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Search results 1 to 100 out of 237 for Trem2

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0.055s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Wu R
Year: 2017
Journal: Mol Brain
Title: TREM2 protects against cerebral ischemia/reperfusion injury.
Volume: 10
Issue: 1
Pages: 20
Publication
First Author: Ulland TK
Year: 2017
Journal: Cell
Title: TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.
Volume: 170
Issue: 4
Pages: 649-663.e13
Publication
First Author: Linnartz-Gerlach B
Year: 2019
Journal: Glia
Title: TREM2 triggers microglial density and age-related neuronal loss.
Volume: 67
Issue: 3
Pages: 539-550
Publication
First Author: Zheng H
Year: 2017
Journal: J Neurosci
Title: TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway.
Volume: 37
Issue: 7
Pages: 1772-1784
Publication
First Author: Zhao Y
Year: 2018
Journal: Neuron
Title: TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.
Volume: 97
Issue: 5
Pages: 1023-1031.e7
Publication
First Author: Cheng-Hathaway PJ
Year: 2018
Journal: Mol Neurodegener
Title: The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.
Volume: 13
Issue: 1
Pages: 29
Publication
First Author: Poliani PL
Year: 2015
Journal: J Clin Invest
Title: TREM2 sustains microglial expansion during aging and response to demyelination.
Volume: 125
Issue: 5
Pages: 2161-70
Publication
First Author: Zhong L
Year: 2017
Journal: J Exp Med
Title: Soluble TREM2 induces inflammatory responses and enhances microglial survival.
Volume: 214
Issue: 3
Pages: 597-607
Publication
First Author: Mazaheri F
Year: 2017
Journal: EMBO Rep
Title: TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.
Volume: 18
Issue: 7
Pages: 1186-1198
Publication
First Author: Lee CYD
Year: 2018
Journal: Neuron
Title: Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models.
Volume: 97
Issue: 5
Pages: 1032-1048.e5
Publication
First Author: Seno H
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Efficient colonic mucosal wound repair requires Trem2 signaling.
Volume: 106
Issue: 1
Pages: 256-61
Publication
First Author: Song WM
Year: 2018
Journal: J Exp Med
Title: Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism.
Volume: 215
Issue: 3
Pages: 745-760
Publication
First Author: Parhizkar S
Year: 2019
Journal: Nat Neurosci
Title: Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.
Volume: 22
Issue: 2
Pages: 191-204
Publication
First Author: Kosack L
Year: 2017
Journal: Sci Rep
Title: The lipid-sensor TREM2 aggravates disease in a model of LCMV-induced hepatitis.
Volume: 7
Issue: 1
Pages: 11289
Publication
First Author: Kleinberger G
Year: 2014
Journal: Sci Transl Med
Title: TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.
Volume: 6
Issue: 243
Pages: 243ra86
Publication
First Author: Xiang X
Year: 2018
Journal: Mol Neurodegener
Title: The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans.
Volume: 13
Issue: 1
Pages: 49
Publication
First Author: Wang Y
Year: 2015
Journal: Cell
Title: TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model.
Volume: 160
Issue: 6
Pages: 1061-71
Publication
First Author: Kim SM
Year: 2017
Journal: Sci Rep
Title: TREM2 promotes Aβ phagocytosis by upregulating C/EBPα-dependent CD36 expression in microglia.
Volume: 7
Issue: 1
Pages: 11118
Publication
First Author: Otero K
Year: 2012
Journal: J Immunol
Title: TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis.
Volume: 188
Issue: 6
Pages: 2612-21
Publication
First Author: Jay TR
Year: 2015
Journal: J Exp Med
Title: TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.
Volume: 212
Issue: 3
Pages: 287-95
Publication
First Author: Filipello F
Year: 2018
Journal: Immunity
Title: The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity.
Volume: 48
Issue: 5
Pages: 979-991.e8
Publication
First Author: Zhong L
Year: 2019
Journal: Nat Commun
Title: Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model.
Volume: 10
Issue: 1
Pages: 1365
Publication
First Author: Cantoni C
Year: 2015
Journal: Acta Neuropathol
Title: TREM2 regulates microglial cell activation in response to demyelination in vivo.
Volume: 129
Issue: 3
Pages: 429-47
Publication
First Author: Leyns CEG
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy.
Volume: 114
Issue: 43
Pages: 11524-11529
Publication  
First Author: Carbajosa G
Year: 2018
Journal: Neurobiol Aging
Title: Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain.
Volume: 69
Pages: 151-166
Publication
First Author: Kleinberger G
Year: 2017
Journal: EMBO J
Title: The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.
