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Search results 1 to 100 out of 538 for Tspo

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
706 | TSPO
Type: gene
Organism: human
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Gene
100144961 | tspo
Type: gene
Organism: frog, western clawed
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Gene
24230 | Tspo
Type: gene
Organism: rat
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Gene
474475 | TSPO
Type: gene
Organism: dog, domestic
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Gene
458887 | TSPO
Type: gene
Organism: chimpanzee
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Gene
281033 | TSPO
Type: gene
Organism: cattle
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Gene
418226 | TSPO
Type: gene
Organism: chicken
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Gene
450011 | tspo
Type: gene
Organism: zebrafish
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Gene
711717 | TSPO
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR030164 | TSPO
Type: Family
Description: The translocator protein (TSPO, also known as translocator protein 18kDa) is a transmembrane protein primarily found in the outer mitochondrial membrane. TSPO is involved in multiple processes, including regulation of cell death, cholesterol transport and steroid biosynthesis, mitochondrial respiration and oxidation and mitochondrial protein import [, ]. It was proposed to form a complex with several proteins of the mitochondrial permeability transition pore (PTP), an important regulator of apoptotic and necrotic cell death during injury. However, its function with PTP is controversial [].
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Protein Coding Gene
MGI:88222 | Tspo
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
24692541 | J:214129
First Author: Å ileikytÄ— J
Year: 2014
Journal: J Biol Chem
Title: Regulation of the mitochondrial permeability transition pore by the outer membrane does not involve the peripheral benzodiazepine receptor (Translocator Protein of 18 kDa (TSPO)).
Volume: 289
Issue: 20
Pages: 13769-81
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Gene
9256 | TSPOAP1
Type: gene
Organism: human
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Protein
P50637
Organism: Mus musculus/domesticus
Length: 169  
Fragment?: false
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Protein
A0A140LIU9
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: true
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Publication
23518318 | -
First Author: Austin CJ
Year: 2013
Journal: Int J Biochem Cell Biol
Title: The translocator protein (TSPO): a novel target for cancer chemotherapy.
Volume: 45
Issue: 7
Pages: 1212-6
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Publication
22364127 | -
First Author: Gatliff J
Year: 2012
Journal: Curr Mol Med
Title: The 18 kDa translocator protein (TSPO): a new perspective in mitochondrial biology.
Volume: 12
Issue: 4
Pages: 356-68
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Publication
35269479 | J:321885
 
First Author: Zhang X
Year: 2022
Journal: Cells
Title: TSPO Deficiency Exacerbates GSDMD-Mediated Macrophage Pyroptosis in Inflammatory Bowel Disease.
Volume: 11
Issue: 5
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Publication
34831289 | J:319937
 
First Author: Farhan F
Year: 2021
Journal: Cells
Title: Deletion of TSPO Causes Dysregulation of Cholesterol Metabolism in Mouse Retina.
Volume: 10
Issue: 11
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Publication
31469345 | J:311803
First Author: Kim S
Year: 2020
Journal: Autophagy
Title: Tanycytic TSPO inhibition induces lipophagy to regulate lipid metabolism and improve energy balance.
Volume: 16
Issue: 7
Pages: 1200-1220
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Publication
25470454 | J:224799
First Author: Gatliff J
Year: 2014
Journal: Autophagy
Title: TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control.
Volume: 10
Issue: 12
Pages: 2279-96
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Publication
27907096 | J:250785
First Author: Wang H
Year: 2016
Journal: PLoS One
Title: Global Deletion of TSPO Does Not Affect the Viability and Gene Expression Profile.
Volume: 11
Issue: 12
Pages: e0167307
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Publication
24599476 | J:209616
First Author: Wang M
Year: 2014
Journal: J Neurosci
Title: Macroglia-microglia interactions via TSPO signaling regulates microglial activation in the mouse retina.
Volume: 34
Issue: 10
Pages: 3793-806
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Publication
26925573 | J:250507
 
First Author: Daugherty DJ
Year: 2016
Journal: Sci Rep
Title: The hGFAP-driven conditional TSPO knockout is protective in a mouse model of multiple sclerosis.
Volume: 6
Pages: 22556
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Publication
26545928 | J:228747
 
First Author: Loth MK
Year: 2016
Journal: Neurobiol Dis
Title: TSPO in a murine model of Sandhoff disease: presymptomatic marker of neurodegeneration and disease pathophysiology.
Volume: 85
Pages: 174-186
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Publication
32046185 | J:302394
 
First Author: Vignal N
Year: 2020
Journal: Cells
Title: Astroglial Connexin 43 Deficiency Protects against LPS-Induced Neuroinflammation: A TSPO Brain µPET Study with [18F]FEPPA.
Volume: 9
Issue: 2
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Publication
38301966 | J:345705
 
