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Search results 1 to 98 out of 98 for Tsks

0.03s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: Testis-specific serine kinase substrate (TSKS) is expressed in the testis and is downregulated in cancerous testicular tissue, in comparison with adjacent normal tissue. TSKS expression is very low to undetectable in seminoma, teratocarcinoma, embryonal, and Leydig cell tumours, while high in testicular tissue adjacent to tumours which contain pre-malignant carcinoma in situ []. Recently it has been shown in human testis to be localised to the equatorial segment of ejaculated human sperm. The finding of a TSKS family member in mature sperm suggests that this family of kinases might play a role in sperm function []. TSKS is localised during spermiogenesis to the centrioles of post-meiotic spermatids, where it reaches its greatest concentration during the period of flagellogenesis [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Xu B
Year: 2008
Journal: Dev Biol
Title: TSKS concentrates in spermatid centrioles during flagellogenesis.
Volume: 319
Issue: 2
Pages: 201-10
Publication
First Author: Shimada K
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: TSKS localizes to nuage in spermatids and regulates cytoplasmic elimination during spermiation.
Volume: 120
Issue: 11
Pages: e2221762120
Publication
First Author: MacLeod G
Year: 2014
Journal: Reproduction
Title: PPP1CC2 can form a kinase/phosphatase complex with the testis-specific proteins TSSK1 and TSKS in the mouse testis.
Volume: 147
Issue: 1
Pages: 1-12
Protein
Organism: Mus musculus/domesticus
Length: 585  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 109  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 185  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 525  
Fragment?: false
Publication
First Author: Hao Z
Year: 2004
Journal: Mol Hum Reprod
Title: Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm.
Volume: 10
Issue: 6
Pages: 433-44
Publication
First Author: Scorilas A
Year: 2001
Journal: Biochem Biophys Res Commun
Title: Identification and characterization of a novel human testis-specific kinase substrate gene which is downregulated in testicular tumors.
Volume: 285
Issue: 2
Pages: 400-8
Publication
First Author: Xu B
Year: 2008
Journal: Dev Biol
Title: Targeted deletion of Tssk1 and 2 causes male infertility due to haploinsufficiency.
Volume: 319
Issue: 2
Pages: 211-22
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression    
Probe: MGI:1196903
Assay Type: Northern blot
Annotation Date: 2015-02-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5615438
Age: postnatal adult
Image: 8
Specimen Label: heart
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:1196903
Assay Type: Northern blot
Annotation Date: 2015-02-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3287428
Stage: TS28
Assay Id: MGI:5615438
Age: postnatal adult
Image: 8
Specimen Label: intestine
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:1196903
Assay Type: Northern blot
Annotation Date: 2015-02-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:5615438
Age: postnatal adult
Image: 8
Specimen Label: liver
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:1196903
Assay Type: Northern blot
Annotation Date: 2015-02-12
Strength: Absent
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:5615438
Age: postnatal adult
Image: 8
Specimen Label: ovary
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:1196903
Assay Type: Northern blot
Annotation Date: 2015-02-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750328
Stage: TS28
Assay Id: MGI:5615438
Age: postnatal adult
Image: 8
Specimen Label: pancreas
Detected: false
Specimen Num: 5
GXD Expression    
Probe: MGI:1196903
Assay Type: Northern blot
Annotation Date: 2015-02-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:5615438
Age: postnatal adult
Image: 8
Specimen Label: skeletal muscle
Detected: false
Specimen Num: 6
GXD Expression    
Probe: MGI:1196903
Assay Type: Northern blot
Annotation Date: 2015-02-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5615438
Age: postnatal adult
Image: 8
Specimen Label: spleen
Detected: false
Specimen Num: 7
GXD Expression    
Probe: MGI:1196903
Assay Type: Northern blot
Annotation Date: 2015-02-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:5615438
Age: postnatal adult
Image: 8
Specimen Label: thymus
Detected: false
Specimen Num: 8
GXD Expression    
Probe: MGI:1196903
Assay Type: Northern blot
Annotation Date: 2015-02-12
Strength: Absent
Sex: Female
Emaps: EMAPS:2991528
Stage: TS28
Assay Id: MGI:5615438
Age: postnatal adult
Image: 8
Specimen Label: uterus
Detected: false
Specimen Num: 9
GXD Expression    
Probe: MGI:1196903
Assay Type: Northern blot
Annotation Date: 2015-02-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:5615438
Age: postnatal adult
Image: 8
Specimen Label: placenta
Detected: false
Specimen Num: 10
GXD Expression    
Probe: MGI:1196903
Assay Type: Northern blot
Annotation Date: 2015-02-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:5615438
Age: embryonic day 13.0
Image: 8
Specimen Label: 13 d embryo
Detected: false
Specimen Num: 11
GXD Expression    
Probe: MGI:1196903
Assay Type: Northern blot
Annotation Date: 2015-02-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:5615438
Age: postnatal adult
Image: 8
Specimen Label: brain
Detected: false
Specimen Num: 12
GXD Expression    
Probe: MGI:1196903
Assay Type: Northern blot
Annotation Date: 2015-02-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5615438
Age: postnatal adult
Image: 8
Specimen Label: kidney
Detected: false
Specimen Num: 13
GXD Expression    
Probe: MGI:1196903
Assay Type: Northern blot
Annotation Date: 2015-02-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:5615438
Age: postnatal adult
Image: 8
Specimen Label: lung
Detected: false
Specimen Num: 14
GXD Expression    
Probe: MGI:1196903
Assay Type: Northern blot
Annotation Date: 2015-02-12
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5615438
