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Search results 1 to 100 out of 789 for Traf6

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: TNF receptor-associated factor 6 (TRAF6) regulates a diverse array of processes, including adaptive immunity, innate immunity, bone metabolism and tissue development. It is a unique member of the TRAF family of adaptor proteins in that it is involved in both the TNF receptor superfamily and the interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) superfamily signal transduction pathways [, , , ]. TRAF6 possesses ubiquitin ligase activity that controls the activation of IKK and NF-kappaB [, ]. TRAF6 contains a RING finger domain, five zinc finger domains, and a TRAF domain.
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Kobayashi T
Year: 2003
Journal: Immunity
Title: TRAF6 is a critical factor for dendritic cell maturation and development.
Volume: 19
Issue: 3
Pages: 353-63
Publication
First Author: Lomaga MA
Year: 1999
Journal: Genes Dev
Title: TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.
Volume: 13
Issue: 8
Pages: 1015-24
Publication
First Author: Sun L
Year: 2004
Journal: Mol Cell
Title: The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes.
Volume: 14
Issue: 3
Pages: 289-301
Protein
Organism: Mus musculus
Length: 530  
Fragment?: false
Publication
First Author: Cejas PJ
Year: 2010
Journal: Blood
Title: TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2.
Volume: 115
Issue: 23
Pages: 4750-7
Publication
First Author: Paul PK
Year: 2010
Journal: J Cell Biol
Title: Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice.
Volume: 191
Issue: 7
Pages: 1395-411
Publication
First Author: Fang J
Year: 2017
Journal: Nat Immunol
Title: Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.
Volume: 18
Issue: 2
Pages: 236-245
Publication
First Author: Arcipowski KM
Year: 2014
Journal: Int Immunol
Title: TRAF6 is a critical regulator of LMP1 functions in vivo.
Volume: 26
Issue: 3
Pages: 149-58
Publication
First Author: Wu H
Year: 2003
Journal: Bioessays
Title: TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology.
Volume: 25
Issue: 11
Pages: 1096-105
Publication  
First Author: Chung JY
Year: 2007
Journal: Adv Exp Med Biol
Title: Molecular basis for the unique specificity of TRAF6.
Volume: 597
Pages: 122-30
Publication
First Author: Lamothe B
Year: 2007
Journal: J Biol Chem
Title: Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation.
Volume: 282
Issue: 6
Pages: 4102-12
Publication
First Author: Hindi SM
Year: 2012
Journal: Mol Cell Biol
Title: Reciprocal interaction between TRAF6 and notch signaling regulates adult myofiber regeneration upon injury.
Volume: 32
Issue: 23
Pages: 4833-45
Publication
First Author: Yang WL
Year: 2009
Journal: Science
Title: The E3 ligase TRAF6 regulates Akt ubiquitination and activation.
Volume: 325
Issue: 5944
Pages: 1134-8
Publication
First Author: Yao K
Year: 2018
Journal: Oncogene
Title: RSK2 is required for TRAF6 phosphorylation-mediated colon inflammation.
Volume: 37
Issue: 26
Pages: 3501-3513
Publication
First Author: Mueck T
Year: 2011
Journal: Differentiation
Title: TRAF6 regulates proliferation and differentiation of skeletal myoblasts.
Volume: 81
Issue: 2
Pages: 99-106
Publication
First Author: King CG
Year: 2008
Journal: J Immunol
Title: Cutting edge: requirement for TRAF6 in the induction of T cell anergy.
Volume: 180
Issue: 1
Pages: 34-8
Publication
First Author: Xiong H
Year: 2004
Journal: J Biol Chem
Title: Interaction of TRAF6 with MAST205 regulates NF-kappaB activation and MAST205 stability.
Volume: 279
Issue: 42
Pages: 43675-83
Publication
First Author: Yamashita M
Year: 2008
Journal: Mol Cell
Title: TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta.
Volume: 31
Issue: 6
Pages: 918-24
Publication
First Author: Han D
Year: 2017
Journal: Int Immunol
Title: Dendritic cell expression of the signaling molecule TRAF6 is required for immune tolerance in the lung.
