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Search results 1 to 100 out of 155 for Trex1

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Yang YG
Year: 2007
Journal: Cell
Title: Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease.
Volume: 131
Issue: 5
Pages: 873-86
Publication
First Author: Mazur DJ
Year: 2001
Journal: J Biol Chem
Title: Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins.
Volume: 276
Issue: 20
Pages: 17022-9
Publication
First Author: Pereira-Lopes S
Year: 2013
Journal: J Immunol
Title: The exonuclease Trex1 restrains macrophage proinflammatory activation.
Volume: 191
Issue: 12
Pages: 6128-35
Publication
First Author: Mazur DJ
Year: 1999
Journal: J Biol Chem
Title: Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases.
Volume: 274
Issue: 28
Pages: 19655-60
Publication
First Author: Stetson DB
Year: 2008
Journal: Cell
Title: Trex1 prevents cell-intrinsic initiation of autoimmunity.
Volume: 134
Issue: 4
Pages: 587-98
Publication  
First Author: Vanpouille-Box C
Year: 2017
Journal: Nat Commun
Title: DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity.
Volume: 8
Pages: 15618
Publication
First Author: Brucet M
Year: 2007
Journal: J Biol Chem
Title: Structure of the dimeric exonuclease TREX1 in complex with DNA displays a proline-rich binding site for WW Domains.
Volume: 282
Issue: 19
Pages: 14547-57
Publication
First Author: de Silva U
Year: 2007
Journal: J Biol Chem
Title: The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering.
Volume: 282
Issue: 14
Pages: 10537-43
Publication
First Author: Hasan M
Year: 2013
Journal: Nat Immunol
Title: Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes.
Volume: 14
Issue: 1
Pages: 61-71
Publication
First Author: Peschke K
Year: 2016
Journal: J Immunol
Title: Loss of Trex1 in Dendritic Cells Is Sufficient To Trigger Systemic Autoimmunity.
Volume: 197
Issue: 6
Pages: 2157-66
Publication
First Author: Achleitner M
Year: 2017
Journal: J Immunol
Title: Lack of Trex1 Causes Systemic Autoimmunity despite the Presence of Antiretroviral Drugs.
Volume: 199
Issue: 7
Pages: 2261-2269
Publication
First Author: Rice G
Year: 2007
Journal: Am J Hum Genet
Title: Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome.
Volume: 80
Issue: 4
Pages: 811-5
Publication
First Author: Lee-Kirsch MA
Year: 2007
Journal: Nat Genet
Title: Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.
Volume: 39
Issue: 9
Pages: 1065-7
Publication  
First Author: Xiao N
Year: 2019
Journal: J Autoimmun
Title: cGAS activation causes lupus-like autoimmune disorders in a TREX1 mutant mouse model.
Volume: 100
Pages: 84-94
Publication
First Author: Jütte BB
Year: 2021
Journal: iScience
Title: Intercellular cGAMP transmission induces innate immune activation and tissue inflammation in Trex1 deficiency.
Volume: 24
Issue: 8
Pages: 102833
Publication
First Author: Morita M
Year: 2004
Journal: Mol Cell Biol
Title: Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis.
Volume: 24
Issue: 15
Pages: 6719-27
Publication
First Author: Yan N
Year: 2010
Journal: Nat Immunol
Title: The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1.
Volume: 11
Issue: 11
Pages: 1005-13
Publication
First Author: Lindahl T
Year: 2009
Journal: Biochem Soc Trans
Title: Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease.
Volume: 37
Issue: Pt 3
Pages: 535-8
Publication
First Author: Grieves JL
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease.
Volume: 112
Issue: 16
Pages: 5117-22
Publication
First Author: Hasan M
Year: 2015
Journal: Immunity
Title: Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation.
Volume: 43
Issue: 3
Pages: 463-74
Publication
First Author: Xu J
Year: 2014
Journal: J Leukoc Biol
Title: TLR ligands up-regulate Trex1 expression in murine conventional dendritic cells through type I Interferon and NF-κB-dependent signaling pathways.
Volume: 96
Issue: 1
Pages: 93-103
Publication
First Author: Venkatadri R
Year: 2022
Journal: Eur J Immunol
Title: Targeting Bcl6 in the TREX1 D18N murine model ameliorates autoimmunity by modulating T-follicular helper cells and germinal center B cells.