First Author: Tang Q
Year: 2024
Journal: Biochem Pharmacol
Title: FGF1(ΔHBS) ameliorates retinal inflammation via suppressing TSPO signal in a type 2 diabetes mouse model.
Volume: 221
Pages: 116039
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Publication
36792609 | J:357620
First Author: Magrì A
Year: 2023
Journal: Cell Death Dis
Title: ERK1/2-dependent TSPO overactivation associates with the loss of mitophagy and mitochondrial respiration in ALS.
Volume: 14
Issue: 2
Pages: 122
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Publication
31562844 | J:280448
 
First Author: Klee K
Year: 2019
Journal: Exp Eye Res
Title: Systemic knockout of Tspo in mice does not affect retinal morphology, function and susceptibility to degeneration.
Volume: 188
Pages: 107816
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Publication
32660586 | J:303446
First Author: Eckenweber F
Year: 2020
Journal: J Neuroinflammation
Title: Longitudinal TSPO expression in tau transgenic P301S mice predicts increased tau accumulation and deteriorated spatial learning.
Volume: 17
Issue: 1
Pages: 208
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Publication
26039990 | J:223376
First Author: Fan J
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Conditional steroidogenic cell-targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation.
Volume: 112
Issue: 23
Pages: 7261-6
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Publication
31563962 | J:309367
First Author: Fu Y
Year: 2020
Journal: Neuro Oncol
Title: TSPO deficiency induces mitochondrial dysfunction, leading to hypoxia, angiogenesis, and a growth-promoting metabolic shift toward glycolysis in glioblastoma.
Volume: 22
Issue: 2
Pages: 240-252
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Publication
30343141 | J:270369
First Author: Fan J
Year: 2019
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Nr5a1-Cre-mediated Tspo conditional knockout mice with low growth rate and prediabetes symptoms - A mouse model of stress diabetes.
Volume: 1865
Issue: 1
Pages: 56-62
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Publication
37467699 | J:354042
 
First Author: Rodriguez-Lopez A
Year: 2023
Journal: J Neuroimmunol
Title: Increased TSPO expression, pyroglutamate-modified amyloid beta (AβN3(pE)) accumulation and transient clustering of microglia in the thalamus of Tg-SwDI mice.
Volume: 382
Pages: 578150
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GXD Expression
GXD Expression
Probe: MGI:6507611
Assay Type: Immunohistochemistry
Annotation Date: 2022-01-07
Strength: Present
Sex: Male
Emaps: EMAPS:2910628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6850045
Age: postnatal adult
Image: 4C
Note: Colocalization of Tspo and Vdac1 expression was noted in Leydig cells and Sertoli cells.
Specimen Label: 4C
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6507611
Assay Type: Immunohistochemistry
Annotation Date: 2022-01-07
Strength: Present
Sex: Male
Emaps: EMAPS:2965528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6850045
Age: postnatal adult
Image: 4C
Note: Colocalization of Tspo and Vdac1 expression was noted in Leydig cells and Sertoli cells.
Specimen Label: 4C
Detected: true
Specimen Num: 2
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Publication
32099945 | J:282838
First Author: Fan J
Year: 2020
Journal: J Endocr Soc
Title: Amhr2-Cre-Mediated Global Tspo Knockout.
Volume: 4
Issue: 2
Pages: bvaa001
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Gene
287609 | Tspoap1
Type: gene
Organism: rat
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Gene
455154 | TSPOAP1
Type: gene
Organism: chimpanzee
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Gene
491112 | TSPOAP1
Type: gene
Organism: dog, domestic
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Gene
518675 | TSPOAP1
Type: gene
Organism: cattle
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Gene
417469 | TSPOAP1
Type: gene
Organism: chicken
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Gene
714301 | TSPOAP1
Type: gene
Organism: macaque, rhesus
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Gene
101887060 | tspoap1
Type: gene
Organism: zebrafish
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Gene
100379872 | tspoap1
Type: gene
Organism: frog, western clawed
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Publication
8114671 | J:18431
First Author: Garnier M
Year: 1994
Journal: Mol Pharmacol
Title: In vitro reconstitution of a functional peripheral-type benzodiazepine receptor from mouse Leydig tumor cells.
Volume: 45
Issue: 2
Pages: 201-11
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Publication
25406832 | J:219189
 
First Author: Banati RB
Year: 2014
Journal: Nat Commun
Title: Positron emission tomography and functional characterization of a complete PBR/TSPO knockout.
Volume: 5
Pages: 5452
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Publication
28358007 | J:244754
 
First Author: Jaipuria G
Year: 2017
Journal: Nat Commun
Title: Cholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure.
Volume: 8
Pages: 14893
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Publication
29127254 | J:255689
First Author: Barron AM
Year: 2018
Journal: Biochem J
Title: Steroidogenic abnormalities in translocator protein knockout mice and significance in the aging male.
Volume: 475
Issue: 1
Pages: 75-85
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Publication
24936060 | J:244386
First Author: Tu LN
Year: 2014
Journal: J Biol Chem
Title: Peripheral benzodiazepine receptor/translocator protein global knock-out mice are viable with no effects on steroid hormone biosynthesis.
Volume: 289
Issue: 40
Pages: 27444-54
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Publication
26959396 | J:231583
First Author: Mirzaei N
Year: 2016
Journal: Glia
Title: In vivo imaging of microglial activation by positron emission tomography with [(11)C]PBR28 in the 5XFAD model of Alzheimer's disease.
Volume: 64
Issue: 6
Pages: 993-1006
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Publication
30385779 | J:268302
First Author: Thai PN
Year: 2018
Journal: Sci Rep
Title: Cardiac-specific Conditional Knockout of the 18-kDa Mitochondrial Translocator Protein Protects from Pressure Overload Induced Heart Failure.
Volume: 8
Issue: 1
Pages: 16213
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Publication
26741196 | J:233836
First Author: Tu LN
Year: 2016
Journal: Endocrinology
Title: Translocator Protein (TSPO) Affects Mitochondrial Fatty Acid Oxidation in Steroidogenic Cells.
Volume: 157
Issue: 3
Pages: 1110-21
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Publication
36060674 | J:328332
 
First Author: Jimenez IA
Year: 2022
Journal: Front Physiol
Title: Mitochondrial translocator protein deficiency exacerbates pathology in acute experimental ulcerative colitis.
Volume: 13
Pages: 896951
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Publication
26733718 | J:237646
First Author: Gatliff J
Year: 2016
Journal: Biochem J
Title: TSPO: kaleidoscopic 18-kDa amid biochemical pharmacology, control and targeting of mitochondria.
Volume: 473
Issue: 2
Pages: 107-21
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Publication
36768796 | J:336280
 
First Author: Liere P
Year: 2023
Journal: Int J Mol Sci
Title: The Comprehensive Steroidome in Complete TSPO/PBR Knockout Mice under Basal Conditions.
Volume: 24
Issue: 3
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Publication
38482552 | J:347651
     
First Author: Firth W
Year: 2024
Journal: J Neurochem
Title: Regulation of astrocyte metabolism by mitochondrial translocator protein 18 kDa.
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Publication
26627829 | J:230044
First Author: Zhao AH
Year: 2016
Journal: J Biol Chem
Title: Mitochondrial Translocator Protein (TSPO) Function Is Not Essential for Heme Biosynthesis.
Volume: 291
Issue: 4
Pages: 1591-603
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Publication
24374318 | J:210025
First Author: Hatty CR
Year: 2014
Journal: Biochim Biophys Acta
Title: Investigating the interactions of the 18kDa translocator protein and its ligand PK11195 in planar lipid bilayers.
Volume: 1838
Issue: 3
Pages: 1019-30
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Publication
25818881 | J:224149
 
First Author: Papadopoulos V
Year: 2015
Journal: Mol Cell Endocrinol
Title: Translocator protein-mediated pharmacology of cholesterol transport and steroidogenesis.
Volume: 408
Pages: 90-8
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Publication
32561881 | J:297068
First Author: Banati RB
Year: 2020
Journal: Sci Rep
Title: Selective, high-contrast detection of syngeneic glioblastoma in vivo.
Volume: 10
Issue: 1
Pages: 9968
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Publication
34423477 | J:339436
First Author: Morrissey NA
Year: 2021
Journal: J Neuroendocrinol
Title: Absence of the mitochondrial translocator protein 18 kDa in mice does not affect body weight or food intake responses to altered energy availability.
Volume: 33
Issue: 9
Pages: e13027
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Protein Coding Gene
MGI:2450877 | Tspoap1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
37640701 | J:340856
First Author: Nutma E
Year: 2023
Journal: Nat Commun
Title: Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases.
Volume: 14
Issue: 1
Pages: 5247
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Publication
19552401 | J:153160
First Author: Rone MB
Year: 2009
Journal: Biochemistry
Title: Targeting and insertion of the cholesterol-binding translocator protein into the outer mitochondrial membrane.
Volume: 48
Issue: 29
Pages: 6909-20
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Publication
37891168 | J:342180
First Author: Pradhan AK
Year: 2023
Journal: Transl Psychiatry
Title: Chronic administration of XBD173 ameliorates cognitive deficits and neuropathology via 18 kDa translocator protein (TSPO) in a mouse model of Alzheimer's disease.
Volume: 13
Issue: 1
Pages: 332
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Publication
24260329 | J:209677
First Author: Thompson MM
Year: 2013
Journal: PLoS One
Title: Translocator protein 18 kDa (TSPO) is regulated in white and brown adipose tissue by obesity.
Volume: 8
Issue: 11
Pages: e79980
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Publication
28189343 | J:243139
 
First Author: Belloli S
Year: 2017
Journal: Neurobiol Aging
Title: Early upregulation of 18-kDa translocator protein in response to acute neurodegenerative damage in TREM2-deficient mice.
Volume: 53
Pages: 159-168
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Publication
32483169 | J:292229
First Author: Wolf A
Year: 2020
Journal: Nat Commun
Title: The TSPO-NOX1 axis controls phagocyte-triggered pathological angiogenesis in the eye.
Volume: 11
Issue: 1
Pages: 2709
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Publication
35228700 | J:335646
First Author: Shi Y
Year: 2022
Journal: Nat Neurosci
Title: Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO).
Volume: 25
Issue: 3
Pages: 317-329
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Publication
24174323 | J:207708
First Author: Morohaku K
Year: 2014
Journal: Endocrinology
Title: Translocator protein/peripheral benzodiazepine receptor is not required for steroid hormone biosynthesis.
Volume: 155
Issue: 1
Pages: 89-97
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Publication
32743737 | J:299107
First Author: Loth MK
Year: 2020
Journal: Mol Neurobiol
Title: A Novel Interaction of Translocator Protein 18 kDa (TSPO) with NADPH Oxidase in Microglia.
Volume: 57
Issue: 11
Pages: 4467-4487
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Publication
24040265 | J:207345
First Author: Morohaku K
Year: 2013
Journal: PLoS One
Title: Developmental expression of translocator protein/peripheral benzodiazepine receptor in reproductive tissues.
Volume: 8
Issue: 9
Pages: e74509
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Publication
17050526 | J:117603
First Author: Liu J
Year: 2006
Journal: J Biol Chem
Title: Protein-protein interactions mediate mitochondrial cholesterol transport and steroid biosynthesis.
Volume: 281
Issue: 50
Pages: 38879-93
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Publication
36787364 | J:340855
First Author: Fairley LH
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Mitochondrial control of microglial phagocytosis by the translocator protein and hexokinase 2 in Alzheimer's disease.
Volume: 120
Issue: 8
Pages: e2209177120
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Protein Coding Gene
MGP_CAROLIEiJ_G0020102 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0022167 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0022126 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0022101 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0022132 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0021902 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_88222 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0022577 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0021424 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0021869 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0021996 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0021975 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0022067 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0021995 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0022592 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0021165 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0021473 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0020108 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0020999 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
8125973 | J:17467
First Author: Taketani S
Year: 1994
Journal: J Biol Chem
Title: Induction of peripheral-type benzodiazepine receptors during differentiation of mouse erythroleukemia cells. A possible involvement of these receptors in heme biosynthesis.
Volume: 269
Issue: 10
Pages: 7527-31
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Publication
7721091 | J:24405
First Author: Yakovlev AG
Year: 1995
Journal: Gene
Title: Comparison of repetitive elements in the third intron of human and rodent mitochondrial benzodiazepine receptor-encoding genes.
Volume: 155
Issue: 2
Pages: 201-5
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Publication
9399693 | J:43654
First Author: McClearn GE
Year: 1997
Journal: Mol Psychiatry
Title: Genotypic selection provides experimental confirmation for an alcohol consumption quantitative trait locus in mouse.
Volume: 2
Issue: 6
Pages: 486-9
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Publication
18329265 | J:136604
First Author: Gottfried-Blackmore A
Year: 2008
Journal: J Steroid Biochem Mol Biol
Title: Brain microglia express steroid-converting enzymes in the mouse.
Volume: 109
Issue: 1-2
Pages: 96-107
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GXD Expression
GXD Expression
     
Probe: MGI:3054409
Assay Type: RT-PCR
Annotation Date: 2004-10-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:3054413
Age: embryonic day 7.0
Specimen Label: 7 dpc
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
     
Probe: MGI:3054409
Assay Type: RT-PCR
Annotation Date: 2004-10-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:3054413
Age: embryonic day 11.0
Specimen Label: 11 dpc
Detected: true
Specimen Num: 11
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