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Search results 1 to 100 out of 156 for Trpm4

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0.042s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: rat
Protein Domain
Type: Family
Description: The TRPM subfamily of mammalian TRP channels includes TRPM4, which is a Ca2+-activated nonselective cation channel that mediates cell membrane depolarisation []. Unlike TRPM5, its closest relative in the transient receptor potential family, TRPM4 proteins are widely expressed in the body []. They are abundant expressed in cardiac cells and are involved in several aspects of cardiac rhythmicity, including cardiac conduction, pace making and action-potential repolarisation []. They are also expressed in cerebral arteries, where they play a role in myogenic vasoconstriction []. TRPM4 proteins also affect T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signalling and NFATC1 localisation [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication  
First Author: Kruse M
Year: 2014
Journal: Curr Opin Pharmacol
Title: TRPM4 channels in the cardiovascular system.
Volume: 15
Pages: 68-73
Publication
First Author: Launay P
Year: 2002
Journal: Cell
Title: TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization.
Volume: 109
Issue: 3
Pages: 397-407
Publication
First Author: Earley S
Year: 2004
Journal: Circ Res
Title: Critical role for transient receptor potential channel TRPM4 in myogenic constriction of cerebral arteries.
Volume: 95
Issue: 9
Pages: 922-9
Publication
First Author: Weber KS
Year: 2010
Journal: J Immunol
Title: Trpm4 differentially regulates Th1 and Th2 function by altering calcium signaling and NFAT localization.
Volume: 185
Issue: 5
Pages: 2836-46
Publication
First Author: Fouchet A
Year: 2023
Journal: Reproduction
Title: TRPM4 contribution in mouse uterine contractions.
Volume: 166
Issue: 2
Pages: 77-87
Publication  
First Author: Yamada D
Year: 2022
Journal: Front Immunol
Title: Gain-of-function of TRPM4 predisposes mice to psoriasiform dermatitis.
Volume: 13
Pages: 1025499
Publication
First Author: Murakami M
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Identification and characterization of the murine TRPM4 channel.
Volume: 307
Issue: 3
Pages: 522-8
Publication
First Author: Mundrucz L
Year: 2023
Journal: BMC Biol
Title: TRPM4 regulates hilar mossy cell loss in temporal lobe epilepsy.
Volume: 21
Issue: 1
Pages: 96
Publication  
First Author: Eckstein E
Year: 2020
Journal: Mol Cell Neurosci
Title: Cyclic regulation of Trpm4 expression in female vomeronasal neurons driven by ovarian sex hormones.
Volume: 105
Pages: 103495
Publication
First Author: Demion M
Year: 2014
Journal: PLoS One
Title: Trpm4 gene invalidation leads to cardiac hypertrophy and electrophysiological alterations.
Volume: 9
Issue: 12
Pages: e115256
Publication
First Author: Shigeto M
Year: 2015
Journal: J Clin Invest
Title: GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation.
Volume: 125
Issue: 12
Pages: 4714-28
Publication
First Author: Gerzanich V
Year: 2009
Journal: Nat Med
Title: De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury.
Volume: 15
Issue: 2
Pages: 185-91
Publication
First Author: Dutta Banik D
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: TRPM4 and TRPM5 are both required for normal signaling in taste receptor cells.
Volume: 115
Issue: 4
Pages: E772-E781
Publication    
First Author: Guo Y
Year: 2021
Journal: Elife
Title: The Ca2+-activated cation channel TRPM4 is a positive regulator of pressure overload-induced cardiac hypertrophy.
Volume: 10
Publication
First Author: Schattling B
Year: 2012
Journal: Nat Med
Title: TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis.
Volume: 18
Issue: 12
Pages: 1805-11
Publication  
First Author: Dutta Banik D
Year: 2023
Journal: Front Cell Neurosci
Title: Defining the role of TRPM4 in broadly responsive taste receptor cells.
