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Search results 1 to 100 out of 841 for Trpc6

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Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
7225 | TRPC6
Type: gene
Organism: human
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Gene
100493327 | trpc6
Type: gene
Organism: frog, western clawed
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Gene
89823 | Trpc6
Type: gene
Organism: rat
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Gene
489435 | TRPC6
Type: gene
Organism: dog, domestic
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Gene
451503 | TRPC6
Type: gene
Organism: chimpanzee
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Gene
407151 | TRPC6
Type: gene
Organism: cattle
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Gene
418989 | TRPC6
Type: gene
Organism: chicken
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Gene
703611 | TRPC6
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:109523 | Trpc6
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
644218 | TRPC6P1
Type: gene
Organism: human
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Gene
650866 | TRPC6P2
Type: gene
Organism: human
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Gene
100288724 | TRPC6P3
Type: gene
Organism: human
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Gene
100422500 | TRPC6P4
Type: gene
Organism: human
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Gene
100422502 | TRPC6P6
Type: gene
Organism: human
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Gene
123464510 | TRPC6P5
Type: gene
Organism: human
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Gene
123464511 | TRPC6P7
Type: gene
Organism: human
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Gene
123464512 | TRPC6P8
Type: gene
Organism: human
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Gene
123464513 | TRPC6P9
Type: gene
Organism: human
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Gene
123464518 | TRPC6P10
Type: gene
Organism: human
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Publication
23636057 | J:204765
First Author: Lindemann O
Year: 2013
Journal: J Immunol
Title: TRPC6 regulates CXCR2-mediated chemotaxis of murine neutrophils.
Volume: 190
Issue: 11
Pages: 5496-505
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Publication
25896763 | J:228370
First Author: Zhao B
Year: 2015
Journal: Biochem Biophys Res Commun
Title: The role of TRPC6 in oxidative stress-induced podocyte ischemic injury.
Volume: 461
Issue: 2
Pages: 413-20
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Publication
35749414 | J:334958
First Author: Boekell KL
Year: 2022
Journal: PLoS One
Title: Trpc6 gain-of-function disease mutation enhances phosphatidylserine exposure in murine platelets.
Volume: 17
Issue: 6
Pages: e0270431
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Publication
33135341 | J:352671
First Author: He C
Year: 2020
Journal: Clin Transl Med
Title: Low-glucose-sensitive TRPC6 dysfunction drives hypoglycemia-induced cognitive impairment in diabetes.
Volume: 10
Issue: 6
Pages: e205
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Publication
14761972 | J:89507
First Author: Hisatsune C
Year: 2004
Journal: J Biol Chem
Title: Regulation of TRPC6 channel activity by tyrosine phosphorylation.
Volume: 279
Issue: 18
Pages: 18887-94
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Publication
18559891 | J:139750
First Author: Tai Y
Year: 2008
Journal: J Cell Sci
Title: TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway.
Volume: 121
Issue: Pt 14
Pages: 2301-7
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Publication
18516035 | J:139372
First Author: Zhou J
Year: 2008
Journal: Nat Neurosci
Title: Critical role of TRPC6 channels in the formation of excitatory synapses.
Volume: 11
Issue: 7
Pages: 741-3
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Publication
20877463 | J:165112
First Author: Krall P
Year: 2010
Journal: PLoS One
Title: Podocyte-specific overexpression of wild type or mutant trpc6 in mice is sufficient to cause glomerular disease.
Volume: 5
Issue: 9
Pages: e12859
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Publication
26604306 | J:228125
First Author: Riazanski V
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: TRPC6 channel translocation into phagosomal membrane augments phagosomal function.
Volume: 112
Issue: 47
Pages: E6486-95
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Publication
23043486 | J:190916
First Author: Li H
Year: 2012
Journal: J Neurochem
Title: TRPC6 inhibited NMDA receptor activities and protected neurons from ischemic excitotoxicity.
Volume: 123
Issue: 6
Pages: 1010-8
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Publication
35194063 | J:322550
First Author: Zheng Z
Year: 2022
Journal: Sci Rep
Title: Role of TRPC6 in kidney damage after acute ischemic kidney injury.
Volume: 12
Issue: 1
Pages: 3038
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Publication
23212367 | J:221241
 
First Author: Xie J
Year: 2012
Journal: Nat Commun
Title: Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart.
Volume: 3
Pages: 1238
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Publication
26520460 | J:228754
 
