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Search results 1 to 100 out of 668 for Tsc2

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Type Details Score
Gene
7249 | TSC2
Type: gene
Organism: human
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Gene
479883 | TSC2
Type: gene
Organism: dog, domestic
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Gene
504985 | TSC2
Type: gene
Organism: cattle
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Gene
416552 | TSC2
Type: gene
Organism: chicken
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Gene
567524 | tsc2
Type: gene
Organism: zebrafish
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Gene
694965 | TSC2
Type: gene
Organism: macaque, rhesus
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Gene
100170546 | tsc2
Type: gene
Organism: frog, western clawed
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Gene
24855 | Tsc2
Type: gene
Organism: rat
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Gene
468086 | TSC2
Type: gene
Organism: chimpanzee
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HT Sample
TSC2
         
Organism Name: mouse, laboratory
Curation Status: Not curated (Transgenic sample)
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Protein Coding Gene
MGI:102548 | Tsc2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
17245776 | J:121748
First Author: Hernandez O
Year: 2007
Journal: Genesis
Title: Generation of a conditional disruption of the Tsc2 gene.
Volume: 45
Issue: 2
Pages: 101-6
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Publication
29509898 | J:261762
First Author: Ogórek B
Year: 2018
Journal: Hum Mol Genet
Title: TSC2 regulates microRNA biogenesis via mTORC1 and GSK3β.
Volume: 27
Issue: 9
Pages: 1654-1663
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Publication
30700906 | J:286196
First Author: Ranek MJ
Year: 2019
Journal: Nature
Title: PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress.
Volume: 566
Issue: 7743
Pages: 264-269
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Publication
23604129 | J:309778
First Author: Guenther GG
Year: 2014
Journal: Oncogene
Title: Loss of TSC2 confers resistance to ceramide and nutrient deprivation.
Volume: 33
Issue: 14
Pages: 1776-87
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Publication
8833243 | J:32010
First Author: Olsson PG
Year: 1996
Journal: Mamm Genome
Title: Expression and differential splicing of the mouse TSC2 homolog.
Volume: 7
Issue: 3
Pages: 212-5
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Publication
28695825 | J:257092
   
First Author: Klover PJ
Year: 2017
Journal: Elife
Title: Tsc2 disruption in mesenchymal progenitors results in tumors with vascular anomalies overexpressing Lgals3.
Volume: 6
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Publication
26868506 | J:236273
 
First Author: Demetriades C
Year: 2016
Journal: Nat Commun
Title: Lysosomal recruitment of TSC2 is a universal response to cellular stress.
Volume: 7
Pages: 10662
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Publication
19357198 | J:149326
First Author: Pollizzi K
Year: 2009
Journal: Hum Mol Genet
Title: A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles.
Volume: 18
Issue: 13
Pages: 2378-87
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Publication
22923640 | J:193437
First Author: Moir LM
Year: 2012
Journal: Am J Physiol Lung Cell Mol Physiol
Title: TSC2 modulates cell adhesion and migration via integrin-α1β1.
Volume: 303
Issue: 8
Pages: L703-10
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Publication
34253722 | J:307919
First Author: Alesi N
Year: 2021
Journal: Nat Commun
Title: TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism.
Volume: 12
Issue: 1
Pages: 4245
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Publication
20145209 | J:260298
First Author: Kuo HP
Year: 2010
Journal: Sci Signal
Title: ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway.
Volume: 3
Issue: 108
Pages: ra9
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Publication
23359422 | J:195049
First Author: Fu C
Year: 2013
Journal: Genesis
Title: Conditional and domain-specific inactivation of the Tsc2 gene in neural progenitor cells.
Volume: 51
Issue: 4
Pages: 284-92
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Publication
24591652 | J:213670
First Author: Riddle RC
Year: 2014
Journal: Mol Cell Biol
Title: Tsc2 is a molecular checkpoint controlling osteoblast development and glucose homeostasis.
Volume: 34
Issue: 10
Pages: 1850-62
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Publication
15851026 | J:120197
First Author: Ma L
Year: 2005
Journal: Cell
Title: Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis.
Volume: 121
Issue: 2
Pages: 179-93
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GXD Expression
GXD Expression
   
Probe: MGI:6185919
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191517
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Tsc2
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6185919
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191517
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Tsc2
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6185919
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191517
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Tsc2
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:6185919
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191517
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Tsc2
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6185919
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191517
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Tsc2
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6185919
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191517
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Tsc2
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6185919
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191517
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Tsc2
Detected: true
Specimen Num: 6
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Publication
35288456 | J:322886
 
