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Search results 1 to 100 out of 517 for Trh

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Type Details Score
Gene
Type: gene
Organism: Not Specified
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: This family consists of several thyrotropin-releasing hormone (TRH) proteins. Thyrotropin-Releasing Hormone (TRH) is a tripeptide (pGlu-His-Pro-NH2) hormone that is primarily produced in the paraventricular nucleus of the hypothalamus and represents the most proximal member of the hypothalamic-pituitary-thyroid (HPT) axis. It plays an important role in maintaining the thyroid hormone (TH) homeostasis [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
GXD Expression  
Probe: MGI:3759830
Assay Type: RNA in situ
Annotation Date: 2008-06-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1625013
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:3790868
Age: embryonic day 8.0-8.5
Image: Trh
Specimen Label: Trh
Detected: true
Specimen Num: 1
Publication
First Author: Chiamolera MI
Year: 2009
Journal: Endocrinology
Title: Minireview: Thyrotropin-releasing hormone and the thyroid hormone feedback mechanism.
Volume: 150
Issue: 3
Pages: 1091-6
Publication
First Author: Nakajima Y
Year: 2012
Journal: PLoS One
Title: NR4A1 (Nur77) mediates thyrotropin-releasing hormone-induced stimulation of transcription of the thyrotropin β gene: analysis of TRH knockout mice.
Volume: 7
Issue: 7
Pages: e40437
Protein
Organism: Mus musculus/domesticus
Length: 256  
Fragment?: false
Publication
First Author: Harder S
Year: 2001
Journal: Endocrinology
Title: Regulator of G protein signaling 4 suppresses basal and thyrotropin releasing-hormone (TRH)-stimulated signaling by two mouse TRH receptors, TRH-R(1) and TRH-R(2).
Volume: 142
Issue: 3
Pages: 1188-94
Publication  
First Author: Martínez-Armenta M
Year: 2015
Journal: Mol Cell Endocrinol
Title: TGFβ2 regulates hypothalamic Trh expression through the TGFβ inducible early gene-1 (TIEG1) during fetal development.
Volume: 400
Pages: 129-39
Publication
First Author: Decherf S
Year: 2013
Journal: Mol Cell Endocrinol
Title: Retinoic X receptor subtypes exert differential effects on the regulation of Trh transcription.
Volume: 381
Issue: 1-2
Pages: 115-23
Publication
First Author: Guissouma H
Year: 2006
Journal: Neurosci Lett
Title: In vivo siRNA delivery to the mouse hypothalamus confirms distinct roles of TR beta isoforms in regulating TRH transcription.
Volume: 406
Issue: 3
Pages: 240-3
Publication
First Author: Kinoshita K
Year: 1995
Journal: Br J Pharmacol
Title: Anti-ataxic effects of TRH and its analogue, TA-0910, in Rolling mouse Nagoya by metabolic normalization of the ventral tegmental area.
Volume: 116
Issue: 8
Pages: 3274-8
GXD Expression    
Probe: MGI:6185774
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191501
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Trh
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6185774
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191501
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Trh
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6185774
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191501
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Trh
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6185774
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191501
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Trh
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6185774
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191501
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Trh
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6185774
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191501
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Trh
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6185774
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191501
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Trh
Detected: true
Specimen Num: 7
Publication
First Author: Yamada M
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Tertiary hypothyroidism and hyperglycemia in mice with targeted disruption of the thyrotropin-releasing hormone gene.
Volume: 94
Issue: 20
Pages: 10862-7
Publication
First Author: Yamada M
Year: 1999
Journal: Endocrinology
Title: Abundance of cyclo (His-Pro)-like immunoreactivity in the brain of TRH-deficient mice.
Volume: 140
Issue: 1
Pages: 538-41
Publication  
First Author: Watanave M
Year: 2018
Journal: Front Cell Neurosci
Title: Contribution of Thyrotropin-Releasing Hormone to Cerebellar Long-Term Depression and Motor Learning.
