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Search results 1 to 100 out of 847 for Trpv4

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: Transient receptor potential (TRP) channels can be described as tetramers formed by subunits with six transmembrane domains and containing cation-selective pores, which in several cases show high calcium permeability. The molecular architecture of TRP channels is reminiscent of voltage-gated channels and comprises six putative transmembrane segments (S1-S6), intracellular N- and C-termini, and a pore-forming reentrant loop between S5 and S6 [].TRP channels represent a superfamily conserved from worms to humans that comprise seven subfamilies []: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin or long TRPs), TRPA (ankyrin, whose only member is Transient receptor potential cation channel subfamily A member 1, TrpA1), TRPP (polycystin), TRPML (mucolipin) and TRPN (Nomp-C homologues), which has a single member that can be found in worms, flies, and zebrafish. TRPs are classified essentially according to their primary amino acid sequence rather than selectivity or ligand affinity, due to their heterogeneous properties and complex regulation.TRP channels are involved in many physiological functions, ranging from pure sensory functions, such as pheromone signalling, taste transduction, nociception, and temperature sensation, over homeostatic functions, such as Ca2+ and Mg2+ reabsorption and osmoregulation, to many other motile functions, such as muscle contraction and vaso-motor control [].The TRPV (vanilloid) subfamily can be divided into two distinct groups. The first, which comprises TrpV1, TrpV2, TrpV3, and TrpV4, with nonselective cation conducting pores, has members which can be activated by temperature as well as chemical stimuli. They are involved in a range of functions including nociception, thermosensing and osmolarity sensing. The second group, which consists of TrpV5 and TrpV6, (also known as epithelial calcium channels 1 and 2), highly calcium selective, are involved in renal Ca2+ absorption/reabsorption [, ].TrpV4 is a non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. It is expressed at high levels in the kidney, liver, heart and central nervous system, and activated by extracellular hypo-osmoticity, leading to increased transcellular ion flux and paracellular permeability, which may allow the cells to adjust to changes in extracellular osmolarity [, , ]. TRPV4 is can also be activated chemically by metabolites of arachidonic acid and alpha-isomers of phorbol esters [], by heat []and other factors []. This protein has been related to infectious diseases []and other pathologies [, ].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: true
GXD Expression      
Probe: MGI:6202567
Assay Type: RT-PCR
Annotation Date: 2018-10-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3602628
Stage: TS28
Assay Id: MGI:6202586
Age: postnatal adult
Specimen Label: TRPV4
Detected: true
Specimen Num: 3
Publication
First Author: Liedtke W
Year: 2000
Journal: Cell
Title: Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor.
Volume: 103
Issue: 3
Pages: 525-35
Publication
First Author: Köttgen M
Year: 2008
Journal: J Cell Biol
Title: TRPP2 and TRPV4 form a polymodal sensory channel complex.
Volume: 182
Issue: 3
Pages: 437-47
Publication
First Author: Watanabe H
Year: 2002
Journal: J Biol Chem
Title: Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives.
Volume: 277
Issue: 16
Pages: 13569-77
Publication
First Author: Berciano J
Year: 2011
Journal: J Neurol
Title: Reduced penetrance in hereditary motor neuropathy caused by TRPV4 Arg269Cys mutation.
Volume: 258
Issue: 8
Pages: 1413-21
Publication
First Author: Doñate-Macián P
Year: 2018
Journal: Nat Commun
Title: The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity.
Volume: 9
Issue: 1
Pages: 2307
Publication
First Author: Garcia-Elias A
Year: 2008
Journal: J Biol Chem
Title: IP3 receptor binds to and sensitizes TRPV4 channel to osmotic stimuli via a calmodulin-binding site.
Volume: 283
Issue: 46
Pages: 31284-8
Protein
Organism: Mus musculus/domesticus
Length: 871  
Fragment?: false
Publication  
First Author: Li D
Year: 2020
Journal: J Mech Behav Biomed Mater
Title: The structural changes of the mutated ankyrin repeat domain of the human TRPV4 channel alter its ATP binding ability.