First Author: Sexton JE
Year: 2016
Journal: Neurosci Lett
Title: The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing.
Volume: 610
Pages: 36-42
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Publication
15924139 | J:99306
First Author: Reiser J
Year: 2005
Journal: Nat Genet
Title: TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function.
Volume: 37
Issue: 7
Pages: 739-44
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Publication
23529130 | J:210574
First Author: Shi J
Year: 2013
Journal: J Physiol
Title: Molecular determinants for cardiovascular TRPC6 channel regulation by Ca2+/calmodulin-dependent kinase II.
Volume: 591
Issue: 11
Pages: 2851-66
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Publication
26581893 | J:228025
 
First Author: Wang J
Year: 2015
Journal: Nat Commun
Title: TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production.
Volume: 6
Pages: 8876
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Publication
14699131 | J:88868
First Author: Chu X
Year: 2004
Journal: J Biol Chem
Title: Interaction of TRPC2 and TRPC6 in erythropoietin modulation of calcium influx.
Volume: 279
Issue: 11
Pages: 10514-22
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Publication
20978238 | J:259315
First Author: Tian D
Year: 2010
Journal: Sci Signal
Title: Antagonistic regulation of actin dynamics and cell motility by TRPC5 and TRPC6 channels.
Volume: 3
Issue: 145
Pages: ra77
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GXD Expression
GXD Expression
     
Probe: MGI:6185895
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6191512
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Trpc6
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6185895
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6191512
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Trpc6
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6185895
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:6191512
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Trpc6
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6185895
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191512
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Trpc6
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6185895
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191512
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Trpc6
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6185895
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191512
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Trpc6
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6185895
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191512
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Trpc6
Detected: true
Specimen Num: 7
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Publication
26392222 | J:229037
First Author: Weber EW
Year: 2015
Journal: J Exp Med
Title: TRPC6 is the endothelial calcium channel that regulates leukocyte transendothelial migration during the inflammatory response.
Volume: 212
Issue: 11
Pages: 1883-99
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Publication
28646178 | J:271483
First Author: Li W
Year: 2017
Journal: Sci Rep
Title: Increased glomerular filtration rate and impaired contractile function of mesangial cells in TRPC6 knockout mice.
Volume: 7
Issue: 1
Pages: 4145
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Publication
39625977 | J:360700
First Author: Matsushita Y
Year: 2024
Journal: Proc Natl Acad Sci U S A
Title: TRPC6 is a mechanosensitive channel essential for ultrasound neuromodulation in the mammalian brain.
Volume: 121
Issue: 50
Pages: e2404877121
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Publication
24462772 | J:210844
First Author: Albarran L
Year: 2014
Journal: Biochim Biophys Acta
Title: TRPC6 participates in the regulation of cytosolic basal calcium concentration in murine resting platelets.
Volume: 1843
Issue: 4
Pages: 789-96
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Publication
36099033 | J:331540
 
First Author: Lin BL
Year: 2022
Journal: JCI Insight
Title: Pharmacological TRPC6 inhibition improves survival and muscle function in mice with Duchenne muscular dystrophy.
Volume: 7
Issue: 19
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Publication
21768109 | J:176613
First Author: Ding Y
Year: 2011
Journal: J Biol Chem
Title: Reactive oxygen species-mediated TRPC6 protein activation in vascular myocytes, a mechanism for vasoconstrictor-regulated vascular tone.
Volume: 286
Issue: 36
Pages: 31799-809
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Publication
30873821 | J:291784
First Author: Hasna J
Year: 2019
Journal: Cell Physiol Biochem
Title: The Deletion of TRPC6 Channels Perturbs Iron and Zinc Homeostasis and Pregnancy Outcome in Mice.
Volume: 52
Issue: 3
Pages: 455-467
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Publication
23385000 | J:195419
First Author: Sonneveld R
Year: 2013
Journal: Am J Pathol
Title: Vitamin D down-regulates TRPC6 expression in podocyte injury and proteinuric glomerular disease.
Volume: 182
Issue: 4
Pages: 1196-204
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Publication
28835433 | J:248140
First Author: Chaudhuri P
Year: 2017
Journal: Am J Physiol Cell Physiol
Title: Integration of TRPC6 and NADPH oxidase activation in lysophosphatidylcholine-induced TRPC5 externalization.
Volume: 313
Issue: 5
Pages: C541-C555
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Publication
22337127 | J:220927
 
First Author: Weissmann N
Year: 2012
Journal: Nat Commun
Title: Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice.
Volume: 3
Pages: 649
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Publication
32412783 | J:298157
First Author: Nemeth Z
Year: 2020
Journal: Am J Physiol Heart Circ Physiol
Title: Pressure-induced constriction of the middle cerebral artery is abolished in TrpC6 knockout mice.
Volume: 319
Issue: 1
Pages: H42-H50
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Publication
30665571 | J:294145
First Author: Wang L
Year: 2019
Journal: Kidney Int
Title: Knockout of TRPC6 promotes insulin resistance and exacerbates glomerular injury in Akita mice.
Volume: 95
Issue: 2
Pages: 321-332
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Publication
24453217 | J:206567
First Author: Seo K
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy.
Volume: 111
Issue: 4
Pages: 1551-6
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Publication
24731445 | J:211094
First Author: Sonneveld R
Year: 2014
Journal: Am J Pathol
Title: Glucose specifically regulates TRPC6 expression in the podocyte in an AngII-dependent manner.
Volume: 184
Issue: 6
Pages: 1715-26
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Publication
38069081 | J:343693
 
