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Search results 1 to 100 out of 253 for Trpm7

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Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
54822 | TRPM7
Type: gene
Organism: human
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Gene
100329113 | trpm7
Type: gene
Organism: frog, western clawed
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Gene
679906 | Trpm7
Type: gene
Organism: rat
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Gene
453429 | TRPM7
Type: gene
Organism: chimpanzee
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Gene
478300 | TRPM7
Type: gene
Organism: dog, domestic
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Gene
514642 | TRPM7
Type: gene
Organism: cattle
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Gene
427502 | TRPM7
Type: gene
Organism: chicken
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Gene
280653 | trpm7
Type: gene
Organism: zebrafish
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Gene
716755 | TRPM7
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR029601 | TRPM7
Type: Family
Description: The TRPM subfamily of mammalian TRP channels includes TRPM7, which is a bifunctional molecule consisting of a TRP ion channel fused to a serine/threonine-protein kinase domain. It conducts Zn(2+), Mg(2+), and Ca(2+) as well as monovalent cations []. The kinase domain is proteolytically cleaved from the channel domain in a cell-type-specific manner, with the cleaved kinase fragments translocating to the nucleus and binding multiple components of chromatin-remodeling complexes []. TRPM7 plays a prominent role in cellular and systemic magnesium homeostasis, and is a key player in embryonic development, global ischemia, cardiovascular disease, and cancer [].
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Protein Coding Gene
MGI:1929996 | Trpm7
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
24855944 | J:222132
First Author: Krapivinsky G
Year: 2014
Journal: Cell
Title: The TRPM7 chanzyme is cleaved to release a chromatin-modifying kinase.
Volume: 157
Issue: 5
Pages: 1061-72
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Publication
31250885 | J:291519
First Author: Rios FJ
Year: 2020
Journal: Cardiovasc Res
Title: Chanzyme TRPM7 protects against cardiovascular inflammation and fibrosis.
Volume: 116
Issue: 3
Pages: 721-735
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Publication
21045827 | J:205665
 
First Author: Ryazanova LV
Year: 2010
Journal: Nat Commun
Title: TRPM7 is essential for Mg(2+) homeostasis in mammals.
Volume: 1
Pages: 109
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Publication
35882956 | J:342306
First Author: Rios FJ
Year: 2022
Journal: Commun Biol
Title: TRPM7 deficiency exacerbates cardiovascular and renal damage induced by aldosterone-salt.
Volume: 5
Issue: 1
Pages: 746
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Publication
26504086 | J:276302
First Author: Watanabe M
Year: 2015
Journal: J Biol Chem
Title: Trpm7 Protein Contributes to Intercellular Junction Formation in Mouse Urothelium.
Volume: 290
Issue: 50
Pages: 29882-92
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Publication
29871911 | J:280850
 
First Author: Krishnamoorthy M
Year: 2018
Journal: Sci Signal
Title: The ion channel TRPM7 is required for B cell lymphopoiesis.
Volume: 11
Issue: 533
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Publication
29515374 | J:263973
 
First Author: Morgan CP
Year: 2018
Journal: Front Cell Neurosci
Title: TRPV6, TRPM6 and TRPM7 Do Not Contribute to Hair-Cell Mechanotransduction.
Volume: 12
Pages: 41
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Publication
24756720 | -
 
First Author: Fleig A
Year: 2014
Journal: Handb Exp Pharmacol
Title: TRPM7.
Volume: 222
Pages: 521-46
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Publication
25534891 | J:280851
 
First Author: Ryazanova LV
Year: 2014
Journal: Sci Rep
Title: Elucidating the role of the TRPM7 alpha-kinase: TRPM7 kinase inactivation leads to magnesium deprivation resistance phenotype in mice.
Volume: 4
Pages: 7599
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Publication
34569930 | J:312457
   
First Author: Jiang ZJ
Year: 2021
Journal: Elife
Title: TRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis.
Volume: 10
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Publication
19734892 | J:154649
First Author: Sun HS
Year: 2009
Journal: Nat Neurosci
Title: Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia.
Volume: 12
Issue: 10
Pages: 1300-7
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Publication
23878236 | J:200702
First Author: Sah R
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity.
Volume: 110
Issue: 32
Pages: E3037-46
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Publication
31650715 | J:294566
First Author: Inoue H
Year: 2019
Journal: Physiol Rep
Title: Functional expression of TRPM7 as a Ca2+ influx pathway in adipocytes.
Volume: 7
Issue: 20
Pages: e14272
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Publication
29871912 | J:281885
 