Volume: 36
Issue: 13
Pages: 1837-1853
Publication
First Author: Thornton P
Year: 2017
Journal: EMBO Mol Med
Title: TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant.
Volume: 9
Issue: 10
Pages: 1366-1378
Publication
First Author: Sayed FA
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy.
Volume: 115
Issue: 40
Pages: 10172-10177
Publication
First Author: Gonçalves LA
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: TREM2 governs Kupffer cell activation and explains belr1 genetic resistance to malaria liver stage infection.
Volume: 110
Issue: 48
Pages: 19531-6
Publication
First Author: Thrash JC
Year: 2009
Journal: Neurochem Res
Title: Developmental regulation of TREM2 and DAP12 expression in the murine CNS: implications for Nasu-Hakola disease.
Volume: 34
Issue: 1
Pages: 38-45
Publication
First Author: Yuan P
Year: 2016
Journal: Neuron
Title: TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.
Volume: 90
Issue: 4
Pages: 724-39
Publication
First Author: Jiang T
Year: 2015
Journal: Neurobiol Aging
Title: Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice.
Volume: 36
Issue: 12
Pages: 3176-3186
Publication
First Author: Varnum MM
Year: 2017
Journal: J Biol Chem
Title: A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells.
Volume: 292
Issue: 25
Pages: 10651-10663
Publication
First Author: Jay TR
Year: 2017
Journal: J Neurosci
Title: Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease.
Volume: 37
Issue: 3
Pages: 637-647
Publication
First Author: Jiang Y
Year: 2018
Journal: Cell Physiol Biochem
Title: Upregulation of TREM2 Ameliorates Neuroinflammatory Responses and Improves Cognitive Deficits Triggered by Surgical Trauma in Appswe/PS1dE9 Mice.
Volume: 46
Issue: 4
Pages: 1398-1411
Publication
First Author: Zhu C
Year: 2015
Journal: Neurobiol Aging
Title: Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains.
Volume: 36
Issue: 5
Pages: 1994-2003
Publication
First Author: Takahashi K
Year: 2005
Journal: J Exp Med
Title: Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2.
Volume: 201
Issue: 4
Pages: 647-57
Publication
First Author: Atagi Y
Year: 2015
Journal: J Biol Chem
Title: Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).
Volume: 290
Issue: 43
Pages: 26043-50
Publication  
First Author: Zhong L
Year: 2017
Journal: Front Aging Neurosci
Title: TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway.
Volume: 9
Pages: 204
Publication
First Author: Cheng Q
Year: 2018
Journal: J Biol Chem
Title: TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function.
Volume: 293
Issue: 32
Pages: 12620-12633
Publication  
First Author: Ulrich JD
Year: 2014
Journal: Mol Neurodegener
Title: Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2.
Volume: 9
Pages: 20
Publication      
First Author: Kang SS
Year: 2017
Journal: Hum Mol Genet
Title: Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal.
Publication  
First Author: Zheng H
Year: 2016
Journal: Neurobiol Aging
Title: Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation.
Volume: 42
Pages: 132-41
Publication
First Author: Kawabori M
Year: 2015
Journal: J Neurosci
Title: Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke.
Volume: 35
Issue: 8
Pages: 3384-96
Publication  
First Author: Lessard CB
Year: 2018
Journal: EMBO Mol Med
Title: High-affinity interactions and signal transduction between Aβ oligomers and TREM2.
Volume: 10
Issue: 11
Publication
First Author: Jiang T
Year: 2014
Journal: Neurobiol Aging
Title: Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice.
Volume: 35
Issue: 6
Pages: 1243-51
Publication
First Author: Park M
Year: 2015
Journal: Diabetes
Title: Triggering receptor expressed on myeloid cells 2 (TREM2) promotes adipogenesis and diet-induced obesity.
Volume: 64
Issue: 1
Pages: 117-27
Publication
First Author: Zhong L
Year: 2018
Journal: Mol Neurodegener
Title: Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2).
Volume: 13
Issue: 1
Pages: 15
Publication
First Author: Sieber MW
Year: 2013
Journal: PLoS One
Title: Attenuated inflammatory response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice following stroke.
Volume: 8
Issue: 1
Pages: e52982
Publication
First Author: Charles JF
Year: 2008
Journal: Infect Immun
Title: The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12.
Volume: 76
Issue: 6
Pages: 2439-47
Publication
First Author: Krasemann S
Year: 2017
Journal: Immunity
Title: The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.
Volume: 47
Issue: 3
Pages: 566-581.e9
Publication
First Author: Wang Y
Year: 2016
Journal: J Exp Med
Title: TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques.
Volume: 213
Issue: 5
Pages: 667-75
Publication  
First Author: Belloli S
Year: 2017
Journal: Neurobiol Aging
Title: Early upregulation of 18-kDa translocator protein in response to acute neurodegenerative damage in TREM2-deficient mice.