Volume: 52
Issue: 5
Pages: 825-834
Publication
First Author: Gehrke N
Year: 2013
Journal: Immunity
Title: Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing.
Volume: 39
Issue: 3
Pages: 482-95
Publication
First Author: Huang KW
Year: 2018
Journal: PLoS Biol
Title: Structural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1.
Volume: 16
Issue: 5
Pages: e2005653
Publication
First Author: Gray EE
Year: 2015
Journal: J Immunol
Title: Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi-Goutières Syndrome.
Volume: 195
Issue: 5
Pages: 1939-43
Publication
First Author: Elsner C
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Absence of cGAS-mediated type I IFN responses in HIV-1-infected T cells.
Volume: 117
Issue: 32
Pages: 19475-19486
Publication  
First Author: Schubert N
Year: 2022
Journal: Front Immunol
Title: Genome Replication Is Associated With Release of Immunogenic DNA Waste.
Volume: 13
Pages: 880413
Publication
First Author: Gall A
Year: 2012
Journal: Immunity
Title: Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease.
Volume: 36
Issue: 1
Pages: 120-31
Publication
First Author: Xiong TC
Year: 2022
Journal: Nat Commun
Title: The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS.
Volume: 13
Issue: 1
Pages: 5973
Publication
First Author: Christmann M
Year: 2010
Journal: Nucleic Acids Res
Title: Three prime exonuclease I (TREX1) is Fos/AP-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damage.
Volume: 38
Issue: 19
Pages: 6418-32
Publication
First Author: Gao D
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases.
Volume: 112
Issue: 42
Pages: E5699-705
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Ullah TR
Year: 2023
Journal: Nat Commun
Title: Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection.
Volume: 14
Issue: 1
Pages: 5666
Publication
First Author: Beck-Engeser GB
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Early onset of autoimmune disease by the retroviral integrase inhibitor raltegravir.
Volume: 106
Issue: 49
Pages: 20865-70
Publication
First Author: Scholtissek B
Year: 2017
Journal: J Invest Dermatol
Title: Immunostimulatory Endogenous Nucleic Acids Drive the Lesional Inflammation in Cutaneous Lupus Erythematosus.
Volume: 137
Issue: 7
Pages: 1484-1492
Publication
First Author: Peschke K
Year: 2014
Journal: J Invest Dermatol
Title: Deregulated type I IFN response in TREX1-associated familial chilblain lupus.
Volume: 134
Issue: 5
Pages: 1456-1459
GXD Expression    
Probe: MGI:7388370
Assay Type: RT-PCR
Annotation Date: 2022-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783824
Stage: TS24
Assay Id: MGI:7388380
Age: embryonic day 16.5
Image: 6
Specimen Label: Control
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7388370
Assay Type: RT-PCR
Annotation Date: 2022-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783824
Stage: TS24
Assay Id: MGI:7388380
Age: embryonic day 16.5
Image: 6
Specimen Label: Mafg<-/->:Mafk<-/->
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7461748
Assay Type: RT-PCR
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3673015
Stage: TS15
Assay Id: MGI:7461775
Age: embryonic day 9.5
Specimen Label: Tbx5+/-
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7461748
Assay Type: RT-PCR
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3673015
Stage: TS15
Assay Id: MGI:7461775
Age: embryonic day 9.5
Specimen Label: Osr1+/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7461748
Assay Type: RT-PCR
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3673015
Stage: TS15
Assay Id: MGI:7461775
Age: embryonic day 9.5
Specimen Label: Tbx5+/-;Osr1+/-
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:7461748
Assay Type: RT-PCR
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3673015
Stage: TS15
Assay Id: MGI:7461775
Age: embryonic day 9.5
Specimen Label: WT
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:7461748
Assay Type: RT-PCR
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3673015
Stage: TS15
Assay Id: MGI:7461779
Age: embryonic day 9.5
Specimen Label: Osr1-/-
Detected: true
Specimen Num: 1
Publication
First Author: Zhang Q
Year: 2020
Journal: Cell Res
Title: USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity.
Volume: 30
Issue: 10
Pages: 914-927
Publication
First Author: Liu ZS
Year: 2019
Journal: Nat Immunol
Title: G3BP1 promotes DNA binding and activation of cGAS.
Volume: 20
Issue: 1
Pages: 18-28
Publication
First Author: Vincent J
Year: 2017
Journal: Nat Commun
Title: Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.