First Author: Krishnamoorthy M
Year: 2018
Journal: Sci Signal
Title: The channel-kinase TRPM7 regulates antigen gathering and internalization in B cells.
Volume: 11
Issue: 533
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Publication
27020697 | J:236828
 
First Author: Stritt S
Year: 2016
Journal: Nat Commun
Title: Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture.
Volume: 7
Pages: 11097
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Publication
29924992 | J:271209
First Author: Liu Y
Year: 2018
Journal: Cell Rep
Title: TRPM7 Is Required for Normal Synapse Density, Learning, and Memory at Different Developmental Stages.
Volume: 23
Issue: 12
Pages: 3480-3491
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Publication
29203869 | J:258392
First Author: Romagnani A
Year: 2017
Journal: Nat Commun
Title: TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut.
Volume: 8
Issue: 1
Pages: 1917
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Publication
28696294 | J:352409
First Author: Abiria SA
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: TRPM7 senses oxidative stress to release Zn(2+) from unique intracellular vesicles.
Volume: 114
Issue: 30
Pages: E6079-E6088
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Publication
34345920 | J:339816
 
First Author: Altman MK
Year: 2021
Journal: Development
Title: TRPM7 is a crucial regulator of pancreatic endocrine development and high-fat-diet-induced β-cell proliferation.
Volume: 148
Issue: 16
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Publication
18590694 | J:137844
First Author: Sahni J
Year: 2008
Journal: Cell Metab
Title: TRPM7 ion channels are required for sustained phosphoinositide 3-kinase signaling in lymphocytes.
Volume: 8
Issue: 1
Pages: 84-93
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Publication
18974357 | J:140630
First Author: Jin J
Year: 2008
Journal: Science
Title: Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis.
Volume: 322
Issue: 5902
Pages: 756-60
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Protein
F6QKC0
Organism: Mus musculus/domesticus
Length: 268  
Fragment?: true
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Publication
29866880 | J:267110
First Author: Cai N
Year: 2018
Journal: J Biol Chem
Title: The kinase activity of the channel-kinase protein TRPM7 regulates stability and localization of the TRPM7 channel in polarized epithelial cells.
Volume: 293
Issue: 29
Pages: 11491-11504
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Publication
36574297 | J:336665
 
First Author: Khajavi N
Year: 2023
Journal: JCI Insight
Title: TRPM7 kinase is required for insulin production and compensatory islet responses during obesity.
Volume: 8
Issue: 3
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Publication
33658993 | J:313865
 
First Author: Nadolni W
Year: 2020
Journal: Front Immunol
Title: TRPM7 Kinase Is Essential for Neutrophil Recruitment and Function via Regulation of Akt/mTOR Signaling.
Volume: 11
Pages: 606893
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Publication
30770447 | J:272317
     
First Author: Mittermeier L
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival.
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Publication
25030553 | J:221252
 
First Author: Kaitsuka T
Year: 2014
Journal: Sci Rep
Title: Inactivation of TRPM7 kinase activity does not impair its channel function in mice.
Volume: 4
Pages: 5718
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Publication
29146750 | J:283404
First Author: Gotru SK
Year: 2018
Journal: Arterioscler Thromb Vasc Biol
Title: TRPM7 Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice.
Volume: 38
Issue: 2
Pages: 344-352
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Publication
30076216 | J:271053
First Author: Huang Y
Year: 2018
Journal: J Biol Chem
Title: TRPM7 channels play a role in high glucose-induced endoplasmic reticulum stress and neuronal cell apoptosis.
Volume: 293
Issue: 37
Pages: 14393-14406
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Publication
30967513 | J:281882
 