Volume: 101
Pages: 103407
Publication
First Author: Tabuchi K
Year: 2005
Journal: Neurosci Lett
Title: Hearing impairment in TRPV4 knockout mice.
Volume: 382
Issue: 3
Pages: 304-8
Publication
First Author: Smith PL
Year: 2006
Journal: J Biol Chem
Title: Bisandrographolide from Andrographis paniculata activates TRPV4 channels.
Volume: 281
Issue: 40
Pages: 29897-904
Publication
First Author: Akiyama T
Year: 2016
Journal: J Invest Dermatol
Title: Involvement of TRPV4 in Serotonin-Evoked Scratching.
Volume: 136
Issue: 1
Pages: 154-60
Publication
First Author: Dupont C
Year: 2020
Journal: Ann Neurol
Title: TRPV4 Antagonism Prevents Mechanically Induced Myotonia.
Volume: 88
Issue: 2
Pages: 297-308
Publication
First Author: Goswami R
Year: 2017
Journal: J Invest Dermatol
Title: TRPV4 ION Channel Is Associated with Scleroderma.
Volume: 137
Issue: 4
Pages: 962-965
Publication
First Author: Scheraga RG
Year: 2016
Journal: J Immunol
Title: TRPV4 Mechanosensitive Ion Channel Regulates Lipopolysaccharide-Stimulated Macrophage Phagocytosis.
Volume: 196
Issue: 1
Pages: 428-36
Publication
First Author: Nilius B
Year: 2004
Journal: Am J Physiol Cell Physiol
Title: TRPV4 calcium entry channel: a paradigm for gating diversity.
Volume: 286
Issue: 2
Pages: C195-205
Publication
First Author: Derouiche S
Year: 2018
Journal: FASEB J
Title: TRPV4 heats up ANO1-dependent exocrine gland fluid secretion.
Volume: 32
Issue: 4
Pages: 1841-1854
Publication  
First Author: Alpizar YA
Year: 2020
Journal: Front Immunol
Title: TRPV4 Mediates Acute Bladder Responses to Bacterial Lipopolysaccharides.
Volume: 11
Pages: 799
Publication
First Author: Sonkusare SK
Year: 2012
Journal: Science
Title: Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function.
Volume: 336
Issue: 6081
Pages: 597-601
Publication
First Author: Güler AD
Year: 2002
Journal: J Neurosci
Title: Heat-evoked activation of the ion channel, TRPV4.
Volume: 22
Issue: 15
Pages: 6408-14
Publication
First Author: Harteneck C
Year: 2007
Journal: Biochem Soc Trans
Title: TRP channels activated by extracellular hypo-osmoticity in epithelia.
Volume: 35
Issue: Pt 1
Pages: 91-5
Publication
First Author: D'hoedt D
Year: 2008
Journal: J Biol Chem
Title: Stimulus-specific modulation of the cation channel TRPV4 by PACSIN 3.
Volume: 283
Issue: 10
Pages: 6272-80
Publication
First Author: Rahaman SO
Year: 2014
Journal: J Clin Invest
Title: TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice.
Volume: 124
Issue: 12
Pages: 5225-38
Publication
First Author: Brierley SM
Year: 2008
Journal: Gastroenterology
Title: Selective role for TRPV4 ion channels in visceral sensory pathways.
Volume: 134
Issue: 7
Pages: 2059-69
Publication
First Author: Zaccor NW
Year: 2020
Journal: J Biol Chem
Title: The nonselective cation channel TRPV4 inhibits angiotensin II receptors.
Volume: 295
Issue: 29
Pages: 9986-9997
Publication
First Author: Masuyama R
Year: 2012
Journal: J Bone Miner Res
Title: Calcium/calmodulin-signaling supports TRPV4 activation in osteoclasts and regulates bone mass.
