Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
Homo sapiens |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
Rattus norvegicus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
TRIM72, also known as MG53, is a cardiac and skeletal muscle-specific TRIM protein. It is involved in cardiac and skeletal muscle membrane repair []. TRIM72 initiates the assembly of cell membrane repair machinery at sarcolemmal membrane injury sites in response to entry of the extracellular oxidative environment []. As an E3 ligase, it negatively regulates skeletal myogenesis and insulin signalling by targeting insulin receptor substrate 1 (IRS-1) [].Tripartite Motif (TRIM) family members share a common domain architecture characterised by the presence of a modular N-terminal RBCC motif, also called the TRIM, which consists of a RING domain, followed by one or two B-box domains and a long coiled coil (CC) region. The RBCC motif is followed by C-terminal functional domains that are often used to categorise family members into subgroups [].TRIM72 C terminus consists of the distinct N-terminal PRY subdomain followed by the SPRY subdomain. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Publication |
First Author: |
Cai C |
Year: |
2009 |
Journal: |
Nat Cell Biol |
Title: |
MG53 nucleates assembly of cell membrane repair machinery. |
Volume: |
11 |
Issue: |
1 |
Pages: |
56-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang X |
Year: |
2010 |
Journal: |
Circ Res |
Title: |
Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair. |
Volume: |
107 |
Issue: |
1 |
Pages: |
76-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yi JS |
Year: |
2013 |
Journal: |
Nat Commun |
Title: |
MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling. |
Volume: |
4 |
|
Pages: |
2354 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee CS |
Year: |
2010 |
Journal: |
Cell Death Differ |
Title: |
TRIM72 negatively regulates myogenesis via targeting insulin receptor substrate-1. |
Volume: |
17 |
Issue: |
8 |
Pages: |
1254-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nagre N |
Year: |
2016 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
TRIM72 modulates caveolar endocytosis in repair of lung cells. |
Volume: |
310 |
Issue: |
5 |
Pages: |
L452-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim SC |
Year: |
2014 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
TRIM72 is required for effective repair of alveolar epithelial cell wounding. |
Volume: |
307 |
Issue: |
6 |
Pages: |
L449-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nagre N |
Year: |
2018 |
Journal: |
Am J Respir Cell Mol Biol |
Title: |
Inhibition of Macrophage Complement Receptor CRIg by TRIM72 Polarizes Innate Immunity of the Lung. |
Volume: |
58 |
Issue: |
6 |
Pages: |
756-766 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ozato K |
Year: |
2008 |
Journal: |
Nat Rev Immunol |
Title: |
TRIM family proteins and their emerging roles in innate immunity. |
Volume: |
8 |
Issue: |
11 |
Pages: |
849-60 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
477
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu F |
Year: |
2015 |
Journal: |
Circulation |
Title: |
Upregulation of MG53 induces diabetic cardiomyopathy through transcriptional activation of peroxisome proliferation-activated receptor α. |
Volume: |
131 |
Issue: |
9 |
Pages: |
795-804 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ham YM |
Year: |
2013 |
Journal: |
Exp Cell Res |
Title: |
Compensation of the AKT signaling by ERK signaling in transgenic mice hearts overexpressing TRIM72. |
Volume: |
319 |
Issue: |
10 |
Pages: |
1451-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jung SY |
Year: |
2010 |
Journal: |
Biochem Biophys Res Commun |
Title: |
TRIM72, a novel negative feedback regulator of myogenesis, is transcriptionally activated by the synergism of MyoD (or myogenin) and MEF2. |
Volume: |
396 |
Issue: |
2 |
Pages: |
238-45 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Cai C |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
MG53 regulates membrane budding and exocytosis in muscle cells. |
Volume: |
284 |
Issue: |
5 |
Pages: |
3314-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2011 |
Journal: |
Cardiovasc Res |
Title: |
MG53 participates in ischaemic postconditioning through the RISK signalling pathway. |
Volume: |
91 |
Issue: |
1 |
Pages: |
108-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Duann P |
Year: |
2015 |
Journal: |
Sci Transl Med |
Title: |
MG53-mediated cell membrane repair protects against acute kidney injury. |
Volume: |
7 |
Issue: |
279 |
Pages: |
279ra36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang C |
Year: |
2017 |
Journal: |
J Mol Cell Cardiol |
Title: |
MG53 is dispensable for T-tubule maturation but critical for maintaining T-tubule integrity following cardiac stress. |
Volume: |
112 |
|
Pages: |
