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Search results 1 to 100 out of 592 for Trpm8

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Domain
Type: Family
Description: The TRPM subfamily of mammalian TRP channels includes TRPM8, which is a cold- and menthol-activated ion channel expressed in peripheral sensory neurons, where it plays a critical role in cold temperature detection []. TRPM8 is also found in the prostate and is up-regulated in prostate cancer and other malignancies [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication
First Author: Colburn RW
Year: 2007
Journal: Neuron
Title: Attenuated cold sensitivity in TRPM8 null mice.
Volume: 54
Issue: 3
Pages: 379-86
Publication
First Author: Morenilla-Palao C
Year: 2009
Journal: J Biol Chem
Title: Lipid raft segregation modulates TRPM8 channel activity.
Volume: 284
Issue: 14
Pages: 9215-24
Publication  
First Author: Almaraz L
Year: 2014
Journal: Handb Exp Pharmacol
Title: TRPM8.
Volume: 222
Pages: 547-79
Publication
First Author: Tsavaler L
Year: 2001
Journal: Cancer Res
Title: Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins.
Volume: 61
Issue: 9
Pages: 3760-9
Publication
First Author: Ramachandran R
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: TRPM8 activation attenuates inflammatory responses in mouse models of colitis.
Volume: 110
Issue: 18
Pages: 7476-81
Publication
First Author: Dhaka A
Year: 2007
Journal: Neuron
Title: TRPM8 is required for cold sensation in mice.
Volume: 54
Issue: 3
Pages: 371-8
Publication
First Author: Ramos-Filho AC
Year: 2014
Journal: PLoS One
Title: Menthol inhibits detrusor contractility independently of TRPM8 activation.
Volume: 9
Issue: 11
Pages: e111616
Publication
First Author: Gkika D
Year: 2015
Journal: J Cell Biol
Title: TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity.
Volume: 208
Issue: 1
Pages: 89-107
Protein
Organism: Mus musculus
Length: 1104  
Fragment?: false
Publication
First Author: Arcas JM
Year: 2019
Journal: J Neurosci
Title: The Immunosuppressant Macrolide Tacrolimus Activates Cold-Sensing TRPM8 Channels.
Volume: 39
Issue: 6
Pages: 949-969
Publication
First Author: McCoy DD
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: Enhanced insulin clearance in mice lacking TRPM8 channels.
Volume: 305
Issue: 1
Pages: E78-88
Publication
First Author: Tajino K
Year: 2011
Journal: PLoS One
Title: Cooling-sensitive TRPM8 is thermostat of skin temperature against cooling.
Volume: 6
Issue: 3
Pages: e17504
Publication
First Author: Zhang X
Year: 2012
Journal: Nat Cell Biol
Title: Direct inhibition of the cold-activated TRPM8 ion channel by Gαq.
Volume: 14
Issue: 8
Pages: 851-8
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Allele
Name: transient receptor potential cation channel, subfamily M, member 8; targeted mutation 2, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Recombinase
Publication categories: ProxyCollection
Strain
Attribute String: coisogenic, mutant strain, targeted mutation
Publication
First Author: Cornejo VH
Year: 2020
Journal: Cell Rep
Title: Non-conventional Axonal Organelles Control TRPM8 Ion Channel Trafficking and Peripheral Cold Sensing.
Volume: 30
Issue: 13
Pages: 4505-4517.e5
Publication  
First Author: Quallo T
Year: 2015
Journal: Nat Commun
Title: TRPM8 is a neuronal osmosensor that regulates eye blinking in mice.
Volume: 6
Pages: 7150
Publication
First Author: Bautista DM
Year: 2007
Journal: Nature
Title: The menthol receptor TRPM8 is the principal detector of environmental cold.
Volume: 448
Issue: 7150
Pages: 204-8
Publication
First Author: Ordás P
Year: 2021
Journal: J Comp Neurol
Title: Expression of the cold thermoreceptor TRPM8 in rodent brain thermoregulatory circuits.
Volume: 529
Issue: 1
Pages: 234-256
Publication
First Author: Takashima Y
Year: 2010
Journal: Neuroscience
Title: The development of peripheral cold neural circuits based on TRPM8 expression.
Volume: 169
Issue: 2
Pages: 828-42
Publication
First Author: Chan H
Year: 2018
Journal: Oncotarget
Title: TRPM8 and RAAS-mediated hypertension is critical for cold-induced immunosuppression in mice.
Volume: 9
Issue: 16
Pages: 12781-12795
Publication
First Author: Dragoni I
Year: 2006
Journal: J Biol Chem
Title: The cold and menthol receptor TRPM8 contains a functionally important double cysteine motif.
Volume: 281
Issue: 49
Pages: 37353-60
Publication
First Author: Moraes MN
Year: 2017
Journal: Biochim Biophys Acta
Title: Cold-sensing TRPM8 channel participates in circadian control of the brown adipose tissue.
Volume: 1864
Issue: 12
Pages: 2415-2427
Publication
First Author: Ota W
Year: 2019
Journal: Sci Rep
Title: Involvement of TRPM2 and TRPM8 in temperature-dependent masking behavior.
Volume: 9
Issue: 1
Pages: 3706
Publication
First Author: Morenilla-Palao C
Year: 2014
Journal: Cell Rep
Title: Ion channel profile of TRPM8 cold receptors reveals a role of TASK-3 potassium channels in thermosensation.
Volume: 8
Issue: 5
Pages: 1571-82
Publication
First Author: Zhang X
Year: 2019
Journal: Cell Rep
Title: Direct Gαq Gating Is the Sole Mechanism for TRPM8 Inhibition Caused by Bradykinin Receptor Activation.
Volume: 27
Issue: 12
Pages: 3672-3683.e4
Publication
First Author: Brenner DS
Year: 2014
Journal: Pain
Title: A dynamic set point for thermal adaptation requires phospholipase C-mediated regulation of TRPM8 in vivo.
Volume: 155
Issue: 10
Pages: 2124-33
Publication
First Author: Ma S
Year: 2012
Journal: J Mol Cell Biol
Title: Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity.
Volume: 4
Issue: 2
Pages: 88-96
Publication
First Author: Bidaux G
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Epidermal TRPM8 channel isoform controls the balance between keratinocyte proliferation and differentiation in a cold-dependent manner.
Volume: 112
Issue: 26
Pages: E3345-54
Publication
First Author: Almeida MC
Year: 2012
Journal: J Neurosci
Title: Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature.
Volume: 32
Issue: 6
Pages: 2086-99
Publication
First Author: Fujita T
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Involvement of TRPV3 and TRPM8 ion channel proteins in induction of mammalian cold-inducible proteins.
Volume: 495
Issue: 1
Pages: 935-940
Publication
First Author: Mohandass A
Year: 2020
Journal: FASEB J
Title: TRPM8 as the rapid testosterone signaling receptor: Implications in the regulation of dimorphic sexual and social behaviors.
Volume: 34
Issue: 8
Pages: 10887-10906
Publication
First Author: Borowiec AS
Year: 2016
Journal: FASEB J
Title: Cold/menthol TRPM8 receptors initiate the cold-shock response and protect germ cells from cold-shock-induced oxidation.
Volume: 30
Issue: 9
Pages: 3155-70
Publication
First Author: Madrid R
Year: 2009
Journal: J Neurosci
Title: Variable threshold of trigeminal cold-thermosensitive neurons is determined by a balance between TRPM8 and Kv1 potassium channels.
Volume: 29
Issue: 10
Pages: 3120-31
Publication
First Author: Vanden Abeele F
Year: 2013
Journal: J Cell Sci
Title: Complex modulation of the cold receptor TRPM8 by volatile anaesthetics and its role in complications of general anaesthesia.
Volume: 126
Issue: Pt 19
Pages: 4479-89
Publication  
First Author: Huang D
Year: 2012
Journal: Mol Pain
Title: Expression of the transient receptor potential channels TRPV1, TRPA1 and TRPM8 in mouse trigeminal primary afferent neurons innervating the dura.
Volume: 8
Pages: 66
Publication
First Author: Feketa VV
Year: 2013
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition.
Volume: 305
Issue: 9
Pages: R1040-50
Publication
First Author: Reimúndez A
Year: 2018
Journal: J Neurosci
Title: Deletion of the Cold Thermoreceptor TRPM8 Increases Heat Loss and Food Intake Leading to Reduced Body Temperature and Obesity in Mice.
Volume: 38
Issue: 15
Pages: 3643-3656
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Bouvier V
Year: 2018
Journal: J Invest Dermatol
Title: Merkel Cells Sense Cooling with TRPM8 Channels.
Volume: 138
Issue: 4
Pages: 946-956
Publication
First Author: Knowlton WM
Year: 2013
Journal: J Neurosci
Title: A sensory-labeled line for cold: TRPM8-expressing sensory neurons define the cellular basis for cold, cold pain, and cooling-mediated analgesia.
Volume: 33
Issue: 7
Pages: 2837-48
Publication  
First Author: Kim YS
Year: 2015
Journal: Neuroscience
Title: Expression of vesicular glutamate transporters in transient receptor potential melastatin 8 (TRPM8)-positive dental afferents in the mouse.
Volume: 303
Pages: 378-88
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Rattus norvegicus
Publication  
First Author: Ongun S
Year: 2018
Journal: Commun Biol
Title: Selective cold pain inhibition by targeted block of TRPM8-expressing neurons with quaternary lidocaine derivative QX-314.
Volume: 1
Pages: 53
Publication
First Author: Shapovalov G
Year: 2013
Journal: Cell Rep
Title: Opiates modulate thermosensation by internalizing cold receptor TRPM8.
Volume: 4
Issue: 3
Pages: 504-15
Publication
First Author: Matos-Cruz V
Year: 2017
Journal: Cell Rep
Title: Molecular Prerequisites for Diminished Cold Sensitivity in Ground Squirrels and Hamsters.
Volume: 21
Issue: 12
Pages: 3329-3337
Publication
First Author: Robbins A
Year: 2012
Journal: Invest Ophthalmol Vis Sci
Title: Menthol activation of corneal cool cells induces TRPM8-mediated lacrimation but not nociceptive responses in rodents.
Volume: 53
Issue: 11
Pages: 7034-42
Publication
First Author: Beukema P
Year: 2018
Journal: J Comp Neurol
Title: TrpM8-mediated somatosensation in mouse neocortex.
Volume: 526
Issue: 9
Pages: 1444-1456
Publication
First Author: Dhaka A
Year: 2008
Journal: J Neurosci
Title: Visualizing cold spots: TRPM8-expressing sensory neurons and their projections.
Volume: 28
Issue: 3
Pages: 566-75
Publication
First Author: Caudle RM
Year: 2017
Journal: PLoS One
Title: Sex differences in mouse Transient Receptor Potential Cation Channel, Subfamily M, Member 8 expressing trigeminal ganglion neurons.
Volume: 12
Issue: 5
Pages: e0176753
Publication  
First Author: Tang Z
Year: 2013
Journal: Nat Commun
Title: Pirt functions as an endogenous regulator of TRPM8.
Volume: 4
Pages: 2179
Publication  
First Author: Ghosh D
Year: 2016
Journal: Nat Commun
Title: VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8.
Volume: 7
Pages: 10489
Publication
First Author: Gkika D
Year: 2020
Journal: FASEB J
Title: Testosterone-androgen receptor: The steroid link inhibiting TRPM8-mediated cold sensitivity.