Volume: 27
Issue: 8
Pages: 1708-21
Publication  
First Author: Yarishkin O
Year: 2018
Journal: Adv Exp Med Biol
Title: TRPV4 Does Not Regulate the Distal Retinal Light Response.
Volume: 1074
Pages: 553-560
Publication
First Author: Karasawa T
Year: 2008
Journal: J Cell Sci
Title: TRPV4 enhances the cellular uptake of aminoglycoside antibiotics.
Volume: 121
Issue: Pt 17
Pages: 2871-9
Publication  
First Author: Weber J
Year: 2020
Journal: JCI Insight
Title: TRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema.
Volume: 5
Issue: 20
Publication
First Author: Sokabe T
Year: 2010
Journal: J Biol Chem
Title: The TRPV4 channel contributes to intercellular junction formation in keratinocytes.
Volume: 285
Issue: 24
Pages: 18749-58
Publication
First Author: Aisenberg WH
Year: 2022
Journal: J Biol Chem
Title: Multiubiquitination of TRPV4 reduces channel activity independent of surface localization.
Volume: 298
Issue: 4
Pages: 101826
Publication
First Author: Chung MK
Year: 2004
Journal: J Biol Chem
Title: TRPV3 and TRPV4 mediate warmth-evoked currents in primary mouse keratinocytes.
Volume: 279
Issue: 20
Pages: 21569-75
Publication
First Author: Chung MK
Year: 2003
Journal: J Biol Chem
Title: Warm temperatures activate TRPV4 in mouse 308 keratinocytes.
Volume: 278
Issue: 34
Pages: 32037-46
Publication
First Author: Janas S
Year: 2016
Journal: Pflugers Arch
Title: TRPV4 is associated with central rather than nephrogenic osmoregulation.
Volume: 468
Issue: 9
Pages: 1595-607
Publication
First Author: Tomilin V
Year: 2019
Journal: Am J Physiol Renal Physiol
Title: TRPV4 deletion protects against hypokalemia during systemic K+ deficiency.
Volume: 316
Issue: 5
Pages: F948-F956
Publication
First Author: Sharma S
Year: 2019
Journal: J Cell Mol Med
Title: TRPV4 regulates matrix stiffness and TGFβ1-induced epithelial-mesenchymal transition.
Volume: 23
Issue: 2
Pages: 761-774
Publication
First Author: Swain SM
Year: 2020
Journal: J Clin Invest
Title: TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation.
Volume: 130
Issue: 5
Pages: 2527-2541
Protein
Organism: Mus musculus/domesticus
Length: 558  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 764  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 811  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 824  
Fragment?: false
GXD Expression      
Probe: MGI:6185911
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6191515
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Trpv4
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:6185911
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191515
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Trpv4
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6185911
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191515
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Trpv4
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6185911
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191515
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Trpv4
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6185911
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191515
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Trpv4
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6185911
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191515
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Trpv4
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6185911
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191515
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Trpv4
Detected: true
Specimen Num: 7
Publication
First Author: Boudaka A
Year: 2020
Journal: Sci Rep
Title: Deletion of TRPV4 enhances in vitro wound healing of murine esophageal keratinocytes.
Volume: 10
Issue: 1
Pages: 11349
Publication
First Author: Luo J
Year: 2018
Journal: Immunity
Title: TRPV4 Channel Signaling in Macrophages Promotes Gastrointestinal Motility via Direct Effects on Smooth Muscle Cells.
Volume: 49
Issue: 1
Pages: 107-119.e4
Publication
First Author: Hamanaka K
Year: 2010
Journal: Am J Physiol Lung Cell Mol Physiol
Title: TRPV4 channels augment macrophage activation and ventilator-induced lung injury.
Volume: 299
Issue: 3
Pages: L353-62
Publication
First Author: Vriens J
Year: 2009
Journal: Mol Pharmacol
Title: Pharmacology of vanilloid transient receptor potential cation channels.
