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Search results 1 to 100 out of 153 for Trim72

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Type Details Score
Gene
Type: gene
Organism: Not Specified
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: TRIM72, also known as MG53, is a cardiac and skeletal muscle-specific TRIM protein. It is involved in cardiac and skeletal muscle membrane repair []. TRIM72 initiates the assembly of cell membrane repair machinery at sarcolemmal membrane injury sites in response to entry of the extracellular oxidative environment []. As an E3 ligase, it negatively regulates skeletal myogenesis and insulin signalling by targeting insulin receptor substrate 1 (IRS-1) [].Tripartite Motif (TRIM) family members share a common domain architecture characterised by the presence of a modular N-terminal RBCC motif, also called the TRIM, which consists of a RING domain, followed by one or two B-box domains and a long coiled coil (CC) region. The RBCC motif is followed by C-terminal functional domains that are often used to categorise family members into subgroups [].TRIM72 C terminus consists of the distinct N-terminal PRY subdomain followed by the SPRY subdomain.
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Cai C
Year: 2009
Journal: Nat Cell Biol
Title: MG53 nucleates assembly of cell membrane repair machinery.
Volume: 11
Issue: 1
Pages: 56-64
Publication
First Author: Wang X
Year: 2010
Journal: Circ Res
Title: Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair.
Volume: 107
Issue: 1
Pages: 76-83
Publication  
First Author: Yi JS
Year: 2013
Journal: Nat Commun
Title: MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling.
Volume: 4
Pages: 2354
Publication
First Author: Lee CS
Year: 2010
Journal: Cell Death Differ
Title: TRIM72 negatively regulates myogenesis via targeting insulin receptor substrate-1.
Volume: 17
Issue: 8
Pages: 1254-65
Publication  
First Author: Fillmore N
Year: 2019
Journal: J Mol Cell Cardiol
Title: A knock-in mutation at cysteine 144 of TRIM72 is cardioprotective and reduces myocardial TRIM72 release.
Volume: 136
Pages: 95-101
Publication
First Author: Nagre N
Year: 2016
Journal: Am J Physiol Lung Cell Mol Physiol
Title: TRIM72 modulates caveolar endocytosis in repair of lung cells.
Volume: 310
Issue: 5
Pages: L452-64
Publication
First Author: McElhanon KE
Year: 2020
Journal: J Clin Invest
Title: Autoantibodies targeting TRIM72 compromise membrane repair and contribute to inflammatory myopathy.
Volume: 130
Issue: 8
Pages: 4440-4455
Publication  
First Author: Ishiwata-Endo H
Year: 2018
Journal: JCI Insight
Title: Role of a TRIM72 ADP-ribosylation cycle in myocardial injury and membrane repair.
Volume: 3
Issue: 22
Publication
First Author: Kim SC
Year: 2014
Journal: Am J Physiol Lung Cell Mol Physiol
Title: TRIM72 is required for effective repair of alveolar epithelial cell wounding.
Volume: 307
Issue: 6
Pages: L449-59
Publication
First Author: Nagre N
Year: 2018
Journal: Am J Respir Cell Mol Biol
Title: Inhibition of Macrophage Complement Receptor CRIg by TRIM72 Polarizes Innate Immunity of the Lung.
Volume: 58
Issue: 6
Pages: 756-766
Publication  
First Author: Wu M
Year: 2023
Journal: Oxid Med Cell Longev
Title: TRIM72 Alleviates Muscle Inflammation in mdx Mice via Promoting Mitophagy-Mediated NLRP3 Inflammasome Inactivation.
Volume: 2023
Pages: 8408574
Publication
First Author: Ozato K
Year: 2008
Journal: Nat Rev Immunol
Title: TRIM family proteins and their emerging roles in innate immunity.
Volume: 8
Issue: 11
Pages: 849-60
Protein
Organism: Mus musculus/domesticus
Length: 477  
Fragment?: false
Publication
First Author: Liu F
Year: 2015
Journal: Circulation
Title: Upregulation of MG53 induces diabetic cardiomyopathy through transcriptional activation of peroxisome proliferation-activated receptor α.
