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Search results 1 to 100 out of 446 for Trpm2

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
470101 | TRPM2
Type: gene
Organism: chimpanzee
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Gene
508029 | TRPM2
Type: gene
Organism: cattle
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Gene
100856408 | TRPM2
Type: gene
Organism: dog, domestic
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Gene
424835 | TRPM2
Type: gene
Organism: chicken
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Gene
799412 | trpm2
Type: gene
Organism: zebrafish
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Gene
722161 | TRPM2
Type: gene
Organism: macaque, rhesus
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Gene
100124999 | trpm2
Type: gene
Organism: frog, western clawed
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Gene
7226 | TRPM2
Type: gene
Organism: human
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Gene
294329 | Trpm2
Type: gene
Organism: rat
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Protein Domain
IPR029594 | TRPM2
Type: Family
Description: The TRPM subfamily of mammalian TRP channels includes TRPM2, which has both Ca(2+)-permeable nonselective ion channel functionality and enzymatic ADP-ribose (ADPr) hydrolase activity []. TRPM2 channels are embedded in the plasma membrane and/or lysosomal compartments and are activated in a synergistic fashion by intracellular ADP-ribose (ADPr) and Ca(2+) []. They are also activated by oxidative stress, and confer susceptibility to cell death []. TRPM2 proteins are widely expressed in a range of tissues, including the brain, immune system, endocrine cells, and endothelia. They are involved in a variety of functions, including cytokine production, insulin release, cell motility and cell death [].
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Protein Coding Gene
MGI:1351901 | Trpm2
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
101928607 | TRPM2-AS
Type: gene
Organism: human
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GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1640522
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1697422
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1674822
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1666822
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3596122
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1620122
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1752522
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1691622
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760622
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1737322
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689522
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666387
Age: embryonic day 10.5
Image: Trpm2 10.5dpc
Specimen Label: Trpm2 10.5dpc
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1619822
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640517
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666387
Age: embryonic day 10.5
Image: Trpm2 10.5dpc
Specimen Label: Trpm2 10.5dpc
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1721322
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1665922
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1706822
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1727022
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609617
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666387
Age: embryonic day 10.5
Image: Trpm2 10.5dpc
Specimen Label: Trpm2 10.5dpc
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1733122
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1778722
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1752322
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1672822
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3598822
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1853522
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666387
Age: embryonic day 10.5
Image: Trpm2 10.5dpc
Specimen Label: Trpm2 10.5dpc
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610517
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666387
Age: embryonic day 10.5
Image: Trpm2 10.5dpc
Specimen Label: Trpm2 10.5dpc
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:2674629
Age: embryonic day 9.5
Image: Trpm2 9.5dpc
Specimen Label: Trpm2 9.5dpc
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1842622
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1674417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666387
Age: embryonic day 10.5
Image: Trpm2 10.5dpc
Specimen Label: Trpm2 10.5dpc
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1684622
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1624717
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666387
Age: embryonic day 10.5
Image: Trpm2 10.5dpc
Specimen Label: Trpm2 10.5dpc
Detected: true
Specimen Num: 1
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1624722
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1718522
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1759722
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1750322
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1775122
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1797222
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3274122
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1776322
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609217
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666387
Age: embryonic day 10.5
Image: Trpm2 10.5dpc
Specimen Label: Trpm2 10.5dpc
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1832122
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666387
Age: embryonic day 10.5
Image: Trpm2 10.5dpc
Specimen Label: Trpm2 10.5dpc
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611717
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666387
Age: embryonic day 10.5
Image: Trpm2 10.5dpc
Specimen Label: Trpm2 10.5dpc
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1668822
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1757722
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666387
Age: embryonic day 10.5
Image: Trpm2 10.5dpc
Specimen Label: Trpm2 10.5dpc
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:642291
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1796222
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666387
Age: embryonic day 14.5
Image: Trpm2 14.5dpc
Specimen Label: Trpm2 14.5dpc
Detected: true
Specimen Num: 2
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Publication
12594222 | -
First Author: Zhang W
Year: 2003
Journal: J Biol Chem
Title: A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death.
Volume: 278
Issue: 18
Pages: 16222-9
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Protein
A0A1W2P6F5
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: true
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Publication
24756715 | -
 
