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Search results 1 to 100 out of 481 for Txnip

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Hits by Strain

Type Details Score
Gene
10628 | TXNIP
Type: gene
Organism: human
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Gene
100492126 | txnip
Type: gene
Organism: frog, western clawed
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Gene
107051021 | TXNIP
Type: gene
Organism: chicken
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Gene
117514 | Txnip
Type: gene
Organism: rat
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Gene
457986 | TXNIP
Type: gene
Organism: chimpanzee
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Gene
475829 | TXNIP
Type: gene
Organism: dog, domestic
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Gene
506790 | TXNIP
Type: gene
Organism: cattle
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Gene
698683 | TXNIP
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1889549 | Txnip
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
 
Probe: MGI:3821058
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3564522
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3825681
Age: embryonic day 14.5
Image: Additional file 4 Txnip
Specimen Label: Additional file 4 Txnip
Detected: true
Specimen Num: 1
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Publication
40610750 | J:374595
First Author: Hwang AR
Year: 2025
Journal: Exp Mol Med
Title: Smooth muscle cell-specific deletion of TXNIP ameliorates medial vascular calcification.
Volume: 57
Issue: 7
Pages: 1519-1535
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Publication
33748706 | J:370377
First Author: Noblet B
Year: 2021
Journal: iScience
Title: Dual regulation of TxNIP by ChREBP and FoxO1 in liver.
Volume: 24
Issue: 3
Pages: 102218
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Publication
33652022 | J:322003
 
First Author: Nakayama Y
Year: 2021
Journal: J Mol Cell Cardiol
Title: Txnip C247S mutation protects the heart against acute myocardial infarction.
Volume: 155
Pages: 36-49
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Publication
18322014 | J:132756
First Author: Hui ST
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Txnip balances metabolic and growth signaling via PTEN disulfide reduction.
Volume: 105
Issue: 10
Pages: 3921-6
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Publication
27199118 | J:234777
First Author: Chen J
Year: 2016
Journal: Am J Physiol Heart Circ Physiol
Title: TXNIP regulates myocardial fatty acid oxidation via miR-33a signaling.
Volume: 311
Issue: 1
Pages: H64-75
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Publication
21508227 | J:171604
First Author: Blouet C
Year: 2011
Journal: J Neurosci
Title: Nutrient-sensing hypothalamic TXNIP links nutrient excess to energy imbalance in mice.
Volume: 31
Issue: 16
Pages: 6019-27
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Publication
36448450 | J:365390
First Author: Woo SH
Year: 2023
Journal: Circ Res
Title: TXNIP Suppresses the Osteochondrogenic Switch of Vascular Smooth Muscle Cells in Atherosclerosis.
Volume: 132
Issue: 1
Pages: 52-71
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Publication
40360637 | J:390424
First Author: Jia J
Year: 2025
Journal: Sci Rep
Title: Thioredoxin-1 inhibits NLRP3-mediated pyroptosis by regulating TXNIP in models of Alzheimer's disease.
Volume: 15
Issue: 1
Pages: 16551
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Publication
22815502 | J:186466
First Author: Blouet C
Year: 2012
Journal: J Neurosci
Title: TXNIP in Agrp neurons regulates adiposity, energy expenditure, and central leptin sensitivity.
Volume: 32
Issue: 29
Pages: 9870-7
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Publication
23584857 | J:198464
First Author: Hand LE
Year: 2013
Journal: Endocrinology
Title: Induction of the metabolic regulator Txnip in fasting-induced and natural torpor.
Volume: 154
Issue: 6
Pages: 2081-91
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Publication
30168649 | J:267337
First Author: Huy H
Year: 2018
Journal: Aging Cell
Title: TXNIP regulates AKT-mediated cellular senescence by direct interaction under glucose-mediated metabolic stress.
Volume: 17
Issue: 6
Pages: e12836
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Publication
32902872 | J:305710
First Author: Muri J
Year: 2021
Journal: Eur J Immunol
Title: The thioredoxin-1 inhibitor Txnip restrains effector T-cell and germinal center B-cell expansion.
Volume: 51
Issue: 1
Pages: 115-124
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Publication
19875615 | J:164164
First Author: Chen J
Year: 2010
Journal: Diabetes
Title: Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated beta-cell death.
Volume: 59
Issue: 2
Pages: 440-7
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Publication
41213907 | J:374761
First Author: Alcon-Rodriguez S
Year: 2025
Journal: Cell Death Dis
Title: TXNIP upregulation controls metabolism and cell cycle during androgen deprivation therapy in prostate cancer.
Volume: 16
Issue: 1
Pages: 817
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Publication
39947474 | J:362737
First Author: Zou M
Year: 2025
Journal: J Biol Chem
Title: Txnip deficiency causes a susceptibility to acute cold stress with brown fat dysfunction in mice.
Volume: 301
Issue: 3
Pages: 108293
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Publication
20299477 | J:169358
First Author: Chutkow WA
Year: 2010
Journal: Diabetes
Title: Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity.
Volume: 59
Issue: 6
Pages: 1424-34
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Publication
34085839 | J:339893
First Author: Mukai N
Year: 2021
Journal: Am J Physiol Heart Circ Physiol
Title: Cardiomyocyte-specific Txnip C247S mutation improves left ventricular functional reserve in streptozotocin-induced diabetic mice.
Volume: 321
Issue: 2
Pages: H259-H274
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Publication
24098117 | J:245936
First Author: Park YJ
Year: 2013
Journal: PLoS Pathog
Title: TXNIP deficiency exacerbates endotoxic shock via the induction of excessive nitric oxide synthesis.
Volume: 9
Issue: 10
Pages: e1003646
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Publication
31620121 | J:297995
 