First Author: Dunkerly-Eyring BL
Year: 2022
Journal: Life Sci Alliance
Title: Single serine on TSC2 exerts biased control over mTORC1 activation mediated by ERK1/2 but not Akt.
Volume: 5
Issue: 6
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Publication
25613864 | J:220337
First Author: Rozas NS
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Prolonging the survival of Tsc2 conditional knockout mice by glutamine supplementation.
Volume: 457
Issue: 4
Pages: 635-9
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Publication
36400753 | J:334189
First Author: Liu X
Year: 2022
Journal: Cell Death Dis
Title: Loss of myeloid Tsc2 predisposes to angiotensin II-induced aortic aneurysm formation in mice.
Volume: 13
Issue: 11
Pages: 972
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Publication
27542907 | J:250631
First Author: García-Aguilar A
Year: 2016
Journal: Biochim Biophys Acta
Title: TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy.
Volume: 1863
Issue: 11
Pages: 2658-2667
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Publication
36357396 | J:331095
First Author: Asrani K
Year: 2022
Journal: Nat Commun
Title: An mTORC1-mediated negative feedback loop constrains amino acid-induced FLCN-Rag activation in renal cells with TSC2 loss.
Volume: 13
Issue: 1
Pages: 6808
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Publication
36586433 | J:339842
 
First Author: Brazill JM
Year: 2023
Journal: Mol Metab
Title: Knockout of TSC2 in Nav1.8+ neurons predisposes to the onset of normal weight obesity.
Volume: 68
Pages: 101664
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Publication
23749404 | J:203971
First Author: Mietzsch U
Year: 2013
Journal: J Comp Neurol
Title: Comparative analysis of Tsc1 and Tsc2 single and double radial glial cell mutants.
Volume: 521
Issue: 16
Pages: 3817-31
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Publication
23820898 | J:221228
First Author: Prizant H
Year: 2013
Journal: Mol Endocrinol
Title: Uterine-specific loss of Tsc2 leads to myometrial tumors in both the uterus and lungs.
Volume: 27
Issue: 9
Pages: 1403-14
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Publication
26693177 | J:239993
 
First Author: Crowell B
Year: 2015
Journal: eNeuro
Title: Complex Neurological Phenotype in Mutant Mice Lacking Tsc2 in Excitatory Neurons of the Developing Forebrain(123).
Volume: 2
Issue: 6
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Publication
21886784 | J:176342
First Author: Koyanagi M
Year: 2011
Journal: PLoS One
Title: Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1.
Volume: 6
Issue: 8
Pages: e23238
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Publication
11741832 | J:73510
First Author: Nellist M
Year: 2001
Journal: Hum Mol Genet
Title: TSC2 missense mutations inhibit tuberin phosphorylation and prevent formation of the tuberin-hamartin complex.
Volume: 10
Issue: 25
Pages: 2889-98
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Publication
10827137 | J:62413
First Author: Pasumarthi KB
Year: 2000
Journal: Circ Res
Title: Enhanced cardiomyocyte DNA synthesis during myocardial hypertrophy in mice expressing a modified TSC2 transgene.
Volume: 86
Issue: 10
Pages: 1069-77
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Publication
27768862 | J:238741
First Author: Ren S
Year: 2016
Journal: Am J Pathol
Title: Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions and Impairs Lung Alveolarization.
Volume: 186
Issue: 12
Pages: 3261-3272
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Publication
23123587 | J:197492
 
First Author: Reith RM
Year: 2013
Journal: Neurobiol Dis
Title: Loss of Tsc2 in Purkinje cells is associated with autistic-like behavior in a mouse model of tuberous sclerosis complex.
Volume: 51
Pages: 93-103
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Publication
37788104 | J:343526
 
First Author: Patel CH
Year: 2023
Journal: JCI Insight
Title: TSC2 S1365A mutation potently regulates CD8+ T cell function and differentiation and improves adoptive cellular cancer therapy.
Volume: 8
Issue: 21
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Publication
31182472 | J:277323
 
First Author: Carlin D
Year: 2019
Journal: eNeuro
Title: Nociceptor Deletion of Tsc2 Enhances Axon Regeneration by Inducing a Conditioning Injury Response in Dorsal Root Ganglia.
Volume: 6
Issue: 3
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Publication
30508035 | J:277580
First Author: M A S
Year: 2019
Journal: Carcinogenesis
Title: Heterozygous Tsc2 (Tsc2+/-) mouse model to study induced renal cancer in response to ionizing radiation at low doses.
Volume: 40
Issue: 6
Pages: 782-790
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Publication
32912901 | J:303713
First Author: Van Nostrand JL
Year: 2020
Journal: Genes Dev
Title: AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation.
Volume: 34
Issue: 19-20
Pages: 1330-1344
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Publication
10096549 | J:52464
First Author: Kobayashi T
Year: 1999
Journal: Cancer Res
Title: Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice.
Volume: 59
Issue: 6
Pages: 1206-11
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Publication
29766046 | J:266779
 
