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Search results 1 to 100 out of 268 for Trem2

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0.037s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Wu R
Year: 2017
Journal: Mol Brain
Title: TREM2 protects against cerebral ischemia/reperfusion injury.
Volume: 10
Issue: 1
Pages: 20
Publication
First Author: Leyns CEG
Year: 2019
Journal: Nat Neurosci
Title: TREM2 function impedes tau seeding in neuritic plaques.
Volume: 22
Issue: 8
Pages: 1217-1222
Publication
First Author: Ulland TK
Year: 2017
Journal: Cell
Title: TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.
Volume: 170
Issue: 4
Pages: 649-663.e13
Publication
First Author: Linnartz-Gerlach B
Year: 2019
Journal: Glia
Title: TREM2 triggers microglial density and age-related neuronal loss.
Volume: 67
Issue: 3
Pages: 539-550
Publication
First Author: Nugent AA
Year: 2020
Journal: Neuron
Title: TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge.
Volume: 105
Issue: 5
Pages: 837-854.e9
Publication
First Author: Zheng H
Year: 2017
Journal: J Neurosci
Title: TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway.
Volume: 37
Issue: 7
Pages: 1772-1784
Publication
First Author: Liu Z
Year: 2020
Journal: Cell Death Dis
Title: TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities.
Volume: 11
Issue: 8
Pages: 678
Publication
First Author: Zhao Y
Year: 2018
Journal: Neuron
Title: TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.
Volume: 97
Issue: 5
Pages: 1023-1031.e7
Publication
First Author: Cheng-Hathaway PJ
Year: 2018
Journal: Mol Neurodegener
Title: The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.
Volume: 13
Issue: 1
Pages: 29
Publication
First Author: Poliani PL
Year: 2015
Journal: J Clin Invest
Title: TREM2 sustains microglial expansion during aging and response to demyelination.
Volume: 125
Issue: 5
Pages: 2161-70
Publication
First Author: Zhong L
Year: 2017
Journal: J Exp Med
Title: Soluble TREM2 induces inflammatory responses and enhances microglial survival.
Volume: 214
Issue: 3
Pages: 597-607
Publication
First Author: Lee CYD
Year: 2018
Journal: Neuron
Title: Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models.
Volume: 97
Issue: 5
Pages: 1032-1048.e5
Publication
First Author: Mazaheri F
Year: 2017
Journal: EMBO Rep
Title: TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.
Volume: 18
Issue: 7
Pages: 1186-1198
Publication
First Author: Seno H
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Efficient colonic mucosal wound repair requires Trem2 signaling.
Volume: 106
Issue: 1
Pages: 256-61
Publication
First Author: Kleinberger G
Year: 2014
Journal: Sci Transl Med
Title: TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.
Volume: 6
Issue: 243
Pages: 243ra86
Publication
First Author: Song WM
Year: 2018
Journal: J Exp Med
Title: Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism.
Volume: 215
Issue: 3
Pages: 745-760
Publication
First Author: Parhizkar S
Year: 2019
Journal: Nat Neurosci
Title: Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.
Volume: 22
Issue: 2
Pages: 191-204
Publication
First Author: Jay TR
Year: 2019
Journal: Glia
Title: TREM2 is required for microglial instruction of astrocytic synaptic engulfment in neurodevelopment.
Volume: 67
Issue: 10
Pages: 1873-1892
Publication
First Author: Kosack L
Year: 2017
Journal: Sci Rep
Title: The lipid-sensor TREM2 aggravates disease in a model of LCMV-induced hepatitis.
Volume: 7
Issue: 1
Pages: 11289
Publication
First Author: Xiang X
Year: 2018
Journal: Mol Neurodegener
Title: The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans.
Volume: 13
Issue: 1
Pages: 49
Publication
First Author: Griciuc A
Year: 2019
Journal: Neuron
Title: TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease.
Volume: 103
Issue: 5
Pages: 820-835.e7
Publication
First Author: Guo Y
Year: 2019
Journal: FASEB J
Title: TREM2 deficiency aggravates α-synuclein-induced neurodegeneration and neuroinflammation in Parkinson's disease models.
Volume: 33
Issue: 11
Pages: 12164-12174
Publication
First Author: Kim SM
Year: 2017
Journal: Sci Rep
Title: TREM2 promotes Aβ phagocytosis by upregulating C/EBPα-dependent CD36 expression in microglia.
Volume: 7
Issue: 1
Pages: 11118
Publication
First Author: Wang Y
Year: 2015
Journal: Cell
Title: TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model.
Volume: 160
Issue: 6
Pages: 1061-71
Publication  
First Author: Jiang T
Year: 2016
Journal: Neuropharmacology
Title: TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice.
Volume: 105
Pages: 196-206
Publication
First Author: Otero K
Year: 2012
Journal: J Immunol
Title: TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis.
Volume: 188
Issue: 6
Pages: 2612-21
Publication
First Author: Filipello F
Year: 2018
Journal: Immunity
Title: The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity.
