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Search results 1 to 100 out of 212 for Tyk2

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Type Details Score
Gene
7297 | TYK2
Type: gene
Organism: human
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Gene
512484 | TYK2
Type: gene
Organism: cattle
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Gene
100361294 | Tyk2
Type: gene
Organism: rat
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Gene
430113 | TYK2
Type: gene
Organism: chicken
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Gene
100536675 | tyk2
Type: gene
Organism: zebrafish
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Gene
574130 | TYK2
Type: gene
Organism: macaque, rhesus
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Gene
100489432 | tyk2
Type: gene
Organism: frog, western clawed
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Gene
476714 | TYK2
Type: gene
Organism: dog, domestic
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Gene
455703 | TYK2
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:1929470 | Tyk2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
11070174 | J:65409
First Author: Shimoda K
Year: 2000
Journal: Immunity
Title: Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function.
Volume: 13
Issue: 4
Pages: 561-71
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Publication
27807284 | J:252210
First Author: Dendrou CA
Year: 2016
Journal: Sci Transl Med
Title: Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity.
Volume: 8
Issue: 363
Pages: 363ra149
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Publication
11070173 | J:65408
First Author: Karaghiosoff M
Year: 2000
Journal: Immunity
Title: Partial impairment of cytokine responses in Tyk2-deficient mice.
Volume: 13
Issue: 4
Pages: 549-60
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Publication
32929218 | J:302820
First Author: Poelzl A
Year: 2021
Journal: Cell Death Differ
Title: TYK2 licenses non-canonical inflammasome activation during endotoxemia.
Volume: 28
Issue: 2
Pages: 748-763
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Publication
36185806 | J:333919
First Author: Moritsch S
Year: 2022
Journal: Oncoimmunology
Title: Tyk2 is a tumor suppressor in colorectal cancer.
Volume: 11
Issue: 1
Pages: 2127271
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Publication
14768057 | J:87674
First Author: Schleicher U
Year: 2004
Journal: Eur J Immunol
Title: Control of Leishmania major in the absence of Tyk2 kinase.
Volume: 34
Issue: 2
Pages: 519-29
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Publication
24345760 | J:307012
First Author: Ishizaki M
Year: 2014
Journal: Int Immunol
Title: Tyk2 is a therapeutic target for psoriasis-like skin inflammation.
Volume: 26
Issue: 5
Pages: 257-67
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Publication
21864028 | J:305930
First Author: Zhang Q
Year: 2011
Journal: J Interferon Cytokine Res
Title: The role of Tyk2 in regulation of breast cancer growth.
Volume: 31
Issue: 9
Pages: 671-7
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Publication
18845149 | J:141119
First Author: Schneider A
Year: 2008
Journal: FEBS Lett
Title: Selective contribution of Tyk2 to cell activation by lipopolysaccharide.
Volume: 582
Issue: 25-26
Pages: 3681-6
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Publication
23217260 | J:195099
First Author: Derecka M
Year: 2012
Journal: Cell Metab
Title: Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity.
Volume: 16
Issue: 6
Pages: 814-24
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Publication
- | J:66799
   
First Author: McCoy B
Year: 1999
Journal: GenBank Submission
Title: Mus musculus tyrosine kinase TYK2 (Tyk2) mRNA, complete cds
Pages: AF173032
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Publication
12679810 | J:83115
First Author: Karaghiosoff M
Year: 2003
Journal: Nat Immunol
Title: Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock.
Volume: 4
Issue: 5
Pages: 471-7
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Publication
24696087 | J:215350
First Author: Vielnascher RM
Year: 2014
Journal: Transgenic Res
Title: Conditional ablation of TYK2 in immunity to viral infection and tumor surveillance.
Volume: 23
Issue: 3
Pages: 519-29
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Publication
19494301 | J:149291
First Author: Spach KM
Year: 2009
Journal: J Immunol
Title: A single nucleotide polymorphism in Tyk2 controls susceptibility to experimental allergic encephalomyelitis.
Volume: 182
Issue: 12
Pages: 7776-83
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Publication
22723949 | J:187818
First Author: Prchal-Murphy M
Year: 2012
Journal: PLoS One
Title: TYK2 kinase activity is required for functional type I interferon responses in vivo.
Volume: 7
Issue: 6
Pages: e39141
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Publication
21765170 | J:176033
First Author: Ishizaki M
Year: 2011
Journal: Int Immunol
Title: Tyk2 deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice.
Volume: 23
Issue: 9
Pages: 575-82
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Publication
25849081 | J:233414
 