First Author: Carlin D
Year: 2018
Journal: eNeuro
Title: Deletion of Tsc2 in Nociceptors Reduces Target Innervation, Ion Channel Expression, and Sensitivity to Heat.
Volume: 5
Issue: 2
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Publication
12504590 | J:81245
First Author: Onda H
Year: 2002
Journal: Mol Cell Neurosci
Title: Tsc2 null murine neuroepithelial cells are a model for human tuber giant cells, and show activation of an mTOR pathway.
Volume: 21
Issue: 4
Pages: 561-74
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Publication
16027168 | J:100094
First Author: Ma L
Year: 2005
Journal: Genes Dev
Title: Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression.
Volume: 19
Issue: 15
Pages: 1779-86
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Publication
25189766 | J:317521
First Author: Kaneko-Tarui T
Year: 2014
Journal: Mol Hum Reprod
Title: Hyperplasia and fibrosis in mice with conditional loss of the TSC2 tumor suppressor in Müllerian duct mesenchyme-derived myometria.
Volume: 20
Issue: 11
Pages: 1126-34
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Publication
26837766 | J:235545
First Author: D'Armiento J
Year: 2016
Journal: Cancer Res
Title: Mesenchymal Tumorigenesis Driven by TSC2 Haploinsufficiency Requires HMGA2 and Is Independent of mTOR Pathway Activation.
Volume: 76
Issue: 4
Pages: 844-54
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Publication
19150975 | J:146159
First Author: Way SW
Year: 2009
Journal: Hum Mol Genet
Title: Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse.
Volume: 18
Issue: 7
Pages: 1252-65
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Publication
21062901 | J:167241
First Author: Zeng LH
Year: 2011
Journal: Hum Mol Genet
Title: Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex.
Volume: 20
Issue: 3
Pages: 445-54
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Publication
18587048 | J:137850
First Author: Rachdi L
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner.
Volume: 105
Issue: 27
Pages: 9250-5
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Publication
20616807 | J:186339
First Author: Kang YJ
Year: 2011
Journal: Cell Death Differ
Title: The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis.
Volume: 18
Issue: 1
Pages: 133-44
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Publication
23732640 | J:214196
First Author: Jacobs BL
Year: 2013
Journal: J Physiol
Title: Eccentric contractions increase the phosphorylation of tuberous sclerosis complex-2 (TSC2) and alter the targeting of TSC2 and the mechanistic target of rapamycin to the lysosome.
Volume: 591
Issue: 18
Pages: 4611-20
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Publication
11438694 | J:70463
First Author: Kobayashi T
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice.
Volume: 98
Issue: 15
Pages: 8762-7
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Publication
31461347 | J:290697
First Author: Gewin LS
Year: 2019
Journal: Am J Physiol Renal Physiol
Title: Inactivation of Tsc2 in Abcg2 lineage-derived cells drives the appearance of polycystic lesions and fibrosis in the adult kidney.
Volume: 317
Issue: 5
Pages: F1201-F1210
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Publication
7558029 | J:27400
First Author: Xu L
Year: 1995
Journal: Genomics
Title: Alternative splicing of the tuberous sclerosis 2 (TSC2) gene in human and mouse tissues.
Volume: 27
Issue: 3
Pages: 475-80
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Publication
22198573 | J:182345
First Author: Chévere-Torres I
Year: 2012
Journal: Neurobiol Dis
Title: Metabotropic glutamate receptor-dependent long-term depression is impaired due to elevated ERK signaling in the ΔRG mouse model of tuberous sclerosis complex.
Volume: 45
Issue: 3
Pages: 1101-10
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Publication
20038814 | J:156692
First Author: Ma J
Year: 2010
Journal: J Clin Invest
Title: Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade.
Volume: 120
Issue: 1
Pages: 103-14
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Publication
22752306 | J:187405
First Author: Yuan E
Year: 2012
Journal: Hum Mol Genet
Title: Graded loss of tuberin in an allelic series of brain models of TSC correlates with survival, and biochemical, histological and behavioral features.
Volume: 21
Issue: 19
Pages: 4286-300
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Publication
11030407 | J:64752
First Author: Cheadle JP
Year: 2000
Journal: Hum Genet
Title: Molecular genetic advances in tuberous sclerosis.
Volume: 107
Issue: 2
Pages: 97-114
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Publication
9799836 | J:50577
First Author: Kawakami S
Year: 1998
Journal: Mamm Genome
Title: Tctex3, related to Drosophila polycomblike, is expressed in male germ cells and mapped to the mouse t-complex.
Volume: 9
Issue: 11
Pages: 874-80
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Publication
30910807 | J:286086
 
