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Search results 1 to 100 out of 228 for Trpv6

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Type Details Score
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: rat
Protein Domain
Type: Family
Description: Transient receptor potential (TRP) channels can be described as tetramers formed by subunits with six transmembrane domains and containing cation-selective pores, which in several cases show high calcium permeability. The molecular architecture of TRP channels is reminiscent of voltage-gated channels and comprises six putative transmembrane segments (S1-S6), intracellular N- and C-termini, and a pore-forming reentrant loop between S5 and S6 [].TRP channels represent a superfamily conserved from worms to humans that comprise seven subfamilies []: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin or long TRPs), TRPA (ankyrin, whose only member is Transient receptor potential cation channel subfamily A member 1, TrpA1), TRPP (polycystin), TRPML (mucolipin) and TRPN (Nomp-C homologues), which has a single member that can be found in worms, flies, and zebrafish. TRPs are classified essentially according to their primary amino acid sequence rather than selectivity or ligand affinity, due to their heterogeneous properties and complex regulation.TRP channels are involved in many physiological functions, ranging from pure sensory functions, such as pheromone signalling, taste transduction, nociception, and temperature sensation, over homeostatic functions, such as Ca2+ and Mg2+ reabsorption and osmoregulation, to many other motile functions, such as muscle contraction and vaso-motor control [].The TRPV (vanilloid) subfamily can be divided into two distinct groups. The first, which comprises TrpV1, TrpV2, TrpV3, and TrpV4, with nonselective cation conducting pores, has memberswhich can be activated by temperature as well as chemical stimuli. They are involved in a range of functions including nociception, thermosensing and osmolarity sensing. The second group, which consists of TrpV5 and TrpV6, (also known as epithelial calcium channels 1 and 2), highly calcium selective, are involved in renal Ca2+ absorption/reabsorption [, ].TrpV6 was originally cloned from rabbit kidney cells, but has also been found in human. It is a calcium selective cation channel that mediates Ca2+ uptake in various tissues, including the intestine and epithelial tissues. [, , , , ]. TrpV6 has been related to a variety of diseases [, ]. Cryo-electron microscopy images of the open and closed states of this channel showed it adopts similar conformations in both states [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Fecher-Trost C
Year: 2013
Journal: J Biol Chem
Title: The in vivo TRPV6 protein starts at a non-AUG triplet, decoded as methionine, upstream of canonical initiation at AUG.
Volume: 288
Issue: 23
Pages: 16629-44
Publication
First Author: Peng JB
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Human calcium transport protein CaT1.
Volume: 278
Issue: 2
Pages: 326-32
Publication
First Author: Bödding M
Year: 2004
Journal: J Biol Chem
Title: Ca2+ dependence of the Ca2+-selective TRPV6 channel.
Volume: 279
Issue: 35
Pages: 36546-52
Publication
First Author: Meena AS
Year: 2022
Journal: Cell Rep
Title: TRPV6 channel mediates alcohol-induced gut barrier dysfunction and systemic response.
Volume: 39
Issue: 11
Pages: 110937
Protein
Organism: Mus musculus/domesticus
Length: 767  
Fragment?: false
Publication
First Author: Suzuki Y
Year: 2008
Journal: J Bone Miner Res
Title: Calcium channel TRPV6 is involved in murine maternal-fetal calcium transport.
Volume: 23
Issue: 8
Pages: 1249-56
Publication
First Author: Weissgerber P
Year: 2011
Journal: Sci Signal
Title: Male fertility depends on Ca²+ absorption by TRPV6 in epididymal epithelia.
Volume: 4
Issue: 171
Pages: ra27
Publication
First Author: Woudenberg-Vrenken TE
Year: 2012
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Functional TRPV6 channels are crucial for transepithelial Ca2+ absorption.
Volume: 303
Issue: 7
Pages: G879-85
Publication
First Author: Suzuki Y
Year: 2018
Journal: Am J Hum Genet
Title: TRPV6 Variants Interfere with Maternal-Fetal Calcium Transport through the Placenta and Cause Transient Neonatal Hyperparathyroidism.
Volume: 102
Issue: 6
Pages: 1104-1114
Publication
First Author: Lieben L
Year: 2010
Journal: Bone
Title: Trpv6 mediates intestinal calcium absorption during calcium restriction and contributes to bone homeostasis.
