|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 86 out of 86 for Trim72

0.024s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
493829 | TRIM72
Type: gene
Organism: Homo sapiens
•
•
•
•
•
Gene
RGD:1562778 | Trim72
Type: gene
Organism: Rattus norvegicus
•
•
•
•
•
Protein Domain
IPR035038 | TRIM72
Type: family
Description: TRIM72, also known as MG53, is a cardiac and skeletal muscle-specific TRIM protein. It is involved in cardiac and skeletal muscle membrane repair []. TRIM72 initiates the assembly of cell membrane repair machinery at sarcolemmal membrane injury sites in response to entry of the extracellular oxidative environment []. As an E3 ligase, it negatively regulates skeletal myogenesis and insulin signalling by targeting insulin receptor substrate 1 (IRS-1) [].Tripartite Motif (TRIM) family members share a common domain architecture characterised by the presence of a modular N-terminal RBCC motif, also called the TRIM, which consists of a RING domain, followed by one or two B-box domains and a long coiled coil (CC) region. The RBCC motif is followed by C-terminal functional domains that are often used to categorise family members into subgroups [].TRIM72 C terminus consists of the distinct N-terminal PRY subdomain followed by the SPRY subdomain.
•
•
•
•
•
Protein Coding Gene
MGI:3612190 | Trim72
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Publication
19043407 | J:146965
First Author: Cai C
Year: 2009
Journal: Nat Cell Biol
Title: MG53 nucleates assembly of cell membrane repair machinery.
Volume: 11
Issue: 1
Pages: 56-64
•
•
•
•
•
Publication
20466981 | J:175051
First Author: Wang X
Year: 2010
Journal: Circ Res
Title: Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair.
Volume: 107
Issue: 1
Pages: 76-83
•
•
•
•
•
Publication
23965929 | J:214362
 