Volume: 131
Issue: 9
Pages: 795-804
Publication
First Author: Ham YM
Year: 2013
Journal: Exp Cell Res
Title: Compensation of the AKT signaling by ERK signaling in transgenic mice hearts overexpressing TRIM72.
Volume: 319
Issue: 10
Pages: 1451-62
Publication
First Author: Jung SY
Year: 2010
Journal: Biochem Biophys Res Commun
Title: TRIM72, a novel negative feedback regulator of myogenesis, is transcriptionally activated by the synergism of MyoD (or myogenin) and MEF2.
Volume: 396
Issue: 2
Pages: 238-45
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Cai C
Year: 2009
Journal: J Biol Chem
Title: MG53 regulates membrane budding and exocytosis in muscle cells.
Volume: 284
Issue: 5
Pages: 3314-22
Publication  
First Author: Zhang C
Year: 2017
Journal: J Mol Cell Cardiol
Title: MG53 is dispensable for T-tubule maturation but critical for maintaining T-tubule integrity following cardiac stress.
Volume: 112
Pages: 123-130
Publication  
First Author: Chandler HL
Year: 2019
Journal: Commun Biol
Title: MG53 promotes corneal wound healing and mitigates fibrotic remodeling in rodents.
Volume: 2
Pages: 71
Publication
First Author: Li H
Year: 2022
Journal: J Cell Mol Med
Title: MG53 attenuates nitrogen mustard-induced acute lung injury.
Volume: 26
Issue: 7
Pages: 1886-1895
Publication
First Author: Hwang M
Year: 2011
Journal: Am J Physiol Cell Physiol
Title: Redox-dependent oligomerization through a leucine zipper motif is essential for MG53-mediated cell membrane repair.
Volume: 301
Issue: 1
Pages: C106-14
Publication
First Author: Cao CM
Year: 2010
Journal: Circulation
Title: MG53 constitutes a primary determinant of cardiac ischemic preconditioning.
Volume: 121
Issue: 23
Pages: 2565-74
Publication
First Author: Zhang Y
Year: 2011
Journal: Cardiovasc Res
Title: MG53 participates in ischaemic postconditioning through the RISK signalling pathway.
Volume: 91
Issue: 1
Pages: 108-15
Publication
First Author: Duann P
Year: 2015
Journal: Sci Transl Med
Title: MG53-mediated cell membrane repair protects against acute kidney injury.
Volume: 7
Issue: 279
Pages: 279ra36
Publication
First Author: Sermersheim M
Year: 2020
Journal: Nat Commun
Title: MG53 suppresses interferon-β and inflammation via regulation of ryanodine receptor-mediated intracellular calcium signaling.
Volume: 11
Issue: 1
Pages: 3624
Publication
First Author: Philouze C
Year: 2021
Journal: PLoS One
Title: MG53 is not a critical regulator of insulin signaling pathway in skeletal muscle.
Volume: 16
Issue: 2
Pages: e0245179
Publication
First Author: Li H
Year: 2015
Journal: J Biol Chem
Title: Modulation of wound healing and scar formation by MG53 protein-mediated cell membrane repair.