Volume: 53
Pages: 159-168
Publication
First Author: Koth LL
Year: 2010
Journal: J Immunol
Title: DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2.
Volume: 184
Issue: 11
Pages: 6522-8
Publication
First Author: Peng Q
Year: 2010
Journal: Sci Signal
Title: TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1.
Volume: 3
Issue: 122
Pages: ra38
Publication
First Author: Humphrey MB
Year: 2006
Journal: J Bone Miner Res
Title: TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function.
Volume: 21
Issue: 2
Pages: 237-45
Publication
First Author: Kobayashi M
Year: 2016
Journal: J Neurosci
Title: TREM2/DAP12 Signal Elicits Proinflammatory Response in Microglia and Exacerbates Neuropathic Pain.
Volume: 36
Issue: 43
Pages: 11138-11150
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Daws MR
Year: 2001
Journal: Eur J Immunol
Title: Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family.
Volume: 31
Issue: 3
Pages: 783-91
Publication
First Author: Floyd HS
Year: 2006
Journal: Mol Carcinog
Title: Genetic and epigenetic alterations in lung tumors from bitransgenic Ki-rasG12C expressing mice.
Volume: 45
Issue: 7
Pages: 506-17
Publication
First Author: Mlodzianoski MJ
Year: 2018
Journal: Nat Methods
Title: Active PSF shaping and adaptive optics enable volumetric localization microscopy through brain sections.
Volume: 15
Issue: 8
Pages: 583-586
Publication
First Author: Beckmann N
Year: 2018
Journal: Acta Neuropathol Commun
Title: Brain region-specific enhancement of remyelination and prevention of demyelination by the CSF1R kinase inhibitor BLZ945.
Volume: 6
Issue: 1
Pages: 9
Publication
First Author: Prada I
Year: 2006
Journal: Neuroscience
Title: Triggering receptor expressed in myeloid cells 2 (TREM2) trafficking in microglial cells: continuous shuttling to and from the plasma membrane regulated by cell stimulation.
Volume: 140
Issue: 4
Pages: 1139-48
Publication
First Author: Piccio L
Year: 2007
Journal: Eur J Immunol
Title: Blockade of TREM-2 exacerbates experimental autoimmune encephalomyelitis.
Volume: 37
Issue: 5
Pages: 1290-301
Publication
First Author: Chang JH
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Enhanced inhibitory effects of a novel CpG motif on osteoclast differentiation via TREM-2 down-regulation.
Volume: 389
Issue: 1
Pages: 28-33
Publication
First Author: Sun M
Year: 2013
Journal: Invest Ophthalmol Vis Sci
Title: TREM-2 promotes host resistance against Pseudomonas aeruginosa infection by suppressing corneal inflammation via a PI3K/Akt signaling pathway.
Volume: 54
Issue: 5
Pages: 3451-62
GXD Expression      
Probe: MGI:3838121
Assay Type: Northern blot
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3838123
Age: postnatal week 6
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:3838121
Assay Type: Northern blot
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3838123
Age: postnatal day 35
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:3838121
Assay Type: Northern blot
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3838123
Age: postnatal day 30
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3838121
Assay Type: Northern blot
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3838123
Age: postnatal day 20
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3838121
Assay Type: Northern blot
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3838123
Age: postnatal day 15
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3838121
Assay Type: Northern blot
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3838123
Age: postnatal day 5
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3838121
Assay Type: Northern blot
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:3838123
Age: postnatal day 1
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3838121
Assay Type: Northern blot
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:3838123
Age: embryonic day 18.0
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3838121
Assay Type: Northern blot
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:3838123
Age: embryonic day 16.0
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3838121
Assay Type: Northern blot
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689422
Stage: TS22
Assay Id: MGI:3838123
Age: embryonic day 14.0
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3838121
Assay Type: RNA in situ
Annotation Date: 2009-04-01
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1647027
Stage: TS27
Assay Id: MGI:3838137
Age: postnatal day 1
Detected: false
Specimen Num: 5
GXD Expression  
Probe: MGI:3838121
Assay Type: RNA in situ
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647028
Pattern: Single cells
Stage: TS28
Assay Id: MGI:3838137
Age: postnatal day 10
Note: Expression is seen in cells surrounding CNP-positive cells (oligodendrocytes).
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:3838121
Assay Type: RNA in situ
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647027
Pattern: Single cells
Stage: TS27
Assay Id: MGI:3838137
Age: postnatal day 1
Note: Expression is seen in cells surrounding CNP-positive cells (oligodendrocytes).
Detected: true
Specimen Num: 1