Volume: 47
Issue: 2
Pages: 301-8
Publication
First Author: Chen F
Year: 2014
Journal: Cell Physiol Biochem
Title: Knockout of TRPV6 causes osteopenia in mice by increasing osteoclastic differentiation and activity.
Volume: 33
Issue: 3
Pages: 796-809
Publication  
First Author: Meena AS
Year: 2023
Journal: Front Immunol
Title: TRPV6 deficiency attenuates stress and corticosterone-mediated exacerbation of alcohol-induced gut barrier dysfunction and systemic inflammation.
Volume: 14
Pages: 1093584
Publication
First Author: Kutuzova GD
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: TRPV6 is not required for 1alpha,25-dihydroxyvitamin D3-induced intestinal calcium absorption in vivo.
Volume: 105
Issue: 50
Pages: 19655-9
Publication
First Author: van de Graaf SF
Year: 2006
Journal: Mol Cell Biol
Title: Direct interaction with Rab11a targets the epithelial Ca2+ channels TRPV5 and TRPV6 to the plasma membrane.
Volume: 26
Issue: 1
Pages: 303-12
Publication
First Author: Beggs MR
Year: 2019
Journal: Cell Mol Gastroenterol Hepatol
Title: TRPV6 and Cav1.3 Mediate Distal Small Intestine Calcium Absorption Before Weaning.
Volume: 8
Issue: 4
Pages: 625-642
Publication
First Author: Bianco SD
Year: 2007
Journal: J Bone Miner Res
Title: Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene.
Volume: 22
Issue: 2
Pages: 274-85
Publication
First Author: Masamune A
Year: 2020
Journal: Gastroenterology
Title: Variants That Affect Function of Calcium Channel TRPV6 Are Associated With Early-Onset Chronic Pancreatitis.
Volume: 158
Issue: 6
Pages: 1626-1641.e8
Publication
First Author: Nakaya K
Year: 2007
Journal: Am J Physiol Renal Physiol
Title: Lack of pendrin HCO3- transport elevates vestibular endolymphatic [Ca2+] by inhibition of acid-sensitive TRPV5 and TRPV6 channels.
Volume: 292
Issue: 5
Pages: F1314-21
Publication
First Author: Weissgerber P
Year: 2012
Journal: J Biol Chem
Title: Excision of Trpv6 gene leads to severe defects in epididymal Ca2+ absorption and male fertility much like single D541A pore mutation.
Volume: 287
Issue: 22
Pages: 17930-41
Publication
First Author: Ma J
Year: 2021
Journal: Cell Prolif
Title: The calcium channel TRPV6 is a novel regulator of RANKL-induced osteoclastic differentiation and bone absorption activity through the IGF-PI3K-AKT pathway.
Volume: 54
Issue: 1
Pages: e12955
Publication
First Author: Little R
Year: 2011
Journal: PLoS One
Title: The transient receptor potential ion channel TRPV6 is expressed at low levels in osteoblasts and has little role in osteoblast calcium uptake.
Volume: 6
Issue: 11
Pages: e28166
Publication
First Author: Niemeyer BA
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Competitive regulation of CaT-like-mediated Ca2+ entry by protein kinase C and calmodulin.
Volume: 98
Issue: 6
Pages: 3600-5
Publication
First Author: McGoldrick LL
Year: 2018
Journal: Nature
Title: Opening of the human epithelial calcium channel TRPV6.
Volume: 553
Issue: 7687
Pages: 233-237
Publication
First Author: Wissenbach U
Year: 2001
Journal: J Biol Chem
Title: Expression of CaT-like, a novel calcium-selective channel, correlates with the malignancy of prostate cancer.
Volume: 276
Issue: 22
Pages: 19461-8
Protein
Organism: Mus musculus/domesticus
Length: 729  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 767  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 727  
Fragment?: false
Publication
First Author: Vriens J
Year: 2009
Journal: Mol Pharmacol
Title: Pharmacology of vanilloid transient receptor potential cation channels.
Volume: 75
Issue: 6
Pages: 1262-79
Publication  
First Author: Samanta A
Year: 2018
Journal: Subcell Biochem
Title: Transient Receptor Potential (TRP) Channels.
Volume: 87
Pages: 141-165
Publication
First Author: Gaudet R
Year: 2008
Journal: J Physiol
Title: TRP channels entering the structural era.
