial Fission Factor Is a Novel Interacting Protein of the Critical B Cell Survival Regulator TRAF3 in B Lymphocytes.
Volume: 12
Pages: 670338
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Publication
35588785 | J:341702
First Author: Han X
Year: 2022
Journal: J Biol Chem
Title: SGK1 negatively regulates inflammatory immune responses and protects against alveolar bone loss through modulation of TRAF3 activity.
Volume: 298
Issue: 6
Pages: 102036
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Publication
32591397 | J:300403
First Author: Chen Z
Year: 2020
Journal: J Immunol
Title: TRAF3 Acts as a Checkpoint of B Cell Receptor Signaling to Control Antibody Class Switch Recombination and Anergy.
Volume: 205
Issue: 3
Pages: 830-841
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Publication
28438834 | J:246962
First Author: Yao Z
Year: 2017
Journal: J Biol Chem
Title: RANKL cytokine enhances TNF-induced osteoclastogenesis independently of TNF receptor associated factor (TRAF) 6 by degrading TRAF3 in osteoclast precursors.
Volume: 292
Issue: 24
Pages: 10169-10179
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Protein
Q3UHJ1
Organism: Mus musculus/domesticus
Length: 542  
Fragment?: false
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Protein
Q3UHM2
Organism: Mus musculus/domesticus
Length: 542  
Fragment?: false
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Protein
D3Z343
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: true
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Publication
26305951 | J:226812
First Author: Lin D
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6.
Volume: 112
Issue: 36
Pages: 11324-9
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Publication
18997794 | J:143167
First Author: Zarnegar BJ
Year: 2008
Journal: Nat Immunol
Title: Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.
Volume: 9
Issue: 12
Pages: 1371-8
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Publication
8660894 | J:34163
First Author: Wang X
Year: 1996
Journal: Dev Biol
Title: A candidate gene for the amnionless gastrulation stage mouse mutation encodes a TRAF-related protein.
Volume: 177
Issue: 1
Pages: 274-90
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Publication
11279523 | J:68615
First Author: Kalantry S
Year: 2001
Journal: Nat Genet
Title: The amnionless gene, essential for mouse gastrulation, encodes a visceral-endoderm-specific protein with an extracellular cysteine-rich domain.
Volume: 27
Issue: 4
Pages: 412-6
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Publication
9851841 | J:51542
First Author: Tomihara-Newberger C
Year: 1998
Journal: Dev Biol
Title: The amn gene product is required in extraembryonic tissues for the generation of middle primitive streak derivatives.
Volume: 204
Issue: 1
Pages: 34-54
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Publication
15485634 | J:93923
First Author: Qian Y
Year: 2004
Journal: Immunity
Title: Act1, a negative regulator in CD40- and BAFF-mediated B cell survival.
Volume: 21
Issue: 4
Pages: 575-87
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Publication
20660351 | J:162859
First Author: Matsushima Y
Year: 2010
Journal: J Immunol
Title: An atopic dermatitis-like skin disease with hyper-IgE-emia develops in mice carrying a spontaneous recessive point mutation in the Traf3ip2 (Act1/CIKS) gene.
Volume: 185
Issue: 4
Pages: 2340-9
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Publication
28219902 | J:241297
First Author: Ma C
Year: 2017
Journal: EMBO Rep
Title: NDR1 protein kinase promotes IL-17- and TNF-α-mediated inflammation by competitively binding TRAF3.
Volume: 18
Issue: 4
Pages: 586-602
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Publication
26034202 | J:260823
First Author: Jiang X
Year: 2015
Journal: Hypertension
Title: Tumor necrosis factor receptor-associated factor 3 is a positive regulator of pathological cardiac hypertrophy.
Volume: 66
Issue: 2
Pages: 356-67
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Publication
22649194 | J:188947
First Author: Zepp JA
Year: 2012
Journal: J Immunol
Title: Cutting edge: TNF receptor-associated factor 4 restricts IL-17-mediated pathology and signaling processes.
Volume: 189
Issue: 1
Pages: 33-7
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Publication
26928339 | J:259954
First Author: Zhou Y
Year: 2016
Journal: Nat Immunol
Title: The kinase CK1ɛ controls the antiviral immune response by phosphorylating the signaling adaptor TRAF3.
Volume: 17
Issue: 4
Pages: 397-405
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Publication
24418753 | J:245012
First Author: Edwards SK
Year: 2014
Journal: Leuk Res
Title: Expression and function of a novel isoform of Sox5 in malignant B cells.
Volume: 38
Issue: 3
Pages: 393-401
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Publication
36550101 | J:334353
First Author: Leng H
Year: 2022
Journal: Nat Commun
Title: Modulating glycosphingolipid metabolism and autophagy improves outcomes in pre-clinical models of myeloma bone disease.
Volume: 13
Issue: 1
Pages: 7868
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Publication
21078888 | J:293415
First Author: Zhu S
Year: 2010
Journal: J Exp Med
Title: Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling.
Volume: 207
Issue: 12
Pages: 2647-62
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Publication
27094905 | J:296106
 
