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Search results 1 to 94 out of 94 for Uba3

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
9039 | UBA3
Type: gene
Organism: human
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Gene
512647 | UBA3
Type: gene
Organism: cattle
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Gene
426073 | UBA3
Type: gene
Organism: chicken
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Gene
406776 | uba3
Type: gene
Organism: zebrafish
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Gene
696493 | UBA3
Type: gene
Organism: macaque, rhesus
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Gene
100124303 | uba3
Type: gene
Organism: frog, western clawed
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Gene
117553 | Uba3
Type: gene
Organism: rat
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Gene
476560 | UBA3
Type: gene
Organism: dog, domestic
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Gene
460496 | UBA3
Type: gene
Organism: chimpanzee
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Protein Domain
IPR030468 | Uba3
Type: Family
Description: This entry represents NEDD8-activating enzyme E1 catalytic subunit from fungi, plants and invertebrates. In budding yeasts, it is also known as Uba3, which is a catalytic subunit of the dimeric Uba3-Ula1 E1 enzyme that activates NEDD8/Rub1 before neddylation, the process by which the ubiquitin-like protein NEDD8 is conjugated to its target proteins []. In C.elegans, Uba3 (also known as rfl-1) is required for cytokinesis and mitotic spindle orientation [].
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Protein Coding Gene
MGI:1341217 | Uba3
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
9545234 | -
First Author: Liakopoulos D
Year: 1998
Journal: EMBO J
Title: A novel protein modification pathway related to the ubiquitin system.
Volume: 17
Issue: 8
Pages: 2208-14
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Publication
11847342 | -
First Author: Kurz T
Year: 2002
Journal: Science
Title: Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway.
Volume: 295
Issue: 5558
Pages: 1294-8
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Protein
Q8C878
Organism: Mus musculus/domesticus
Length: 462  
Fragment?: false
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Protein
Q66JT6
Organism: Mus musculus/domesticus
Length: 438  
Fragment?: true
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Protein
Q3TL72
Organism: Mus musculus/domesticus
Length: 448  
Fragment?: false
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Publication
10207026 | J:54622
First Author: Gong L
Year: 1999
Journal: J Biol Chem
Title: Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway.
Volume: 274
Issue: 17
Pages: 12036-42
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Publication
34506605 | J:317342
First Author: Zhao M
Year: 2021
Journal: PLoS Pathog
Title: Myeloid neddylation targets IRF7 and promotes host innate immunity against RNA viruses.
Volume: 17
Issue: 9
Pages: e1009901
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Publication
31941714 | J:285347
First Author: Zhang X
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Hepatic neddylation targets and stabilizes electron transfer flavoproteins to facilitate fatty acid β-oxidation.
Volume: 117
Issue: 5
Pages: 2473-2483
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Publication
11696557 | J:72808
First Author: Tateishi K
Year: 2001
Journal: J Cell Biol
Title: The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice.
Volume: 155
Issue: 4
Pages: 571-9
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Publication
27593482 | J:325424
First Author: Zhang X
Year: 2016
Journal: Cell Mol Immunol
Title: Neddylation is required for herpes simplex virus type I (HSV-1)-induced early phase interferon-beta production.
Volume: 13
Issue: 5
Pages: 578-83
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Protein Coding Gene
MGP_CAROLIEiJ_G0028678 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0031074 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0031043 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0030974 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0031054 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0030654 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1341217 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0031513 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0030161 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0030740 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0030893 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0030847 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0030973 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0030881 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0031540 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0029877 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0030245 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0022428 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0029705 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:4844717
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1619815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848584
Age: embryonic day 9.5
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4844717
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1640519
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:4848584
Age: embryonic day 11.5
Note: Staining is present in the antero-distal and posterior-distal regions of the limb.
Specimen Label: Table S4 - E11.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4844717
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3270517
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:4848584
Age: embryonic day 10.5
Note: Staining is present in the progress zone.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4844717
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3270519
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:4848584
Age: embryonic day 11.5
Note: Staining is present in the progress zone and middle and proximal limb.
Specimen Label: Table S4 - E11.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:3839845
Assay Type: Immunohistochemistry
Annotation Date: 2009-04-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160398
Pattern: Not Specified
Stage: TS08
Assay Id: MGI:3839925
Age: embryonic day 6.0
Image: 2A
Specimen Label: 2A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3839845
Assay Type: Immunohistochemistry
Annotation Date: 2009-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160398
Stage: TS08
Assay Id: MGI:3839925
Age: embryonic day 6.0
Image: 2E
Specimen Label: 2E
Detected: false
Specimen Num: 2
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Publication
19245792 | J:146824
First Author: Ohki Y
Year: 2009
Journal: Biochem Biophys Res Commun
Title: The mechanism of poly-NEDD8 chain formation in vitro.
Volume: 381
Issue: 3
Pages: 443-7
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Publication
30462731 | J:332166
First Author: Cheng Q
Year: 2018
Journal: PLoS Pathog
Title: Neddylation contributes to CD4+ T cell-mediated protective immunity against blood-stage Plasmodium infection.
Volume: 14
Issue: 11
Pages: e1007440
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Publication
20937703 | J:166065
First Author: Flomerfelt FA
Year: 2010
Journal: J Exp Med
Title: Tbata modulates thymic stromal cell proliferation and thymus function.
Volume: 207
Issue: 11
Pages: 2521-32
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Publication
- | J:59376
     