Volume: 586
Issue: 15
Pages: 3565-75
Publication
First Author: Latorre R
Year: 2009
Journal: Q Rev Biophys
Title: Structure-functional intimacies of transient receptor potential channels.
Volume: 42
Issue: 3
Pages: 201-46
Publication
First Author: Gees M
Year: 2010
Journal: Cold Spring Harb Perspect Biol
Title: The role of transient receptor potential cation channels in Ca2+ signaling.
Volume: 2
Issue: 10
Pages: a003962
Publication    
First Author: Lee JJ
Year: 2019
Journal: JCI Insight
Title: Activation of the calcium sensing receptor attenuates TRPV6-dependent intestinal calcium absorption.
Volume: 5
Publication
First Author: Song T
Year: 2017
Journal: J Cell Physiol
Title: Regulation of chondrocyte functions by transient receptor potential cation channel V6 in osteoarthritis.
Volume: 232
Issue: 11
Pages: 3170-3181
Publication  
First Author: Kumar S
Year: 2017
Journal: Neuroscience
Title: Transient receptor potential vanilloid 6 (TRPV6) in the mouse brain: Distribution and estrous cycle-related changes in the hypothalamus.
Volume: 344
Pages: 204-216
Publication
First Author: Hoenderop JG
Year: 2003
Journal: EMBO J
Title: Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6.
Volume: 22
Issue: 4
Pages: 776-85
Publication
First Author: van Abel M
Year: 2006
Journal: Am J Physiol Renal Physiol
Title: Age-dependent alterations in Ca2+ homeostasis: role of TRPV5 and TRPV6.
Volume: 291
Issue: 6
Pages: F1177-83
Publication  
First Author: Morgan CP
Year: 2018
Journal: Front Cell Neurosci
Title: TRPV6, TRPM6 and TRPM7 Do Not Contribute to Hair-Cell Mechanotransduction.
Volume: 12
Pages: 41
Publication
First Author: Cui M
Year: 2012
Journal: J Bone Miner Res
Title: Villin promoter-mediated transgenic expression of transient receptor potential cation channel, subfamily V, member 6 (TRPV6) increases intestinal calcium absorption in wild-type and vitamin D receptor knockout mice.
Volume: 27
Issue: 10
Pages: 2097-107
Publication
First Author: Noguchi TK
Year: 2012
Journal: Gene Expr Patterns
Title: Novel cell surface genes expressed in the stomach primordium during gastrointestinal morphogenesis of mouse embryos.
Volume: 12
Issue: 3-4
Pages: 154-63
Publication
First Author: Kim HJ
Year: 2007
Journal: Biochem Biophys Res Commun
Title: PDZ domain-containing protein as a physiological modulator of TRPV6.
Volume: 361
Issue: 2
Pages: 433-8
Publication
First Author: Benn BS
Year: 2008
Journal: Endocrinology
Title: Active intestinal calcium transport in the absence of transient receptor potential vanilloid type 6 and calbindin-D9k.