Volume: 48
Issue: 5
Pages: 979-991.e8
Publication
First Author: Zhong L
Year: 2019
Journal: Nat Commun
Title: Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model.
Volume: 10
Issue: 1
Pages: 1365
Publication
First Author: Jay TR
Year: 2015
Journal: J Exp Med
Title: TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.
Volume: 212
Issue: 3
Pages: 287-95
Publication
First Author: Cantoni C
Year: 2015
Journal: Acta Neuropathol
Title: TREM2 regulates microglial cell activation in response to demyelination in vivo.
Volume: 129
Issue: 3
Pages: 429-47
Publication
First Author: Kleinberger G
Year: 2017
Journal: EMBO J
Title: The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.
Volume: 36
Issue: 13
Pages: 1837-1853
Publication
First Author: Thornton P
Year: 2017
Journal: EMBO Mol Med
Title: TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant.
Volume: 9
Issue: 10
Pages: 1366-1378
Publication
First Author: Leyns CEG
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy.
Volume: 114
Issue: 43
Pages: 11524-11529
Publication  
First Author: Carbajosa G
Year: 2018
Journal: Neurobiol Aging
Title: Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain.
Volume: 69
Pages: 151-166
Publication
First Author: Bemiller SM
Year: 2017
Journal: Mol Neurodegener
Title: TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy.
Volume: 12
Issue: 1
Pages: 74
Publication
First Author: Price BR
Year: 2020
Journal: J Neuroinflammation
Title: Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition.
Volume: 17
Issue: 1
Pages: 238
Publication
First Author: Liu C
Year: 2019
Journal: J Transl Med
Title: TREM2 regulates obesity-induced insulin resistance via adipose tissue remodeling in mice of high-fat feeding.
Volume: 17
Issue: 1
Pages: 300
Publication
First Author: Bhattacharjee S
Year: 2016
Journal: PLoS One
Title: microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration.
Volume: 11
Issue: 3
Pages: e0150211
Publication
First Author: Gonçalves LA
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: TREM2 governs Kupffer cell activation and explains belr1 genetic resistance to malaria liver stage infection.
Volume: 110
Issue: 48
Pages: 19531-6
Publication  
First Author: Götzl JK
Year: 2019
Journal: EMBO Mol Med
Title: Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism.
Volume: 11
Issue: 6
Publication
First Author: Sayed FA
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy.
Volume: 115
Issue: 40
Pages: 10172-10177
Publication
First Author: Yuan P
Year: 2016
Journal: Neuron
Title: TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.
Volume: 90
Issue: 4
Pages: 724-39
Publication
First Author: Thrash JC
Year: 2009
Journal: Neurochem Res
Title: Developmental regulation of TREM2 and DAP12 expression in the murine CNS: implications for Nasu-Hakola disease.
Volume: 34
Issue: 1
Pages: 38-45
Publication
First Author: Jiang T
Year: 2015
Journal: Neurobiol Aging
Title: Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice.
Volume: 36
Issue: 12
Pages: 3176-3186
Publication
First Author: Varnum MM
Year: 2017
Journal: J Biol Chem
Title: A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells.
Volume: 292
Issue: 25
Pages: 10651-10663
Publication
First Author: Jay TR
Year: 2017
Journal: J Neurosci
Title: Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease.
Volume: 37
Issue: 3
Pages: 637-647
Publication
First Author: Jiang Y
Year: 2018
Journal: Cell Physiol Biochem
Title: Upregulation of TREM2 Ameliorates Neuroinflammatory Responses and Improves Cognitive Deficits Triggered by Surgical Trauma in Appswe/PS1dE9 Mice.
Volume: 46
Issue: 4
Pages: 1398-1411
Publication  
First Author: Lefterov I
Year: 2015
Journal: Neurobiol Dis
Title: RNA-sequencing reveals transcriptional up-regulation of Trem2 in response to bexarotene treatment.
Volume: 82
Pages: 132-140
Publication
First Author: Sheng L
Year: 2019
Journal: FASEB J
Title: Microglial Trem2 induces synaptic impairment at early stage and prevents amyloidosis at late stage in APP/PS1 mice.
Volume: 33
Issue: 9
Pages: 10425-10442
Publication
First Author: Meilandt WJ
Year: 2020
Journal: J Neurosci
Title: Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model.
Volume: 40
Issue: 9
Pages: 1956-1974
Publication  
First Author: Castranio EL
Year: 2017
Journal: Neurobiol Dis
Title: Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury.
Volume: 105
Pages: 1-14
Publication
First Author: Zhou Y
Year: 2020
Journal: Nat Med
Title: Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease.
Volume: 26
Issue: 1
Pages: 131-142
Publication
First Author: Zhu C
Year: 2015
Journal: Neurobiol Aging
Title: Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains.
Volume: 36
Issue: 5
Pages: 1994-2003
Publication  
First Author: Qu W
Year: 2018
Journal: Front Immunol
Title: Triggering Receptors Expressed on Myeloid Cells 2 Promotes Corneal Resistance Against Pseudomonas aeruginosa by Inhibiting Caspase-1-Dependent Pyroptosis.
