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Search results 1 to 100 out of 211 for Trpm7

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0.023s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: The TRPM subfamily of mammalian TRP channels includes TRPM7, which is a bifunctional molecule consisting of a TRP ion channel fused to a serine/threonine-protein kinase domain. It conducts Zn(2+), Mg(2+), and Ca(2+) as well as monovalent cations []. The kinase domain is proteolytically cleaved from the channel domain in a cell-type-specific manner, with the cleaved kinase fragments translocating to the nucleus and binding multiple components of chromatin-remodeling complexes []. TRPM7 plays a prominent role in cellular and systemic magnesium homeostasis, and is a key player in embryonic development, global ischemia, cardiovascular disease, and cancer [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Krapivinsky G
Year: 2014
Journal: Cell
Title: The TRPM7 chanzyme is cleaved to release a chromatin-modifying kinase.
Volume: 157
Issue: 5
Pages: 1061-72
Publication
First Author: Rios FJ
Year: 2020
Journal: Cardiovasc Res
Title: Chanzyme TRPM7 protects against cardiovascular inflammation and fibrosis.
Volume: 116
Issue: 3
Pages: 721-735
Publication  
First Author: Ryazanova LV
Year: 2010
Journal: Nat Commun
Title: TRPM7 is essential for Mg(2+) homeostasis in mammals.
Volume: 1
Pages: 109
Publication
First Author: Watanabe M
Year: 2015
Journal: J Biol Chem
Title: Trpm7 Protein Contributes to Intercellular Junction Formation in Mouse Urothelium.
Volume: 290
Issue: 50
Pages: 29882-92
Publication  
First Author: Krishnamoorthy M
Year: 2018
Journal: Sci Signal
Title: The ion channel TRPM7 is required for B cell lymphopoiesis.
Volume: 11
Issue: 533
Publication
First Author: Sah R
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity.
Volume: 110
Issue: 32
Pages: E3037-46
Publication  
First Author: Ryazanova LV
Year: 2014
Journal: Sci Rep
Title: Elucidating the role of the TRPM7 alpha-kinase: TRPM7 kinase inactivation leads to magnesium deprivation resistance phenotype in mice.
Volume: 4
Pages: 7599
Publication
First Author: Sun HS
Year: 2009
Journal: Nat Neurosci
Title: Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia.
Volume: 12
Issue: 10
Pages: 1300-7
Publication
First Author: Inoue H
Year: 2019
Journal: Physiol Rep
Title: Functional expression of TRPM7 as a Ca2+ influx pathway in adipocytes.
Volume: 7
Issue: 20
Pages: e14272
Publication  
First Author: Krishnamoorthy M
Year: 2018
Journal: Sci Signal
Title: The channel-kinase TRPM7 regulates antigen gathering and internalization in B cells.
Volume: 11
Issue: 533
Publication
First Author: Romagnani A
Year: 2017
Journal: Nat Commun
Title: TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut.
Volume: 8
Issue: 1
Pages: 1917
Publication
First Author: Liu Y
Year: 2018
Journal: Cell Rep
Title: TRPM7 Is Required for Normal Synapse Density, Learning, and Memory at Different Developmental Stages.
Volume: 23
Issue: 12
Pages: 3480-3491
Publication  
First Author: Stritt S
Year: 2016
Journal: Nat Commun
Title: Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture.
Volume: 7
Pages: 11097
Publication  
First Author: Fleig A
Year: 2014
Journal: Handb Exp Pharmacol
Title: TRPM7.
Volume: 222
Pages: 521-46
Publication
First Author: Jin J
Year: 2008
Journal: Science
Title: Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis.
Volume: 322
Issue: 5902
Pages: 756-60
Publication
First Author: Sahni J
Year: 2008
Journal: Cell Metab
Title: TRPM7 ion channels are required for sustained phosphoinositide 3-kinase signaling in lymphocytes.
Volume: 8
Issue: 1
Pages: 84-93
Publication
First Author: Cai N
Year: 2018
Journal: J Biol Chem
Title: The kinase activity of the channel-kinase protein TRPM7 regulates stability and localization of the TRPM7 channel in polarized epithelial cells.
Volume: 293
Issue: 29
Pages: 11491-11504
Publication      
First Author: Mittermeier L
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival.
Publication  
First Author: Kaitsuka T
Year: 2014
Journal: Sci Rep
Title: Inactivation of TRPM7 kinase activity does not impair its channel function in mice.
Volume: 4
Pages: 5718
Publication
First Author: Gotru SK
Year: 2018
Journal: Arterioscler Thromb Vasc Biol
Title: TRPM7 Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice.
Volume: 38
Issue: 2
Pages: 344-352
Publication  
First Author: Qian N
Year: 2019
Journal: Sci Signal
Title: TRPM7 channels mediate spontaneous Ca2+ fluctuations in growth plate chondrocytes that promote bone development.