Volume: 290
Issue: 40
Pages: 24592-603
GXD Expression      
Probe: MGI:5285930
Assay Type: Western blot
Annotation Date: 2011-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610526
Stage: TS26
Assay Id: MGI:5285931
Age: embryonic day 18.0
Specimen Label: E18.0
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5285930
Assay Type: Western blot
Annotation Date: 2011-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610526
Stage: TS26
Assay Id: MGI:5285931
Age: embryonic day 19.0
Specimen Label: E19.0
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5285930
Assay Type: Western blot
Annotation Date: 2011-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:5285931
Age: postnatal day 1
Specimen Label: D1
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5285930
Assay Type: Western blot
Annotation Date: 2011-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:5285931
Age: postnatal day 3
Specimen Label: D3
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5285930
Assay Type: Western blot
Annotation Date: 2011-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5285931
Age: postnatal week 2
Specimen Label: 2W
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5285930
Assay Type: Western blot
Annotation Date: 2011-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5285931
Age: postnatal month 1
Specimen Label: 1M
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5285930
Assay Type: Western blot
Annotation Date: 2011-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1732128
Stage: TS28
Assay Id: MGI:5285932
Age: postnatal adult
Specimen Label: RA
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5285930
Assay Type: Western blot
Annotation Date: 2011-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1731528
Stage: TS28
Assay Id: MGI:5285932
Age: postnatal adult
Specimen Label: LA
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5285930
Assay Type: Western blot
Annotation Date: 2011-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1734028
Stage: TS28
Assay Id: MGI:5285932
Age: postnatal adult
Specimen Label: RV
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5285930
Assay Type: Western blot
Annotation Date: 2011-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1733728
Stage: TS28
Assay Id: MGI:5285932
Age: postnatal adult
Specimen Label: LV
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6798068
Assay Type: Northern blot
Annotation Date: 2021-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6798074
Age: postnatal
Specimen Label: Heart
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6798068
Assay Type: Northern blot
Annotation Date: 2021-11-10
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6798074
Age: postnatal
Specimen Label: Brain
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:6798068
Assay Type: Northern blot
Annotation Date: 2021-11-10
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:6798074
Age: postnatal
Specimen Label: Spleen
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:6798068
Assay Type: Northern blot
Annotation Date: 2021-11-10
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:6798074
Age: postnatal
Specimen Label: Lung
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:6798068
Assay Type: Northern blot
Annotation Date: 2021-11-10
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6798074
Age: postnatal
Specimen Label: Liver
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:6798068
Assay Type: Northern blot
Annotation Date: 2021-11-10
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6798074
Age: postnatal
Specimen Label: Kidney
Detected: false
Specimen Num: 7
GXD Expression      
Probe: MGI:6798068
Assay Type: Northern blot
Annotation Date: 2021-11-10
Strength: Absent
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:6798074
Age: postnatal
Specimen Label: Testis
Detected: false
Specimen Num: 8
GXD Expression      
Probe: MGI:6798072
Assay Type: Western blot
Annotation Date: 2021-11-10
Strength: Present
Sex: Male
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6798075
Age: postnatal week 12
Specimen Label: Heart
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6798072
Assay Type: Western blot
Annotation Date: 2021-11-10
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6798075
Age: postnatal week 12
Specimen Label: Brain
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:6798072
Assay Type: Western blot
Annotation Date: 2021-11-10
Strength: Absent
Sex: Male
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:6798075
Age: postnatal week 12
Specimen Label: Spleen
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:6798072
Assay Type: Western blot
Annotation Date: 2021-11-10
Strength: Absent
Sex: Male
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:6798075
Age: postnatal week 12
Specimen Label: Lung
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:6798072
Assay Type: Western blot
Annotation Date: 2021-11-10
Strength: Absent
Sex: Male
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6798075
Age: postnatal week 12
Specimen Label: Liver
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:6798072
Assay Type: Western blot
Annotation Date: 2021-11-10