First Author: Yi JS
Year: 2013
Journal: Nat Commun
Title: MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling.
Volume: 4
Pages: 2354
•
•
•
•
•
Publication
20139895 | J:186368
First Author: Lee CS
Year: 2010
Journal: Cell Death Differ
Title: TRIM72 negatively regulates myogenesis via targeting insulin receptor substrate-1.
Volume: 17
Issue: 8
Pages: 1254-65
•
•
•
•
•
Publication
26637632 | J:233179
First Author: Nagre N
Year: 2016
Journal: Am J Physiol Lung Cell Mol Physiol
Title: TRIM72 modulates caveolar endocytosis in repair of lung cells.
Volume: 310
Issue: 5
Pages: L452-64
•
•
•
•
•
Publication
25106429 | J:222068
First Author: Kim SC
Year: 2014
Journal: Am J Physiol Lung Cell Mol Physiol
Title: TRIM72 is required for effective repair of alveolar epithelial cell wounding.
Volume: 307
Issue: 6
Pages: L449-59
•
•
•
•
•
Publication
29268030 | J:275635
First Author: Nagre N
Year: 2018
Journal: Am J Respir Cell Mol Biol
Title: Inhibition of Macrophage Complement Receptor CRIg by TRIM72 Polarizes Innate Immunity of the Lung.
Volume: 58
Issue: 6
Pages: 756-766
•
•
•
•
•
Publication
18836477 | -
First Author: Ozato K
Year: 2008
Journal: Nat Rev Immunol
Title: TRIM family proteins and their emerging roles in innate immunity.
Volume: 8
Issue: 11
Pages: 849-60
•
•
•
•
•
Protein
Q1XH17
Organism: Mus musculus
Length: 477  
Fragment?: false
•
•
•
•
•
Publication
25637627 | J:234132
First Author: Liu F
Year: 2015
Journal: Circulation
Title: Upregulation of MG53 induces diabetic cardiomyopathy through transcriptional activation of peroxisome proliferation-activated receptor α.
Volume: 131
Issue: 9
Pages: 795-804
•
•
•
•
•
Publication
23567182 | J:199942
First Author: Ham YM
Year: 2013
Journal: Exp Cell Res
Title: Compensation of the AKT signaling by ERK signaling in transgenic mice hearts overexpressing TRIM72.
Volume: 319
Issue: 10
Pages: 1451-62
•
•
•
•
•
Publication
20399744 | J:162523
First Author: Jung SY
Year: 2010
Journal: Biochem Biophys Res Commun
Title: TRIM72, a novel negative feedback regulator of myogenesis, is transcriptionally activated by the synergism of MyoD (or myogenin) and MEF2.
Volume: 396
Issue: 2
Pages: 238-45
•
•
•
•
•
Protein Coding Gene
MGP_CAROLIEiJ_G0030535 | -
Type: protein_coding_gene
Organism: Mus caroli
•
•
•
•
•
Protein Coding Gene
MGP_129S1SvImJ_G0033069 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_AJ_G0033052 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_AKRJ_G0032984 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_BALBcJ_G0033053 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_C3HHeJ_G0032767 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGI_C57BL6J_3612190 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_C57BL6NJ_G0033562 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_CASTEiJ_G0032096 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_CBAJ_G0032740 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_DBA2J_G0032892 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_FVBNJ_G0032845 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_LPJ_G0032986 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_NODShiLtJ_G0032877 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_NZOHlLtJ_G0033582 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_PWKPhJ_G0031803 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_WSBEiJ_G0032208 | -
Type: protein_coding_gene
Organism: Mus musculus
•
•
•
•
•
Protein Coding Gene
MGP_PahariEiJ_G0013742 | -
Type: protein_coding_gene
Organism: Mus pahari
•
•
•
•
•
Protein Coding Gene
MGP_SPRETEiJ_G0031649 | -
Type: protein_coding_gene
Organism: Mus spretus
•
•
•
•
•
Publication
19029292 | J:147228
First Author: Cai C
Year: 2009
Journal: J Biol Chem
Title: MG53 regulates membrane budding and exocytosis in muscle cells.
Volume: 284
Issue: 5
Pages: 3314-22
•
•
•
•
•
Publication
20516375 | J:174044
First Author: Cao CM
Year: 2010
Journal: Circulation
Title: MG53 constitutes a primary determinant of cardiac ischemic preconditioning.
Volume: 121
Issue: 23
Pages: 2565-74
•
•
•
•
•
Publication
21525429 | J:175670
First Author: Hwang M
Year: 2011
Journal: Am J Physiol Cell Physiol
Title: Redox-dependent oligomerization through a leucine zipper motif is essential for MG53-mediated cell membrane repair.
Volume: 301
Issue: 1
Pages: C106-14
•
•
•
•
•
Publication
25787762 | J:233995
First Author: Duann P
Year: 2015
Journal: Sci Transl Med
Title: MG53-mediated cell membrane repair protects against acute kidney injury.
Volume: 7
Issue: 279
Pages: 279ra36
•
•
•
•
•
Publication
28822805 | J:253954
 
First Author: Zhang C
Year: 2017
Journal: J Mol Cell Cardiol
Title: MG53 is dispensable for T-tubule maturation but critical for maintaining T-tubule integrity following cardiac stress.
Volume: 112
Pages: 123-130
•
•
•
•
•
Publication
21285295 | J:191635
First Author: Zhang Y
Year: 2011
Journal: Cardiovasc Res
Title: MG53 participates in ischaemic postconditioning through the RISK signalling pathway.
Volume: 91
Issue: 1
Pages: 108-15
•
•
•
•
•
Publication
30793049 | J:286012
 
