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Search results 1 to 100 out of 263 for Tyrobp

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
7305 | TYROBP
Type: gene
Organism: human
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Gene
455968 | TYROBP
Type: gene
Organism: chimpanzee
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Gene
282390 | TYROBP
Type: gene
Organism: cattle
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Gene
100101461 | tyrobp
Type: gene
Organism: zebrafish
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Gene
100493958 | tyrobp
Type: gene
Organism: frog, western clawed
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Gene
574207 | TYROBP
Type: gene
Organism: macaque, rhesus
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Gene
361537 | Tyrobp
Type: gene
Organism: rat
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Gene
476477 | TYROBP
Type: gene
Organism: dog, domestic
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Gene
key_79010 | TYROBP
Type: gene
Organism: pig, domestic
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Protein Domain
IPR026200 | Tyrobp
Type: Family
Description: TYRO protein tyrosine kinase-binding protein (Tyrobp), also called DNAX-activation protein 12 (DAP12), is expressed by NK cells and myeloid cells and mediates signalling for numerous cell-surface receptors expressedby these cells. It has been shown to both potentiate and attenuate the activation of these cells [, ]. More than 20receptor chains have been shown to associate with DAP12. It is involved for instance in neutrophil activation mediated by integrin [].
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Protein Coding Gene
MGI:1277211 | Tyrobp
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
17086186 | J:116120
First Author: Mócsai A
Year: 2006
Journal: Nat Immunol
Title: Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs.
Volume: 7
Issue: 12
Pages: 1326-33
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GXD Expression
GXD Expression
     
Probe: MGI:4354569
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754422
Stage: TS22
Assay Id: MGI:4354973
Age: embryonic day 14.5
Specimen Label: Table S5 - Tyrobp
Detected: false
Specimen Num: 1
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Publication
28502803 | J:259161
 
First Author: Castranio EL
Year: 2017
Journal: Neurobiol Dis
Title: Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury.
Volume: 105
Pages: 1-14
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Protein
O54885
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: false
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Protein
A0A140LI31
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: true
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Protein
Q3U419
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: false
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Protein
A0A140LHP7
Organism: Mus musculus/domesticus
Length: 141  
Fragment?: true
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Publication
17220916 | -
First Author: Turnbull IR
Year: 2007
Journal: Nat Rev Immunol
Title: Activating and inhibitory functions of DAP12.
Volume: 7
Issue: 2
Pages: 155-61
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Publication
17100880 | -
 