First Author: Wang M
Year: 2023
Journal: Int J Mol Sci
Title: TRPC6 Deletion Enhances eNOS Expression and Reduces LPS-Induced Acute Lung Injury.
Volume: 24
Issue: 23
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Publication
36362339 | J:331579
 
First Author: Zernov N
Year: 2022
Journal: Int J Mol Sci
Title: New Positive TRPC6 Modulator Penetrates Blood-Brain Barrier, Eliminates Synaptic Deficiency and Restores Memory Deficit in 5xFAD Mice.
Volume: 23
Issue: 21
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Publication
31162976 | J:294014
First Author: Numaga-Tomita T
Year: 2019
Journal: FASEB J
Title: TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN.
Volume: 33
Issue: 9
Pages: 9785-9796
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Publication
27979597 | J:315425
First Author: Wu YL
Year: 2017
Journal: Kidney Int
Title: Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho.
Volume: 91
Issue: 4
Pages: 830-841
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Publication
28790356 | J:275284
First Author: Oda S
Year: 2017
Journal: Sci Rep
Title: TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice.
Volume: 7
Issue: 1
Pages: 7511
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Publication
24740790 | J:211091
First Author: Hall G
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity.
Volume: 306
Issue: 12
Pages: F1442-50
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Publication
30779919 | J:277912
First Author: Chen QZ
Year: 2019
Journal: Exp Cell Res
Title: TRPC6 modulates adhesion of neutrophils to airway epithelial cells via NF-κB activation and ICAM-1 expression with ozone exposure.
Volume: 377
Issue: 1-2
Pages: 56-66
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Publication
26858457 | J:230418
First Author: Chaudhuri P
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Membrane translocation of TRPC6 channels and endothelial migration are regulated by calmodulin and PI3 kinase activation.
Volume: 113
Issue: 8
Pages: 2110-5
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Publication
22724068 | J:311177
First Author: Quick K
Year: 2012
Journal: Open Biol
Title: TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells.
Volume: 2
Issue: 5
Pages: 120068
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Publication
20448219 | J:175052
First Author: Kinoshita H
Year: 2010
Journal: Circ Res
Title: Inhibition of TRPC6 channel activity contributes to the antihypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heart.
Volume: 106
Issue: 12
Pages: 1849-60
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Publication
21839714 | J:179938
First Author: Nijenhuis T
Year: 2011
Journal: Am J Pathol
Title: Angiotensin II contributes to podocyte injury by increasing TRPC6 expression via an NFAT-mediated positive feedback signaling pathway.
Volume: 179
Issue: 4
Pages: 1719-32
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Publication
22031853 | J:180243
First Author: Kim EY
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: Insulin increases surface expression of TRPC6 channels in podocytes: role of NADPH oxidases and reactive oxygen species.
Volume: 302
Issue: 3
Pages: F298-307
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Publication
27879271 | J:238425
First Author: Bernichtein S
Year: 2017
Journal: Cancer Res
Title: Vitamin D3 Prevents Calcium-Induced Progression of Early-Stage Prostate Tumors by Counteracting TRPC6 and Calcium Sensing Receptor Upregulation.
Volume: 77
Issue: 2
Pages: 355-365
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Publication
24553432 | J:210530
First Author: Roshanravan H
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: ATP acting through P2Y receptors causes activation of podocyte TRPC6 channels: role of podocin and reactive oxygen species.
Volume: 306
Issue: 9
Pages: F1088-97
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Publication
26193076 | J:231240
First Author: Kim EY
Year: 2015
Journal: Biochim Biophys Acta
Title: Syndecan-4 ectodomain evokes mobilization of podocyte TRPC6 channels and their associated pathways: An essential role for integrin signaling.
Volume: 1853
Issue: 10 Pt A
Pages: 2610-20
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Publication
36224261 | J:350158
First Author: El Hamdaoui Y
Year: 2022
Journal: Mol Psychiatry
Title: Analysis of hyperforin (St. John's wort) action at TRPC6 channel leads to the development of a new class of antidepressant drugs.
Volume: 27
Issue: 12
Pages: 5070-5085
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Publication
23814119 | J:264473
First Author: Chen W
Year: 2013
Journal: Arterioscler Thromb Vasc Biol
Title: Atrial natriuretic peptide-mediated inhibition of microcirculatory endothelial Ca2+ and permeability response to histamine involves cGMP-dependent protein kinase I and TRPC6 channels.
Volume: 33
Issue: 9
Pages: 2121-9
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Publication
34547679 | J:331157
 