First Author: Lui PY
Year: 2016
Journal: Emerg Microbes Infect
Title: Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3.
Volume: 5
Pages: e39
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Publication
23650438 | J:200964
First Author: Yi Z
Year: 2013
Journal: J Exp Med
Title: TNF receptor associated factor 3 plays a key role in development and function of invariant natural killer T cells.
Volume: 210
Issue: 6
Pages: 1079-86
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Publication
21084666 | J:168017
First Author: Xie P
Year: 2011
Journal: J Immunol
Title: TNF receptor-associated factor 3 is required for T cell-mediated immunity and TCR/CD28 signaling.
Volume: 186
Issue: 1
Pages: 143-55
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Publication
25516495 | J:227868
First Author: Gu H
Year: 2015
Journal: Toxicol Sci
Title: The miR-322-TRAF3 circuit mediates the pro-apoptotic effect of high glucose on neural stem cells.
Volume: 144
Issue: 1
Pages: 186-96
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Publication
15494504 | J:93747
First Author: Xie P
Year: 2004
Journal: J Immunol
Title: Roles of TNF receptor-associated factor 3 in signaling to B lymphocytes by carboxyl-terminal activating regions 1 and 2 of the EBV-encoded oncoprotein latent membrane protein 1.
Volume: 173
Issue: 9
Pages: 5546-55
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Publication
23871208 | J:208241
First Author: Wang Y
Year: 2013
Journal: Immunity
Title: The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity.
Volume: 39
Issue: 1
Pages: 111-22
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Publication
17723217 | J:124329
First Author: Xie P
Year: 2007
Journal: Immunity
Title: Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs.
Volume: 27
Issue: 2
Pages: 253-67
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Publication
32779804 | J:307301
First Author: Hao D
Year: 2020
Journal: FASEB J
Title: SHP-1 suppresses the antiviral innate immune response by targeting TRAF3.
Volume: 34
Issue: 9
Pages: 12392-12405
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Publication
30018345 | J:266317
First Author: Parvatiyar K
Year: 2018
Journal: Nat Commun
Title: A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling.
Volume: 9
Issue: 1
Pages: 2770
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Publication
22503542 | J:187326
First Author: Allen IC
Year: 2012
Journal: Immunity
Title: NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling.
Volume: 36
Issue: 5
Pages: 742-54
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Publication
17015635 | J:124635
First Author: He JQ
Year: 2006
Journal: J Exp Med
Title: Rescue of TRAF3-null mice by p100 NF-kappa B deficiency.
Volume: 203
Issue: 11
Pages: 2413-8
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Publication
31826940 | J:282976
First Author: Gokhale S
Year: 2020
Journal: J Immunol
Title: Elevated Choline Kinase α-Mediated Choline Metabolism Supports the Prolonged Survival of TRAF3-Deficient B Lymphocytes.
Volume: 204
Issue: 2
Pages: 459-471
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Publication
21971520 | J:178855
First Author: Xie P
Year: 2011
Journal: J Leukoc Biol
Title: Enhanced Toll-like receptor (TLR) responses of TNFR-associated factor 3 (TRAF3)-deficient B lymphocytes.
Volume: 90
Issue: 6
Pages: 1149-57
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Publication
33639170 | J:304820
   
First Author: Whillock AL
Year: 2021
Journal: J Biol Chem
Title: TNF receptor-associated factor 3 restrains B cell receptor signaling in normal and malignant B cells.
Pages: 100465
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Publication
34418432 | J:313026
First Author: Li H
Year: 2021
Journal: J Biol Chem
Title: Multiple mechanisms for TRAF3-mediated regulation of the T cell costimulatory receptor GITR.
Volume: 297
Issue: 3
Pages: 101097
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Publication
25565375 | J:219748
 
First Author: Jin J
Year: 2015
Journal: Nat Commun
Title: Proinflammatory TLR signalling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages.
Volume: 6
Pages: 5930
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Publication
12711536 | J:83327
First Author: Ohazama A
Year: 2003
Journal: Gene Expr Patterns
Title: Expression of TNF-receptor-associated factor genes in murine tooth development.
Volume: 3
Issue: 2
Pages: 127-9
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Publication
19198591 | J:146475
First Author: Rub A
Year: 2009
Journal: Nat Immunol
Title: Cholesterol depletion associated with Leishmania major infection alters macrophage CD40 signalosome composition and effector function.
Volume: 10
Issue: 3
Pages: 273-80
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Publication
36883978 | J:335521
First Author: Gokhale S
Year: 2023
Journal: J Immunol
Title: Upregulated Expression of the IL-9 Receptor on TRAF3-Deficient B Lymphocytes Confers Ig Isotype Switching Responsiveness to IL-9 in the Presence of Antigen Receptor Engagement and IL-4.
Volume: 210
Issue: 8
Pages: 1059-1073
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Publication
32416098 | J:293416
First Author: Hu G
Year: 2020
Journal: Am J Pathol
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