First Author: Takaki R
Year: 2006
Journal: Immunol Rev
Title: DAP12: an adapter protein with dual functionality.
Volume: 214
Pages: 118-29
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Publication
30283032 | J:295554
First Author: Haure-Mirande JV
Year: 2019
Journal: Mol Psychiatry
Title: Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden.
Volume: 24
Issue: 3
Pages: 431-446
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Publication
23690625 | J:197407
First Author: Nakamura K
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Fratricide of natural killer cells dressed with tumor-derived NKG2D ligand.
Volume: 110
Issue: 23
Pages: 9421-6
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Publication
29272492 | J:328091
First Author: Biagioli M
Year: 2017
Journal: Inflamm Bowel Dis
Title: Genetic and Pharmacological Dissection of the Role of Spleen Tyrosine Kinase (Syk) in Intestinal Inflammation and Immune Dysfunction in Inflammatory Bowel Diseases.
Volume: 24
Issue: 1
Pages: 123-135
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Publication
28612290 | J:311298
First Author: Haure-Mirande JV
Year: 2017
Journal: Acta Neuropathol
Title: Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology.
Volume: 134
Issue: 5
Pages: 769-788
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Publication
25366966 | J:219657
First Author: Nabekura T
Year: 2014
Journal: J Exp Med
Title: Antigen-specific expansion and differentiation of natural killer cells by alloantigen stimulation.
Volume: 211
Issue: 12
Pages: 2455-65
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Publication
16339401 | J:131235
First Author: Orabona C
Year: 2006
Journal: Blood
Title: Toward the identification of a tolerogenic signature in IDO-competent dendritic cells.
Volume: 107
Issue: 7
Pages: 2846-54
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Publication
19251634 | J:147155
First Author: Inui M
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Signal adaptor DAP10 associates with MDL-1 and triggers osteoclastogenesis in cooperation with DAP12.
Volume: 106
Issue: 12
Pages: 4816-21
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Publication
16418779 | J:273549
First Author: Humphrey MB
Year: 2006
Journal: J Bone Miner Res
Title: TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function.
Volume: 21
Issue: 2
Pages: 237-45
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Protein Coding Gene
MGP_CAROLIEiJ_G0029517 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032017 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0031994 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0031927 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032001 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0031720 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1277211 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0032467 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031054 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0031686 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0031838 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0031795 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0031919 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0031831 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0032495 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0030780 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0031164 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0012751 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0030613 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
9490415 | J:49202
First Author: Lanier LL
Year: 1998
Journal: Nature
Title: Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells.
Volume: 391
Issue: 6668
Pages: 703-7
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Publication
9852069 | J:51515
First Author: Tomasello E
Year: 1998
Journal: J Biol Chem
Title: Gene structure, expression pattern, and biological activity of mouse killer cell activating receptor-associated protein (KARAP)/DAP-12.
Volume: 273
Issue: 51
Pages: 34115-9
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Publication
12569157 | J:81823
First Author: Kaifu T
Year: 2003
Journal: J Clin Invest
Title: Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice.
Volume: 111
Issue: 3
Pages: 323-32
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Publication
25690660 | J:221150
First Author: Kobayashi M
Year: 2015
Journal: Glia
Title: A DAP12-dependent signal promotes pro-inflammatory polarization in microglia following nerve injury and exacerbates degeneration of injured neurons.
Volume: 63
Issue: 6
Pages: 1073-82
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Publication
11021532 | J:64763
First Author: Bakker AB
Year: 2000
Journal: Immunity
Title: DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming.
Volume: 13
Issue: 3
Pages: 345-53
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Publication
23906311 | J:209550
First Author: Montalvo V
Year: 2013
Journal: Immunology