123-130 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hwang M |
Year: |
2011 |
Journal: |
Am J Physiol Cell Physiol |
Title: |
Redox-dependent oligomerization through a leucine zipper motif is essential for MG53-mediated cell membrane repair. |
Volume: |
301 |
Issue: |
1 |
Pages: |
C106-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cao CM |
Year: |
2010 |
Journal: |
Circulation |
Title: |
MG53 constitutes a primary determinant of cardiac ischemic preconditioning. |
Volume: |
121 |
Issue: |
23 |
Pages: |
2565-74 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5285930 |
Assay Type: |
Western blot |
Annotation Date: |
2011-09-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1733728 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5285932 |
Age: |
postnatal adult |
|
|
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5285930 |
Assay Type: |
Western blot |
Annotation Date: |
2011-09-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5285931 |
Age: |
postnatal month 1 |
|
|
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5285930 |
Assay Type: |
Western blot |
Annotation Date: |
2011-09-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5285931 |
Age: |
postnatal week 2 |
|
|
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5285930 |
Assay Type: |
Western blot |
Annotation Date: |
2011-09-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610527 |
|
Stage: |
TS27 |
Assay Id: |
MGI:5285931 |
Age: |
postnatal day 3 |
|
|
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5285930 |
Assay Type: |
Western blot |
Annotation Date: |
2011-09-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610527 |
|
Stage: |
TS27 |
Assay Id: |
MGI:5285931 |
Age: |
postnatal day 1 |
|
|
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5285930 |
Assay Type: |
Western blot |
Annotation Date: |
2011-09-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610526 |
|
Stage: |
TS26 |
Assay Id: |
MGI:5285931 |
Age: |
embryonic day 19.0 |
|
|
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5285930 |
Assay Type: |
Western blot |
Annotation Date: |
2011-09-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610526 |
|
Stage: |
TS26 |
Assay Id: |
MGI:5285931 |
Age: |
embryonic day 18.0 |
|
|
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5285930 |
Assay Type: |
Western blot |
Annotation Date: |
2011-09-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1734028 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5285932 |
Age: |
postnatal adult |
|
|
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5285930 |
Assay Type: |
Western blot |
Annotation Date: |
2011-09-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1732128 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5285932 |
Age: |
postnatal adult |
|
|
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5285930 |
Assay Type: |
Western blot |
Annotation Date: |
2011-09-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1731528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5285932 |
Age: |
postnatal adult |
|
|
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lemckert FA |
Year: |
2016 |
Journal: |
Cardiovasc Res |
Title: |
Lack of MG53 in human heart precludes utility as a biomarker of myocardial injury or endogenous cardioprotective factor. |
Volume: |
110 |
Issue: |
2 |
Pages: |
178-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cai C |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
Membrane repair defects in muscular dystrophy are linked to altered interaction between MG53, caveolin-3, and dysferlin. |
Volume: |
284 |
Issue: |
23 |
Pages: |
15894-902 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin P |
Year: |
2012 |
Journal: |
FASEB J |
Title: |
Nonmuscle myosin IIA facilitates vesicle trafficking for MG53-mediated cell membrane repair. |
Volume: |
26 |
Issue: |
5 |
Pages: |
1875-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Song R |
Year: |
2013 |
Journal: |
Nature |
Title: |
Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders. |
Volume: |
494 |
Issue: |
7437 |
Pages: |
375-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
Data Curation Using Mouse Genome Assembly |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
|
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
|
Title: |
Gene Ontology Annotation by the MGI Curatorial Staff |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2000 |
|
Title: |
Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics, the Protein Information Resource and the Protein Ontology Consortium |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1, Rui-Ping Xiao |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
Publication categories: |
ProxyCollection |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, transgenic |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Myh6-Trim72)1Rpx/? |
Background: |
C57BL/6-Tg(Myh6-Trim72)1Rpx |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|