Volume: 12
Pages: 490
Publication
First Author: Hashida T
Year: 2002
Journal: Endocrinology
Title: A novel TRH-PFTAIRE protein kinase 1 pathway in the cerebellum: subtractive hybridization analysis of TRH-deficient mice.
Volume: 143
Issue: 7
Pages: 2808-11
Publication
First Author: Yamada M
Year: 2006
Journal: Endocrinology
Title: Prolactin secretion in mice with thyrotropin-releasing hormone deficiency.
Volume: 147
Issue: 5
Pages: 2591-6
Publication
First Author: Nikrodhanond AA
Year: 2006
Journal: J Biol Chem
Title: Dominant role of thyrotropin-releasing hormone in the hypothalamic-pituitary-thyroid axis.
Volume: 281
Issue: 8
Pages: 5000-7
Publication
First Author: Shibusawa N
Year: 2000
Journal: Mol Endocrinol
Title: Requirement of thyrotropin-releasing hormone for the postnatal functions of pituitary thyrotrophs: ontogeny study of congenital tertiary hypothyroidism in mice.
Volume: 14
Issue: 1
Pages: 137-46
Publication  
First Author: Tsuneoka Y
Year: 2022
Journal: eNeuro
Title: Oxytocin Facilitates Allomaternal Behavior under Stress in Laboratory Mice.
Volume: 9
Issue: 1
Allele
Name: thyrotropin releasing hormone; targeted mutation 1, Makoto M Taketo
Allele Type: Targeted
Attribute String: Null/knockout
Publication
First Author: Katakami H
Year: 1984
Journal: J Endocrinol Invest
Title: Hypothalamic hypothyroidism due to isolated thyrotropin-releasing hormone (TRH) deficiency.
Volume: 7
Issue: 3
Pages: 231-3
Publication
First Author: Kwon JT
Year: 2021
Journal: Nature
Title: An amygdala circuit that suppresses social engagement.
Volume: 593
Issue: 7857
Pages: 114-118
Publication
First Author: Satoh T
Year: 1992
Journal: Brain Res Mol Brain Res
Title: Cloning of the mouse hypothalamic preprothyrotropin-releasing hormone (TRH) cDNA and tissue distribution of its mRNA.
Volume: 14
Issue: 1-2
Pages: 131-5
Publication
First Author: Hara J
Year: 2009
Journal: J Neurosci
Title: Thyrotropin-releasing hormone increases behavioral arousal through modulation of hypocretin/orexin neurons.
Volume: 29
Issue: 12
Pages: 3705-14
Publication
First Author: Zhang X
Year: 2012
Journal: J Neurosci
Title: Thyrotropin-releasing hormone (TRH) inhibits melanin-concentrating hormone neurons: implications for TRH-mediated anorexic and arousal actions.
Volume: 32
Issue: 9
Pages: 3032-43
Publication
First Author: Zeng H
Year: 2007
Journal: Mol Endocrinol
Title: Thyrotropin-releasing hormone receptor 1-deficient mice display increased depression and anxiety-like behavior.
Volume: 21
Issue: 11
Pages: 2795-804
Publication
First Author: Pérez-Monter C
Year: 2011
Journal: Mol Cell Endocrinol
Title: The Krüppel-like factor 4 controls biosynthesis of thyrotropin-releasing hormone during hypothalamus development.
Volume: 333
Issue: 2
Pages: 127-33
Publication
First Author: Chiappini F
Year: 2013
Journal: Mol Cell Endocrinol
Title: Family members CREB and CREM control thyrotropin-releasing hormone (TRH) expression in the hypothalamus.
Volume: 365
Issue: 1
Pages: 84-94
Publication
First Author: Nillni EA
Year: 2002
Journal: J Biol Chem
Title: Deficiencies in pro-thyrotropin-releasing hormone processing and abnormalities in thermoregulation in Cpefat/fat mice.
Volume: 277
Issue: 50
Pages: 48587-95
Publication
First Author: Waniek A
Year: 2015
Journal: Biochim Biophys Acta
Title: Identification of thyrotropin-releasing hormone as hippocampal glutaminyl cyclase substrate in neurons and reactive astrocytes.