First Author: The UK Mouse Genome Centre European Consortium
Year: 2000
Journal: Database Release
Title: European Consortium EST Radiation Hybrid Database
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Publication
- | J:175597
     
First Author: Overbeek PA
Year: 2011
Journal: MGI Direct Data Submission
Title: Direct Data Submission for Overbeek Lentiviral Transgenic Lines
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Publication
- | J:342601
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniPathway vocabulary mapping
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Publication
- | J:94338
     
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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UniProt Feature
UniProt Feature
Begin: 211
Description: Interaction with UBA3
Type: site
End: 211
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Publication
14623327 | -
First Author: Yashiroda H
Year: 2003
Journal: Biochem Biophys Res Commun
Title: But1 and But2 proteins bind to Uba3, a catalytic subunit of E1 for neddylation, in fission yeast.
Volume: 311
Issue: 3
Pages: 691-5
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Protein Domain
IPR018620 | Ubiquitin3-bd_protein_But2_C
Type: Domain
Description: This entry represents a presumed C-terminal domain of ubiquitin 3 binding proteins (But2). But2 is conserved in yeasts. It binds to Uba3 and is involved in the NEDD8 signalling pathway [].
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Publication
12646924 | -
First Author: Walden H
Year: 2003
Journal: Nature
Title: Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8.
Volume: 422
Issue: 6929
Pages: 330-4
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Publication
10722740 | -
First Author: Chen Y
Year: 2000
Journal: J Biol Chem
Title: The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons.
Volume: 275
Issue: 12
Pages: 8929-35
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Publication
16628230 | -
First Author: Kim HJ
Year: 2007
Journal: Cell Death Differ
Title: Drosophila homolog of APP-BP1 (dAPP-BP1) interacts antagonistically with APPL during Drosophila development.
Volume: 14
Issue: 1
Pages: 103-15
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Protein Domain
IPR030667 | APP-BP1
Type: Family
Description: APP-BP1 (beta-Amyloid precursor protein binding protein 1), also known as Ula1 in yeasts, is a regulatory subunit of the E1 enzyme. Human APP-BP1 is necessary for cell cycle progression through the S-M checkpoint []. Drosophila APP-BP1 interacts antagonistically with APPL (APP-like protein) during Drosophila development [].Ubiquitin-like proteins (ublps) are conjugated to their targets by the sequential action of E1, E2 and often E3 enzymes. Each Ublp has a dedicated E1, or activating enzyme, that initiates its conjugation cascade. In humans the NEDD8 activating E1 enzyme is a heterodimer composed of APP-BP1 and UBA3 subunits. The ubiquitin-like protein (Ublp) NEDD8 regulates cell division, signalling and embryogenesis [].
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Protein
Q8VBW6
Organism: Mus musculus/domesticus
Length: 534  
Fragment?: false
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Protein
Q3UK27
Organism: Mus musculus/domesticus
Length: 534  
Fragment?: false
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Protein
E0CZE0
Organism: Mus musculus/domesticus
Length: 510  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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