First Author: Chandler HL
Year: 2019
Journal: Commun Biol
Title: MG53 promotes corneal wound healing and mitigates fibrotic remodeling in rodents.
Volume: 2
Pages: 71
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5285930
Assay Type: Western blot
Annotation Date: 2011-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1733728
Stage: TS28
Assay Id: MGI:5285932
Age: postnatal adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5285930
Assay Type: Western blot
Annotation Date: 2011-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5285931
Age: postnatal month 1
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5285930
Assay Type: Western blot
Annotation Date: 2011-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5285931
Age: postnatal week 2
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5285930
Assay Type: Western blot
Annotation Date: 2011-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:5285931
Age: postnatal day 3
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5285930
Assay Type: Western blot
Annotation Date: 2011-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:5285931
Age: postnatal day 1
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5285930
Assay Type: Western blot
Annotation Date: 2011-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610526
Stage: TS26
Assay Id: MGI:5285931
Age: embryonic day 19.0
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5285930
Assay Type: Western blot
Annotation Date: 2011-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610526
Stage: TS26
Assay Id: MGI:5285931
Age: embryonic day 18.0
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5285930
Assay Type: Western blot
Annotation Date: 2011-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1734028
Stage: TS28
Assay Id: MGI:5285932
Age: postnatal adult
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5285930
Assay Type: Western blot
Annotation Date: 2011-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1732128
Stage: TS28
Assay Id: MGI:5285932
Age: postnatal adult
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5285930
Assay Type: Western blot
Annotation Date: 2011-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1731528
Stage: TS28
Assay Id: MGI:5285932
Age: postnatal adult
Detected: true
Specimen Num: 2
•
•
•
•
•
Publication
26790476 | J:252641
First Author: Lemckert FA
Year: 2016
Journal: Cardiovasc Res
Title: Lack of MG53 in human heart precludes utility as a biomarker of myocardial injury or endogenous cardioprotective factor.
Volume: 110
Issue: 2
Pages: 178-87
•
•
•
•
•
Publication
30760025 | J:286638
First Author: Liu W
Year: 2019
Journal: Circulation
Title: MG53, A Novel Regulator of KChIP2 and Ito,f, Plays a Critical Role in Electrophysiological Remodeling in Cardiac Hypertrophy.
Volume: 139
Issue: 18
Pages: 2142-2156
•
•
•
•
•
Publication
19380584 | J:150684
First Author: Cai C
Year: 2009
Journal: J Biol Chem
Title: Membrane repair defects in muscular dystrophy are linked to altered interaction between MG53, caveolin-3, and dysferlin.
Volume: 284
Issue: 23
Pages: 15894-902
•
•
•
•
•
Publication
22253476 | J:183293
First Author: Lin P
Year: 2012
Journal: FASEB J
Title: Nonmuscle myosin IIA facilitates vesicle trafficking for MG53-mediated cell membrane repair.
Volume: 26
Issue: 5
Pages: 1875-83
•
•
•
•
•
Publication
23354051 | J:194550
First Author: Song R
Year: 2013
Journal: Nature
Title: Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders.
Volume: 494
Issue: 7437
Pages: 375-9
•
•
•
•
•
Publication
- | J:94077
     
First Author: Mutant Mouse Regional Resource Centers
Year: 2004
Journal: Unpublished
Title: Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC)
•
•
•
•
•
Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
•
•
•
•
•
Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
•
•
•
•
•
Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
•
•
•
•
•
Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
•
•
•
•
•
Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
•
•
•
•
•
Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
•
•
•
•
•
Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
•
•
•
•
•
Publication
- | J:23000
         
First Author: MGD Nomenclature Committee
Year: 1995
•
•
•
•
•
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
•
•
•
•
•
Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
•
•
•
•
•
Publication
- | J:72247
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
•
•
•
•
•
Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
•
•
•
•
•
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
•
•
•
•
•
Publication
21873635 | J:265628
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
•
•
•
•
•
Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics, the Protein Information Resource and the Protein Ontology Consortium
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
31536744 | J:283679
 
First Author: Fillmore N
Year: 2019
Journal: J Mol Cell Cardiol
Title: A knock-in mutation at cysteine 144 of TRIM72 is cardioprotective and reduces myocardial TRIM72 release.
Volume: 136
Pages: 95-101
•
•
•
•
•
Allele
Tg(Myh6-Trim72)1Rpx | MGI:5792805
Name: transgene insertion 1, Rui-Ping Xiao
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Publication categories: ProxyCollection
•
•
•
•
•
Strain
MGI:5792806 | C57BL/6-Tg(Myh6-Trim72)1Rpx
Attribute String: coisogenic, mutant strain, transgenic
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Myh6-Trim72)1Rpx/?
Background: C57BL/6-Tg(Myh6-Trim72)1Rpx
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom