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Search results 1 to 100 out of 191 for Trpv3

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: Transient receptor potential (TRP) channels can be described as tetramers formed by subunits with six transmembrane domains and containing cation-selective pores, which in several cases show high calcium permeability. The molecular architecture of TRP channels is reminiscent of voltage-gated channels and comprises six putative transmembrane segments (S1-S6), intracellular N- and C-termini, and a pore-forming reentrant loop between S5 and S6 [].TRP channels represent a superfamily conserved from worms to humans that comprise seven subfamilies []: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin or long TRPs), TRPA (ankyrin, whose only member is Transient receptor potential cation channel subfamily A member 1, TrpA1), TRPP (polycystin), TRPML (mucolipin) and TRPN (Nomp-C homologues), which has a single member that can be found in worms, flies, and zebrafish. TRPs are classified essentially according to their primary amino acid sequence rather than selectivity or ligand affinity, due to their heterogeneous properties and complex regulation.TRP channels are involved in many physiological functions, ranging from pure sensory functions, such as pheromone signalling, taste transduction, nociception, and temperature sensation, over homeostatic functions, such as Ca2+ and Mg2+ reabsorption and osmoregulation, to many other motile functions, such as muscle contraction and vaso-motor control [].The TRPV (vanilloid) subfamily can be divided into two distinct groups. The first, which comprises TrpV1, TrpV2, TrpV3, and TrpV4, with nonselective cation conductingpores, has members which can be activated by temperature as well as chemical stimuli. They are involved in a range of functions including nociception, thermosensing and osmolarity sensing. The second group, which consists of TrpV5 and TrpV6, (also known as epithelial calcium channels 1 and 2), highly calcium selective, are involved in renal Ca2+ absorption/reabsorption [, ].TrpV3 is a thermosensitive ion channel expressed predominantly in the skin and neural tissues. It is activated at innocuous (warm) temperatures and shows an increased response at noxious temperatures. This provides a mechanism for skin cells to detect detect heat via molecules similar to those in heat-sensing neurons []. TrpV3 can also be activated by various natural compounds that cause either feelings of warmth and/or act as skin sensitisers eg carvacrol, thymol and eugenol [, ]. It suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression, negatively regulating hair growth and cycling [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Peier AM
Year: 2002
Journal: Science
Title: A heat-sensitive TRP channel expressed in keratinocytes.
Volume: 296
Issue: 5575
Pages: 2046-9
Publication
First Author: Xu H
Year: 2006
Journal: Nat Neurosci
Title: Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels.
Volume: 9
Issue: 5
Pages: 628-35
Protein
Organism: Mus musculus/domesticus
Length: 791  
Fragment?: false
Publication
First Author: Carvacho I
Year: 2013
Journal: Cell Rep
Title: TRPV3 channels mediate strontium-induced mouse-egg activation.
Volume: 5
Issue: 5
Pages: 1375-86
Publication
First Author: Yamamoto-Kasai E
Year: 2012
Journal: J Invest Dermatol
Title: TRPV3 as a therapeutic target for itch.
Volume: 132
Issue: 8
Pages: 2109-12
Publication
First Author: Imura K
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Influence of TRPV3 mutation on hair growth cycle in mice.
Volume: 363
Issue: 3
Pages: 479-83
Publication
First Author: Wang Y
Year: 2021
Journal: Cell Biol Toxicol
Title: TRPV3 enhances skin keratinocyte proliferation through EGFR-dependent signaling pathways.
Volume: 37
Issue: 2
Pages: 313-330
Publication
First Author: Zhao J
Year: 2020
Journal: J Invest Dermatol
Title: PAR2 Mediates Itch via TRPV3 Signaling in Keratinocytes.
Volume: 140
Issue: 8
Pages: 1524-1532
Publication
First Author: Chung MK
Year: 2004
Journal: J Biol Chem
Title: TRPV3 and TRPV4 mediate warmth-evoked currents in primary mouse keratinocytes.
Volume: 279
Issue: 20
Pages: 21569-75
Publication    
First Author: Liu Q
Year: 2021
Journal: Elife
Title: Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine.
Volume: 10
Publication
First Author: Grandl J
Year: 2008
Journal: Nat Neurosci
Title: Pore region of TRPV3 ion channel is specifically required for heat activation.
Volume: 11
Issue: 9
Pages: 1007-13
Publication
First Author: Aijima R
Year: 2015
Journal: FASEB J
Title: The thermosensitive TRPV3 channel contributes to rapid wound healing in oral epithelia.
Volume: 29
Issue: 1
Pages: 182-92
Publication
First Author: Song Z
Year: 2021
Journal: J Invest Dermatol
Title: Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes.
Volume: 141
Issue: 8
Pages: 1964-1974
Publication
First Author: Asakawa M
Year: 2006
Journal: J Invest Dermatol
Title: Association of a mutation in TRPV3 with defective hair growth in rodents.
Volume: 126
Issue: 12
Pages: 2664-72
Publication
First Author: Sun XY
Year: 2018
Journal: Mol Pharmacol
Title: Antipruritic Effect of Natural Coumarin Osthole through Selective Inhibition of Thermosensitive TRPV3 Channel in the Skin.
Volume: 94
Issue: 4
Pages: 1164-1173
Publication
First Author: Qu Y
Year: 2019
Journal: Mol Pharmacol
Title: Inhibition of the Warm Temperature-Activated Ca2+-Permeable Transient Receptor Potential Vanilloid TRPV3 Channel Attenuates Atopic Dermatitis.
Volume: 96
Issue: 3
Pages: 393-400
Publication
First Author: Fromy B
Year: 2018
Journal: J Invest Dermatol
Title: Disruption of TRPV3 Impairs Heat-Evoked Vasodilation and Thermoregulation: A Critical Role of CGRP.
Volume: 138
Issue: 3
Pages: 688-696
Publication
First Author: Moussaieff A
Year: 2008
Journal: FASEB J
Title: Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain.
Volume: 22
Issue: 8
Pages: 3024-34
Publication
First Author: Wu SW
Year: 2016
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Genetic and pharmacological evidence for low-abundance TRPV3 expression in primary vagal afferent neurons.
Volume: 310
Issue: 9
Pages: R794-805
Publication
First Author: Hu H
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4.
Volume: 106
Issue: 5
Pages: 1626-31
Publication
First Author: Marics I
Year: 2014
Journal: PLoS One
Title: Acute heat-evoked temperature sensation is impaired but not abolished in mice lacking TRPV1 and TRPV3 channels.
Volume: 9
Issue: 6
Pages: e99828
Publication
First Author: Yoshioka T
Year: 2009
Journal: J Invest Dermatol
Title: Impact of the Gly573Ser substitution in TRPV3 on the development of allergic and pruritic dermatitis in mice.
Volume: 129
Issue: 3
Pages: 714-22
Publication
First Author: Brown TE
Year: 2013
Journal: Hippocampus
Title: Loss of interneuron LTD and attenuated pyramidal cell LTP in Trpv1 and Trpv3 KO mice.
Volume: 23
Issue: 8
Pages: 662-71
Publication
First Author: Fujita T
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Involvement of TRPV3 and TRPM8 ion channel proteins in induction of mammalian cold-inducible proteins.
Volume: 495
Issue: 1
Pages: 935-940
Publication  
First Author: Mehregan A
Year: 2021
Journal: J Cell Sci
Title: Deletion of TRPV3 and CaV3.2 T-type channels in mice undermines fertility and Ca2+ homeostasis in oocytes and eggs.
Volume: 134
Issue: 13
Publication
First Author: Cui TT
Year: 2018
Journal: Acta Pharmacol Sin
Title: A pivotal role for the activation of TRPV3 channel in itch sensations induced by the natural skin sensitizer carvacrol.
Volume: 39
Issue: 3
Pages: 331-335
Publication
First Author: Vogt-Eisele AK
Year: 2007
Journal: Br J Pharmacol
Title: Monoterpenoid agonists of TRPV3.
Volume: 151
Issue: 4
Pages: 530-40
Publication
First Author: Borbíró I
Year: 2011
Journal: J Invest Dermatol
Title: Activation of transient receptor potential vanilloid-3 inhibits human hair growth.
Volume: 131
Issue: 8
Pages: 1605-14
Protein
Organism: Mus musculus/domesticus
Length: 790  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 791  
Fragment?: false
Publication
First Author: Vriens J
Year: 2009
Journal: Mol Pharmacol
Title: Pharmacology of vanilloid transient receptor potential cation channels.
Volume: 75
Issue: 6
Pages: 1262-79
Publication  
First Author: Samanta A
Year: 2018
Journal: Subcell Biochem
Title: Transient Receptor Potential (TRP) Channels.
Volume: 87
Pages: 141-165
Publication
First Author: Gaudet R
Year: 2008
Journal: J Physiol
Title: TRP channels entering the structural era.
Volume: 586
Issue: 15
Pages: 3565-75
Publication
First Author: Latorre R
Year: 2009
Journal: Q Rev Biophys
Title: Structure-functional intimacies of transient receptor potential channels.
Volume: 42
Issue: 3
Pages: 201-46
Publication
First Author: Gees M
Year: 2010
Journal: Cold Spring Harb Perspect Biol
Title: The role of transient receptor potential cation channels in Ca2+ signaling.
Volume: 2
Issue: 10
Pages: a003962
Publication
First Author: Moqrich A
Year: 2005
Journal: Science
Title: Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin.
Volume: 307
Issue: 5714
Pages: 1468-72
Publication
First Author: Yamanoi Y
Year: 2023
Journal: Commun Biol
Title: TRPV3-ANO1 interaction positively regulates wound healing in keratinocytes.
Volume: 6
Issue: 1
Pages: 88
Publication  
First Author: Wang S
Year: 2019
Journal: Front Mol Neurosci
Title: Transient Receptor Potential Cation Channel Subfamily Vanilloid 4 and 3 in the Inner Ear Protect Hearing in Mice.
Volume: 12
Pages: 296
Publication
First Author: Chung MK
Year: 2004
Journal: J Neurosci
Title: 2-aminoethoxydiphenyl borate activates and sensitizes the heat-gated ion channel TRPV3.
Volume: 24
Issue: 22
Pages: 5177-82
Publication
First Author: Chung MK
Year: 2005
Journal: J Biol Chem
Title: Biphasic currents evoked by chemical or thermal activation of the heat-gated ion channel, TRPV3.
Volume: 280
Issue: 16
Pages: 15928-41
Publication
First Author: Huang SM
Year: 2008
Journal: J Neurosci
Title: Overexpressed transient receptor potential vanilloid 3 ion channels in skin keratinocytes modulate pain sensitivity via prostaglandin E2.
Volume: 28
Issue: 51
Pages: 13727-37
Publication
First Author: Yamada T
Year: 2010
Journal: Exp Eye Res
Title: Functional expression of transient receptor potential vanilloid 3 (TRPV3) in corneal epithelial cells: involvement in thermosensation and wound healing.
Volume: 90
Issue: 1
Pages: 121-9
Publication
First Author: Cheng X
Year: 2010
Journal: Cell
Title: TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation.
Volume: 141
Issue: 2
Pages: 331-43
Publication
First Author: Chung MK
Year: 2003
Journal: J Biol Chem
Title: Warm temperatures activate TRPV4 in mouse 308 keratinocytes.
Volume: 278
Issue: 34
Pages: 32037-46
Publication
First Author: Cheung SY
Year: 2015
Journal: Endocrinology
Title: Activation of transient receptor potential vanilloid 3 channel suppresses adipogenesis.
Volume: 156
Issue: 6
Pages: 2074-86
Publication
First Author: Hu HZ
Year: 2004
Journal: J Biol Chem
Title: 2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3.
Volume: 279
Issue: 34
Pages: 35741-8
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Haraguchi M
Year: 1997
Journal: Exp Anim
Title: Naturally occurring dermatitis associated with Staphylococcus aureus in DS-Nh mice.
Volume: 46
Issue: 3
Pages: 225-9
Publication
First Author: Yoshioka T
Year: 2007
Journal: Immunology
Title: Impact of T-cell receptor Vbeta haplotypes on the development of dermatitis in DS-Nh mice: synergistic production of interleukin-13 caused by staphylococcal enterotoxin C and peptide glycans from Staphylococcus aureus.
Volume: 121
Issue: 1
Pages: 51-61
Publication
First Author: Watanabe A
Year: 2003
Journal: Exp Anim
Title: Spontaneous development of dermatitis in DS-Nh mice under specific pathogen-free conditions.
Volume: 52
Issue: 1
Pages: 77-80
Publication
First Author: Yoshioka T
Year: 2006
Journal: Immunology
Title: Spontaneous scratching behaviour in DS-Nh mice as a possible model for pruritus in atopic dermatitis.
Volume: 118
Issue: 3
Pages: 293-301
GXD Expression      
Probe: MGI:4821991
Assay Type: RT-PCR
Annotation Date: 2010-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759725
Stage: TS25
Assay Id: MGI:4822336
Age: embryonic day 17.0
Specimen Label: E17
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4821991
Assay Type: RT-PCR
Annotation Date: 2010-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759726
Stage: TS26
Assay Id: MGI:4822336
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:4821991
Assay Type: RT-PCR
Annotation Date: 2010-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759727
Stage: TS27
Assay Id: MGI:4822336
Age: postnatal day 0
Specimen Label: P0
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:4821991
Assay Type: RT-PCR
Annotation Date: 2010-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759727
Stage: TS27
Assay Id: MGI:4822336
Age: postnatal day 2
Specimen Label: P2
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:4821991
Assay Type: RT-PCR
Annotation Date: 2010-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:4822336
Age: postnatal day 4
Specimen Label: P4
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:4821991
Assay Type: RT-PCR
Annotation Date: 2010-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:4822336
Age: postnatal day 6
Specimen Label: P6
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:4821991
Assay Type: RT-PCR
Annotation Date: 2010-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:4822336
Age: postnatal day 8
Specimen Label: P8
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:4884812
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691619
Pattern: Scattered
Stage: TS19
Assay Id: MGI:4945183
Age: embryonic day 11.5
Image: g00645 E11.5
Specimen Label: g00645 E11.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4884812
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691623
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945183
Age: embryonic day 15.5
Image: g00645 E15.5
Specimen Label: g00645 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4884812
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284223
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945183
Age: embryonic day 15.5
Image: g00645 E15.5
Specimen Label: g00645 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4884812
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945183
Age: postnatal day 7
Image: g00645 P7
Specimen Label: g00645 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4884812
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945183
Age: postnatal day 42
Image: g00645 Adult
Specimen Label: g00645 Adult
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4884812
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697419
Pattern: Scattered
Stage: TS19
Assay Id: MGI:4945183
Age: embryonic day 11.5
Image: g00645 E11.5
Specimen Label: g00645 E11.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4884812
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697423
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945183
Age: embryonic day 15.5
Image: g00645 E15.5
Specimen Label: g00645 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4884812
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697428
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945183
Age: postnatal day 7
Image: g00645 P7
Specimen Label: g00645 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4884812
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697428
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945183
Age: postnatal day 42
Image: g00645 Adult
Specimen Label: g00645 Adult
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4884812
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945183
Age: embryonic day 15.5
Image: g00645 E15.5
Specimen Label: g00645 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4884812
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945183
Age: postnatal day 7
Image: g00645 P7
Specimen Label: g00645 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4884812
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945183
Age: postnatal day 42
Image: g00645 Adult
Specimen Label: g00645 Adult
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4884812
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753623
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945183
Age: embryonic day 15.5
Image: g00645 E15.5
Specimen Label: g00645 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4884812
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753628
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945183
Age: postnatal day 7
Image: g00645 P7
Specimen Label: g00645 P7
Detected: true
Specimen Num: 3