Age: postnatal adult
Image: 8
Specimen Label: testis
Detected: true
Specimen Num: 15
GXD Expression    
Probe: MGI:1196903
Assay Type: Northern blot
Annotation Date: 2015-02-12
Strength: Absent
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5615441
Age: postnatal week 1
Image: 8
Specimen Label: 1 week
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:1196903
Assay Type: Northern blot
Annotation Date: 2015-02-12
Strength: Absent
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5615441
Age: postnatal week 2
Image: 8
Specimen Label: 2 weeks
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:1196903
Assay Type: Northern blot
Annotation Date: 2015-02-12
Strength: Absent
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5615441
Age: postnatal week 3
Image: 8
Specimen Label: 3 weeks
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:1196903
Assay Type: Northern blot
Annotation Date: 2015-02-12
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5615441
Age: postnatal week 4
Image: 8
Specimen Label: 4 weeks
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:1196903
Assay Type: Northern blot
Annotation Date: 2015-02-12
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5615441
Age: postnatal week 7
Image: 8
Specimen Label: 7 weeks
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:1196903
Assay Type: Northern blot
Annotation Date: 2015-02-12
Strength: Absent
Sex: Male
Emaps: EMAPS:1929028
Stage: TS28
Assay Id: MGI:5615441
Age: postnatal
Image: 8
Specimen Label: epididymis
Detected: false
Specimen Num: 6
GXD Expression    
Probe: MGI:5615427
Assay Type: Western blot
Annotation Date: 2015-02-12
Strength: Absent
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5615443
Age: postnatal week 2
Image: 8
Specimen Label: 2 weeks
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5615427
Assay Type: Western blot
Annotation Date: 2015-02-12
Strength: Absent
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5615443
Age: postnatal week 3
Image: 8
Specimen Label: 3 weeks
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5615427
Assay Type: Western blot
Annotation Date: 2015-02-12
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5615443
Age: postnatal week 3.5
Image: 8
Specimen Label: 3.5 weeks
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:5615427
Assay Type: Western blot
Annotation Date: 2015-02-12
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5615443
Age: postnatal week 4
Image: 8
Specimen Label: 4 weeks
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:5615427
Assay Type: Western blot
Annotation Date: 2015-02-12
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5615443
Age: postnatal week 8
Image: 8
Specimen Label: 8 weeks
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:5615427
Assay Type: Western blot
Annotation Date: 2015-02-12
Strength: Absent
Sex: Male
Emaps: EMAPS:1929028
Stage: TS28
Assay Id: MGI:5615443
Age: postnatal
Image: 8
Specimen Label: epidimymis
Detected: false
Specimen Num: 6
GXD Expression    
Probe: MGI:5615427
Assay Type: Immunohistochemistry
Annotation Date: 2015-02-12
Strength: Absent
Sex: Male
Emaps: EMAPS:3148428
Stage: TS28
Assay Id: MGI:5615444
Age: postnatal adult
Image: 9a
Specimen Label: 9a
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5615427
Assay Type: Immunohistochemistry
Annotation Date: 2015-02-12
Strength: Absent
Sex: Male
Emaps: EMAPS:2910628
Stage: TS28
Assay Id: MGI:5615444
Age: postnatal adult
Image: 9a
Specimen Label: 9a
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5615427
Assay Type: Immunohistochemistry
Annotation Date: 2015-02-12
Strength: Absent
Sex: Male
Emaps: EMAPS:2965528
Stage: TS28
Assay Id: MGI:5615444
Age: postnatal adult
Image: 9a
Specimen Label: 9a
Detected: false
Specimen Num: 1
GXD Expression
Probe: MGI:5615427
Assay Type: Immunohistochemistry
Annotation Date: 2015-02-12
Strength: Present
Sex: Male
Emaps: EMAPS:3147628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5615444
Age: postnatal adult
Image: 9a
Note: Expression is in spermatids located in the luminal layer of the seminiferous tubules.
Specimen Label: 9a
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:5615427
Assay Type: Immunohistochemistry
Annotation Date: 2015-02-12
Strength: Present
Sex: Male
Emaps: EMAPS:3148628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5615444
Age: postnatal adult
Image: 9a
Note: Expression is in spermatids located in the luminal layer of the seminiferous tubules.
Specimen Label: 9a
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:5615427
Assay Type: Immunohistochemistry
Annotation Date: 2015-02-12
Strength: Present
Sex: Male
Emaps: EMAPS:3148628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5615444
Age: postnatal adult
Image: 9b
Note: Staining was either homogeneous or punctate.
Specimen Label: 9b
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:5615427
Assay Type: Immunohistochemistry
Annotation Date: 2015-02-12
Strength: Present
Sex: Male
Emaps: EMAPS:3148628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5615444
Age: postnatal adult
Image: 9c
Specimen Label: 9c
Detected: true
Specimen Num: 3
Publication
First Author: Kueng P
Year: 1997
Journal: J Cell Biol
Title: A novel family of serine/threonine kinases participating in spermiogenesis.
Volume: 139
Issue: 7
Pages: 1851-9
Publication
First Author: Shang P
Year: 2010
Journal: J Cell Sci
Title: Functional transformation of the chromatoid body in mouse spermatids requires testis-specific serine/threonine kinases.
Volume: 123
Issue: Pt 3
Pages: 331-9
Publication      
First Author: Copeland NG
Year: 1999
Journal: Database Release
Title: Copeland-Jenkins (Frederick) Interspecific Backcross Mapping Data
Publication      
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Allele
Name: testis-specific serine kinase substrate; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Publication  
First Author: Bai S
Year: 2018
Journal: Development
Title: Sox30 initiates transcription of haploid genes during late meiosis and spermiogenesis in mouse testes.
Volume: 145
Issue: 13