Volume: 34
Issue: 6
Pages: 7483-7499
Publication    
First Author: Janssens A
Year: 2016
Journal: Elife
Title: Definition of two agonist types at the mammalian cold-activated channel TRPM8.
Volume: 5
Publication
First Author: Wang S
Year: 2017
Journal: EMBO Mol Med
Title: A clinical and mechanistic study of topical borneol-induced analgesia.
Volume: 9
Issue: 6
Pages: 802-815
Publication  
First Author: Lemon CH
Year: 2019
Journal: eNeuro
Title: The TRPA1 Ion Channel Contributes to Sensory-Guided Avoidance of Menthol in Mice.
Volume: 6
Issue: 6
Publication  
First Author: Memon T
Year: 2017
Journal: Neuroscience
Title: TRPA1 expression levels and excitability brake by KV channels influence cold sensitivity of TRPA1-expressing neurons.
Volume: 353
Pages: 76-86
Publication
First Author: Gibbs GM
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Cysteine-rich secretory protein 4 is an inhibitor of transient receptor potential M8 with a role in establishing sperm function.
Volume: 108
Issue: 17
Pages: 7034-9
Publication
First Author: Mandadi S
Year: 2009
Journal: Neuroscience
Title: Locomotor networks are targets of modulation by sensory transient receptor potential vanilloid 1 and transient receptor potential melastatin 8 channels.
Volume: 162
Issue: 4
Pages: 1377-97
Publication
First Author: Vetter I
Year: 2013
Journal: J Neurosci
Title: Amplified cold transduction in native nociceptors by M-channel inhibition.
Volume: 33
Issue: 42
Pages: 16627-41
Publication
First Author: Peier AM
Year: 2002
Journal: Cell
Title: A TRP channel that senses cold stimuli and menthol.
Volume: 108
Issue: 5
Pages: 705-15
Publication
First Author: Paricio-Montesinos R
Year: 2020
Journal: Neuron
Title: The Sensory Coding of Warm Perception.
Volume: 106
Issue: 5
Pages: 830-841.e3
Publication
First Author: Clemmensen C
Year: 2018
Journal: Nat Commun
Title: Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes.
Volume: 9
Issue: 1
Pages: 4304
Publication
First Author: Luiz AP
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Cold sensing by NaV1.8-positive and NaV1.8-negative sensory neurons.
Volume: 116
Issue: 9
Pages: 3811-3816
Publication
First Author: Pogorzala LA
Year: 2013
Journal: J Neurosci
Title: The cellular code for mammalian thermosensation.
Volume: 33
Issue: 13
Pages: 5533-41
Publication
First Author: Lippoldt EK
Year: 2013
Journal: J Neurosci
Title: Artemin, a glial cell line-derived neurotrophic factor family member, induces TRPM8-dependent cold pain.
Volume: 33
Issue: 30
Pages: 12543-52
Publication
First Author: Hu HZ
Year: 2004
Journal: J Biol Chem
Title: 2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3.
Volume: 279
Issue: 34
Pages: 35741-8
Publication  
First Author: Ren AJ
Year: 2014
Journal: Nat Commun
Title: ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons.
Volume: 5
Pages: 4984
Publication
First Author: Tamura S
Year: 2005
Journal: Neuroscience
Title: TRPV2, a capsaicin receptor homologue, is expressed predominantly in the neurotrophin-3-dependent subpopulation of primary sensory neurons.
Volume: 130
Issue: 1
Pages: 223-8
Publication
First Author: Staaf S
Year: 2010
Journal: Gene Expr Patterns
Title: Dynamic expression of the TRPM subgroup of ion channels in developing mouse sensory neurons.
Volume: 10
Issue: 1
Pages: 65-74
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Milenkovic N
Year: 2014
Journal: Nat Neurosci
Title: A somatosensory circuit for cooling perception in mice.
Volume: 17
Issue: 11
Pages: 1560-6