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Search results 1 to 15 out of 15 for Ttc37

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Type Details Score
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: human
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
DO Term
Publication
First Author: Brown JT
Year: 2000
Journal: RNA
Title: The yeast antiviral proteins Ski2p, Ski3p, and Ski8p exist as a complex in vivo.
Volume: 6
Issue: 3
Pages: 449-57
Publication
First Author: Zhu B
Year: 2005
Journal: Genes Dev
Title: The human PAF complex coordinates transcription with events downstream of RNA synthesis.
Volume: 19
Issue: 14
Pages: 1668-73
Publication
First Author: Fabre A
Year: 2012
Journal: Am J Hum Genet
Title: SKIV2L mutations cause syndromic diarrhea, or trichohepatoenteric syndrome.
Volume: 90
Issue: 4
Pages: 689-92
Publication
First Author: Schmidt C
Year: 2016
Journal: Science
Title: The cryo-EM structure of a ribosome-Ski2-Ski3-Ski8 helicase complex.
Volume: 354
Issue: 6318
Pages: 1431-1433
Protein Domain
Type: Family
Description: This entry includes superkiller protein 3 (Ski3) from yeasts and plants and tetratricopeptide repeat protein 37 (TTC37) from animals. They are a component of the Ski complex required for exosome-mediated RNA surveillance []. In budding yeasts, the SKI complex (Ski2-Ski3-Ski8) is a helicase complex functioning with the RNA-degrading exosome to mediate the 3'-5' messenger RNA (mRNA) decay in turnover and quality-control pathways []. Ski3 has also been shown to repress dsRNA virus propagation by specifically blocking translation of viral mRNAs []. In humans, TTC37 is also a component of the SKI complex. However, unlike yeast SKI, which is cytoplasmic, human SKI is both nuclear and cytoplasmic []. Mutations in the TTC37 gene cause Syndromic diarrhea/Trichohepatoenteric (SD/THE) syndrome [].
Protein
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 273  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1563  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 469  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 808  
Fragment?: true