First Author: Izumi K
Year: 2015
Journal: Nat Commun
Title: Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes.
Volume: 6
Pages: 6748
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Publication
15578097 | J:95477
First Author: Stoiber D
Year: 2004
Journal: J Clin Invest
Title: TYK2 is a key regulator of the surveillance of B lymphoid tumors.
Volume: 114
Issue: 11
Pages: 1650-8
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Publication
32149730 | J:302653
First Author: Gracey E
Year: 2020
Journal: J Clin Invest
Title: TYK2 inhibition reduces type 3 immunity and modifies disease progression in murine spondyloarthritis.
Volume: 130
Issue: 4
Pages: 1863-1878
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Publication
17048270 | J:117001
First Author: Aizu K
Year: 2006
Journal: Eur J Immunol
Title: An important role of Tyk2 in APC function of dendritic cells for priming CD8+ T cells producing IFN-gamma.
Volume: 36
Issue: 11
Pages: 3060-70
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Publication
17372006 | J:145141
First Author: Li W
Year: 2007
Journal: J Immunol
Title: Tyk2 signaling in host environment plays an important role in contraction of antigen-specific CD8+ T cells following a microbial infection.
Volume: 178
Issue: 7
Pages: 4482-8
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Publication
16982690 | J:114648
First Author: Potla R
Year: 2006
Journal: Mol Cell Biol
Title: Tyk2 tyrosine kinase expression is required for the maintenance of mitochondrial respiration in primary pro-B lymphocytes.
Volume: 26
Issue: 22
Pages: 8562-71
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Publication
20080754 | J:156524
First Author: Bieber AJ
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Allelic variation in the Tyk2 and EGF genes as potential genetic determinants of CNS repair.
Volume: 107
Issue: 2
Pages: 792-7
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Publication
30718299 | J:272938
First Author: Simonović N
Year: 2019
Journal: J Immunol
Title: NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity.
Volume: 202
Issue: 6
Pages: 1724-1734
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Publication
18086385 | J:140278
First Author: Painz R
Year: 2007
Journal: Immunobiology
Title: Organ-specific and differential requirement of TYK2 and IFNAR1 for LPS-induced iNOS expression in vivo.
Volume: 212
Issue: 9-10
Pages: 863-75
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Publication
16751369 | J:132232
First Author: Shaw MH
Year: 2006
Journal: J Immunol
Title: Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation.
Volume: 176
Issue: 12
Pages: 7263-71
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Publication
14500783 | J:85848
First Author: Shaw MH
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity.
Volume: 100
Issue: 20
Pages: 11594-9
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Publication
12391177 | J:79815
First Author: Shimoda K
Year: 2002
Journal: J Immunol
Title: Cutting edge: tyk2 is required for the induction and nuclear translocation of Daxx which regulates IFN-alpha-induced suppression of B lymphocyte formation.
Volume: 169
Issue: 9
Pages: 4707-11
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Publication
17395783 | J:145403
First Author: Tokumasa N
Year: 2007
Journal: Blood
Title: Expression of Tyk2 in dendritic cells is required for IL-12, IL-23, and IFN-gamma production and the induction of Th1 cell differentiation.
Volume: 110
Issue: 2
Pages: 553-60
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Publication
16601124 | J:113742
First Author: Gamero AM
Year: 2006
Journal: J Biol Chem
Title: Activation of Tyk2 and Stat3 is required for the apoptotic actions of interferon-beta in primary pro-B cells.
Volume: 281
Issue: 24
Pages: 16238-44
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Publication
21606247 | J:175947
First Author: Ishizaki M
Year: 2011
Journal: J Immunol
Title: Involvement of tyrosine kinase-2 in both the IL-12/Th1 and IL-23/Th17 axes in vivo.
Volume: 187
Issue: 1
Pages: 181-9
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Publication
30131584 | J:273613
First Author: Prutsch N
Year: 2019
Journal: Leukemia
Title: Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma.
Volume: 33
Issue: 3
Pages: 696-709
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Publication
27802075 | J:247177
First Author: Raje V
Year: 2017
Journal: Endocrinology
Title: Kinase Inactive Tyrosine Kinase (Tyk2) Supports Differentiation of Brown Fat Cells.
Volume: 158
Issue: 1
Pages: 148-157
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Publication
20338026 | J:307339
 
First Author: Vogl C
Year: 2010
Journal: BMC Genomics
Title: Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes.
Volume: 11
Pages: 199
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Publication
12517976 | J:81171
First Author: Seto Y
Year: 2003
Journal: J Immunol
Title: Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice.
Volume: 170
Issue: 2
Pages: 1077-83
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Publication
30740104 | J:283092
 