Strength: Present
Sex: Male
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:6798075
Age: postnatal week 12
Specimen Label: Skeletal muscle
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6798072
Assay Type: Western blot
Annotation Date: 2021-11-10
Strength: Absent
Sex: Male
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6798075
Age: postnatal week 12
Specimen Label: Kidney
Detected: false
Specimen Num: 7
GXD Expression      
Probe: MGI:6798072
Assay Type: Western blot
Annotation Date: 2021-11-10
Strength: Absent
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:6798075
Age: postnatal week 12
Specimen Label: Testis
Detected: false
Specimen Num: 8
GXD Expression      
Probe: MGI:6798072
Assay Type: Western blot
Annotation Date: 2021-11-10
Strength: Absent
Sex: Male
Emaps: EMAPS:1885228
Stage: TS28
Assay Id: MGI:6798075
Age: postnatal week 12
Specimen Label: Duodenum
Detected: false
Specimen Num: 9
GXD Expression      
Probe: MGI:6798072
Assay Type: Western blot
Annotation Date: 2021-11-10
Strength: Absent
Sex: Male
Emaps: EMAPS:1702128
Stage: TS28
Assay Id: MGI:6798075
Age: postnatal week 12
Specimen Label: Stomach
Detected: false
Specimen Num: 10
GXD Expression      
Probe: MGI:6798072
Assay Type: Western blot
Annotation Date: 2021-11-10
Strength: Absent
Sex: Male
Emaps: EMAPS:3287428
Stage: TS28
Assay Id: MGI:6798075
Age: postnatal week 12
Specimen Label: Intestine
Detected: false
Specimen Num: 11
GXD Expression      
Probe: MGI:6798072
Assay Type: Western blot
Annotation Date: 2021-11-10
Strength: Absent
Sex: Male
Emaps: EMAPS:1750328
Stage: TS28
Assay Id: MGI:6798075
Age: postnatal week 12
Specimen Label: Pancreas
Detected: false
Specimen Num: 12
GXD Expression      
Probe: MGI:6798072
Assay Type: Western blot
Annotation Date: 2021-11-10
Strength: Absent
Sex: Male
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:6798075
Age: postnatal week 12
Specimen Label: Thymus
Detected: false
Specimen Num: 13
GXD Expression      
Probe: MGI:6798072
Assay Type: Western blot
Annotation Date: 2021-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598823
Stage: TS23
Assay Id: MGI:6798080
Age: embryonic day 15.5
Specimen Label: E15.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6798072
Assay Type: Western blot
Annotation Date: 2021-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598824
Stage: TS24
Assay Id: MGI:6798080
Age: embryonic day 16.5
Specimen Label: E16.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6798072
Assay Type: Western blot
Annotation Date: 2021-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598825
Stage: TS25
Assay Id: MGI:6798080
Age: embryonic day 17.5
Specimen Label: E17.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6798072
Assay Type: Western blot
Annotation Date: 2021-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598826
Stage: TS26
Assay Id: MGI:6798080
Age: embryonic day 18.5
Specimen Label: E18.5
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6798072
Assay Type: Western blot
Annotation Date: 2021-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598827
Stage: TS27
Assay Id: MGI:6798080
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6798072
Assay Type: Western blot
Annotation Date: 2021-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598827
Stage: TS27
Assay Id: MGI:6798080
Age: postnatal day 3
Specimen Label: P3
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6798072
Assay Type: Western blot
Annotation Date: 2021-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:6798080
Age: postnatal day 5
Specimen Label: P5
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:6798072
Assay Type: Western blot
Annotation Date: 2021-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:6798080
Age: postnatal day 7
Specimen Label: P7
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:6798072
Assay Type: Western blot
Annotation Date: 2021-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:6798080
Age: postnatal day 9
Specimen Label: P9
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:6798072
Assay Type: Western blot
Annotation Date: 2021-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:6798080
Age: postnatal day 12
Specimen Label: P12
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:6798072
Assay Type: Western blot
Annotation Date: 2021-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:6798080
Age: postnatal adult
Specimen Label: Adult
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:6798072
Assay Type: Western blot
Annotation Date: 2021-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610523
Stage: TS23
Assay Id: MGI:6798082
Age: embryonic day 15.5
Specimen Label: E15.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6798072
Assay Type: Western blot
Annotation Date: 2021-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610524
Stage: TS24
Assay Id: MGI:6798082
Age: embryonic day 16.5
Specimen Label: E16.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6798072
Assay Type: Western blot
Annotation Date: 2021-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610525
Stage: TS25
Assay Id: MGI:6798082
Age: embryonic day 17.5
Specimen Label: E17.5
Detected: true
Specimen Num: 3