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Search results 1 to 100 out of 420 for Txnip

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Type Details Score
Gene
10628 | TXNIP
Type: gene
Organism: human
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Gene
457986 | TXNIP
Type: gene
Organism: chimpanzee
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Gene
475829 | TXNIP
Type: gene
Organism: dog, domestic
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Gene
506790 | TXNIP
Type: gene
Organism: cattle
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Gene
698683 | TXNIP
Type: gene
Organism: macaque, rhesus
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Gene
100492126 | txnip
Type: gene
Organism: frog, western clawed
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Gene
107051021 | TXNIP
Type: gene
Organism: chicken
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Gene
117514 | Txnip
Type: gene
Organism: rat
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Protein Coding Gene
MGI:1889549 | Txnip
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
 
Probe: MGI:3821058
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3564522
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3825681
Age: embryonic day 14.5
Image: Additional file 4 Txnip
Specimen Label: Additional file 4 Txnip
Detected: true
Specimen Num: 1
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Publication
33652022 | J:322003
 
First Author: Nakayama Y
Year: 2021
Journal: J Mol Cell Cardiol
Title: Txnip C247S mutation protects the heart against acute myocardial infarction.
Volume: 155
Pages: 36-49
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Publication
27199118 | J:234777
First Author: Chen J
Year: 2016
Journal: Am J Physiol Heart Circ Physiol
Title: TXNIP regulates myocardial fatty acid oxidation via miR-33a signaling.
Volume: 311
Issue: 1
Pages: H64-75
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Publication
18322014 | J:132756
First Author: Hui ST
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Txnip balances metabolic and growth signaling via PTEN disulfide reduction.
Volume: 105
Issue: 10
Pages: 3921-6
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Publication
21508227 | J:171604
First Author: Blouet C
Year: 2011
Journal: J Neurosci
Title: Nutrient-sensing hypothalamic TXNIP links nutrient excess to energy imbalance in mice.
Volume: 31
Issue: 16
Pages: 6019-27
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Publication
23584857 | J:198464
First Author: Hand LE
Year: 2013
Journal: Endocrinology
Title: Induction of the metabolic regulator Txnip in fasting-induced and natural torpor.
Volume: 154
Issue: 6
Pages: 2081-91
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Publication
22815502 | J:186466
First Author: Blouet C
Year: 2012
Journal: J Neurosci
Title: TXNIP in Agrp neurons regulates adiposity, energy expenditure, and central leptin sensitivity.
Volume: 32
Issue: 29
Pages: 9870-7
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Publication
24098117 | J:245936
First Author: Park YJ
Year: 2013
Journal: PLoS Pathog
Title: TXNIP deficiency exacerbates endotoxic shock via the induction of excessive nitric oxide synthesis.
Volume: 9
Issue: 10
Pages: e1003646
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Publication
31620121 | J:297995
 
First Author: Tseng PC
Year: 2019
Journal: Front Immunol
Title: HECT E3 Ubiquitin Ligase-Regulated Txnip Degradation Facilitates TLR2-Mediated Inflammation During Group A Streptococcal Infection.
Volume: 10
Pages: 2147
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Publication
32902872 | J:305710
First Author: Muri J
Year: 2021
Journal: Eur J Immunol
Title: The thioredoxin-1 inhibitor Txnip restrains effector T-cell and germinal center B-cell expansion.
Volume: 51
Issue: 1
Pages: 115-124
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Publication
30168649 | J:267337
First Author: Huy H
Year: 2018
Journal: Aging Cell
Title: TXNIP regulates AKT-mediated cellular senescence by direct interaction under glucose-mediated metabolic stress.
Volume: 17
Issue: 6
Pages: e12836
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Publication
19875615 | J:164164
First Author: Chen J
Year: 2010
Journal: Diabetes
Title: Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated beta-cell death.
Volume: 59
Issue: 2
Pages: 440-7
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Publication
20299477 | J:169358
First Author: Chutkow WA
Year: 2010
Journal: Diabetes
Title: Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity.
Volume: 59
Issue: 6
Pages: 1424-34
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Publication
34085839 | J:339893
First Author: Mukai N
Year: 2021
Journal: Am J Physiol Heart Circ Physiol
Title: Cardiomyocyte-specific Txnip C247S mutation improves left ventricular functional reserve in streptozotocin-induced diabetic mice.
Volume: 321
Issue: 2
Pages: H259-H274
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Publication
38169654 | J:344177
First Author: Jung E
Year: 2024
Journal: Int J Biol Sci
Title: TXNIP in liver sinusoidal endothelial cells ameliorates alcohol-associated liver disease via nitric oxide production.
Volume: 20
Issue: 2
Pages: 606-620
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Publication
23823478 | J:199235
First Author: Jung H
Year: 2013
Journal: Cell Metab
Title: TXNIP maintains the hematopoietic cell pool by switching the function of p53 under oxidative stress.
Volume: 18
Issue: 1
Pages: 75-85
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Publication
28591573 | J:256247
First Author: Waldhart AN
Year: 2017
Journal: Cell Rep
Title: Phosphorylation of TXNIP by AKT Mediates Acute Influx of Glucose in Response to Insulin.
Volume: 19
Issue: 10
Pages: 2005-2013
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Publication
28669627 | J:319254
 
First Author: Tian D
Year: 2017
Journal: Free Radic Biol Med
Title: Endogenous hydrogen sulfide-mediated MAPK inhibition preserves endothelial function through TXNIP signaling.
Volume: 110
Pages: 291-299
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Publication
29322219 | J:262180
First Author: Qin K
Year: 2018
Journal: Diabetologia
Title: SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice.
Volume: 61
Issue: 4
Pages: 906-918
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Publication
33508319 | J:302167
   
First Author: Beg M
Year: 2021
Journal: J Biol Chem
Title: ATGL activity regulates GLUT1-mediated glucose uptake and lactate production via TXNIP stability in adipocytes.
Pages: 100332
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Publication
32726606 | J:296609
First Author: Thielen LA
Year: 2020
Journal: Cell Metab
Title: Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action.
Volume: 32
Issue: 3
Pages: 353-365.e8
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Protein
Q91X82
Organism: Mus musculus/domesticus
Length: 400  
Fragment?: false
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Publication
21439280 | J:171282
First Author: Andres AM
Year: 2011
Journal: FEBS Lett
Title: Diminished AMPK signaling response to fasting in thioredoxin-interacting protein knockout mice.
Volume: 585
Issue: 8
Pages: 1223-30
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Publication
21510938 | J:173209
First Author: Shi Y
Year: 2011
Journal: FEBS Lett
Title: Knockdown of thioredoxin interacting protein attenuates high glucose-induced apoptosis and activation of ASK1 in mouse mesangial cells.
Volume: 585
Issue: 12
Pages: 1789-95
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Publication
32927265 | J:338655
First Author: Shah A
Year: 2020
Journal: iScience
Title: Thioredoxin Interacting Protein Is Required for a Chronic Energy-Rich Diet to Promote Intestinal Fructose Absorption.
Volume: 23
Issue: 9
Pages: 101521
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Publication
34348139 | J:311481
First Author: Waldhart AN
Year: 2021
Journal: Cell Rep
Title: Excess dietary carbohydrate affects mitochondrial integrity as observed in brown adipose tissue.
Volume: 36
Issue: 5
Pages: 109488
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Publication
37456843 | J:338326
First Author: Avequin T
Year: 2023
Journal: iScience
Title: Differential effects of sugar and fat on adipose tissue inflammation.
Volume: 26
Issue: 7
Pages: 107163
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Publication
37168572 | J:335573
First Author: Waldhart AN
Year: 2023
Journal: iScience
Title: Optimal HSF1 activation in response to acute cold stress in BAT requires nuclear TXNIP.
Volume: 26
Issue: 5
Pages: 106538
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Publication
19625652 | J:151788
First Author: Jeong M
Year: 2009
Journal: J Immunol
Title: Thioredoxin-interacting protein regulates hematopoietic stem cell quiescence and mobilization under stress conditions.
Volume: 183
Issue: 4
Pages: 2495-505
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Publication
22883234 | J:187376
First Author: Oslowski CM
Year: 2012
Journal: Cell Metab
Title: Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome.
Volume: 16
Issue: 2
Pages: 265-73
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Publication
20624390 | J:163475
First Author: Ren Y
Year: 2010
Journal: FEBS Lett
Title: p38 MAPK pathway is involved in high glucose-induced thioredoxin interacting protein induction in mouse mesangial cells.
Volume: 584
Issue: 15
Pages: 3480-5
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Publication
29401599 | J:272187
First Author: Bedarida T
Year: 2018
Journal: FASEB J
Title: Reduced endothelial thioredoxin-interacting protein protects arteries from damage induced by metabolic stress in vivo.
Volume: 32
Issue: 6
Pages: 3108-3118
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Publication
31900750 | J:301160
First Author: Domingues A
Year: 2020
Journal: Angiogenesis
Title: Targeting endothelial thioredoxin-interacting protein (TXNIP) protects from metabolic disorder-related impairment of vascular function and post-ischemic revascularisation.
Volume: 23
Issue: 2
Pages: 249-264
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Publication
15047687 | J:90735
First Author: Hui TY
Year: 2004
Journal: J Biol Chem
Title: Mice lacking thioredoxin-interacting protein provide evidence linking cellular redox state to appropriate response to nutritional signals.
Volume: 279
Issue: 23
Pages: 24387-93
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Publication
16607285 | J:112292
First Author: Sheth SS
Year: 2006
Journal: Oncogene
Title: Hepatocellular carcinoma in Txnip-deficient mice.
Volume: 25
Issue: 25
Pages: 3528-36
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Publication
15520447 | J:94707
First Author: Sheth SS
Year: 2005
Journal: J Lipid Res
Title: Thioredoxin-interacting protein deficiency disrupts the fasting-feeding metabolic transition.
Volume: 46
Issue: 1
Pages: 123-34
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Publication
24482226 | J:211210
First Author: DeBalsi KL
Year: 2014
Journal: J Biol Chem
Title: Targeted metabolomics connects thioredoxin-interacting protein (TXNIP) to mitochondrial fuel selection and regulation of specific oxidoreductase enzymes in skeletal muscle.
Volume: 289
Issue: 12
Pages: 8106-20
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Publication
24843047 | J:232290
First Author: Lee S
Year: 2014
Journal: EMBO Mol Med
Title: Thioredoxin-interacting protein regulates protein disulfide isomerases and endoplasmic reticulum stress.
Volume: 6
Issue: 6
Pages: 732-43
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Publication
32892310 | J:328948
First Author: Deng W
Year: 2020
Journal: Endocrine
Title: Thioredoxin-interacting protein: a critical link between autophagy disorders and pancreatic β-cell dysfunction.
Volume: 70
Issue: 3
Pages: 526-537
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Publication
31781121 | J:297742
 
First Author: Yoon SJ
Year: 2019
Journal: Front Immunol
Title: Thioredoxin-Interacting Protein Promotes Phagosomal Acidification Upon Exposure to Escherichia coli Through Inflammasome-Mediated Caspase-1 Activation in Macrophages.
Volume: 10
Pages: 2636
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Publication
21771725 | J:176433
First Author: Nishizawa K
Year: 2011
Journal: Carcinogenesis
Title: Thioredoxin-interacting protein suppresses bladder carcinogenesis.
Volume: 32
Issue: 10
Pages: 1459-66
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Publication
25600403 | J:230266
First Author: Gasiorek JJ
Year: 2015
Journal: Exp Hematol
Title: Thioredoxin-interacting protein regulates the differentiation of murine erythroid precursors.
Volume: 43
Issue: 5
Pages: 393-403.e2
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Publication
32492941 | J:305377
 
First Author: Mohamed IN
Year: 2020
Journal: Int J Mol Sci
Title: Deletion of Thioredoxin-Interacting Protein (TXNIP) Abrogates High Fat Diet-induced Retinal Leukostasis, Barrier Dysfunction and Microvascular Degeneration in a Mouse Obesity Model.
Volume: 21
Issue: 11
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Publication
17998203 | J:130601
First Author: Chutkow WA
Year: 2008
Journal: J Biol Chem
Title: Thioredoxin-interacting protein (Txnip) is a critical regulator of hepatic glucose production.
Volume: 283
Issue: 4
Pages: 2397-406
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Publication
23976953 | J:206349
First Author: Lee SY
Year: 2013
Journal: PLoS One
Title: Thioredoxin-interacting protein regulates glucose metabolism and affects cytoplasmic streaming in mouse oocytes.
Volume: 8
Issue: 8
Pages: e70708
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Publication
29884908 | J:313214
First Author: Wu M
Year: 2018
Journal: Lab Invest
Title: Thioredoxin-interacting protein deficiency ameliorates kidney inflammation and fibrosis in mice with unilateral ureteral obstruction.
Volume: 98
Issue: 9
Pages: 1211-1224
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Publication
27929088 | J:243236
 