First Author: Gorman JA
Year: 2019
Journal: Front Immunol
Title: The TYK2-P1104A Autoimmune Protective Variant Limits Coordinate Signals Required to Generate Specialized T Cell Subsets.
Volume: 10
Pages: 44
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Publication
21787891 | J:309838
First Author: Grunert T
Year: 2011
Journal: J Proteomics
Title: A comparative proteome analysis links tyrosine kinase 2 (Tyk2) to the regulation of cellular glucose and lipid metabolism in response to poly(I:C).
Volume: 74
Issue: 12
Pages: 2866-80
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Publication
19917699 | J:157511
First Author: Oyamada A
Year: 2009
Journal: J Immunol
Title: Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis.
Volume: 183
Issue: 11
Pages: 7539-46
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Publication
11877284 | J:115369
First Author: Shimoda K
Year: 2002
Journal: Blood
Title: Partial impairment of interleukin-12 (IL-12) and IL-18 signaling in Tyk2-deficient mice.
Volume: 99
Issue: 6
Pages: 2094-9
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Publication
18641345 | J:139234
First Author: Nakamura R
Year: 2008
Journal: J Immunol
Title: Tyk2-signaling plays an important role in host defense against Escherichia coli through IL-23-induced IL-17 production by gammadelta T cells.
Volume: 181
Issue: 3
Pages: 2071-5
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Publication
19118004 | J:143032
First Author: Simma O
Year: 2009
Journal: Cancer Res
Title: Identification of an indispensable role for tyrosine kinase 2 in CTL-mediated tumor surveillance.
Volume: 69
Issue: 1
Pages: 203-11
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Publication
14617019 | J:109408
First Author: Kato K
Year: 2003
Journal: Br J Haematol
Title: Intracellular signal transduction of interferon on the suppression of haematopoietic progenitor cell growth.
Volume: 123
Issue: 3
Pages: 528-35
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Publication
14662340 | J:86970
First Author: Aoki K
Year: 2003
Journal: Exp Hematol
Title: Limitin, an interferon-like cytokine, transduces inhibitory signals on B-cell growth through activation of Tyk2, but not Stat1, followed by induction and nuclear translocation of Daxx.
Volume: 31
Issue: 12
Pages: 1317-22
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Publication
20713887 | J:163818
First Author: Radwan M
Year: 2010
Journal: J Immunol
Title: Tyrosine kinase 2 controls IL-1ß production at the translational level.
Volume: 185
Issue: 6
Pages: 3544-53
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Publication
15226272 | J:91540
First Author: Kamezaki K
Year: 2004
Journal: Int Immunol
Title: The role of Tyk2, Stat1 and Stat4 in LPS-induced endotoxin signals.
Volume: 16
Issue: 8
Pages: 1173-9
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Publication
16148148 | J:116703
First Author: Strobl B
Year: 2005
Journal: J Immunol
Title: Novel functions of tyrosine kinase 2 in the antiviral defense against murine cytomegalovirus.
Volume: 175
Issue: 6
Pages: 4000-8
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Publication
24604832 | J:212012
First Author: Bosmann M
Year: 2014
Journal: J Leukoc Biol
Title: Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27.
Volume: 96
Issue: 1
Pages: 123-31
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Publication
15781341 | J:97143
First Author: Ishida N
Year: 2005
Journal: Exp Hematol
Title: Differential effects of a novel IFN-zeta/limitin and IFN-alpha on signals for Daxx induction and Crk phosphorylation that couple with growth control of megakaryocytes.
Volume: 33
Issue: 4
Pages: 495-503
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Publication
25057888 | J:215673
First Author: Babon JJ
Year: 2014
Journal: Biochem J
Title: The molecular regulation of Janus kinase (JAK) activation.
Volume: 462
Issue: 1
Pages: 1-13
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Publication
29016674 | J:247148
First Author: Wilbers RHP
Year: 2017
Journal: PLoS One
Title: Re-evaluation of IL-10 signaling reveals novel insights on the contribution of the intracellular domain of the IL-10R2 chain.
Volume: 12
Issue: 10
Pages: e0186317
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Protein Coding Gene
MGP_CAROLIEiJ_G0031861 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0034441 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0034419 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0034346 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0034410 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0034122 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1929470 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0034931 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0033445 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0034095 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0034254 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0034197 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0034339 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0034240 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0034951 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0033151 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0033560 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0014727 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0032985 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
18082134 | J:130706
First Author: Schuster C
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Commentary on H. Ide et al., "Tyk2 expression and its signaling enhances the invasiveness of prostate cancer cells".
Volume: 366
Issue: 4
Pages: 869-70
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Publication
24729620 | J:302062
First Author: Hashiguchi T
Year: 2014
Journal: J Immunol
Title: Tyk2-dependent bystander activation of conventional and nonconventional Th1 cell subsets contributes to innate host defense against Listeria monocytogenes infection.
Volume: 192
Issue: 10
Pages: 4739-47
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Publication
25109392 | J:301701
 