Volume: 12
Issue: 576
Publication
First Author: Huang Y
Year: 2018
Journal: J Biol Chem
Title: TRPM7 channels play a role in high glucose-induced endoplasmic reticulum stress and neuronal cell apoptosis.
Volume: 293
Issue: 37
Pages: 14393-14406
Publication
First Author: Clark K
Year: 2008
Journal: J Mol Biol
Title: TRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation.
Volume: 378
Issue: 4
Pages: 790-803
Publication
First Author: Schappe MS
Year: 2018
Journal: Immunity
Title: Chanzyme TRPM7 Mediates the Ca2+ Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation.
Volume: 48
Issue: 1
Pages: 59-74.e5
Publication
First Author: Bernhardt ML
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: TRPM7 and CaV3.2 channels mediate Ca2+ influx required for egg activation at fertilization.
Volume: 115
Issue: 44
Pages: E10370-E10378
Publication
First Author: Sah R
Year: 2013
Journal: Circulation
Title: Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization.
Volume: 128
Issue: 2
Pages: 101-14
Publication
First Author: Ogata K
Year: 2017
Journal: Sci Rep
Title: The crucial role of the TRPM7 kinase domain in the early stage of amelogenesis.
Volume: 7
Issue: 1
Pages: 18099
Publication
First Author: Beesetty P
Year: 2018
Journal: Sci Rep
Title: Inactivation of TRPM7 kinase in mice results in enlarged spleens, reduced T-cell proliferation and diminished store-operated calcium entry.
Volume: 8
Issue: 1
Pages: 3023
Protein
Organism: Mus musculus
Length: 268  
Fragment?: true
Publication  
First Author: Nakano Y
Year: 2016
Journal: Front Physiol
Title: A Critical Role of TRPM7 As an Ion Channel Protein in Mediating the Mineralization of the Craniofacial Hard Tissues.
Volume: 7
Pages: 258
Publication
First Author: Cuffe JS
Year: 2015
Journal: PLoS One
Title: Differential mRNA expression and glucocorticoid-mediated regulation of TRPM6 and TRPM7 in the heart and kidney throughout murine pregnancy and development.
Volume: 10
Issue: 2
Pages: e0117978
Protein
Organism: Mus musculus
Length: 1863  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1863  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1862  
Fragment?: false
Publication
First Author: Zhao Y
Year: 2020
Journal: Geroscience
Title: CD82-TRPM7-Numb signaling mediates age-related cognitive impairment.
Volume: 42
Issue: 2
Pages: 595-611
Publication
First Author: Cai Z
Year: 2014
Journal: Nat Cell Biol
Title: Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis.
Volume: 16
Issue: 1
Pages: 55-65
Publication
First Author: Jin J
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: The channel kinase, TRPM7, is required for early embryonic development.
Volume: 109
Issue: 5
Pages: E225-33
Publication
First Author: He Y
Year: 2005
Journal: Circ Res
Title: Transient receptor potential melastatin 7 ion channels regulate magnesium homeostasis in vascular smooth muscle cells: role of angiotensin II.
Volume: 96
Issue: 2
Pages: 207-15
Publication
First Author: Li M
Year: 2007
Journal: J Biol Chem
Title: Molecular determinants of Mg2+ and Ca2+ permeability and pH sensitivity in TRPM6 and TRPM7.
Volume: 282
Issue: 35
Pages: 25817-30
Publication
First Author: Inoue K
Year: 2010
Journal: J Biol Chem
Title: Zinc-induced neurotoxicity mediated by transient receptor potential melastatin 7 channels.
Volume: 285
Issue: 10
Pages: 7430-9
Publication
First Author: Guinamard R
Year: 2012
Journal: Biochim Biophys Acta
Title: A calcium-permeable non-selective cation channel in the thick ascending limb apical membrane of the mouse kidney.
Volume: 1818
Issue: 5
Pages: 1135-41
Publication
First Author: Antunes TT
Year: 2016
Journal: Hypertension
Title: Transient Receptor Potential Melastatin 7 Cation Channel Kinase: New Player in Angiotensin II-Induced Hypertension.
Volume: 67
Issue: 4
Pages: 763-73
Publication
First Author: Shin MK
Year: 2019
Journal: Circ Res
Title: Leptin Induces Hypertension Acting on Transient Receptor Potential Melastatin 7 Channel in the Carotid Body.
Volume: 125
Issue: 11
Pages: 989-1002
Publication
First Author: Crawley SW
Year: 2008
Journal: Biochim Biophys Acta
Title: Determinants for substrate phosphorylation by Dictyostelium myosin II heavy chain kinases A and B and eukaryotic elongation factor-2 kinase.