Volume: 75
Issue: 6
Pages: 1262-79
Publication  
First Author: Samanta A
Year: 2018
Journal: Subcell Biochem
Title: Transient Receptor Potential (TRP) Channels.
Volume: 87
Pages: 141-165
Publication
First Author: Gaudet R
Year: 2008
Journal: J Physiol
Title: TRP channels entering the structural era.
Volume: 586
Issue: 15
Pages: 3565-75
Publication
First Author: Latorre R
Year: 2009
Journal: Q Rev Biophys
Title: Structure-functional intimacies of transient receptor potential channels.
Volume: 42
Issue: 3
Pages: 201-46
Publication
First Author: Gees M
Year: 2010
Journal: Cold Spring Harb Perspect Biol
Title: The role of transient receptor potential cation channels in Ca2+ signaling.
Volume: 2
Issue: 10
Pages: a003962
Publication
First Author: Ciura S
Year: 2018
Journal: Cell Rep
Title: Trpv4 Mediates Hypotonic Inhibition of Central Osmosensory Neurons via Taurine Gliotransmission.
Volume: 23
Issue: 8
Pages: 2245-2253
Publication
First Author: Ye L
Year: 2012
Journal: Cell
Title: TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis.
Volume: 151
Issue: 1
Pages: 96-110
Publication
First Author: Palaniyandi S
Year: 2020
Journal: Lab Invest
Title: TRPV4 is dispensable for the development of airway allergic asthma.
Volume: 100
Issue: 2
Pages: 265-273
Publication    
First Author: Harraz OF
Year: 2018
Journal: Elife
Title: PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells.
Volume: 7
Publication
First Author: Takayama Y
Year: 2014
Journal: FASEB J
Title: Modulation of water efflux through functional interaction between TRPV4 and TMEM16A/anoctamin 1.
Volume: 28
Issue: 5
Pages: 2238-48
Publication  
First Author: O'Conor CJ
Year: 2016
Journal: Sci Rep
Title: Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis.
Volume: 6
Pages: 29053
Publication
First Author: Okada Y
Year: 2016
Journal: PLoS One
Title: Loss of TRPV4 Function Suppresses Inflammatory Fibrosis Induced by Alkali-Burning Mouse Corneas.
Volume: 11
Issue: 12
Pages: e0167200
Publication
First Author: Chen Y
Year: 2013
Journal: Pain
Title: Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion.
Volume: 154
Issue: 8
Pages: 1295-304
Publication
First Author: Scheraga RG
Year: 2020
Journal: J Immunol
Title: TRPV4 Protects the Lung from Bacterial Pneumonia via MAPK Molecular Pathway Switching.
Volume: 204
Issue: 5
Pages: 1310-1321
Publication
First Author: Thoppil RJ
Year: 2016
Journal: Oncotarget
Title: TRPV4 channels regulate tumor angiogenesis via modulation of Rho/Rho kinase pathway.
Volume: 7
Issue: 18
Pages: 25849-61
Publication
First Author: Shibasaki K
Year: 2020
Journal: Lab Invest
Title: Temperature elevation in epileptogenic foci exacerbates epileptic discharge through TRPV4 activation.
Volume: 100
Issue: 2
Pages: 274-284
Publication
First Author: Adapala RK
Year: 2016
Journal: Oncogene
Title: Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy.
Volume: 35
Issue: 3
Pages: 314-22
Publication  
First Author: Pivonkova H
Year: 2018
Journal: Neuroscience
Title: The Contribution of TRPV4 Channels to Astrocyte Volume Regulation and Brain Edema Formation.
Volume: 394
Pages: 127-143
Publication
First Author: Mamenko MV
Year: 2017
Journal: Kidney Int
Title: The renal TRPV4 channel is essential for adaptation to increased dietary potassium.
Volume: 91
Issue: 6
Pages: 1398-1409
Publication
First Author: Alpizar YA
Year: 2017
Journal: Nat Commun
Title: TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells.