Title: Environmental factors determine DAP12 deficiency to either enhance or suppress immunopathogenic processes.
Volume: 140
Issue: 4
Pages: 475-82
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Publication
24935196 | J:332467
First Author: Yoshida O
Year: 2014
Journal: Am J Transplant
Title: DAP12 deficiency in liver allografts results in enhanced donor DC migration, augmented effector T cell responses and abrogation of transplant tolerance.
Volume: 14
Issue: 8
Pages: 1791-805
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Publication
17785840 | J:152030
First Author: Divangahi M
Year: 2007
Journal: J Immunol
Title: Critical negative regulation of type 1 T cell immunity and immunopathology by signaling adaptor DAP12 during intracellular infection.
Volume: 179
Issue: 6
Pages: 4015-26
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Publication
26030755 | J:237722
First Author: Kamimura M
Year: 2015
Journal: PLoS One
Title: Impaired Fracture Healing Caused by Deficiency of the Immunoreceptor Adaptor Protein DAP12.
Volume: 10
Issue: 6
Pages: e0128210
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Publication
16061725 | J:100556
First Author: Turnbull IR
Year: 2005
Journal: J Exp Med
Title: DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis.
Volume: 202
Issue: 3
Pages: 363-9
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Publication
21908731 | J:179319
First Author: McCormick S
Year: 2011
Journal: J Immunol
Title: Control of pathogenic CD4 T cells and lethal immunopathology by signaling immunoadaptor DAP12 during influenza infection.
Volume: 187
Issue: 8
Pages: 4280-92
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Publication
21108475 | J:174574
First Author: Smrz D
Year: 2010
Journal: Eur J Immunol
Title: TLR-mediated signaling pathways circumvent the requirement for DAP12 in mast cells for the induction of inflammatory mediator release.
Volume: 40
Issue: 12
Pages: 3557-69
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Publication
11927627 | J:124749
First Author: Sjölin H
Year: 2002
Journal: J Exp Med
Title: Pivotal role of KARAP/DAP12 adaptor molecule in the natural killer cell-mediated resistance to murine cytomegalovirus infection.
Volume: 195
Issue: 7
Pages: 825-34
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Publication
36658241 | J:337692
First Author: Zhou Y
Year: 2023
Journal: Nat Immunol
Title: Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia.
Volume: 24
Issue: 3
Pages: 545-557
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Publication
15632019 | J:95232
First Author: Nataf S
Year: 2005
Journal: Am J Pathol
Title: Brain and bone damage in KARAP/DAP12 loss-of-function mice correlate with alterations in microglia and osteoclast lineages.
Volume: 166
Issue: 1
Pages: 275-86
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Publication
16206234 | J:131882
First Author: Orabona C
Year: 2005
Journal: Eur J Immunol
Title: Enhanced tryptophan catabolism in the absence of the molecular adapter DAP12.
Volume: 35
Issue: 11
Pages: 3111-8
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Publication
18925576 | J:143267
First Author: Hall HT
Year: 2008
Journal: Eur J Immunol
Title: Increased diabetes development and decreased function of CD4+CD25+ Treg in the absence of a functional DAP12 adaptor protein.
Volume: 38
Issue: 11
Pages: 3191-9
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Publication
15886320 | J:118513
First Author: Coudert JD
Year: 2005
Journal: Blood
Title: Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand-expressing tumor cells.
Volume: 106
Issue: 5
Pages: 1711-7
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Publication
11846404 | J:75177
First Author: Aoki N
Year: 2002
Journal: Biochem Biophys Res Commun
Title: DAP12 ITAM motif regulates differentiation and apoptosis in M1 leukemia cells.
Volume: 291
Issue: 2
Pages: 296-304
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Publication
10866110 | J:62569
First Author: Yim D
Year: 2000
Journal: Immunogenetics
Title: Molecular cloning, gene structure, and expression pattern of pig immunoreceptor DAP12.
Volume: 51
Issue: 6
Pages: 436-42
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Publication
12165492 | J:78244
First Author: McVicar DW
Year: 2002
Journal: J Immunol
Title: Aberrant DAP12 signaling in the 129 strain of mice: implications for the analysis of gene-targeted mice.
Volume: 169
Issue: 4
Pages: 1721-8
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Publication
16920926 | J:138757
First Author: Sjölin H
Year: 2006
Journal: J Immunol
Title: DAP12 signaling regulates plasmacytoid dendritic cell homeostasis and down-modulates their function during viral infection.
Volume: 177
Issue: 5
Pages: 2908-16
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Publication
19121286 | J:144513
First Author: Vassilieva EV
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Flotillin-1 stabilizes caveolin-1 in intestinal epithelial cells.
Volume: 379
Issue: 2
Pages: 460-5
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GXD Expression
GXD Expression
     