Volume: 1852
Issue: 1
Pages: 146-55
Publication
First Author: Chung S
Year: 2012
Journal: Endocrinology
Title: Disruption of the melanin-concentrating hormone receptor 1 (MCH1R) affects thyroid function.
Volume: 153
Issue: 12
Pages: 6145-54
Publication
First Author: McKnight KD
Year: 2007
Journal: Dev Dyn
Title: Dynamic expression of thyrotropin-releasing hormone in the mouse definitive endoderm.
Volume: 236
Issue: 10
Pages: 2909-17
Publication
First Author: Gotoh K
Year: 2013
Journal: J Neurochem
Title: Nesfatin-1, corticotropin-releasing hormone, thyrotropin-releasing hormone, and neuronal histamine interact in the hypothalamus to regulate feeding behavior.
Volume: 124
Issue: 1
Pages: 90-9
Publication
First Author: Thirunarayanan N
Year: 2013
Journal: Neuropsychopharmacology
Title: Thyrotropin-releasing hormone receptor type 1 (TRH-R1), not TRH-R2, primarily mediates taltirelin actions in the CNS of mice.
Volume: 38
Issue: 6
Pages: 950-6
Publication
First Author: Valli E
Year: 2023
Journal: FASEB J
Title: Hypothyroidism-associated immunosuppression involves induction of galectin-1-producing regulatory T cells.
Volume: 37
Issue: 4
Pages: e22865
Publication
First Author: Grzelka K
Year: 2023
Journal: Cell Metab
Title: A synaptic amplifier of hunger for regaining body weight in the hypothalamus.
Volume: 35
Issue: 5
Pages: 770-785.e5
Publication
First Author: Horn S
Year: 2013
Journal: Endocrinology
Title: Tetrac can replace thyroid hormone during brain development in mouse mutants deficient in the thyroid hormone transporter mct8.
Volume: 154
Issue: 2
Pages: 968-79
Publication
First Author: Fonseca TL
Year: 2013
Journal: J Clin Invest
Title: Coordination of hypothalamic and pituitary T3 production regulates TSH expression.
Volume: 123
Issue: 4
Pages: 1492-500
Publication
First Author: Dupré SM
Year: 2004
Journal: Endocrinology
Title: Both thyroid hormone receptor (TR)beta 1 and TR beta 2 isoforms contribute to the regulation of hypothalamic thyrotropin-releasing hormone.
Volume: 145
Issue: 5
Pages: 2337-45
Publication
First Author: Sun Y
Year: 2012
Journal: Nat Genet
Title: Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement.
Volume: 44
Issue: 12
Pages: 1375-81
Publication    
First Author: Ren J
Year: 2019
Journal: Elife
Title: Single-cell transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and median raphe nuclei.
Volume: 8
Publication    
First Author: Yao S
Year: 2017
Journal: Elife
Title: Oxytocin signaling in the medial amygdala is required for sex discrimination of social cues.
Volume: 6
Publication
First Author: Goshu E
Year: 2004
Journal: Mol Endocrinol
Title: Sim2 contributes to neuroendocrine hormone gene expression in the anterior hypothalamus.
Volume: 18
Issue: 5
Pages: 1251-62
Publication
First Author: Campbell JN
Year: 2017
Journal: Nat Neurosci
Title: A molecular census of arcuate hypothalamus and median eminence cell types.
Volume: 20
Issue: 3
Pages: 484-496
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Foresti V
Year: 1985
Journal: J Endocrinol Invest
Title: Central hypothyroidism: isolated thyrotropin-releasing hormone deficiency or resistance of pituitary thyrotropes?
Volume: 8
Issue: 6
Pages: 577
Publication
First Author: O'Leary R
Year: 1995
Journal: J Neurochem
Title: Thyrotropin-releasing hormone.
Volume: 65
Issue: 3
Pages: 953-63
Publication
First Author: Roller ML
Year: 1995
Journal: Mamm Genome
Title: Localization of the thyrotropin-releasing hormone gene, Trh, on mouse chromosome 6.
