|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 100 for Ttll1

0.038s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Protein Domain
Type: Family
Description: Tubulin polyglutamylation plays an important role for several MT-related processes, such as motility of cilia and flagella, stability of centrosomes, and neurite outgrowth. Glutamylation is catalyzed by polyglutamylases, also called as tubulin tyrosine ligase-like (TTLL) enzymes[].TTLL1 is a catalytic subunit of the neuronal tubulin polyglutamylase complex. It modifies alpha and beta tubulin, generating side chains of glutamate on the γ-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha and beta tubulin [].
Gene
Type: gene
Organism: rat
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Janke C
Year: 2005
Journal: Science
Title: Tubulin polyglutamylase enzymes are members of the TTL domain protein family.
Volume: 308
Issue: 5729
Pages: 1758-62
Publication
First Author: van Dijk J
Year: 2007
Journal: Mol Cell
Title: A targeted multienzyme mechanism for selective microtubule polyglutamylation.
Volume: 26
Issue: 3
Pages: 437-48
Protein
Organism: Mus musculus/domesticus
Length: 423  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 89  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 297  
Fragment?: false
Gene
Type: gene
Organism: human
Publication  
First Author: Ping Y
Year: 2023
Journal: Biomolecules
Title: Tubulin Polyglutamylation by TTLL1 and TTLL7 Regulate Glutamate Concentration in the Mice Brain.
Volume: 13
Issue: 5
Publication
First Author: Wu HY
Year: 2022
Journal: PLoS Genet
Title: TTLL1 and TTLL4 polyglutamylases are required for the neurodegenerative phenotypes in pcd mice.
Volume: 18
Issue: 4
Pages: e1010144
Publication
First Author: Vogel P
Year: 2010
Journal: Vet Pathol
Title: Tubulin tyrosine ligase-like 1 deficiency results in chronic rhinosinusitis and abnormal development of spermatid flagella in mice.
Volume: 47
Issue: 4
Pages: 703-12
Publication
First Author: Ikegami K
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Tubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry.
Volume: 107
Issue: 23
Pages: 10490-5
Publication
First Author: Ye B
Year: 2018
Journal: Nat Commun
Title: Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice.
Volume: 9
Issue: 1
Pages: 1261
Publication
First Author: Berezniuk I
Year: 2012
Journal: J Biol Chem
Title: Cytosolic carboxypeptidase 1 is involved in processing α- and β-tubulin.
Volume: 287
Issue: 9
Pages: 6503-17
Gene
Type: gene
Organism: dog, domestic
Publication
First Author: Genova M
Year: 2023
Journal: EMBO J
Title: Tubulin polyglutamylation differentially regulates microtubule-interacting proteins.
Volume: 42
Issue: 5
Pages: e112101
Publication
First Author: Bodakuntla S
Year: 2021
Journal: EMBO J
Title: Distinct roles of α- and β-tubulin polyglutamylation in controlling axonal transport and in neurodegeneration.
Volume: 40
Issue: 17
Pages: e108498
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Iwata T
Year: 2015
Journal: PLoS One
Title: Mechanical Stimulation by Postnasal Drip Evokes Cough.
Volume: 10
Issue: 11
Pages: e0141823
Publication
First Author: Suzuki H
Year: 2018
Journal: Sci Rep
Title: Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice.
Volume: 8
Issue: 1
Pages: 2904
GXD Expression    
Probe: MGI:7446622
Assay Type: RT-PCR
Annotation Date: 2023-03-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160331
Stage: TS01
Assay Id: MGI:7446651
Age: embryonic day 0.5
Image: S2
Specimen Label: 1 cell
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7446622
Assay Type: RT-PCR
Annotation Date: 2023-03-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318653
Stage: TS03
Assay Id: MGI:7446651
Age: embryonic day 2.5
Image: S2
Specimen Label: 8 cell
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:4428103
Assay Type: RNA in situ
Annotation Date: 2023-08-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7516851
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:7446610
Assay Type: Immunohistochemistry
Annotation Date: 2023-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360355
Pattern: Not Specified
Stage: TS05
Assay Id: MGI:7446735
Age: embryonic day 3.5
Image: 8a Ttll1+/+
Specimen Label: 8a Ttll1+/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7446610
Assay Type: Immunohistochemistry
Annotation Date: 2023-03-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:360355
Stage: TS05
Assay Id: MGI:7446735
Age: embryonic day 3.5
Image: 8a Ttll1-/-
Specimen Label: 8a Ttll1-/-
Detected: false
Specimen Num: 2
Publication  
First Author: Magiera MM
Year: 2018
Journal: EMBO J
Title: Excessive tubulin polyglutamylation causes neurodegeneration and perturbs neuronal transport.
Volume: 37
Issue: 23
Publication
First Author: Ikegami K
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Loss of alpha-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function.
Volume: 104
Issue: 9
Pages: 3213-8
Publication
First Author: Silva CG
Year: 2018
Journal: Cell
Title: Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis.
Volume: 172
Issue: 5
Pages: 1063-1078.e19
Publication
First Author: Ho KH
Year: 2023
Journal: Dev Cell
Title: Choroid plexuses carry nodal-like cilia that undergo axoneme regression from early adult stage.
Volume: 58
Issue: 23
Pages: 2641-2651.e6
Publication        
First Author: Mouse Genome Sequence and Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Mouse Genome Sequence Project Annotation
Publication      
First Author: Mouse Genome Informatics and the Europhenome Mouse Phenotyping Resource
Year: 2010
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from Europhenome
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
Publication  
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
UniProt Feature
Begin: 1
Description: Polyglutamylase complex subunit TTLL1
Type: chain
End: 423
Publication
First Author: Bosch Grau M
Year: 2013
Journal: J Cell Biol
Title: Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia.
Volume: 202
Issue: 3
Pages: 441-51
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Carninci P
Year: 2000
Journal: Genome Res
Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Volume: 10
Issue: 10
Pages: 1617-30
Publication  
First Author: Carninci P
Year: 1999
Journal: Methods Enzymol
Title: High-efficiency full-length cDNA cloning.
Volume: 303
Pages: 19-44
Publication
First Author: Shibata K
Year: 2000
Journal: Genome Res
Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Volume: 10
Issue: 11
Pages: 1757-71
Publication
First Author: Katayama S
Year: 2005
Journal: Science
Title: Antisense transcription in the mammalian transcriptome.
Volume: 309
Issue: 5740
Pages: 1564-6
Publication
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
Publication
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112