Volume: 17
Pages: 1148995
Publication
First Author: Crnich R
Year: 2010
Journal: Am J Physiol Cell Physiol
Title: Vasoconstriction resulting from dynamic membrane trafficking of TRPM4 in vascular smooth muscle cells.
Volume: 299
Issue: 3
Pages: C682-94
Publication
First Author: Boukenna M
Year: 2023
Journal: Am J Physiol Heart Circ Physiol
Title: Multiomics uncover the proinflammatory role of Trpm4 deletion after myocardial infarction in mice.
Volume: 324
Issue: 4
Pages: H504-H518
Publication
First Author: Serafini N
Year: 2012
Journal: J Immunol
Title: The TRPM4 channel controls monocyte and macrophage, but not neutrophil, function for survival in sepsis.
Volume: 189
Issue: 7
Pages: 3689-99
Publication
First Author: Li K
Year: 2021
Journal: Cell Rep
Title: TRPM4 mediates a subthreshold membrane potential oscillation in respiratory chemoreceptor neurons that drives pacemaker firing and breathing.
Volume: 34
Issue: 5
Pages: 108714
Publication
First Author: Kecskés M
Year: 2015
Journal: Basic Res Cardiol
Title: The Ca(2+)-activated cation channel TRPM4 is a negative regulator of angiotensin II-induced cardiac hypertrophy.
Volume: 110
Issue: 4
Pages: 43
Publication
First Author: Yamasaki E
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Faulty TRPM4 channels underlie age-dependent cerebral vascular dysfunction in Gould syndrome.
Volume: 120
Issue: 5
Pages: e2217327120
Publication
First Author: Barbet G
Year: 2008
Journal: Nat Immunol
Title: The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells.
Volume: 9
Issue: 10
Pages: 1148-56
Publication
First Author: Arullampalam P
Year: 2023
Journal: Physiol Rep
Title: Knockdown of the TRPM4 channel alters cardiac electrophysiology and hemodynamics in a sex- and age-dependent manner in mice.
Volume: 11
Issue: 16
Pages: e15783
Protein
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: true
Publication  
First Author: Mathar I
Year: 2014
Journal: Handb Exp Pharmacol
Title: TRPM4.
Volume: 222
Pages: 461-87
Publication  
First Author: Koizumi H
Year: 2018
Journal: eNeuro
Title: Transient Receptor Potential Channels TRPM4 and TRPC3 Critically Contribute to Respiratory Motor Pattern Formation but not Rhythmogenesis in Rodent Brainstem Circuits.
Volume: 5
Issue: 1
Publication
First Author: O'Malley JJ
Year: 2020
Journal: J Neurosci
Title: TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations.
Volume: 40
Issue: 25
Pages: 4813-4823
Protein
Organism: Mus musculus/domesticus
Length: 1213  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1066  
Fragment?: false
Publication
First Author: Chen J
Year: 2022
Journal: J Neuroinflammation
Title: Flufenamic acid improves survival and neurologic outcome after successful cardiopulmonary resuscitation in mice.
Volume: 19
Issue: 1
Pages: 214
Publication  
First Author: Liu K
Year: 2021
Journal: JCI Insight
Title: Attenuation of cerebral edema facilitates recovery of glymphatic system function after status epilepticus.
Volume: 6
Issue: 17
Publication  
First Author: Ozhathil LC
Year: 2021
Journal: Int J Mol Sci
Title: Deletion of Trpm4 Alters the Function of the Nav1.5 Channel in Murine Cardiac Myocytes.
Volume: 22
Issue: 7
Publication
First Author: Nilius B
Year: 2003
Journal: J Biol Chem
Title: Voltage dependence of the Ca2+-activated cation channel TRPM4.
Volume: 278
Issue: 33
Pages: 30813-20
Publication
First Author: Guo J
Year: 2017
Journal: Nature
Title: Structures of the calcium-activated, non-selective cation channel TRPM4.
Volume: 552
Issue: 7684
Pages: 205-209
Publication
First Author: Vennekens R
Year: 2007
Journal: Nat Immunol
Title: Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4.
Volume: 8
Issue: 3
Pages: 312-20
Publication
First Author: Fearey BC
Year: 2022
Journal: Sci Rep
Title: A glibenclamide-sensitive TRPM4-mediated component of CA1 excitatory postsynaptic potentials appears in experimental autoimmune encephalomyelitis.
Volume: 12
Issue: 1
Pages: 6000
Publication
First Author: Mathar I
Year: 2010
Journal: J Clin Invest
Title: Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice.
Volume: 120
Issue: 9
Pages: 3267-79
Publication
First Author: Mathar I
Year: 2014
Journal: Circ Res
Title: Increased β-adrenergic inotropy in ventricular myocardium from Trpm4-/- mice.
Volume: 114
Issue: 2
Pages: 283-94
Publication
First Author: Jacobs G
Year: 2015
Journal: Cardiovasc Res
Title: Enhanced β-adrenergic cardiac reserve in Trpm4⁻/⁻ mice with ischaemic heart failure.
Volume: 105
Issue: 3
Pages: 330-9
Publication
First Author: Menigoz A
Year: 2016
Journal: Pflugers Arch
Title: TRPM4-dependent post-synaptic depolarization is essential for the induction of NMDA receptor-dependent LTP in CA1 hippocampal neurons.
Volume: 468
Issue: 4
Pages: 593-607
Publication
First Author: Chen X
Year: 2020
Journal: J Neuropathol Exp Neurol
Title: Knockout of Transient Receptor Potential Melastatin 4 Channel Mitigates Cerebral Edema and Neuronal Injury After Status Epilepticus in Mice.
Volume: 79
Issue: 12
Pages: 1354-1364
Publication
First Author: Demion M
Year: 2007
Journal: Cardiovasc Res
Title: TRPM4, a Ca2+-activated nonselective cation channel in mouse sino-atrial node cells.
Volume: 73
Issue: 3
Pages: 531-8
Publication  
First Author: Yarishkin O
Year: 2022
Journal: Front Immunol
Title: Emergent Temporal Signaling in Human Trabecular Meshwork Cells: Role of TRPV4-TRPM4 Interactions.
Volume: 13
Pages: 805076
Publication
First Author: Kurland DB
Year: 2016
Journal: J Neuroinflammation
Title: The Sur1-Trpm4 channel regulates NOS2 transcription in TLR4-activated microglia.
Volume: 13
Issue: 1
Pages: 130
Publication  
First Author: Uhl S
Year: 2014
Journal: J Mol Cell Cardiol
Title: Adenylyl cyclase-mediated effects contribute to increased Isoprenaline-induced cardiac contractility in TRPM4-deficient mice.
Volume: 74
Pages: 307-17
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Woo SK
Year: 2013
Journal: J Biol Chem
Title: Complex N-glycosylation stabilizes surface expression of transient receptor potential melastatin 4b protein.
Volume: 288
Issue: 51
Pages: 36409-17
GXD Expression    
Probe: MGI:4457691
Assay Type: RT-PCR
Annotation Date: 2010-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666820
Stage: TS20
Assay Id: MGI:4457753
Age: embryonic day 12.0
Image: 1
Specimen Label: E12
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4457691
Assay Type: RT-PCR
Annotation Date: 2010-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666822
Stage: TS22
Assay Id: MGI:4457753
Age: embryonic day 14.0
Image: 1
Specimen Label: E14
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:4457691
Assay Type: RT-PCR
Annotation Date: 2010-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666826
Stage: TS26
Assay Id: MGI:4457753
Age: embryonic day 18.0
Image: 1
Specimen Label: E18
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:4457691
Assay Type: RT-PCR
Annotation Date: 2010-07-06
Strength: Present
Sex: Female
Emaps: EMAPS:1666827
Stage: TS27
Assay Id: MGI:4457753
Age: postnatal day 0
Image: 1
Specimen Label: P0
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:4457691
Assay Type: RT-PCR
Annotation Date: 2010-07-06
Strength: Present
Sex: Female
Emaps: EMAPS:1666828
Stage: TS28
Assay Id: MGI:4457753
Age: postnatal day 4
Image: 1
Specimen Label: P4
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:4457691
Assay Type: RT-PCR
Annotation Date: 2010-07-06
Strength: Present
Sex: Female
Emaps: EMAPS:1666828
Stage: TS28
Assay Id: MGI:4457753
Age: postnatal day 12
Image: 1
Specimen Label: P12
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:4457691
Assay Type: RT-PCR
Annotation Date: 2010-07-06
Strength: Present
Sex: Female
Emaps: EMAPS:1666828
Stage: TS28
Assay Id: MGI:4457753
Age: postnatal adult
Image: 1
Specimen Label: Adult
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:4457691
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666820
Stage: TS20
Assay Id: MGI:4458105
Age: embryonic day 12.0
Image: 6
Specimen Label: E12
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4457691
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1715520
Stage: TS20
Assay Id: MGI:4458105
Age: embryonic day 12.0
Image: 6
Specimen Label: E12
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:4457691
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666822
Stage: TS22
Assay Id: MGI:4458105
Age: embryonic day 14.0
Image: 6
Specimen Label: E14
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:4457691
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1715522
Stage: TS22
Assay Id: MGI:4458105
Age: embryonic day 14.0
Image: 6
Specimen Label: E14
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:4457691
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666826
Stage: TS26
Assay Id: MGI:4458105
Age: embryonic day 18.0
Image: 6
Specimen Label: E18
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:4457691
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1715526
Stage: TS26
Assay Id: MGI:4458105
Age: embryonic day 18.0
Image: 6
Specimen Label: E18
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:4457691
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Female
Emaps: EMAPS:1666827
Stage: TS27
Assay Id: MGI:4458105
Age: postnatal day 0
Image: 6
Specimen Label: P0
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:4457691
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Female
Emaps: EMAPS:1679827
Stage: TS27
Assay Id: MGI:4458105
Age: postnatal day 0
Image: 6
Specimen Label: P0
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:4457691
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Female
Emaps: EMAPS:1666828
Stage: TS28
Assay Id: MGI:4458105
Age: postnatal day 4
Image: 6
Specimen Label: P4
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:4457691
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Female
Emaps: EMAPS:1679828
Stage: TS28
Assay Id: MGI:4458105
Age: postnatal day 4
Image: 6
Specimen Label: P4
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:4457691
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Female
Emaps: EMAPS:1666828
Stage: TS28
Assay Id: MGI:4458105
Age: postnatal day 12
Image: 6
Specimen Label: P12
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:4457691
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Female
Emaps: EMAPS:1679828
Stage: TS28
Assay Id: MGI:4458105
Age: postnatal day 12
Image: 6
Specimen Label: P12
Detected: true
Specimen Num: 12
GXD Expression    
Probe: MGI:4457691
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Female
Emaps: EMAPS:1666828
Stage: TS28
Assay Id: MGI:4458105
Age: postnatal adult
Image: 6
Specimen Label: Adult
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:4457691
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Female
Emaps: EMAPS:1679828
Stage: TS28
Assay Id: MGI:4458105
Age: postnatal adult
Image: 6
Specimen Label: Adult
Detected: true
Specimen Num: 14
GXD Expression      
Probe: MGI:4821982
Assay Type: RT-PCR
Annotation Date: 2010-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759725
Stage: TS25
Assay Id: MGI:4822330
Age: embryonic day 17.0
Specimen Label: E17
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4821982
Assay Type: RT-PCR
Annotation Date: 2010-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759726
Stage: TS26
Assay Id: MGI:4822330
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:4821982
Assay Type: RT-PCR
Annotation Date: 2010-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759727
Stage: TS27
Assay Id: MGI:4822330
Age: postnatal day 0
Specimen Label: P0
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:4821982
Assay Type: RT-PCR
Annotation Date: 2010-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759727
Stage: TS27
Assay Id: MGI:4822330
Age: postnatal day 2
Specimen Label: P2
Detected: true
Specimen Num: 4