Volume: 149
Issue: 6
Pages: 3196-205
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:4821997
Assay Type: RT-PCR
Annotation Date: 2010-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759725
Stage: TS25
Assay Id: MGI:4822339
Age: embryonic day 17.0
Specimen Label: E17
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4821997
Assay Type: RT-PCR
Annotation Date: 2010-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759726
Stage: TS26
Assay Id: MGI:4822339
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:4821997
Assay Type: RT-PCR
Annotation Date: 2010-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759727
Stage: TS27
Assay Id: MGI:4822339
Age: postnatal day 0
Specimen Label: P0
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:4821997
Assay Type: RT-PCR
Annotation Date: 2010-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759727
Stage: TS27
Assay Id: MGI:4822339
Age: postnatal day 2
Specimen Label: P2
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:4821997
Assay Type: RT-PCR
Annotation Date: 2010-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:4822339
Age: postnatal day 4
Specimen Label: P4
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:4821997
Assay Type: RT-PCR
Annotation Date: 2010-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:4822339
Age: postnatal day 6
Specimen Label: P6
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:4821997
Assay Type: RT-PCR
Annotation Date: 2010-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:4822339
Age: postnatal day 8
Specimen Label: P8
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:6100962
Assay Type: RT-PCR
Annotation Date: 2017-12-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1654815
Stage: TS15
Assay Id: MGI:6102923
Age: embryonic day 9.5
Image: 2
Specimen Label: Fr
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:6100962
Assay Type: RT-PCR
Annotation Date: 2017-12-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1625515
Stage: TS15
Assay Id: MGI:6102923
Age: embryonic day 9.5
Image: 2
Specimen Label: Md
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:6100962
Assay Type: RT-PCR
Annotation Date: 2017-12-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1671515
Stage: TS15
Assay Id: MGI:6102923
Age: embryonic day 9.5
Image: 2
Specimen Label: Hd
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:6100962
Assay Type: RT-PCR
Annotation Date: 2017-12-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1683319
Stage: TS19
Assay Id: MGI:6102923
Age: embryonic day 11.5
Image: 2
Specimen Label: Es
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:6100962
Assay Type: RT-PCR
Annotation Date: 2017-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1702119
Stage: TS19
Assay Id: MGI:6102923
Age: embryonic day 11.5
Image: 2
Specimen Label: St
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6100962
Assay Type: RT-PCR
Annotation Date: 2017-12-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3287419
Stage: TS19
Assay Id: MGI:6102923
Age: embryonic day 11.5
Image: 2
Specimen Label: In
Detected: false
Specimen Num: 6
GXD Expression    
Probe: MGI:6100962
Assay Type: RT-PCR
Annotation Date: 2017-12-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1683321
Stage: TS21
Assay Id: MGI:6102923
Age: embryonic day 13.5
Image: 2
Specimen Label: Es
Detected: false
Specimen Num: 7
GXD Expression    
Probe: MGI:6100962
Assay Type: RT-PCR
Annotation Date: 2017-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1702121
Stage: TS21
Assay Id: MGI:6102923
Age: embryonic day 13.5
Image: 2
Specimen Label: St
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:6100962
Assay Type: RT-PCR
Annotation Date: 2017-12-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3287421
Stage: TS21
Assay Id: MGI:6102923
Age: embryonic day 13.5
Image: 2
Specimen Label: In
Detected: false
Specimen Num: 9
GXD Expression    
Probe: MGI:6100962
Assay Type: RT-PCR
Annotation Date: 2017-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6102932
Age: postnatal adult
Image: 2
Specimen Label: 6
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6771659
Assay Type: RT-PCR
Annotation Date: 2021-10-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893928
Stage: TS28
Assay Id: MGI:6771717
Age: postnatal adult
Image: 4
Specimen Label: Normal +/+
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6771659
Assay Type: RT-PCR
Annotation Date: 2021-10-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893928
Stage: TS28
Assay Id: MGI:6771717
Age: postnatal adult
Image: 4
Specimen Label: Normal +/-
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:7492470
Assay Type: RT-PCR
Annotation Date: 2023-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604226
Stage: TS26
Assay Id: MGI:7492495
Age: embryonic day 18.5
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7492470
Assay Type: RT-PCR
Annotation Date: 2023-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:7492495
Age: embryonic day 18.5
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7492470
Assay Type: RT-PCR
Annotation Date: 2023-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604226
Stage: TS26
Assay Id: MGI:7492495
Age: embryonic day 18.5
Specimen Label: -/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7492470
Assay Type: RT-PCR
Annotation Date: 2023-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:7492495
Age: embryonic day 18.5
Specimen Label: -/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7492470
Assay Type: RT-PCR
Annotation Date: 2023-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604226
Stage: TS26
Assay Id: MGI:7492495
Age: embryonic day 18.5
Specimen Label: +/-
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:7492470
Assay Type: RT-PCR
Annotation Date: 2023-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:7492495
Age: embryonic day 18.5
Specimen Label: +/-
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4882742
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691619
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945186
Age: embryonic day 11.5
Image: g00648 E11.5
Specimen Label: g00648 E11.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4882742
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691623
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945186
Age: embryonic day 15.5
Image: g00648 E15.5
Specimen Label: g00648 E15.5
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:6100979
Assay Type: RNA in situ
Annotation Date: 2017-12-17
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1737321
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:6102892
Age: embryonic day 13.5
Image: 8C
Note: Expression is in some of the primordial tube-like structures.
Specimen Label: 8C
Detected: true
Specimen Num: 12