Volume: 6
Issue: 6
Pages: 443-4
GXD Expression      
Probe: MGI:3586832
Assay Type: RT-PCR
Annotation Date: 2005-11-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3605501
Age: postnatal day 6
Specimen Label: None
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3620670
Assay Type: Northern blot
Annotation Date: 2006-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753628
Stage: TS28
Assay Id: MGI:3620686
Age: postnatal day 15
Image: 9
Specimen Label: None
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3620670
Assay Type: Northern blot
Annotation Date: 2006-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753628
Stage: TS28
Assay Id: MGI:3620686
Age: postnatal day 15
Image: 9
Specimen Label: None
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3620670
Assay Type: Northern blot
Annotation Date: 2006-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753628
Stage: TS28
Assay Id: MGI:3620686
Age: postnatal adult
Image: 9
Specimen Label: None
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3620670
Assay Type: Northern blot
Annotation Date: 2006-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753628
Stage: TS28
Assay Id: MGI:3620686
Age: postnatal adult
Image: 9
Specimen Label: None
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3759823
Assay Type: RT-PCR
Annotation Date: 2007-11-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160399
Stage: TS09
Assay Id: MGI:3759833
Age: embryonic day 6.5
Image: 1
Specimen Label: E6.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3759823
Assay Type: RT-PCR
Annotation Date: 2007-11-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:3759833
Age: embryonic day 7.5
Image: 1
Specimen Label: E7.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3759823
Assay Type: RT-PCR
Annotation Date: 2007-11-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:3759833
Age: embryonic day 8.5
Image: 1
Specimen Label: E8.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3759823
Assay Type: RT-PCR
Annotation Date: 2007-11-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3759833
Age: postnatal adult
Image: 1
Specimen Label: Adult Brain
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3790832
Assay Type: RT-PCR
Annotation Date: 2008-06-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1625013
Stage: TS13
Assay Id: MGI:3790850
Age: embryonic day 8.5
Image: 3
Specimen Label: F
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3790832
Assay Type: RT-PCR
Annotation Date: 2008-06-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1625313
Stage: TS13
Assay Id: MGI:3790850
Age: embryonic day 8.5
Image: 3
Specimen Label: H
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:7442803
Assay Type: RNA in situ
Annotation Date: 2023-03-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3529727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:7442836
Age: postnatal day 0
Image: 6I
Specimen Label: 6I
Detected: true
Specimen Num: 5
GXD Expression
Probe: MGI:7442803
Assay Type: RNA in situ
Annotation Date: 2023-03-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3529727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:7442836
Age: postnatal day 0
Image: 6J
Note: Similar as in the control.
Specimen Label: 6J
Detected: true
Specimen Num: 6
GXD Expression
Probe: MGI:3759830
Assay Type: RNA in situ
Annotation Date: 2007-11-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614814
Pattern: Not Specified
Stage: TS14
Assay Id: MGI:3759841
Age: embryonic day 9.0
Image: 4L
Note: Expression is present at the midbrain-hindbrain junction.
Specimen Label: 4L
Detected: true
Specimen Num: 37
GXD Expression
Probe: MGI:3759830
Assay Type: RNA in situ
Annotation Date: 2007-11-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614814
Pattern: Not Specified
Stage: TS14
Assay Id: MGI:3759841
Age: embryonic day 9.0
Image: 4O
Note: Expression is present at the midbrain-hindbrain junction.
Specimen Label: 4O
Detected: true
Specimen Num: 40
GXD Expression    
Probe: MGI:5002192
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2769723
Stage: TS23
Assay Id: MGI:5542746
Age: embryonic day 15.5
Image: GUDMAP:11548
Specimen Label: GUDMAP:11548
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5002192
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2769723
Stage: TS23
Assay Id: MGI:5542746
Age: embryonic day 15.5
Image: GUDMAP:11563
Specimen Label: GUDMAP:11563
Detected: false
Specimen Num: 2