First Author: Tseng PC
Year: 2019
Journal: Front Immunol
Title: HECT E3 Ubiquitin Ligase-Regulated Txnip Degradation Facilitates TLR2-Mediated Inflammation During Group A Streptococcal Infection.
Volume: 10
Pages: 2147
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Publication
42015926 | J:390222
First Author: Nakayama Y
Year: 2026
Journal: Am J Physiol Heart Circ Physiol
Title: Mutations in the Txnip PPXY motifs protect against myocardial infarction despite enhanced protein stability.
Volume: 330
Issue: 6
Pages: H1732-H1748
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Publication
23823478 | J:199235
First Author: Jung H
Year: 2013
Journal: Cell Metab
Title: TXNIP maintains the hematopoietic cell pool by switching the function of p53 under oxidative stress.
Volume: 18
Issue: 1
Pages: 75-85
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Publication
38169654 | J:344177
First Author: Jung E
Year: 2024
Journal: Int J Biol Sci
Title: TXNIP in liver sinusoidal endothelial cells ameliorates alcohol-associated liver disease via nitric oxide production.
Volume: 20
Issue: 2
Pages: 606-620
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Publication
28591573 | J:256247
First Author: Waldhart AN
Year: 2017
Journal: Cell Rep
Title: Phosphorylation of TXNIP by AKT Mediates Acute Influx of Glucose in Response to Insulin.
Volume: 19
Issue: 10
Pages: 2005-2013
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Publication
37172394 | J:348484
 
First Author: Kim J
Year: 2023
Journal: Redox Biol
Title: TXNIP contributes to induction of pro-inflammatory phenotype and caspase-3 activation in astrocytes during Alzheimer's diseases.
Volume: 63
Pages: 102735
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Publication
29322219 | J:262180
First Author: Qin K
Year: 2018
Journal: Diabetologia
Title: SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice.
Volume: 61
Issue: 4
Pages: 906-918
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Publication
33508319 | J:302167
 
First Author: Beg M
Year: 2021
Journal: J Biol Chem
Title: ATGL activity regulates GLUT1-mediated glucose uptake and lactate production via TXNIP stability in adipocytes.
Volume: 296
Pages: 100332
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Publication
28669627 | J:319254
 
