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Search results 1 to 90 out of 90 for Ttll4

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
9654 | TTLL4
Type: gene
Organism: human
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Gene
100144652 | ttll4
Type: gene
Organism: frog, western clawed
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Gene
690512 | Ttll4
Type: gene
Organism: rat
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Gene
488525 | TTLL4
Type: gene
Organism: dog, domestic
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Gene
459949 | TTLL4
Type: gene
Organism: chimpanzee
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Gene
511853 | TTLL4
Type: gene
Organism: cattle
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Gene
424209 | TTLL4
Type: gene
Organism: chicken
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Gene
558702 | ttll4
Type: gene
Organism: zebrafish
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Gene
700064 | TTLL4
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1914784 | Ttll4
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
35404950 | J:323874
First Author: Wu HY
Year: 2022
Journal: PLoS Genet
Title: TTLL1 and TTLL4 polyglutamylases are required for the neurodegenerative phenotypes in pcd mice.
Volume: 18
Issue: 4
Pages: e1010144
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Protein
Q80UG8
Organism: Mus musculus/domesticus
Length: 1193  
Fragment?: false
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Publication
17499049 | J:130247
First Author: van Dijk J
Year: 2007
Journal: Mol Cell
Title: A targeted multienzyme mechanism for selective microtubule polyglutamylation.
Volume: 26
Issue: 3
Pages: 437-48
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Publication
21074048 | J:166837
First Author: Rogowski K
Year: 2010
Journal: Cell
Title: A family of protein-deglutamylating enzymes associated with neurodegeneration.
Volume: 143
Issue: 4
Pages: 564-78
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Publication
29593216 | J:259707
First Author: Ye B
Year: 2018
Journal: Nat Commun
Title: Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice.
Volume: 9
Issue: 1
Pages: 1261
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Publication
20530212 | J:162689
First Author: Lacroix B
Year: 2010
Journal: J Cell Biol
Title: Tubulin polyglutamylation stimulates spastin-mediated microtubule severing.
Volume: 189
Issue: 6
Pages: 945-54
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Publication
26829768 | J:231311
First Author: Xia P
Year: 2016
Journal: Nat Immunol
Title: Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity.
Volume: 17
Issue: 4
Pages: 369-78
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Publication
23897886 | J:201638
First Author: Bosch Grau M
Year: 2013
Journal: J Cell Biol
Title: Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia.
Volume: 202
Issue: 3
Pages: 441-51
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Protein
D3YY08
Organism: Mus musculus/domesticus
Length: 1129  
Fragment?: false
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Protein Coding Gene
MGP_CAROLIEiJ_G0014271 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0016159 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0016142 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0016099 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0016097 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0015928 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1914784 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0016550 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0015512 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0015901 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0016002 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0016005 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0016074 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0016025 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0016597 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0015299 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0015574 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0027509 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0015077 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:7446623
Assay Type: RT-PCR
Annotation Date: 2023-03-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160331
Stage: TS01
Assay Id: MGI:7446652
Age: embryonic day 0.5
Image: S2
Specimen Label: 1 cell
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7446623
Assay Type: RT-PCR
Annotation Date: 2023-03-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318653
Stage: TS03
Assay Id: MGI:7446652
Age: embryonic day 2.5
Image: S2
Specimen Label: 8 cell
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:7446612
Assay Type: Immunohistochemistry
Annotation Date: 2023-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360355
Pattern: Not Specified
Stage: TS05
Assay Id: MGI:7446743
Age: embryonic day 3.5
Image: 8a Ttll4+/+
Specimen Label: 8a Ttll4+/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7446612
Assay Type: Immunohistochemistry
Annotation Date: 2023-03-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:360355
Stage: TS05
Assay Id: MGI:7446743
Age: embryonic day 3.5
Image: 8a Ttll4-/-
Specimen Label: 8a Ttll4-/-
Detected: false
Specimen Num: 2
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Publication
28794449 | J:252746
First Author: Liu B
Year: 2017
Journal: Nat Commun
Title: IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development.
Volume: 8
Issue: 1
Pages: 231
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Publication
34995116 | J:317829
First Author: Wang F
Year: 2022
Journal: Sci Adv
Title: Single-cell architecture and functional requirement of alternative splicing during hematopoietic stem cell formation.
Volume: 8
Issue: 1
Pages: eabg5369
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Publication
37890489 | J:343289
First Author: Ho KH
Year: 2023
Journal: Dev Cell
Title: Choroid plexuses carry nodal-like cilia that undergo axoneme regression from early adult stage.
Volume: 58
Issue: 23
Pages: 2641-2651.e6
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Publication
- | J:165965
     
First Author: Mouse Genome Informatics and the Europhenome Mouse Phenotyping Resource
Year: 2010
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from Europhenome
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Publication
10512203 | J:93290
First Author: Araki K
Year: 1999
Journal: Cell Mol Biol (Noisy-le-grand)
Title: Exchangeable gene trap using the Cre/mutated lox system.
Volume: 45
Issue: 5
Pages: 737-50
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Publication
15840001 | J:110088
First Author: Taniwaki T
Year: 2005
Journal: Dev Growth Differ
Title: Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.
Volume: 47
Issue: 3
Pages: 163-72
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Publication
- | J:175295
     
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 1
Description: Tubulin monoglutamylase TTLL4
Type: chain
End: 1193
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Publication
20519502 | J:168379
First Author: Kimura Y
Year: 2010
Journal: J Biol Chem
Title: Identification of tubulin deglutamylase among Caenorhabditis elegans and mammalian cytosolic carboxypeptidases (CCPs).
Volume: 285
Issue: 30
Pages: 22936-41
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Protein Domain
IPR027748 | TTLL-4
Type: Family
Description: Tubulin polyglutamylation plays an important role for several MT-related processes, such as motility of cilia and flagella, stability of centrosomes, and neurite outgrowth. Glutamylation is catalyzed by polyglutamylases, also called as tubulin tyrosine ligase-like (TTLL) enzymes[].TTLL-4 is a polyglutamylase which preferentially modifies beta-tubulin and nucleosome assembly proteins NAP1 and NAP2. It is involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step [, ]. In Caenorhabditis elegans, it is involved in side-chain polyglutamylation of tubulin in sensory cilia [].
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Protein
D3Z7H1
Organism: Mus musculus/domesticus
Length: 103  
Fragment?: true
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Protein
D3Z402
Organism: Mus musculus/domesticus
Length: 113  
Fragment?: true
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Publication
32747782 | J:297726
First Author: Mahalingan KK
Year: 2020
Journal: Nat Struct Mol Biol
Title: Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes.
Volume: 27
Issue: 9
Pages: 802-813
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Publication
25332286 | J:233744
First Author: Ye B
Year: 2014
Journal: J Exp Med
Title: Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation.
Volume: 211
Issue: 12
Pages: 2439-54
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Publication
14621295 | J:86686
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 4
Pages: 167-80
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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