First Author: Ãœbel C
Year: 2014
Journal: Sci Rep
Title: Role of Tyk-2 in Th9 and Th17 cells in allergic asthma.
Volume: 4
Pages: 5865
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Publication
11313413 | J:69051
First Author: Ortmann R
Year: 2001
Journal: J Immunol
Title: A heritable defect in IL-12 signaling in B10.Q/J mice. I. In vitro analysis.
Volume: 166
Issue: 9
Pages: 5712-9
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Publication
- | J:66800
   
First Author: Lassnig C
Year: 1998
Journal: GenBank Submission
Title: Mus musculus non-receptor tyrosine kinase (Tyk2) gene, partial cds
Pages: AF052607
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Publication
21471442 | J:173100
First Author: Peng DJ
Year: 2011
Journal: J Immunol
Title: Noncanonical K27-linked polyubiquitination of TIEG1 regulates Foxp3 expression and tumor growth.
Volume: 186
Issue: 10
Pages: 5638-47
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Publication
19680139 | J:164174
First Author: Deb C
Year: 2009
Journal: J Neuropathol Exp Neurol
Title: Demyelinated axons and motor function are protected by genetic deletion of perforin in a mouse model of multiple sclerosis.
Volume: 68
Issue: 9
Pages: 1037-48
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Publication
26824662 | J:230644
First Author: Mostafavi S
Year: 2016
Journal: Cell
Title: Parsing the Interferon Transcriptional Network and Its Disease Associations.
Volume: 164
Issue: 3
Pages: 564-78
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Publication
11313414 | J:120304
First Author: Yap GS
Year: 2001
Journal: J Immunol
Title: A heritable defect in IL-12 signaling in B10.Q/J mice. II. Effect on acute resistance to Toxoplasma gondii and rescue by IL-18 treatment.
Volume: 166
Issue: 9
Pages: 5720-5
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Publication
21408089 | J:169918
First Author: Blanc M
Year: 2011
Journal: PLoS Biol
Title: Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis.
Volume: 9
Issue: 3
Pages: e1000598
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Publication
17785781 | J:152056
First Author: Wesley JD
Year: 2007
Journal: J Immunol
Title: A Y chromosome-linked factor impairs NK T development.
Volume: 179
Issue: 6
Pages: 3480-7
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Publication
23836059 | J:205704
First Author: Smith CL
Year: 2013
Journal: J Immunol
Title: IL-22 regulates iron availability in vivo through the induction of hepcidin.
Volume: 191
Issue: 4
Pages: 1845-55
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Publication
15491990 | J:95152
First Author: Gingras S
Year: 2004
Journal: J Biol Chem
Title: Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of toll-like receptor signaling.
Volume: 279
Issue: 52
Pages: 54702-7
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Publication
23653476 | J:197445
First Author: Alazawi W
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Stat2 loss leads to cytokine-independent, cell-mediated lethality in LPS-induced sepsis.
Volume: 110
Issue: 21
Pages: 8656-61
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Publication
12023369 | J:76845
First Author: Parham C
Year: 2002
Journal: J Immunol
Title: A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.
Volume: 168
Issue: 11
Pages: 5699-708
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Publication
8943050 | J:37050
First Author: Presky DH
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits.
Volume: 93
Issue: 24
Pages: 14002-7
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Publication
21878673 | J:178381
First Author: Schuster C
Year: 2011
Journal: Blood
Title: The cooperating mutation or "second hit" determines the immunologic visibility toward MYC-induced murine lymphomas.
Volume: 118
Issue: 17
Pages: 4635-45
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Publication
18424713 | J:134314
First Author: Wilson DC
Year: 2008
Journal: J Immunol
Title: IL-12 signaling drives CD8+ T cell IFN-gamma production and differentiation of KLRG1+ effector subpopulations during Toxoplasma gondii Infection.
Volume: 180
Issue: 9
Pages: 5935-45
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Publication
16482511 | J:320271
First Author: Hoeve MA
Year: 2006
Journal: Eur J Immunol
Title: Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells.
Volume: 36
Issue: 3
Pages: 661-70
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Publication
11114383 | J:65966
First Author: Oppmann B
Year: 2000
Journal: Immunity
Title: Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.
Volume: 13
Issue: 5
Pages: 715-25
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Publication
19088061 | J:319975
First Author: van de Wetering D
Year: 2009
Journal: Int Immunol
Title: IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12.
Volume: 21
Issue: 2
Pages: 145-53
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