First Author: Tian D
Year: 2017
Journal: Free Radic Biol Med
Title: Endogenous hydrogen sulfide-mediated MAPK inhibition preserves endothelial function through TXNIP signaling.
Volume: 110
Pages: 291-299
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Publication
40360509 | J:369788
First Author: Baek EB
Year: 2025
Journal: Nat Commun
Title: Vitamin D supplementation ameliorates ductular reaction, liver inflammation and fibrosis in mice by upregulating TXNIP in ductular cells.
Volume: 16
Issue: 1
Pages: 4420
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Publication
32726606 | J:296609
First Author: Thielen LA
Year: 2020
Journal: Cell Metab
Title: Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action.
Volume: 32
Issue: 3
Pages: 353-365.e8
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Publication
30980800 | J:277219
First Author: Fertan E
Year: 2019
Journal: Am J Pathol
Title: Cognitive Decline, Cerebral-Spleen Tryptophan Metabolism, Oxidative Stress, Cytokine Production, and Regulation of the Txnip Gene in a Triple Transgenic Mouse Model of Alzheimer Disease.
Volume: 189
Issue: 7
Pages: 1435-1450
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Publication
37168572 | J:335573
First Author: Waldhart AN
Year: 2023
Journal: iScience
Title: Optimal HSF1 activation in response to acute cold stress in BAT requires nuclear TXNIP.
Volume: 26
Issue: 5
Pages: 106538
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Publication
37456843 | J:338326
First Author: Avequin T
Year: 2023
Journal: iScience
Title: Differential effects of sugar and fat on adipose tissue inflammation.
Volume: 26
Issue: 7
Pages: 107163
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Publication
34348139 | J:311481
First Author: Waldhart AN
Year: 2021
Journal: Cell Rep
Title: Excess dietary carbohydrate affects mitochondrial integrity as observed in brown adipose tissue.
Volume: 36
Issue: 5
Pages: 109488
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Publication
32927265 | J:338655
First Author: Shah A
Year: 2020
Journal: iScience
Title: Thioredoxin Interacting Protein Is Required for a Chronic Energy-Rich Diet to Promote Intestinal Fructose Absorption.
Volume: 23
Issue: 9
Pages: 101521
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Publication
21439280 | J:171282
First Author: Andres AM
Year: 2011
Journal: FEBS Lett
Title: Diminished AMPK signaling response to fasting in thioredoxin-interacting protein knockout mice.
Volume: 585
Issue: 8
Pages: 1223-30
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Publication
20624390 | J:163475
First Author: Ren Y
Year: 2010
Journal: FEBS Lett
Title: p38 MAPK pathway is involved in high glucose-induced thioredoxin interacting protein induction in mouse mesangial cells.
Volume: 584
Issue: 15
Pages: 3480-5
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Publication
21510938 | J:173209
First Author: Shi Y
Year: 2011
Journal: FEBS Lett
Title: Knockdown of thioredoxin interacting protein attenuates high glucose-induced apoptosis and activation of ASK1 in mouse mesangial cells.
Volume: 585
Issue: 12
Pages: 1789-95
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Publication
16607285 | J:112292
First Author: Sheth SS
Year: 2006
Journal: Oncogene
Title: Hepatocellular carcinoma in Txnip-deficient mice.
Volume: 25
Issue: 25
Pages: 3528-36
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Publication
15520447 | J:94707
First Author: Sheth SS
Year: 2005
Journal: J Lipid Res
Title: Thioredoxin-interacting protein deficiency disrupts the fasting-feeding metabolic transition.
Volume: 46
Issue: 1
Pages: 123-34
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Publication
31900750 | J:301160
First Author: Domingues A
Year: 2020
Journal: Angiogenesis
Title: Targeting endothelial thioredoxin-interacting protein (TXNIP) protects from metabolic disorder-related impairment of vascular function and post-ischemic revascularisation.
Volume: 23
Issue: 2
Pages: 249-264
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Publication
38329960 | J:351013
First Author: Kim S
Year: 2024
Journal: PLoS One
Title: TXNIP-mediated crosstalk between oxidative stress and glucose metabolism.
Volume: 19
Issue: 2
Pages: e0292655
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Publication
17998203 | J:130601
First Author: Chutkow WA
Year: 2008
Journal: J Biol Chem
Title: Thioredoxin-interacting protein (Txnip) is a critical regulator of hepatic glucose production.
Volume: 283
Issue: 4
Pages: 2397-406
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Publication
15047687 | J:90735
First Author: Hui TY
Year: 2004
Journal: J Biol Chem
Title: Mice lacking thioredoxin-interacting protein provide evidence linking cellular redox state to appropriate response to nutritional signals.
Volume: 279
Issue: 23
Pages: 24387-93
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Publication
34340312 | J:351906
First Author: Rodriguez YA
Year: 2021
Journal: ACS Chem Neurosci
Title: Novologue Therapy Requires Heat Shock Protein 70 and Thioredoxin-Interacting Protein to Improve Mitochondrial Bioenergetics and Decrease Mitophagy in Diabetic Sensory Neurons.
Volume: 12
Issue: 16
Pages: 3049-3059
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Publication
35314758 | J:366119
First Author: Miyahara H
Year: 2022
Journal: Sci Rep
Title: Thioredoxin interacting protein protects mice from fasting induced liver steatosis by activating ER stress and its downstream signaling pathways.
Volume: 12
Issue: 1
Pages: 4819
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Publication
24482226 | J:211210
First Author: DeBalsi KL
Year: 2014
Journal: J Biol Chem
Title: Targeted metabolomics connects thioredoxin-interacting protein (TXNIP) to mitochondrial fuel selection and regulation of specific oxidoreductase enzymes in skeletal muscle.
Volume: 289
Issue: 12
Pages: 8106-20
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Publication
25600403 | J:230266
First Author: Gasiorek JJ
Year: 2015
Journal: Exp Hematol
Title: Thioredoxin-interacting protein regulates the differentiation of murine erythroid precursors.
Volume: 43
Issue: 5
Pages: 393-403.e2
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Publication
32892310 | J:328948
First Author: Deng W
Year: 2020
Journal: Endocrine
Title: Thioredoxin-interacting protein: a critical link between autophagy disorders and pancreatic ?-cell dysfunction.
Volume: 70
Issue: 3
Pages: 526-537
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Publication
40658786 | J:389938
 