Volume: 8
Issue: 1
Pages: 750
Publication  
First Author: Ahn J
Year: 2014
Journal: Nat Commun
Title: Inflammation-driven carcinogenesis is mediated through STING.
Volume: 5
Pages: 5166
Publication
First Author: Zang Y
Year: 2014
Journal: J Immunol
Title: Conservation of pathogenic TCR homology across class II restrictions in anti-ribonucleoprotein autoimmunity: extended efficacy of T cell vaccine therapy.
Volume: 192
Issue: 9
Pages: 4093-102
Publication
First Author: Li S
Year: 2018
Journal: Cell Rep
Title: The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING.
Volume: 25
Issue: 12
Pages: 3405-3421.e7
Publication
First Author: Schimenti JC
Year: 1999
Journal: Mamm Genome
Title: ORFless, intronless, and mutant transcription units in the mouse t complex responder (Tcr) locus.
Volume: 10
Issue: 10
Pages: 969-76
Publication
First Author: Maltbaek JH
Year: 2022
Journal: Immunity
Title: ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP.
Volume: 55
Issue: 10
Pages: 1799-1812.e4
Publication
First Author: McIntyre RE
Year: 2016
Journal: G3 (Bethesda)
Title: A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice.
Volume: 6
Issue: 8
Pages: 2343-54
Publication
First Author: Sun C
Year: 2013
Journal: PLoS One
Title: Filamin-A regulates neutrophil uropod retraction through RhoA during chemotaxis.
Volume: 8
Issue: 10
Pages: e79009
Publication
First Author: Behrendt R
Year: 2013
Journal: Cell Rep
Title: Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response.
Volume: 4
Issue: 4
Pages: 689-96
Publication
First Author: Jiao H
Year: 2022
Journal: Nature
Title: ADAR1 averts fatal type I interferon induction by ZBP1.
Volume: 607
Issue: 7920
Pages: 776-783
Publication
First Author: Jakobsen MR
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication.
Volume: 110
Issue: 48
Pages: E4571-80
Publication
First Author: Lee MN
Year: 2013
Journal: Nat Immunol
Title: Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach.
Volume: 14
Issue: 2
Pages: 179-85
Publication
First Author: Gray EE
Year: 2016
Journal: Immunity
Title: The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA.
Volume: 45
Issue: 2
Pages: 255-66
Publication
First Author: Ahn J
Year: 2018
Journal: Cancer Cell
Title: Extrinsic Phagocyte-Dependent STING Signaling Dictates the Immunogenicity of Dying Cells.
Volume: 33
Issue: 5
Pages: 862-873.e5
Publication
First Author: Hubbard NW
Year: 2022
Journal: Nature
Title: ADAR1 mutation causes ZBP1-dependent immunopathology.
Volume: 607
Issue: 7920
Pages: 769-775
Publication
First Author: Hasan M
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism.
Volume: 114
Issue: 4
Pages: 746-751
Publication
First Author: Yoshioka K
Year: 2006
Journal: Mol Cell
Title: ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts.
Volume: 22
Issue: 4
Pages: 501-10
Publication  
First Author: Patel SD
Year: 2022
Journal: Front Cell Dev Biol
Title: Deficiency of the bZIP transcription factors Mafg and Mafk causes misexpression of genes in distinct pathways and results in lens embryonic developmental defects.
Volume: 10
Pages: 981893
Publication
First Author: Bürckstümmer T
Year: 2009
Journal: Nat Immunol
Title: An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome.
Volume: 10
Issue: 3
Pages: 266-72
Publication
First Author: Zhang KK
Year: 2016
Journal: Hum Mol Genet
Title: Gene network and familial analyses uncover a gene network involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial septation.
Volume: 25
Issue: 6
Pages: 1140-51
Publication
First Author: Kenney-Hunt JP
Year: 2006
Journal: Mamm Genome
Title: Quantitative trait loci for body size components in mice.
Volume: 17
Issue: 6
Pages: 526-37
Publication      
First Author: European Mouse Mutant Archive
Year: 2003
Journal: Unpublished
Title: Information obtained from the European Mouse Mutant Archive (EMMA)
Publication      
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
Publication      
First Author: The Jackson Laboratory
Year: 2005
Journal: Unpublished
Title: Information obtained from The Jackson Laboratory, Bar Harbor, ME
Publication      
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
Publication
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
Publication      
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project