Volume: 29
Issue: 2
Pages: 71-78
Publication
First Author: Ohazama A
Year: 2004
Journal: Dev Dyn
Title: Traf6 is essential for murine tooth cusp morphogenesis.
Volume: 229
Issue: 1
Pages: 131-5
Publication
First Author: Zhang X
Year: 2016
Journal: Mol Cell
Title: TRAF6 Restricts p53 Mitochondrial Translocation, Apoptosis, and Tumor Suppression.
Volume: 64
Issue: 4
Pages: 803-814
Publication
First Author: Yoon K
Year: 2008
Journal: Cell Death Differ
Title: TRAF6 deficiency promotes TNF-induced cell death through inactivation of GSK3beta.
Volume: 15
Issue: 4
Pages: 730-8
Publication
First Author: King CG
Year: 2006
Journal: Nat Med
Title: TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis.
Volume: 12
Issue: 9
Pages: 1088-92
Publication
First Author: Paul PK
Year: 2012
Journal: Mol Cell Biol
Title: The E3 ubiquitin ligase TRAF6 intercedes in starvation-induced skeletal muscle atrophy through multiple mechanisms.
Volume: 32
Issue: 7
Pages: 1248-59
Publication
First Author: Motegi H
Year: 2011
Journal: Genes Cells
Title: TRAF6 negatively regulates the Jak1-Erk pathway in interleukin-2 signaling.
Volume: 16
Issue: 2
Pages: 179-89
Publication
First Author: Shimo Y
Year: 2011
Journal: Genes Cells
Title: TRAF6 directs commitment to regulatory T cells in thymocytes.
Volume: 16
Issue: 4
Pages: 437-47
Publication
First Author: Muto G
Year: 2013
Journal: PLoS One
Title: TRAF6 is essential for maintenance of regulatory T cells that suppress Th2 type autoimmunity.
Volume: 8
Issue: 9
Pages: e74639
Publication  
First Author: Yamamoto M
Year: 2019
Journal: Commun Biol
Title: TRAF6 maintains mammary stem cells and promotes pregnancy-induced mammary epithelial cell expansion.
Volume: 2
Pages: 292
Publication
First Author: Fang J
Year: 2018
Journal: Cell Rep
Title: TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis.
Volume: 22
Issue: 5
Pages: 1250-1262
Publication
First Author: Han D
Year: 2013
Journal: Immunity
Title: Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance.
Volume: 38
Issue: 6
Pages: 1211-22
Publication
First Author: Zhu Z
Year: 2016
Journal: J Immunol
Title: Cutting Edge: A Cullin-5-TRAF6 Interaction Promotes TRAF6 Polyubiquitination and Lipopolysaccharide Signaling.
Volume: 197
Issue: 1
Pages: 21-6
Publication
First Author: Vlantis K
Year: 2016
Journal: Gut
Title: TLR-independent anti-inflammatory function of intestinal epithelial TRAF6 signalling prevents DSS-induced colitis in mice.
Volume: 65
Issue: 6
Pages: 935-43
Publication
First Author: Wang Y
Year: 2015
Journal: Mol Immunol
Title: TRAF6 is required for the GM-CSF-induced JNK, p38 and Akt activation.
Volume: 65
Issue: 2
Pages: 224-9
Publication  
First Author: Ko R
Year: 2015
Journal: Nat Commun
Title: Glycogen synthase kinase 3β ubiquitination by TRAF6 regulates TLR3-mediated pro-inflammatory cytokine production.
Volume: 6
Pages: 6765
Publication
First Author: Wang Y
Year: 2006
Journal: Nat Immunol
Title: Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling.
Volume: 7
Issue: 2
Pages: 139-47
Publication
First Author: Xing Y
Year: 2017
Journal: J Immunol
Title: Cutting Edge: TRAF6 Mediates TLR/IL-1R Signaling-Induced Nontranscriptional Priming of the NLRP3 Inflammasome.
Volume: 199
Issue: 5
Pages: 1561-1566
Publication
First Author: Hindi SM
Year: 2014
Journal: Hum Mol Genet
Title: Distinct roles of TRAF6 at early and late stages of muscle pathology in the mdx model of Duchenne muscular dystrophy.
Volume: 23
Issue: 6
Pages: 1492-505
Publication
First Author: Xia X
Year: 2011
Journal: Immunity
Title: NLRX1 negatively regulates TLR-induced NF-κB signaling by targeting TRAF6 and IKK.
Volume: 34
Issue: 6
Pages: 843-53
Publication  
First Author: Wu DJ
Year: 2016
Journal: J Autoimmun
Title: Autophagy-linked FYVE containing protein WDFY3 interacts with TRAF6 and modulates RANKL-induced osteoclastogenesis.
Volume: 73
Pages: 73-84
Publication
First Author: Zhang P
Year: 2005
Journal: EMBO Rep
Title: Activation of IKK by thymosin alpha1 requires the TRAF6 signalling pathway.
Volume: 6
Issue: 6
Pages: 531-7
Publication
First Author: Hindi SM
Year: 2016
Journal: J Clin Invest
Title: TRAF6 regulates satellite stem cell self-renewal and function during regenerative myogenesis.
Volume: 126
Issue: 1
Pages: 151-68
Publication
First Author: Panda S
Year: 2015
Journal: Immunity
Title: Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation of TRAF3 and TRAF6 Complexes.
Volume: 43
Issue: 4
Pages: 647-59
Publication  
First Author: Ji YX
Year: 2016
Journal: Nat Commun
Title: The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling.
Volume: 7
Pages: 11267
Publication
First Author: Yang YJ
Year: 2008
Journal: J Biol Chem
Title: TRAF6 specifically contributes to FcepsilonRI-mediated cytokine production but not mast cell degranulation.
Volume: 283
Issue: 46
Pages: 32110-8
Publication
First Author: Strickson S
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling.
Volume: 114
Issue: 17
Pages: E3481-E3489
Publication
First Author: Kisiswa L
Year: 2018
Journal: Cell Rep
Title: RIP2 Gates TRAF6 Interaction with Death Receptor p75NTR to Regulate Cerebellar Granule Neuron Survival.
Volume: 24
Issue: 4
Pages: 1013-1024
Publication
First Author: Lamothe B
Year: 2007
Journal: Biochem Biophys Res Commun
Title: TRAF6 ubiquitin ligase is essential for RANKL signaling and osteoclast differentiation.
Volume: 359
Issue: 4
Pages: 1044-9
Publication
First Author: Shi CS
Year: 2010
Journal: Sci Signal
Title: TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy.
Volume: 3
Issue: 123
Pages: ra42
Publication
First Author: Li T
Year: 2017
Journal: J Neurosci
Title: The Ubiquitin E3 Ligase TRAF6 Exacerbates Ischemic Stroke by Ubiquitinating and Activating Rac1.
Volume: 37
Issue: 50
Pages: 12123-12140
Publication
First Author: Chen H
Year: 2006
Journal: FEBS Lett
Title: Hsp70 inhibits lipopolysaccharide-induced NF-kappaB activation by interacting with TRAF6 and inhibiting its ubiquitination.
Volume: 580
Issue: 13
Pages: 3145-52
Publication
First Author: He L
Year: 2006
Journal: J Biol Chem
Title: TRAF6 regulates cell fate decisions by inducing caspase 8-dependent apoptosis and the activation of NF-kappaB.
Volume: 281
Issue: 16
Pages: 11235-49
Publication
First Author: Lamothe B
Year: 2008
Journal: J Biol Chem
Title: The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL.
Volume: 283
Issue: 36
Pages: 24871-80
Publication
First Author: Feng Y
Year: 2007
Journal: J Biol Chem
Title: The LIM protein, Limd1, regulates AP-1 activation through an interaction with Traf6 to influence osteoclast development.
Volume: 282
Issue: 1
Pages: 39-48
Publication
First Author: Yoshida R
Year: 2008
Journal: J Biol Chem
Title: TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.
Volume: 283
Issue: 52
Pages: 36211-20
Publication
First Author: Schneider M
Year: 2012
Journal: Nat Immunol
Title: The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB.
Volume: 13
Issue: 9
Pages: 823-31
Publication
First Author: Jabara H
Year: 2002
Journal: Immunity
Title: The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching.
Volume: 17
Issue: 3
Pages: 265-76
Publication
First Author: Kobayashi T
Year: 2009
Journal: PLoS One
Title: TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and -independent humoral immune responses.
Volume: 4
Issue: 3
Pages: e4736
Publication
First Author: Lin YC
Year: 2013
Journal: Sci Signal
Title: The tyrosine kinase Syk differentially regulates Toll-like receptor signaling downstream of the adaptor molecules TRAF6 and TRAF3.
Volume: 6
Issue: 289
Pages: ra71
Publication
First Author: Ning S
Year: 2008
Journal: Mol Cell Biol
Title: TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the tumor necrosis factor receptor family member latent membrane protein 1.
Volume: 28
Issue: 20
Pages: 6536-46
Publication
First Author: Han D
Year: 2015
Journal: PLoS One
Title: Microbiota-Independent Ameliorative Effects of Antibiotics on Spontaneous Th2-Associated Pathology of the Small Intestine.
Volume: 10
Issue: 2
Pages: e0118795
Publication
First Author: Takatsuna H
Year: 2003
Journal: J Biol Chem
Title: Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling.
Volume: 278
Issue: 14
Pages: 12144-50
Publication
First Author: Bonito AJ
Year: 2013
Journal: J Clin Invest
Title: Medullary thymic epithelial cell depletion leads to autoimmune hepatitis.
Volume: 123
Issue: 8
Pages: 3510-24
Publication
First Author: Yao Z
Year: 2017
Journal: J Biol Chem
Title: RANKL cytokine enhances TNF-induced osteoclastogenesis independently of TNF receptor associated factor (TRAF) 6 by degrading TRAF3 in osteoclast precursors.
Volume: 292
Issue: 24
Pages: 10169-10179
Publication
First Author: Kanaya T
Year: 2018
Journal: J Exp Med
Title: Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling.
Volume: 215
Issue: 2
Pages: 501-519
Publication
First Author: Pearce EL
Year: 2009
Journal: Nature
Title: Enhancing CD8 T-cell memory by modulating fatty acid metabolism.
Volume: 460
Issue: 7251
Pages: 103-7
Publication  
First Author: Inoue J
Year: 2007
Journal: Adv Exp Med Biol
Title: Characteristics and biological functions of TRAF6.
Volume: 597
Pages: 72-9
Publication
First Author: Kaji K
Year: 2001
Journal: J Bone Miner Res
Title: Tumor necrosis factor alpha-induced osteoclastogenesis requires tumor necrosis factor receptor-associated factor 6.
Volume: 16
Issue: 9
Pages: 1593-9
Publication
First Author: Kanamori M
Year: 2002
Journal: FEBS Lett
Title: NF-kappaB activator Act1 associates with IL-1/Toll pathway adaptor molecule TRAF6.
Volume: 532
Issue: 1-2
Pages: 241-6
Publication
First Author: Chen L
Year: 2008
Journal: FEBS Lett
Title: Protein phosphatase 4 negatively regulates LPS cascade by inhibiting ubiquitination of TRAF6.
Volume: 582
Issue: 19
Pages: 2843-9
Publication
First Author: Gohda J
Year: 2004
Journal: J Immunol
Title: Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling.
Volume: 173
Issue: 5
Pages: 2913-7
Publication
First Author: Dickson KM
Year: 2004
Journal: Dev Dyn
Title: TRAF6-dependent NF-kB transcriptional activity during mouse development.
Volume: 231
Issue: 1
Pages: 122-7
Publication
First Author: Geetha T
Year: 2005
Journal: Mol Cell
Title: Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling.
Volume: 20
Issue: 2
Pages: 301-12
Publication
First Author: Starczynowski DT
Year: 2010
Journal: Nat Med
Title: Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype.
Volume: 16
Issue: 1
Pages: 49-58
Publication
First Author: Kim IK
Year: 2015
Journal: Nat Med
Title: Glucocorticoid-induced tumor necrosis factor receptor-related protein co-stimulation facilitates tumor regression by inducing IL-9-producing helper T cells.
Volume: 21
Issue: 9
Pages: 1010-7
Publication
First Author: Siednienko J
Year: 2012
Journal: Nat Immunol
Title: Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons.
Volume: 13
Issue: 11
Pages: 1055-62
Publication
First Author: Yoon K
Year: 2008
Journal: Biochem Biophys Res Commun
Title: TRAF6-mediated regulation of the PI3 kinase (PI3K)-Akt-GSK3beta cascade is required for TNF-induced cell survival.
Volume: 371
Issue: 1
Pages: 118-21
Publication
First Author: Mashima R
Year: 2005
Journal: J Biol Chem
Title: FLN29, a novel interferon- and LPS-inducible gene acting as a negative regulator of toll-like receptor signaling.
Volume: 280
Issue: 50
Pages: 41289-97
Publication
First Author: Magilnick N
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: miR-146a-Traf6 regulatory axis controls autoimmunity and myelopoiesis, but is dispensable for hematopoietic stem cell homeostasis and tumor suppression.
Volume: 114
Issue: 34
Pages: E7140-E7149
Publication
First Author: Rosenberger CM
Year: 2017
Journal: PLoS Pathog
Title: miR-144 attenuates the host response to influenza virus by targeting the TRAF6-IRF7 signaling axis.
Volume: 13
Issue: 4
Pages: e1006305
Publication
First Author: Opaluch AM
Year: 2014
Journal: PLoS One
Title: Positive regulation of TRAF6-dependent innate immune responses by protein phosphatase PP1-γ.
Volume: 9
Issue: 2
Pages: e89284
Publication
First Author: Naito A
Year: 1999
Journal: Genes Cells
Title: Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice.
Volume: 4
Issue: 6
Pages: 353-62
Publication
First Author: Varney ME
Year: 2015
Journal: J Exp Med
Title: Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling.
Volume: 212
Issue: 11
Pages: 1967-85
Publication
First Author: Kobayashi N
Year: 2001
Journal: EMBO J
Title: Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis.
Volume: 20
Issue: 6
Pages: 1271-80
Publication
First Author: Noguchi K
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Autoimmune sialadenitis is associated with the upregulation of chemokine/chemokine receptor pairs in T cell-specific TRAF6-deficient mice.
Volume: 504
Issue: 1
Pages: 245-250
Publication
First Author: Geetha T
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Polyubiquitination of the neurotrophin receptor p75 directs neuronal cell survival.
Volume: 421
Issue: 2
Pages: 286-90
Publication
First Author: Ichikawa D
Year: 2006
Journal: Biochem Biophys Res Commun
Title: TNF-receptor associated factor 6-deficient fibroblast is sensitive to the TNF-alpha-induced cell death: involvement of reactive oxygen species.
Volume: 351
Issue: 1
Pages: 93-8
Publication
First Author: Kim E
Year: 2017
Journal: Sci Adv
Title: Inositol polyphosphate multikinase promotes Toll-like receptor-induced inflammation by stabilizing TRAF6.
Volume: 3
Issue: 4
Pages: e1602296
Publication
First Author: Ahonen C
Year: 2002
Journal: Nat Immunol
Title: The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells.
Volume: 3
Issue: 5
Pages: 451-6
Publication
First Author: Honda K
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling.
Volume: 101
Issue: 43
Pages: 15416-21
Publication
First Author: Petroski MD
Year: 2007
Journal: J Biol Chem
Title: Substrate modification with lysine 63-linked ubiquitin chains through the UBC13-UEV1A ubiquitin-conjugating enzyme.
Volume: 282
Issue: 41
Pages: 29936-45
Publication
First Author: Jiao S
Year: 2015
Journal: Nat Immunol
Title: The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6.
Volume: 16
Issue: 3
Pages: 246-57
Publication
First Author: Linares JF
Year: 2013
Journal: Mol Cell
Title: K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells.
Volume: 51
Issue: 3
Pages: 283-96
Publication
First Author: Shembade N
Year: 2007
Journal: EMBO J
Title: Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling.
Volume: 26
Issue: 17
Pages: 3910-22
Publication
First Author: Hu Y
Year: 2011
Journal: J Immunol
Title: Guanylate binding protein 4 negatively regulates virus-induced type I IFN and antiviral response by targeting IFN regulatory factor 7.
Volume: 187
Issue: 12
Pages: 6456-62