Volume: 9
Pages: 1121
Publication
First Author: Takahashi K
Year: 2005
Journal: J Exp Med
Title: Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2.
Volume: 201
Issue: 4
Pages: 647-57
Publication
First Author: Sudom A
Year: 2018
Journal: J Biol Chem
Title: Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.
Volume: 293
Issue: 32
Pages: 12634-12646
Publication  
First Author: Ulrich JD
Year: 2014
Journal: Mol Neurodegener
Title: Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2.
Volume: 9
Pages: 20
Publication  
First Author: Zhong L
Year: 2017
Journal: Front Aging Neurosci
Title: TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway.
Volume: 9
Pages: 204
Publication
First Author: Atagi Y
Year: 2015
Journal: J Biol Chem
Title: Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).
Volume: 290
Issue: 43
Pages: 26043-50
Publication      
First Author: Kang SS
Year: 2017
Journal: Hum Mol Genet
Title: Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal.
Publication
First Author: Saber M
Year: 2017
Journal: J Neurotrauma
Title: Triggering Receptor Expressed on Myeloid Cells 2 Deficiency Alters Acute Macrophage Distribution and Improves Recovery after Traumatic Brain Injury.
Volume: 34
Issue: 2
Pages: 423-435
Publication
First Author: Kawabori M
Year: 2015
Journal: J Neurosci
Title: Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke.
Volume: 35
Issue: 8
Pages: 3384-96
Publication  
First Author: Lessard CB
Year: 2018
Journal: EMBO Mol Med
Title: High-affinity interactions and signal transduction between Aβ oligomers and TREM2.
Volume: 10
Issue: 11
Publication
First Author: Jiang T
Year: 2014
Journal: Neurobiol Aging
Title: Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice.
Volume: 35
Issue: 6
Pages: 1243-51
Publication
First Author: Park M
Year: 2015
Journal: Diabetes
Title: Triggering receptor expressed on myeloid cells 2 (TREM2) promotes adipogenesis and diet-induced obesity.
Volume: 64
Issue: 1
Pages: 117-27
Publication
First Author: Cheng Q
Year: 2018
Journal: J Biol Chem
Title: TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function.
Volume: 293
Issue: 32
Pages: 12620-12633
Publication
First Author: Jaitin DA
Year: 2019
Journal: Cell
Title: Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner.
Volume: 178
Issue: 3
Pages: 686-698.e14
Publication
First Author: Zhong L
Year: 2018
Journal: Mol Neurodegener
Title: Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2).
Volume: 13
Issue: 1
Pages: 15
Publication
First Author: Sieber MW
Year: 2013
Journal: PLoS One
Title: Attenuated inflammatory response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice following stroke.
Volume: 8
Issue: 1
Pages: e52982
Publication
First Author: Krasemann S
Year: 2017
Journal: Immunity
Title: The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.
Volume: 47
Issue: 3
Pages: 566-581.e9
Publication  
First Author: Zheng H
Year: 2016
Journal: Neurobiol Aging
Title: Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation.
Volume: 42
Pages: 132-41
Publication  
First Author: Belloli S
Year: 2017
Journal: Neurobiol Aging
Title: Early upregulation of 18-kDa translocator protein in response to acute neurodegenerative damage in TREM2-deficient mice.
Volume: 53
Pages: 159-168
Publication
First Author: Zhou J
Year: 2019
Journal: Neurochem Res
Title: Imbalance of Microglial TLR4/TREM2 in LPS-Treated APP/PS1 Transgenic Mice: A Potential Link Between Alzheimer's Disease and Systemic Inflammation.
Volume: 44
Issue: 5
Pages: 1138-1151
Publication
First Author: Charles JF
Year: 2008
Journal: Infect Immun
Title: The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12.
Volume: 76
Issue: 6
Pages: 2439-47
Publication
First Author: Wang Y
Year: 2016
Journal: J Exp Med
Title: TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques.
Volume: 213
Issue: 5
Pages: 667-75
Publication
First Author: Koth LL
Year: 2010
Journal: J Immunol
Title: DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2.
Volume: 184
Issue: 11
Pages: 6522-8
Publication
First Author: Anderson SR
Year: 2019
Journal: Cell Rep
Title: Developmental Apoptosis Promotes a Disease-Related Gene Signature and Independence from CSF1R Signaling in Retinal Microglia.
Volume: 27
Issue: 7
Pages: 2002-2013.e5
Publication
First Author: Peng Q
Year: 2010
Journal: Sci Signal
Title: TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1.
Volume: 3
Issue: 122
Pages: ra38
Publication
First Author: Humphrey MB
Year: 2006
Journal: J Bone Miner Res
Title: TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function.
Volume: 21
Issue: 2
Pages: 237-45
Publication
First Author: Kobayashi M
Year: 2016
Journal: J Neurosci
Title: TREM2/DAP12 Signal Elicits Proinflammatory Response in Microglia and Exacerbates Neuropathic Pain.
Volume: 36
Issue: 43
Pages: 11138-11150
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus