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Search results 1 to 8 out of 8 for Tyw2

0.01s

Type

Details

Score

Protein

Q8BG71

Organism:	Mus musculus/domesticus
Length:	446
Fragment?:	false

•

Protein Coding Gene

MGI:1915510 | Trmt12

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein Domain

IPR030382 | MeTrfase_TRM5/TYW2

Type:

Domain

Description:

This entry represents a domain found in the Trm5/Tyw2-type methyltransferase. Trm5 and Tyw2 are S-adenosylmethionine-dependent methyltransferases involved in tRNA methylation []. Wybutosine synthesis is a multienzymatic process that comprises six sequential enzymatic reactions involving five enzymes. The initial step, the formation of m1G-37 (guanosine-37 methylated in the N1 position) in precursor tRNAPhe is catalysed by tRNA wybutosine-synthesising protein 5 (Trm5). Tyw2 catalyses the second step, consisting of the alpha-amino-alpha-carboxypropyl (acp) group being transferred from S-AdoMet to the side chain at the C7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86 [].

•

Publication

19717466 | -

First Author:	Umitsu M
Year:	2009
Journal:	Proc Natl Acad Sci U S A
Title:	Structural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW2.
Volume:	106
Issue:	37
Pages:	15616-21

•

Protein Domain

IPR030867 | TYW2_archaea

Type:

Family

Description:

This entry represents tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase TYW2 from archaea. It is a s-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. It catalyses the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe) [].

•

Publication

20382657 | -

First Author:	de Crécy-Lagard V
Year:	2010
Journal:	Mol Biol Evol
Title:	Biosynthesis of wyosine derivatives in tRNA: an ancient and highly diverse pathway in Archaea.
Volume:	27
Issue:	9
Pages:	2062-77

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Protein

Q9D0C4

Organism:	Mus musculus/domesticus
Length:	501
Fragment?:	false

•

Publication

16642040 | -

First Author:	Noma A
Year:	2006
Journal:	EMBO J
Title:	Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA.
Volume:	25
Issue:	10
Pages:	2142-54

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