First Author: Wang L
Year: 2021
Journal: Int Immunopharmacol
Title: Role of transient receptor potential channel 6 in the osteogenesis of periodontal ligament cells.
Volume: 100
Pages: 108134
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Protein
Q6NV56
Organism: Mus musculus/domesticus
Length: 406  
Fragment?: false
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Publication
23022034 | J:189077
First Author: Davis J
Year: 2012
Journal: Dev Cell
Title: A TRPC6-dependent pathway for myofibroblast transdifferentiation and wound healing in vivo.
Volume: 23
Issue: 4
Pages: 705-15
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Publication
36460692 | J:334628
First Author: Tang N
Year: 2022
Journal: Nat Commun
Title: TRPC channels blockade abolishes endotoxemic cardiac dysfunction by hampering intracellular inflammation and Ca(2+) leakage.
Volume: 13
Issue: 1
Pages: 7455
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Publication
16055711 | J:106082
First Author: Dietrich A
Year: 2005
Journal: Mol Cell Biol
Title: Increased vascular smooth muscle contractility in TRPC6-/- mice.
Volume: 25
Issue: 16
Pages: 6980-9
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Publication
17142322 | J:118269
First Author: Weissmann N
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange.
Volume: 103
Issue: 50
Pages: 19093-8
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Publication
22206677 | J:180287
First Author: Paez Espinosa EV
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Mouse transient receptor potential channel 6: role in hemostasis and thrombogenesis.
Volume: 417
Issue: 2
Pages: 853-6
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Publication
36940798 | J:349842
First Author: May CJ
Year: 2023
Journal: Kidney Int
Title: Podocyte protease activated receptor 1 stimulation in mice produces focal segmental glomerulosclerosis mirroring human disease signaling events.
Volume: 104
Issue: 2
Pages: 265-278
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Publication
35537100 | J:325671
First Author: Wang Z
Year: 2022
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Transient receptor potential cation channel 6 deficiency leads to increased body weight and metabolic dysfunction.
Volume: 323
Issue: 1
Pages: R81-R97
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Publication
27932059 | J:254041
First Author: Hofmann K
Year: 2017
Journal: Biochim Biophys Acta
Title: Classical transient receptor potential 6 (TRPC6) channels support myofibroblast differentiation and development of experimental pulmonary fibrosis.
Volume: 1863
Issue: 2
Pages: 560-568
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Publication
22176814 | J:330460
First Author: Ramanathan G
Year: 2012
Journal: J Thromb Haemost
Title: Defective diacylglycerol-induced Ca2+ entry but normal agonist-induced activation responses in TRPC6-deficient mouse platelets.
Volume: 10
Issue: 3
Pages: 419-29
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Publication
24074949 | J:317966
First Author: Berna-Erro A
Year: 2014
Journal: Blood Cells Mol Dis
Title: The canonical transient receptor potential 6 (TRPC6) channel is sensitive to extracellular pH in mouse platelets.
Volume: 52
Issue: 2-3
Pages: 108-15
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Publication
26239116 | J:231354
First Author: Lopez E
Year: 2015
Journal: Biochim Biophys Acta
Title: FKBP25 and FKBP38 regulate non-capacitative calcium entry through TRPC6.
Volume: 1853
Issue: 10 Pt A
Pages: 2684-96
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Publication
17360584 | J:248261
First Author: Liao Y
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Orai proteins interact with TRPC channels and confer responsiveness to store depletion.
Volume: 104
Issue: 11
Pages: 4682-7
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Publication
19094061 | J:143042
First Author: Tu P
Year: 2009
Journal: J Neurochem
Title: Diacylglycerol analogues activate second messenger-operated calcium channels exhibiting TRPC-like properties in cortical neurons.
Volume: 108
Issue: 1
Pages: 126-38
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Publication
24194522 | J:315314
First Author: Kistler AD
Year: 2013
Journal: J Biol Chem
Title: Transient receptor potential channel 6 (TRPC6) protects podocytes during complement-mediated glomerular disease.
Volume: 288
Issue: 51
Pages: 36598-609
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Publication
34866402 | J:345068
First Author: Wang Z
Year: 2022
Journal: Am J Physiol Renal Physiol
Title: Transient receptor potential cation channel 6 contributes to kidney injury induced by diabetes and hypertension.
Volume: 322
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