First Author: Qian N
Year: 2019
Journal: Sci Signal
Title: TRPM7 channels mediate spontaneous Ca2+ fluctuations in growth plate chondrocytes that promote bone development.
Volume: 12
Issue: 576
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Publication
18394644 | J:170796
First Author: Clark K
Year: 2008
Journal: J Mol Biol
Title: TRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation.
Volume: 378
Issue: 4
Pages: 790-803
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Protein
Q923J1
Organism: Mus musculus/domesticus
Length: 1863  
Fragment?: false
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Protein
B9EK83
Organism: Mus musculus/domesticus
Length: 1863  
Fragment?: false
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Protein
A2AI57
Organism: Mus musculus/domesticus
Length: 1862  
Fragment?: false
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Publication
29343440 | J:272346
First Author: Schappe MS
Year: 2018
Journal: Immunity
Title: Chanzyme TRPM7 Mediates the Ca2+ Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation.
Volume: 48
Issue: 1
Pages: 59-74.e5
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Publication
30322909 | J:267075
First Author: Bernhardt ML
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: TRPM7 and CaV3.2 channels mediate Ca2+ influx required for egg activation at fertilization.
Volume: 115
Issue: 44
Pages: E10370-E10378
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Publication
33354894 | J:329404
First Author: Beesetty P
Year: 2021
Journal: FEBS J
Title: Phagocytic activity of splenic macrophages is enhanced and accompanied by cytosolic alkalinization in TRPM7 kinase-dead mice.
Volume: 288
Issue: 11
Pages: 3585-3601
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Publication
37824328 | J:342550
First Author: Gupta N
Year: 2023
Journal: Cell Rep
Title: Essential role of Mg(2+) in mouse preimplantation embryo development revealed by TRPM7 chanzyme-deficient gametes.
Volume: 42
Issue: 10
Pages: 113232
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Publication
29273814 | J:286893
First Author: Ogata K
Year: 2017
Journal: Sci Rep
Title: The crucial role of the TRPM7 kinase domain in the early stage of amelogenesis.
Volume: 7
Issue: 1
Pages: 18099
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Publication
23734001 | J:218651
First Author: Sah R
Year: 2013
Journal: Circulation
Title: Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization.
Volume: 128
Issue: 2
Pages: 101-14
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Publication
29445164 | J:262737
First Author: Beesetty P
Year: 2018
Journal: Sci Rep
Title: Inactivation of TRPM7 kinase in mice results in enlarged spleens, reduced T-cell proliferation and diminished store-operated calcium entry.
Volume: 8
Issue: 1
Pages: 3023
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Publication
27458382 | J:289938
 
First Author: Nakano Y
Year: 2016
Journal: Front Physiol
Title: A Critical Role of TRPM7 As an Ion Channel Protein in Mediating the Mineralization of the Craniofacial Hard Tissues.
Volume: 7
Pages: 258
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Publication
36210025 | J:330577
 
First Author: Shin M
Year: 2022
Journal: Bone
Title: Mesenchymal cell TRPM7 expression is required for bone formation via the regulation of chondrogenesis.
Volume: 166
Pages: 116579
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Publication
25692682 | J:229122
First Author: Cuffe JS
Year: 2015
Journal: PLoS One
Title: Differential mRNA expression and glucocorticoid-mediated regulation of TRPM6 and TRPM7 in the heart and kidney throughout murine pregnancy and development.
Volume: 10
Issue: 2
Pages: e0117978
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Publication
28821869 | J:355633
First Author: Ferioli S
Year: 2017
Journal: Sci Rep
Title: TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg(2+) and Mg·ATP.
Volume: 7
Issue: 1
Pages: 8806
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Publication
34686339 | J:321349
First Author: Schütz A
Year: 2021
Journal: Cell Rep
Title: Trophectoderm cell failure leads to peri-implantation lethality in Trpm7-deficient mouse embryos.
Volume: 37
Issue: 3
Pages: 109851
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Publication
30108148 | J:352408
First Author: Duan J
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Structure of the mammalian TRPM7, a magnesium channel required during embryonic development.
Volume: 115
Issue: 35
Pages: E8201-E8210
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Publication
32088828 | J:305845
First Author: Zhao Y
Year: 2020
Journal: Geroscience
Title: CD82-TRPM7-Numb signaling mediates age-related cognitive impairment.
Volume: 42
Issue: 2
Pages: 595-611
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Publication
24316671 | J:208282
First Author: Cai Z
Year: 2014
Journal: Nat Cell Biol
Title: Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis.
Volume: 16
Issue: 1
Pages: 55-65
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Publication
22203997 | J:181963
First Author: Jin J
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: The channel kinase, TRPM7, is required for early embryonic development.
Volume: 109
Issue: 5
Pages: E225-33
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Publication
32706027 | J:326334
First Author: Zou ZG
Year: 2020
Journal: Clin Sci (Lond)
Title: Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function.
Volume: 134
Issue: 15
Pages: 2019-2035
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Publication
15591230 | J:105374
First Author: He Y
Year: 2005
Journal: Circ Res
Title: Transient receptor potential melastatin 7 ion channels regulate magnesium homeostasis in vascular smooth muscle cells: role of angiotensin II.
Volume: 96
Issue: 2
Pages: 207-15
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Publication
17599911 | J:124988
First Author: Li M
Year: 2007
Journal: J Biol Chem
Title: Molecular determinants of Mg2+ and Ca2+ permeability and pH sensitivity in TRPM6 and TRPM7.
Volume: 282
Issue: 35
Pages: 25817-30
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Publication
20048154 | J:165956
First Author: Inoue K
Year: 2010
Journal: J Biol Chem
Title: Zinc-induced neurotoxicity mediated by transient receptor potential melastatin 7 channels.
Volume: 285
Issue: 10
Pages: 7430-9
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Publication
22230350 | J:185090
First Author: Guinamard R
Year: 2012
Journal: Biochim Biophys Acta
Title: A calcium-permeable non-selective cation channel in the thick ascending limb apical membrane of the mouse kidney.
Volume: 1818
Issue: 5
Pages: 1135-41
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Publication
26928801 | J:279811
First Author: Antunes TT
Year: 2016
Journal: Hypertension
Title: Transient Receptor Potential Melastatin 7 Cation Channel Kinase: New Player in Angiotensin II-Induced Hypertension.
Volume: 67
Issue: 4
Pages: 763-73
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Publication
18381083 | J:136775
First Author: Crawley SW
Year: 2008
Journal: Biochim Biophys Acta
Title: Determinants for substrate phosphorylation by Dictyostelium myosin II heavy chain kinases A and B and eukaryotic elongation factor-2 kinase.
Volume: 1784
Issue: 6
Pages: 908-15
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Publication
16407977 | J:105078
First Author: Clark K
Year: 2006
Journal: EMBO J
Title: TRPM7, a novel regulator of actomyosin contractility and cell adhesion.
Volume: 25
Issue: 2
Pages: 290-301
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Publication
31545149 | J:298410
First Author: Shin MK
Year: 2019
Journal: Circ Res
Title: Leptin Induces Hypertension Acting on Transient Receptor Potential Melastatin 7 Channel in the Carotid Body.
Volume: 125
Issue: 11
Pages: 989-1002
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Protein Coding Gene
MGP_CAROLIEiJ_G0024243 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0026445 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0026409 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0026384 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0026421 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026164 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1929996 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0026866 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0025625 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0026144 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026278 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0026242 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0026383 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026262 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0026921 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0025361 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0025699 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0025689 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025163 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
11385574 | J:354154
First Author: Nadler MJ
Year: 2001
Journal: Nature
Title: LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability.
Volume: 411
Issue: 6837
Pages: 590-5
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GXD Expression
GXD Expression
   
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666820
Stage: TS20
Assay Id: MGI:4457756
Age: embryonic day 12.0
Image: 1
Specimen Label: E12
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666822
Stage: TS22
Assay Id: MGI:4457756
Age: embryonic day 14.0
Image: 1
Specimen Label: E14
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666826
Stage: TS26
Assay Id: MGI:4457756
Age: embryonic day 18.0
Image: 1
Specimen Label: E18
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-06
Strength: Present
Sex: Female
Emaps: EMAPS:1666827
Stage: TS27
Assay Id: MGI:4457756
Age: postnatal day 0
Image: 1
Specimen Label: P0
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-06
Strength: Present
Sex: Female
Emaps: EMAPS:1666828
Stage: TS28
Assay Id: MGI:4457756
Age: postnatal day 4
Image: 1
Specimen Label: P4
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-06
Strength: Present
Sex: Female
Emaps: EMAPS:1666828
Stage: TS28
Assay Id: MGI:4457756
Age: postnatal day 12
Image: 1
Specimen Label: P12
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-06
Strength: Present
Sex: Female
Emaps: EMAPS:1666828
Stage: TS28
Assay Id: MGI:4457756
Age: postnatal adult
Image: 1
Specimen Label: Adult
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666820
Stage: TS20
Assay Id: MGI:4458108
Age: embryonic day 12.0
Image: 6
Specimen Label: E12
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1715520
Stage: TS20
Assay Id: MGI:4458108
Age: embryonic day 12.0
Image: 6
Specimen Label: E12
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666822
Stage: TS22
Assay Id: MGI:4458108
Age: embryonic day 14.0
Image: 6
Specimen Label: E14
Detected: true
Specimen Num: 3
•
•
•
•
•




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