Volume: 1784
Issue: 6
Pages: 908-15
Publication
First Author: Clark K
Year: 2006
Journal: EMBO J
Title: TRPM7, a novel regulator of actomyosin contractility and cell adhesion.
Volume: 25
Issue: 2
Pages: 290-301
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression    
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1715520
Stage: TS20
Assay Id: MGI:4458108
Age: embryonic day 12.0
Image: 6
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1715522
Stage: TS22
Assay Id: MGI:4458108
Age: embryonic day 14.0
Image: 6
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1715526
Stage: TS26
Assay Id: MGI:4458108
Age: embryonic day 18.0
Image: 6
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666820
Stage: TS20
Assay Id: MGI:4457756
Age: embryonic day 12.0
Image: 1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666822
Stage: TS22
Assay Id: MGI:4457756
Age: embryonic day 14.0
Image: 1
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666826
Stage: TS26
Assay Id: MGI:4457756
Age: embryonic day 18.0
Image: 1
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-06
Strength: Present
Sex: Female
Emaps: EMAPS:1666827
Stage: TS27
Assay Id: MGI:4457756
Age: postnatal day 0
Image: 1
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-06
Strength: Present
Sex: Female
Emaps: EMAPS:1666828
Stage: TS28
Assay Id: MGI:4457756
Age: postnatal day 4
Image: 1
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-06
Strength: Present
Sex: Female
Emaps: EMAPS:1666828
Stage: TS28
Assay Id: MGI:4457756
Age: postnatal day 12
Image: 1
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-06
Strength: Present
Sex: Female
Emaps: EMAPS:1666828
Stage: TS28
Assay Id: MGI:4457756
Age: postnatal adult
Image: 1
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666820
Stage: TS20
Assay Id: MGI:4458108
Age: embryonic day 12.0
Image: 6
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666822
Stage: TS22
Assay Id: MGI:4458108
Age: embryonic day 14.0
Image: 6
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666826
Stage: TS26
Assay Id: MGI:4458108
Age: embryonic day 18.0
Image: 6
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Female
Emaps: EMAPS:1666827
Stage: TS27
Assay Id: MGI:4458108
Age: postnatal day 0
Image: 6
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Female
Emaps: EMAPS:1666828
Stage: TS28
Assay Id: MGI:4458108
Age: postnatal day 4
Image: 6
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Female
Emaps: EMAPS:1666828
Stage: TS28
Assay Id: MGI:4458108
Age: postnatal day 12
Image: 6
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Female
Emaps: EMAPS:1666828
Stage: TS28
Assay Id: MGI:4458108
Age: postnatal adult
Image: 6
Detected: true
Specimen Num: 13
GXD Expression      
Probe: MGI:4821986
Assay Type: RT-PCR
Annotation Date: 2010-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759725
Stage: TS25
Assay Id: MGI:4822333
Age: embryonic day 17.0
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4821986
Assay Type: RT-PCR
Annotation Date: 2010-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759726
Stage: TS26
Assay Id: MGI:4822333
Age: embryonic day 18.0
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:4821986
Assay Type: RT-PCR
Annotation Date: 2010-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759727
Stage: TS27
Assay Id: MGI:4822333
Age: postnatal day 0
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:4821986
Assay Type: RT-PCR
Annotation Date: 2010-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759727
Stage: TS27
Assay Id: MGI:4822333
Age: postnatal day 2
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:4821986
Assay Type: RT-PCR
Annotation Date: 2010-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:4822333
Age: postnatal day 4
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:4821986
Assay Type: RT-PCR
Annotation Date: 2010-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:4822333
Age: postnatal day 6
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:4821986
Assay Type: RT-PCR
Annotation Date: 2010-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:4822333
Age: postnatal day 8
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Female
Emaps: EMAPS:1679827
Stage: TS27
Assay Id: MGI:4458108
Age: postnatal day 0
Image: 6
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Female
Emaps: EMAPS:1679828
Stage: TS28
Assay Id: MGI:4458108
Age: postnatal day 4
Image: 6
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Female
Emaps: EMAPS:1679828
Stage: TS28
Assay Id: MGI:4458108
Age: postnatal day 12
Image: 6
Detected: true
Specimen Num: 12
GXD Expression    
Probe: MGI:4457695
Assay Type: RT-PCR
Annotation Date: 2010-07-07
Strength: Present
Sex: Female
Emaps: EMAPS:1679828
Stage: TS28
Assay Id: MGI:4458108
Age: postnatal adult
Image: 6
Detected: true
Specimen Num: 14
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1777828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692279
Age: postnatal adult
Image: MRC Harwell_1972963
Detected: true
Specimen Num: 8
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1777828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692279
Age: postnatal adult
Image: MRC Harwell_1972971
Detected: true
Specimen Num: 16
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692279
Age: postnatal adult
Image: MRC Harwell_1972965
Note: kidney
Detected: true
Specimen Num: 10