First Author: Faouzi M
Year: 2014
Journal: Handb Exp Pharmacol
Title: TRPM2.
Volume: 222
Pages: 403-26
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Publication
21135052 | -
First Author: Sumoza-Toledo A
Year: 2011
Journal: J Physiol
Title: TRPM2: a multifunctional ion channel for calcium signalling.
Volume: 589
Issue: Pt 7
Pages: 1515-25
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Protein
Q3UYE9
Organism: Mus musculus/domesticus
Length: 807  
Fragment?: true
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Publication
24569808 | J:206793
First Author: Kheradpezhouh E
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: TRPM2 channels mediate acetaminophen-induced liver damage.
Volume: 111
Issue: 8
Pages: 3176-81
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Publication
32788732 | J:294053
First Author: Vilar B
Year: 2020
Journal: Nature
Title: Heat detection by the TRPM2 ion channel.
Volume: 584
Issue: 7820
Pages: E5-E12
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Publication
23443543 | J:221237
 
First Author: Liu X
Year: 2013
Journal: Nat Commun
Title: Loss of TRPM2 function protects against irradiation-induced salivary gland dysfunction.
Volume: 4
Pages: 1515
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Publication
33244095 | J:299699
First Author: Zhao Q
Year: 2020
Journal: Sci Rep
Title: TRPM2 promotes autophagic degradation in vascular smooth muscle cells.
Volume: 10
Issue: 1
Pages: 20719
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Protein
Q91YD4
Organism: Mus musculus/domesticus
Length: 1506  
Fragment?: false
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Publication
27533035 | J:236608
First Author: Tan CH
Year: 2016
Journal: Nature
Title: The TRPM2 ion channel is required for sensitivity to warmth.
Volume: 536
Issue: 7617
Pages: 460-3
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Publication
23371039 | J:321461
First Author: Oda S
Year: 2013
Journal: Pflugers Arch
Title: TRPM2 contributes to antigen-stimulated Ca²⁺ influx in mucosal mast cells.
Volume: 465
Issue: 7
Pages: 1023-30
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Publication
28223219 | J:251106
First Author: Jeong H
Year: 2017
Journal: Biochem Biophys Res Commun
Title: TRPM2 contributes to LPC-induced intracellular Ca2+ influx and microglial activation.
Volume: 485
Issue: 2
Pages: 301-306
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Publication
30999030 | J:282855
 
First Author: Kakae M
Year: 2019
Journal: Neuroscience
Title: Pathophysiological Role of TRPM2 in Age-Related Cognitive Impairment in Mice.
Volume: 408
Pages: 204-213
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Publication
24492610 | J:210676
First Author: Miller BA
Year: 2014
Journal: J Biol Chem
Title: TRPM2 channels protect against cardiac ischemia-reperfusion injury: role of mitochondria.
Volume: 289
Issue: 11
Pages: 7615-29
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Publication
22275755 | J:184637
First Author: Zhang Z
Year: 2012
Journal: Am J Physiol Endocrinol Metab
Title: TRPM2 Ca2+ channel regulates energy balance and glucose metabolism.
Volume: 302
Issue: 7
Pages: E807-16
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Publication
35095852 | J:319727
 
First Author: Lory NC
Year: 2021
Journal: Front Immunol
Title: TRPM2 Is Not Required for T-Cell Activation and Differentiation.
Volume: 12
Pages: 778916
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Publication
25295536 | J:217606
First Author: Gao G
Year: 2014
Journal: J Clin Invest
Title: TRPM2 mediates ischemic kidney injury and oxidant stress through RAC1.
Volume: 124
Issue: 11
Pages: 4989-5001
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Publication
35563730 | J:334676
 
First Author: Zhang Y
Year: 2022
Journal: Cells
Title: TRPM2 Promotes Atherosclerotic Progression in a Mouse Model of Atherosclerosis.
Volume: 11
Issue: 9
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Publication
31911949 | J:285409
First Author: Li Y
Year: 2020
Journal: Sci Adv
Title: Deficiency of TRPM2 leads to embryonic neurogenesis defects in hyperthermia.
Volume: 6
Issue: 1
Pages: eaay6350
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Publication
27562954 | J:235274
First Author: Song K
Year: 2016
Journal: Science
Title: The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia.
Volume: 353
Issue: 6306
Pages: 1393-1398
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Publication
35421327 | J:326058
First Author: Zong P
Year: 2022
Journal: Neuron
Title: Functional coupling of TRPM2 and extrasynaptic NMDARs exacerbates excitotoxicity in ischemic brain injury.
Volume: 110
Issue: 12
Pages: 1944-1958.e8
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Publication
22101731 | J:178997
First Author: Di A
Year: 2011
Journal: Nat Immunol
Title: The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation.
Volume: 13
Issue: 1
Pages: 29-34
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Publication
23801245 | J:321082
First Author: Shimizu T
Year: 2013
Journal: J Cereb Blood Flow Metab
Title: Androgen and PARP-1 regulation of TRPM2 channels after ischemic injury.
Volume: 33
Issue: 10
Pages: 1549-55
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Publication
20921208 | J:169329
First Author: Uchida K
Year: 2011
Journal: Diabetes
Title: Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice.
Volume: 60
Issue: 1
Pages: 119-26
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Publication
23129587 | J:210287
First Author: Hiroi T
Year: 2013
Journal: Cardiovasc Res
Title: Neutrophil TRPM2 channels are implicated in the exacerbation of myocardial ischaemia/reperfusion injury.
Volume: 97
Issue: 2
Pages: 271-81
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Publication
30273551 | J:272920
 
First Author: Andoh C
Year: 2019
Journal: Brain Res
Title: TRPM2 confers susceptibility to social stress but is essential for behavioral flexibility.
Volume: 1704
Pages: 68-77
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Publication
37649595 | J:340580
First Author: Yu B
Year: 2023
Journal: Theranostics
Title: TRPM2 protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction via modulating autophagy.
Volume: 13
Issue: 13
Pages: 4356-4375
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Publication
23077651 | J:192207
First Author: Melzer N
Year: 2012
Journal: PLoS One
Title: TRPM2 cation channels modulate T cell effector functions and contribute to autoimmune CNS inflammation.
Volume: 7
Issue: 10
Pages: e47617
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Publication
34367466 | J:343980
 
First Author: Hu X
Year: 2021
Journal: Oxid Med Cell Longev
Title: Deficiency of ROS-Activated TRPM2 Channel Protects Neurons from Cerebral Ischemia-Reperfusion Injury through Upregulating Autophagy.
Volume: 2021
Pages: 7356266
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Publication
30842533 | J:275913
First Author: Ota W
Year: 2019
Journal: Sci Rep
Title: Involvement of TRPM2 and TRPM8 in temperature-dependent masking behavior.
Volume: 9
Issue: 1
Pages: 3706
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Publication
24413888 | J:213690
First Author: Jang Y
Year: 2014
Journal: Pflugers Arch
Title: TRPM2 mediates the lysophosphatidic acid-induced neurite retraction in the developing brain.
Volume: 466
Issue: 10
Pages: 1987-98
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Publication
28970008 | J:253867
First Author: Gally F
Year: 2018
Journal: Biochim Biophys Acta
Title: The TRPM2 ion channel contributes to cytokine hyperproduction in a mouse model of Down Syndrome.
Volume: 1864
Issue: 1
Pages: 126-132
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Publication
24174660 | J:204666
First Author: Alim I
Year: 2013
Journal: J Neurosci
Title: Modulation of NMDAR subunit expression by TRPM2 channels regulates neuronal vulnerability to ischemic cell death.
Volume: 33
Issue: 44
Pages: 17264-77
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Publication
31450153 | J:293175
 
First Author: Zhu T
Year: 2019
Journal: Int Immunopharmacol
Title: TRPM2 channel regulates cytokines production in astrocytes and aggravates brain disorder during lipopolysaccharide-induced endotoxin sepsis.
Volume: 75
Pages: 105836
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Publication
22423113 | J:183236
First Author: Haraguchi K
Year: 2012
Journal: J Neurosci
Title: TRPM2 contributes to inflammatory and neuropathic pain through the aggravation of pronociceptive inflammatory responses in mice.
Volume: 32
Issue: 11
Pages: 3931-41
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Publication
25576627 | J:220747
First Author: Hoffman NE
Year: 2015
Journal: Am J Physiol Heart Circ Physiol
Title: Ca²⁺ entry via Trpm2 is essential for cardiac myocyte bioenergetics maintenance.
Volume: 308
Issue: 6
Pages: H637-50
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Publication
30215158 | J:321857
First Author: Jang Y
Year: 2019
Journal: Mol Neurobiol
Title: Trpm2 Ablation Accelerates Protein Aggregation by Impaired ADPR and Autophagic Clearance in the Brain.
Volume: 56
Issue: 5
Pages: 3819-3832
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Publication
28082421 | J:246192
First Author: Di A
Year: 2017
Journal: J Cell Sci
Title: Role of the phagosomal redox-sensitive TRP channel TRPM2 in regulating bactericidal activity of macrophages.
Volume: 130
Issue: 4
Pages: 735-744
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Publication
37648036 | J:339985
 
First Author: Chen C
Year: 2023
Journal: Neurobiol Dis
Title: Trpm2 deficiency in microglia attenuates neuroinflammation during epileptogenesis by upregulating autophagy via the AMPK/mTOR pathway.
Volume: 186
Pages: 106273
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