First Author: Jung H
Year: 2016
Journal: Nat Commun
Title: Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity.
Volume: 7
Pages: 13674
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Publication
25916556 | J:222791
 
First Author: Qiao S
Year: 2015
Journal: Nat Commun
Title: A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity.
Volume: 6
Pages: 7014
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Publication
19223654 | J:149778
First Author: Masson E
Year: 2009
Journal: Am J Physiol Endocrinol Metab
Title: High beta-cell mass prevents streptozotocin-induced diabetes in thioredoxin-interacting protein-deficient mice.
Volume: 296
Issue: 6
Pages: E1251-61
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Publication
24515523 | J:247165
First Author: Spindel ON
Year: 2014
Journal: Circ Res
Title: Thioredoxin-interacting protein is a biomechanical regulator of Src activity: key role in endothelial cell stress fiber formation.
Volume: 114
Issue: 7
Pages: 1125-32
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Publication
25329456 | J:223552
First Author: Abdelsaid MA
Year: 2014
Journal: PLoS One
Title: Deletion of thioredoxin interacting protein (TXNIP) augments hyperoxia-induced vaso-obliteration in a mouse model of oxygen induced-retinopathy.
Volume: 9
Issue: 10
Pages: e110388
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Publication
27725089 | J:238752
   
First Author: Dotimas JR
Year: 2016
Journal: Elife
Title: Diabetes regulates fructose absorption through thioredoxin-interacting protein.
Volume: 5
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Publication
20023662 | J:158410
First Author: Zhou R
Year: 2010
Journal: Nat Immunol
Title: Thioredoxin-interacting protein links oxidative stress to inflammasome activation.
Volume: 11
Issue: 2
Pages: 136-40
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Publication
32096759 | J:294330
   
First Author: Muri J
Year: 2020
Journal: Elife
Title: Thioredoxin-1 distinctly promotes NF-κB target DNA binding and NLRP3 inflammasome activation independently of Txnip.
Volume: 9
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Publication
22883233 | J:187377
First Author: Lerner AG
Year: 2012
Journal: Cell Metab
Title: IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.
Volume: 16
Issue: 2
Pages: 250-64
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Publication
29101219 | J:258058
First Author: Jo S
Year: 2018
Journal: Diabetes
Title: miR-204 Controls Glucagon-Like Peptide 1 Receptor Expression and Agonist Function.
Volume: 67
Issue: 2
Pages: 256-264
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Publication
23975026 | J:202036
First Author: Xu G
Year: 2013
Journal: Nat Med
Title: Thioredoxin-interacting protein regulates insulin transcription through microRNA-204.
Volume: 19
Issue: 9
Pages: 1141-6
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Publication
22267843 | J:192695
First Author: Wang XQ
Year: 2012
Journal: Circ Res
Title: Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2.
Volume: 110
Issue: 4
Pages: 560-8
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Publication
35957590 | J:335467
 
First Author: Lu B
Year: 2022
Journal: Endocrinology
Title: Alpha Cell Thioredoxin-interacting Protein Deletion Improves Diabetes-associated Hyperglycemia and Hyperglucagonemia.
Volume: 163
Issue: 11
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Publication
23715727 | J:199256
First Author: Zervou S
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: A role for thioredoxin-interacting protein (Txnip) in cellular creatine homeostasis.
Volume: 305
Issue: 2
Pages: E263-70
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Publication
18344994 | J:136099
First Author: Papadia S
Year: 2008
Journal: Nat Neurosci
Title: Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses.
Volume: 11
Issue: 4
Pages: 476-87
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Publication
25391656 | J:302802
First Author: Filios SR
Year: 2014
Journal: J Biol Chem
Title: MicroRNA-200 is induced by thioredoxin-interacting protein and regulates Zeb1 protein signaling and beta cell apoptosis.
Volume: 289
Issue: 52
Pages: 36275-83
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Publication
18171713 | J:135529
First Author: Chen J
Year: 2008
Journal: Diabetes
Title: Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis.
Volume: 57
Issue: 4
Pages: 938-44
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Publication
18552236 | J:140264
First Author: Chen J
Year: 2008
Journal: FASEB J
Title: Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes.
Volume: 22
Issue: 10
Pages: 3581-94
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Publication
17916779 | J:141487
First Author: Yoshioka J
Year: 2007
Journal: Circ Res
Title: Targeted deletion of thioredoxin-interacting protein regulates cardiac dysfunction in response to pressure overload.
Volume: 101
Issue: 12
Pages: 1328-38
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Publication
22201682 | J:184389
First Author: Yoshioka J
Year: 2012
Journal: J Clin Invest
Title: Deletion of thioredoxin-interacting protein in mice impairs mitochondrial function but protects the myocardium from ischemia-reperfusion injury.
Volume: 122
Issue: 1
Pages: 267-79
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Publication
28499273 | J:276244
First Author: He K
Year: 2017
Journal: Oncotarget
Title: Inhibition of NLRP3 inflammasome by thioredoxin-interacting protein in mouse Kupffer cells as a regulatory mechanism for non-alcoholic fatty liver disease development.
Volume: 8
Issue: 23
Pages: 37657-37672
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Publication
34029695 | J:312201
 