Probe: MGI:3838122
Assay Type: Northern blot
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689422
Stage: TS22
Assay Id: MGI:3838124
Age: embryonic day 14.0
Specimen Label: E14
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3838122
Assay Type: Northern blot
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:3838124
Age: embryonic day 16.0
Specimen Label: E16
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3838122
Assay Type: Northern blot
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:3838124
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:3838122
Assay Type: Northern blot
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:3838124
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:3838122
Assay Type: Northern blot
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3838124
Age: postnatal day 5
Specimen Label: P5
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:3838122
Assay Type: Northern blot
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3838124
Age: postnatal day 15
Specimen Label: P15
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:3838122
Assay Type: Northern blot
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3838124
Age: postnatal day 20
Specimen Label: P20
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:3838122
Assay Type: Northern blot
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3838124
Age: postnatal day 30
Specimen Label: P30
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:3838122
Assay Type: Northern blot
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3838124
Age: postnatal day 35
Specimen Label: P35
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
     
Probe: MGI:3838122
Assay Type: Northern blot
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3838124
Age: postnatal week 6
Specimen Label: 6wk
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
   
Probe: MGI:3838122
Assay Type: RNA in situ
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3525328
Pattern: Single cells
Stage: TS28
Assay Id: MGI:3838133
Age: postnatal day 10
Specimen Label: 4B i,ii
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:3838122
Assay Type: RNA in situ
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647027
Pattern: Single cells
Stage: TS27
Assay Id: MGI:3838133
Age: postnatal day 1
Note: Expression is seen in cells surrounding CNP-positive cells (oligodendrocytes).
Specimen Label: 3A i,ii
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3838122
Assay Type: RNA in situ
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647027
Pattern: Single cells
Stage: TS27
Assay Id: MGI:3838133
Age: postnatal day 1
Specimen Label: 3B i,ii
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3838122
Assay Type: RNA in situ
Annotation Date: 2009-04-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647028
Pattern: Single cells
Stage: TS28
Assay Id: MGI:3838133
Age: postnatal day 10
Note: Expression is seen in cells surrounding CNP-positive cells (oligodendrocytes).
Specimen Label: 4A i,ii
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:3838122
Assay Type: RNA in situ
Annotation Date: 2009-04-01
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1647027
Stage: TS27
Assay Id: MGI:3838133
Age: postnatal day 1
Specimen Label: 5A
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:2344882
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1603923
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4829040
Age: embryonic day 14.5
Image: euxassay_005252_08
Specimen Label: euxassay_005252_08
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:2344882
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1603923
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4829041
Age: embryonic day 14.5
Image: euxassay_005681_09
Specimen Label: euxassay_005681_09
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:2344882
Assay Type: RNA in situ
Annotation Date: 2019-01-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274322
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:6274343
Age: embryonic day 14.5
Specimen Label: Table S1
Detected: true
Specimen Num: 1
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Publication
9647200 | J:49203
First Author: Smith KM
Year: 1998
Journal: J Immunol
Title: Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors.
Volume: 161
Issue: 1
Pages: 7-10
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Publication
11491539 | J:71139
First Author: Wilson MJ
Year: 2001
Journal: Immunogenetics
Title: The mouse Dap10 gene.
Volume: 53
Issue: 4
Pages: 347-50
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Publication
10449773 | J:57105
First Author: Bakker AB
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells.
Volume: 96
Issue: 17
Pages: 9792-6
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Publication
20212065 | J:158811
First Author: Joyce-Shaikh B
Year: 2010
Journal: J Exp Med
Title: Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis.
Volume: 207
Issue: 3
Pages: 579-89
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Publication
14969392 | J:111212
First Author: Humphrey MB
Year: 2004
Journal: J Bone Miner Res
Title: The signaling adapter protein DAP12 regulates multinucleation during osteoclast development.
Volume: 19
Issue: 2
Pages: 224-34
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Publication
21727189 | J:177613
First Author: Nakano-Yokomizo T
Year: 2011
Journal: J Exp Med
Title: The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses.
Volume: 208
Issue: 8
Pages: 1661-71
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Publication
16715077 | J:110786
First Author: Takegahara N
Year: 2006
Journal: Nat Cell Biol
Title: Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis.
Volume: 8
Issue: 6
Pages: 615-22
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Publication
17611621 | J:129303
First Author: Wu Y
Year: 2007
Journal: PLoS One
Title: Bone microenvironment specific roles of ITAM adapter signaling during bone remodeling induced by acute estrogen-deficiency.
Volume: 2
Issue: 7
Pages: e586
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Publication
27810928 | J:237515
First Author: Nabekura T
Year: 2016
Journal: J Exp Med
Title: Tracking the fate of antigen-specific versus cytokine-activated natural killer cells after cytomegalovirus infection.
Volume: 213
Issue: 12
Pages: 2745-2758
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Publication
15895090 | J:98956
First Author: Hamerman JA
Year: 2005
Journal: Nat Immunol
Title: Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12.
Volume: 6
Issue: 6
Pages: 579-86
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Publication
20720152 | J:164233
First Author: Zou W
Year: 2010
Journal: J Cell Sci
Title: Cytoskeletal dysfunction dominates in DAP12-deficient osteoclasts.
Volume: 123
Issue: Pt 17
Pages: 2955-63
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Publication
30647146 | J:280998
 
First Author: Takahashi M
Year: 2019
Journal: Sci Signal
Title: The phytosphingosine-CD300b interaction promotes zymosan-induced, nitric oxide-dependent neutrophil recruitment.
Volume: 12
Issue: 564
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