Volume: 8
Issue: 1
Pages: 1059
Publication    
First Author: Zhang Y
Year: 2022
Journal: Elife
Title: Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion.
Volume: 11
Publication  
First Author: Gualdani R
Year: 2020
Journal: Sci Signal
Title: Mechanical activation of TRPV4 channels controls albumin reabsorption by proximal tubule cells.
Volume: 13
Issue: 653
Publication
First Author: Hoshi Y
Year: 2018
Journal: J Neurosci
Title: Ischemic Brain Injury Leads to Brain Edema via Hyperthermia-Induced TRPV4 Activation.
Volume: 38
Issue: 25
Pages: 5700-5709
Publication  
First Author: Tomilin VN
Year: 2021
Journal: Cells
Title: With-No-Lysine Kinase 1 (WNK1) Augments TRPV4 Function in the Aldosterone-Sensitive Distal Nephron.
Volume: 10
Issue: 6
Publication
First Author: Hartmannsgruber V
Year: 2007
Journal: PLoS One
Title: Arterial response to shear stress critically depends on endothelial TRPV4 expression.
Volume: 2
Issue: 9
Pages: e827
Publication
First Author: Ota H
Year: 2013
Journal: PLoS One
Title: TRPV1 and TRPV4 play pivotal roles in delayed onset muscle soreness.
Volume: 8
Issue: 6
Pages: e65751
Publication  
First Author: Ueda T
Year: 2015
Journal: Biochem Biophys Rep
Title: Basal cells express functional TRPV4 channels in the mouse nasal epithelium.
Volume: 4
Pages: 169-174
Publication
First Author: Seghers F
Year: 2016
Journal: J Physiol
Title: TRPV4 participates in pressure-induced inhibition of renin secretion by juxtaglomerular cells.
Volume: 594
Issue: 24
Pages: 7327-7340
Publication
First Author: Feng X
Year: 2020
Journal: Commun Biol
Title: Increased TRPV4 expression in non-myelinating Schwann cells is associated with demyelination after sciatic nerve injury.
Volume: 3
Issue: 1
Pages: 716
Publication
First Author: Mueller-Tribbensee SM
Year: 2015
Journal: PLoS One
Title: Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice.
Volume: 10
Issue: 7
Pages: e0128242
Publication    
First Author: Servin-Vences MR
Year: 2017
Journal: Elife
Title: Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes.
Volume: 6
Publication
First Author: Cuajungco MP
Year: 2006
Journal: J Biol Chem
Title: PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4.
Volume: 281
Issue: 27
Pages: 18753-62
Publication
First Author: Wegierski T
Year: 2009
Journal: J Biol Chem
Title: Tyrosine phosphorylation modulates the activity of TRPV4 in response to defined stimuli.
Volume: 284
Issue: 5
Pages: 2923-33
Publication  
First Author: McFarland SJ
Year: 2020
Journal: Int J Mol Sci
Title: Ablation of Endothelial TRPV4 Channels Alters the Dynamic Ca2+ Signaling Profile in Mouse Carotid Arteries.
Volume: 21
Issue: 6
Publication  
First Author: Naert R
Year: 2019
Journal: Int J Mol Sci
Title: Expression and Functional Role of TRPV4 in Bone Marrow-Derived CD11c+ Cells.
Volume: 20
Issue: 14
Publication
First Author: Kusudo T
Year: 2012
Journal: J Appl Physiol (1985)
Title: TRPV4 deficiency increases skeletal muscle metabolic capacity and resistance against diet-induced obesity.
Volume: 112
Issue: 7
Pages: 1223-32
Publication
First Author: Mochizuki T
Year: 2009
Journal: J Biol Chem
Title: The TRPV4 cation channel mediates stretch-evoked Ca2+ influx and ATP release in primary urothelial cell cultures.
Volume: 284
Issue: 32
Pages: 21257-64