First Author: Ismael S
Year: 2021
Journal: Neurobiol Dis
Title: Thioredoxin interacting protein regulates age-associated neuroinflammation.
Volume: 156
Pages: 105399
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Publication
27037370 | J:234809
First Author: Myers RB
Year: 2016
Journal: Am J Physiol Heart Circ Physiol
Title: Deletion of thioredoxin-interacting protein improves cardiac inotropic reserve in the streptozotocin-induced diabetic heart.
Volume: 310
Issue: 11
Pages: H1748-59
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Publication
38142581 | J:344317
 
First Author: Aldoghachi AF
Year: 2024
Journal: Biochem Biophys Res Commun
Title: Fluorinated curcumin derivative (Shiga-Y6) modulates the level of thioredoxin-interacting protein (TXNIP) in a mouse model of diabetes.
Volume: 694
Pages: 149392
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Publication
22869588 | J:312802
First Author: He X
Year: 2012
Journal: Mol Pharmacol
Title: Redox regulation by nuclear factor erythroid 2-related factor 2: gatekeeping for the basal and diabetes-induced expression of thioredoxin-interacting protein.
Volume: 82
Issue: 5
Pages: 887-97
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Publication
25138219 | J:217221
First Author: Abais JM
Year: 2014
Journal: J Biol Chem
Title: Nod-like receptor protein 3 (NLRP3) inflammasome activation and podocyte injury via thioredoxin-interacting protein (TXNIP) during hyperhomocysteinemia.
Volume: 289
Issue: 39
Pages: 27159-68
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Publication
29477360 | J:319288
 
First Author: Wen Y
Year: 2018
Journal: Int J Biochem Cell Biol
Title: mROS-TXNIP axis activates NLRP3 inflammasome to mediate renal injury during ischemic AKI.
Volume: 98
Pages: 43-53
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Publication
29813102 | J:262387
First Author: Panse M
Year: 2018
Journal: PLoS One
Title: Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms.
Volume: 13
Issue: 5
Pages: e0198016
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Publication
16766796 | J:116467
First Author: Patwari P
Year: 2006
Journal: J Biol Chem
Title: The interaction of thioredoxin with Txnip. Evidence for formation of a mixed disulfide by disulfide exchange.
Volume: 281
Issue: 31
Pages: 21884-91
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Publication
24627476 | J:212421
First Author: Jing G
Year: 2014
Journal: J Biol Chem
Title: Thioredoxin-interacting protein promotes islet amyloid polypeptide expression through miR-124a and FoxA2.
Volume: 289
Issue: 17
Pages: 11807-15
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Publication
25003952 | J:220566
First Author: Park MJ
Year: 2014
Journal: J Hepatol
Title: Thioredoxin-interacting protein mediates hepatic lipogenesis and inflammation via PRMT1 and PGC-1α regulation in vitro and in vivo.
Volume: 61
Issue: 5
Pages: 1151-7
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Publication
11753387 | J:75395
First Author: Bodnar JS
Year: 2002
Journal: Nat Genet
Title: Positional cloning of the combined hyperlipidemia gene Hyplip1.
Volume: 30
Issue: 1
Pages: 110-6
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Protein Coding Gene
MGP_CAROLIEiJ_G0025378 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0027619 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0027581 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0027548 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0027591 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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•
Protein Coding Gene
MGP_C3HHeJ_G0027323 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI_C57BL6J_1889549 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C57BL6NJ_G0028037 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CASTEiJ_G0026778 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CBAJ_G0027298 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_DBA2J_G0027441 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_FVBNJ_G0027410 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_LPJ_G0027546 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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