First Author: Rushing GV
Year: 2019
Journal: Life Sci Alliance
Title: Location-dependent maintenance of intrinsic susceptibility to mTORC1-driven tumorigenesis.
Volume: 2
Issue: 2
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Publication
8777431 | J:33186
First Author: Kim KK
Year: 1995
Journal: Cell Mol Biol Res
Title: Cloning, developmental expression, and evidence for alternative splicing of the murine tuberous sclerosis (TSC2) gene product.
Volume: 41
Issue: 6
Pages: 515-26
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Publication
18316403 | J:135811
First Author: Shigeyama Y
Year: 2008
Journal: Mol Cell Biol
Title: Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosis complex 2 in mice.
Volume: 28
Issue: 9
Pages: 2971-9
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Publication
20062052 | J:156683
First Author: Nie D
Year: 2010
Journal: Nat Neurosci
Title: Tsc2-Rheb signaling regulates EphA-mediated axon guidance.
Volume: 13
Issue: 2
Pages: 163-72
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Publication
34222844 | J:308160
First Author: Unachukwu U
Year: 2021
Journal: iScience
Title: Renal neoplasms in tuberous sclerosis mice are neurocristopathies.
Volume: 24
Issue: 7
Pages: 102684
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Publication
24529379 | J:338164
First Author: Menon S
Year: 2014
Journal: Cell
Title: Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.
Volume: 156
Issue: 4
Pages: 771-85
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Publication
11703097 | J:73317
First Author: Lou D
Year: 2001
Journal: Mol Cell Biol Res Commun
Title: The tuberous sclerosis 2 gene product can localize to nuclei in a phosphorylation-dependent manner.
Volume: 4
Issue: 6
Pages: 374-80
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Publication
23955302 | J:201593
First Author: Zhang J
Year: 2013
Journal: Nat Cell Biol
Title: A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS.
Volume: 15
Issue: 10
Pages: 1186-96
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Publication
10491404 | J:57631
First Author: Onda H
Year: 1999
Journal: J Clin Invest
Title: Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background.
Volume: 104
Issue: 6
Pages: 687-95
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Publication
22532572 | J:185369
First Author: Way SW
Year: 2012
Journal: Hum Mol Genet
Title: The differential effects of prenatal and/or postnatal rapamycin on neurodevelopmental defects and cognition in a neuroglial mouse model of tuberous sclerosis complex.
Volume: 21
Issue: 14
Pages: 3226-36
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Publication
21419848 | J:174327
First Author: Reith RM
Year: 2011
Journal: Neurobiol Dis
Title: Loss of the tuberous sclerosis complex protein tuberin causes Purkinje cell degeneration.
Volume: 43
Issue: 1
Pages: 113-22
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Publication
34806651 | J:316405
 
First Author: Thomas A
Year: 2021
Journal: JCI Insight
Title: Benign tumors in TSC are amenable to treatment by GD3 CAR T cells in mice.
Volume: 6
Issue: 22
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Publication
23035046 | J:188257
First Author: Goncharova EA
Year: 2012
Journal: Sci Transl Med
Title: Prevention of alveolar destruction and airspace enlargement in a mouse model of pulmonary lymphangioleiomyomatosis (LAM).
Volume: 4
Issue: 154
Pages: 154ra134
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Publication
29635516 | J:262779
First Author: McKenna J 3rd
Year: 2018
Journal: Hum Mol Genet
Title: Metabolomic studies identify changes in transmethylation and polyamine metabolism in a brain-specific mouse model of tuberous sclerosis complex.
Volume: 27
Issue: 12
Pages: 2113-2124
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Publication
25700280 | J:222879
First Author: Hobbs RM
Year: 2015
Journal: EMBO Rep
Title: Distinct germline progenitor subsets defined through Tsc2-mTORC1 signaling.
Volume: 16
Issue: 4
Pages: 467-80
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Publication
16390268 | J:107438
First Author: Brown AB
Year: 2005
Journal: Hum Gene Ther
Title: Magnetic resonance imaging and characterization of spontaneous lesions in a transgenic mouse model of tuberous sclerosis as a model for endothelial cell-based transgene delivery.
Volume: 16
Issue: 12
Pages: 1367-76
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Publication
19527517 | J:157342
 
First Author: Pollizzi K
Year: 2009
Journal: Mol Cancer
Title: Equivalent benefit of mTORC1 blockade and combined PI3K-mTOR blockade in a mouse model of tuberous sclerosis.
Volume: 8
Pages: 38
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Publication
15972957 | J:99509
First Author: Mak BC
Year: 2005
Journal: Am J Pathol
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