Type |
Details |
Score |
Protein Domain |
Type: |
Family |
Description: |
The Tsx gene resides at the X-inactivation centre and once thought to encode a protein expressed in testis. However, this was disputed upon further analysis. ORF and immunostaining analysis concluded that Tsx may be non-coding. Tsx long transcript is abundantly expressed in meiotic germ cells, embryonic stem cells, and brain []. |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Anguera MC |
Year: |
2011 |
Journal: |
PLoS Genet |
Title: |
Tsx produces a long noncoding RNA and has general functions in the germline, stem cells, and brain. |
Volume: |
7 |
Issue: |
9 |
Pages: |
e1002248 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
144
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
144
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
144
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
144
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
53
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
144
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
144
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
144
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Simmler MC |
Year: |
1996 |
Journal: |
Hum Mol Genet |
Title: |
A 94 kb genomic sequence 3' to the murine Xist gene reveals an AT rich region containing a new testis specific gene Tsx. |
Volume: |
5 |
Issue: |
11 |
Pages: |
1713-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cunningham DB |
Year: |
1998 |
Journal: |
Dev Biol |
Title: |
The mouse Tsx gene is expressed in Sertoli cells of the adult testis and transiently in premeiotic germ cells during puberty. |
Volume: |
204 |
Issue: |
2 |
Pages: |
345-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chureau C |
Year: |
2002 |
Journal: |
Genome Res |
Title: |
Comparative sequence analysis of the X-inactivation center region in mouse, human, and bovine. |
Volume: |
12 |
Issue: |
6 |
Pages: |
894-908 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Unhavaithaya Y |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation. |
Volume: |
284 |
Issue: |
10 |
Pages: |
6507-19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Deng W |
Year: |
2002 |
Journal: |
Dev Cell |
Title: |
miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis. |
Volume: |
2 |
Issue: |
6 |
Pages: |
819-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Beyret E |
Year: |
2011 |
Journal: |
Dev Biol |
Title: |
Pinpointing the expression of piRNAs and function of the PIWI protein subfamily during spermatogenesis in the mouse. |
Volume: |
355 |
Issue: |
2 |
Pages: |
215-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Costoya JA |
Year: |
2004 |
Journal: |
Nat Genet |
Title: |
Essential role of Plzf in maintenance of spermatogonial stem cells. |
Volume: |
36 |
Issue: |
6 |
Pages: |
653-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Function or Process or Component Unknown following Literature Review |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Debrand E |
Year: |
1999 |
Journal: |
Mol Cell Biol |
Title: |
Functional analysis of the DXPas34 locus, a 3' regulator of Xist expression. |
Volume: |
19 |
Issue: |
12 |
Pages: |
8513-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Morey C |
Year: |
2004 |
Journal: |
EMBO J |
Title: |
The region 3' to Xist mediates X chromosome counting and H3 Lys-4 dimethylation within the Xist gene. |
Volume: |
23 |
Issue: |
3 |
Pages: |
594-604 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rowntree RK |
Year: |
2006 |
Journal: |
Mol Cell Biol |
Title: |
Mapping of DNA replication origins to noncoding genes of the X-inactivation center. |
Volume: |
26 |
Issue: |
10 |
Pages: |
3707-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bao J |
Year: |
2013 |
Journal: |
Biol Reprod |
Title: |
Expression profiling reveals developmentally regulated lncRNA repertoire in the mouse male germline. |
Volume: |
89 |
Issue: |
5 |
Pages: |
107 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5707836 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2016-02-10 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:2910628 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5707858 |
Age: |
postnatal adult |
Image: |
3C |
|
Specimen Label: |
3C |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5707836 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2016-02-10 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:2910628 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5707858 |
Age: |
postnatal adult |
Image: |
S2C |
|
Specimen Label: |
S2C |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5707836 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2016-02-10 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:2910628 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5707858 |
Age: |
postnatal adult |
Image: |
S2D |
|
Specimen Label: |
S2D |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5816888 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2017-01-08 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:2910628 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5816886 |
Age: |
postnatal adult |
|
|
Specimen Label: |
3D |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bremer E |
Year: |
1990 |
Journal: |
Gene |
Title: |
Analysis of the tsx gene, which encodes a nucleoside-specific channel-forming protein (Tsx) in the outer membrane of Escherichia coli. |
Volume: |
96 |
Issue: |
1 |
Pages: |
59-65 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The tsx gene of Escherichia coli encodes an outer membrane protein, Tsx,which constitutes the receptor for colicin K and Bacteriophage T6, and functions as a substrate-specific channel for nucleosides and deoxy-nucleosides []. The protein contains 294 amino acids, the first 22 of which are characteristic of a bacterial signal sequence peptide. The putative mature form of Tsx contains 272 residues with a calculated Mr of31418. The Tsx sequence shows an even distribution of charged residuesand lacks extensive hydrophobic stretches []. Tsx shows no significant similarities to the channel-forming proteins OmpC, OmpF, PhoE and LamB from the E. coli outer membrane. |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
1 |
Description: |
Testis-specific protein TSX |
Type: |
chain |
End: |
144 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Homologous_superfamily |
Description: |
The tsx gene of Escherichia coli encodes an outer membrane protein, Tsx, which constitutes the receptor for colicin K and Bacteriophage T6, and functions as a substrate-specific channel for nucleosides and deoxy-nucleosides []. The protein contains 294 amino acids, the first 22 of which are characteristic of a bacterial signal sequence peptide. The putative mature form of Tsx contains 272 residues with a calculated Mr of 31418. The Tsx sequence shows an even distribution of charged residues and lacks extensive hydrophobic stretches []. Tsx shows no significant similarities to the channel-forming proteins OmpC, OmpF, PhoE and LamB from the E. coli outer membrane.This entry also contains related proteins of unknown function. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The tsx gene of Escherichia coli encodes an outer membrane protein, Tsx, which constitutes the receptor for colicin K and Bacteriophage T6, and functions as a substrate-specific channel for nucleosides and deoxy-nucleosides []. The protein contains 294 amino acids, the first 22 of which are characteristic of a bacterial signal sequence peptide. The putative mature form of Tsx contains 272 residues with a calculated Mrof 31418. The Tsx sequence shows an even distribution of charged residues and lacks extensive hydrophobic stretches []. Tsx shows no significant similarities to the channel-forming proteins OmpC, OmpF, PhoE and LamB from the E. coli outer membrane.This entry also contains related proteins of unknown function. |
|
•
•
•
•
•
|
Publication |
First Author: |
Barnéoud-Arnoulet A |
Year: |
2010 |
Journal: |
J Bacteriol |
Title: |
Interaction of the colicin K bactericidal toxin with components of its import machinery in the periplasm of Escherichia coli. |
Volume: |
192 |
Issue: |
22 |
Pages: |
5934-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pilsl H |
Year: |
1995 |
Journal: |
J Bacteriol |
Title: |
Strong function-related homology between the pore-forming colicins K and 5. |
Volume: |
177 |
Issue: |
23 |
Pages: |
6973-7 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Colicins are bacterial toxins produced by Escherichia coli strains and are active against E. coli or related strains. These bacterial antibiotic toxins play an important role in the E. coli colonization of environmental niches. Colicin K uses the Tsx nucleoside-specific receptor for binding at the cell surface, the OmpA protein for translocation through the outer membrane, and the TolABQR proteins for the transit through the periplasm. The N-terminal domain interacts with components of its import machinery, including the TolB and TolQ proteins []. Members of this family are colicin K immunity proteins. These proteins are able to protect a cell against colicin K []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
|
•
•
•
•
•
|