First Author: Liao X
Year: 2025
Journal: Hepatol Commun
Title: METTL3 inhibits liver fibrosis via RBX1 stability and TXNIP-mediated ferroptosis.
Volume: 9
Issue: 8
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Publication
27929088 | J:243236
 
First Author: Jung H
Year: 2016
Journal: Nat Commun
Title: Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity.
Volume: 7
Pages: 13674
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Publication
19625652 | J:151788
First Author: Jeong M
Year: 2009
Journal: J Immunol
Title: Thioredoxin-interacting protein regulates hematopoietic stem cell quiescence and mobilization under stress conditions.
Volume: 183
Issue: 4
Pages: 2495-505
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Publication
25916556 | J:222791
 
First Author: Qiao S
Year: 2015
Journal: Nat Commun
Title: A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity.
Volume: 6
Pages: 7014
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Publication
24515523 | J:247165
First Author: Spindel ON
Year: 2014
Journal: Circ Res
Title: Thioredoxin-interacting protein is a biomechanical regulator of Src activity: key role in endothelial cell stress fiber formation.
Volume: 114
Issue: 7
Pages: 1125-32
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Publication
19223654 | J:149778
First Author: Masson E
Year: 2009
Journal: Am J Physiol Endocrinol Metab
Title: High beta-cell mass prevents streptozotocin-induced diabetes in thioredoxin-interacting protein-deficient mice.
Volume: 296
Issue: 6
Pages: E1251-61
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Publication
35379773 | J:386878
First Author: Sbai O
Year: 2022
Journal: Cell Death Dis
Title: AGE-TXNIP axis drives inflammation in Alzheimer's by targeting A?? to mitochondria in microglia.
Volume: 13
Issue: 4
Pages: 302
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Publication
25329456 | J:223552
First Author: Abdelsaid MA
Year: 2014
Journal: PLoS One
Title: Deletion of thioredoxin interacting protein (TXNIP) augments hyperoxia-induced vaso-obliteration in a mouse model of oxygen induced-retinopathy.
Volume: 9
Issue: 10
Pages: e110388
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Publication
29282201 | J:258313
First Author: Richards P
Year: 2018
Journal: Diabetes
Title: MondoA Is an Essential Glucose-Responsive Transcription Factor in Human Pancreatic ?-Cells.
Volume: 67
Issue: 3
Pages: 461-472
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Publication
22883234 | J:187376
First Author: Oslowski CM
Year: 2012
Journal: Cell Metab
Title: Thioredoxin-interacting protein mediates ER stress-induced ? cell death through initiation of the inflammasome.
Volume: 16
Issue: 2
Pages: 265-73
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Publication
27725089 | J:238752
   
First Author: Dotimas JR
Year: 2016
Journal: Elife
Title: Diabetes regulates fructose absorption through thioredoxin-interacting protein.
Volume: 5
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Publication
22267843 | J:192695
First Author: Wang XQ
Year: 2012
Journal: Circ Res
Title: Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2.
Volume: 110
Issue: 4
Pages: 560-8
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Publication
32723174 | J:296859
First Author: Zhou W
Year: 2020
Journal: Am J Physiol Endocrinol Metab
Title: Glucagon-like peptide-1 receptor mediates the beneficial effect of liraglutide in an acute lung injury mouse model involving the thioredoxin-interacting protein.
Volume: 319
Issue: 3
Pages: E568-E578
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Publication
24843047 | J:232290
First Author: Lee S
Year: 2014
Journal: EMBO Mol Med
Title: Thioredoxin-interacting protein regulates protein disulfide isomerases and endoplasmic reticulum stress.
Volume: 6
Issue: 6
Pages: 732-43
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Publication
23715727 | J:199256
First Author: Zervou S
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: A role for thioredoxin-interacting protein (Txnip) in cellular creatine homeostasis.
Volume: 305
Issue: 2
Pages: E263-70
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Publication
35957590 | J:335467
 
First Author: Lu B
Year: 2022
Journal: Endocrinology
Title: Alpha Cell Thioredoxin-interacting Protein Deletion Improves Diabetes-associated Hyperglycemia and Hyperglucagonemia.
Volume: 163
Issue: 11
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Publication
23976953 | J:206349
First Author: Lee SY
Year: 2013
Journal: PLoS One
Title: Thioredoxin-interacting protein regulates glucose metabolism and affects cytoplasmic streaming in mouse oocytes.
Volume: 8
Issue: 8
Pages: e70708
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Publication
22883233 | J:187377
First Author: Lerner AG
Year: 2012
Journal: Cell Metab
Title: IRE1? induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.
Volume: 16
Issue: 2
Pages: 250-64
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Publication
33847261 | J:364669
   
First Author: Xue Y
Year: 2021
Journal: Elife
Title: AAV-Txnip prolongs cone survival and vision in mouse models of retinitis pigmentosa.
Volume: 10
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Publication
20023662 | J:158410
First Author: Zhou R
Year: 2010
Journal: Nat Immunol
Title: Thioredoxin-interacting protein links oxidative stress to inflammasome activation.
Volume: 11
Issue: 2
Pages: 136-40
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Publication
32096759 | J:294330
   
First Author: Muri J
Year: 2020
Journal: Elife
Title: Thioredoxin-1 distinctly promotes NF-?B target DNA binding and NLRP3 inflammasome activation independently of Txnip.
Volume: 9
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Publication
28606928 | J:247199
First Author: Chau GC
Year: 2017
Journal: J Cell Biol
Title: mTOR controls ChREBP transcriptional activity and pancreatic ? cell survival under diabetic stress.
Volume: 216
Issue: 7
Pages: 2091-2105
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Publication
18344994 | J:136099
First Author: Papadia S
Year: 2008
Journal: Nat Neurosci
Title: Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses.
Volume: 11
Issue: 4
Pages: 476-87
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Publication
38142581 | J:344317
 
First Author: Aldoghachi AF
Year: 2024
Journal: Biochem Biophys Res Commun
Title: Fluorinated curcumin derivative (Shiga-Y6) modulates the level of thioredoxin-interacting protein (TXNIP) in a mouse model of diabetes.
Volume: 694
Pages: 149392
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Publication
18552236 | J:140264
First Author: Chen J
Year: 2008
Journal: FASEB J
Title: Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes.
Volume: 22
Issue: 10
Pages: 3581-94
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Publication
25391656 | J:302802
First Author: Filios SR
Year: 2014
Journal: J Biol Chem
Title: MicroRNA-200 is induced by thioredoxin-interacting protein and regulates Zeb1 protein signaling and beta cell apoptosis.
Volume: 289
Issue: 52
Pages: 36275-83
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Publication
39895486 | J:385713
First Author: Jo S
Year: 2025
Journal: Diabetes Obes Metab
Title: Oral TIX100 protects against obesity-associated glucose intolerance and diet-induced adiposity.
Volume: 27
Issue: 4
Pages: 2223-2231
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Publication
18171713 | J:135529
First Author: Chen J
Year: 2008
Journal: Diabetes
Title: Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis.
Volume: 57
Issue: 4
Pages: 938-44
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Publication
22869588 | J:312802
First Author: He X
Year: 2012
Journal: Mol Pharmacol
Title: Redox regulation by nuclear factor erythroid 2-related factor 2: gatekeeping for the basal and diabetes-induced expression of thioredoxin-interacting protein.
Volume: 82
Issue: 5
Pages: 887-97
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Publication
17916779 | J:141487
First Author: Yoshioka J
Year: 2007
Journal: Circ Res
Title: Targeted deletion of thioredoxin-interacting protein regulates cardiac dysfunction in response to pressure overload.
Volume: 101
Issue: 12
Pages: 1328-38
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Publication
27037370 | J:234809
First Author: Myers RB
Year: 2016
Journal: Am J Physiol Heart Circ Physiol
Title: Deletion of thioredoxin-interacting protein improves cardiac inotropic reserve in the streptozotocin-induced diabetic heart.
Volume: 310
Issue: 11
Pages: H1748-59
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Publication
22201682 | J:184389
First Author: Yoshioka J
Year: 2012
Journal: J Clin Invest
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Title: Thioredoxin-Interacting Protein Promotes Phagosomal Acidification Upon Exposure to Escherichia coli Through Inflammasome-Mediated Caspase-1 Activation in Macrophages.
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Journal: Neurobiol Dis
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Title: FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX.
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