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Search results 1 to 89 out of 89 for Ubap1

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
51271 | UBAP1
Type: gene
Organism: human
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Gene
517788 | UBAP1
Type: gene
Organism: cattle
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Gene
431652 | UBAP1
Type: gene
Organism: chicken
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Gene
393183 | ubap1
Type: gene
Organism: zebrafish
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Gene
701140 | UBAP1
Type: gene
Organism: macaque, rhesus
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Gene
448284 | ubap1
Type: gene
Organism: frog, western clawed
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Gene
362502 | Ubap1
Type: gene
Organism: rat
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Gene
474745 | UBAP1
Type: gene
Organism: dog, domestic
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Gene
747117 | UBAP1
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:2149543 | Ubap1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR038870 | UBAP1
Type: Family
Description: UBAP1 is a subunit of ESCRT-I, a complex facilitating endosomal sorting of ubiquitinated cargo []. It interacts with ubiquitin via a SOUBA domain [].
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Publication
31203368 | J:298764
First Author: Lin X
Year: 2019
Journal: Brain
Title: Stop-gain mutations in UBAP1 cause pure autosomal-dominant spastic paraplegia.
Volume: 142
Issue: 8
Pages: 2238-2252
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Publication
35962060 | J:332139
First Author: Shimozono K
Year: 2022
Journal: J Hum Genet
Title: Ubap1 knock-in mice reproduced the phenotype of SPG80.
Volume: 67
Issue: 12
Pages: 679-686
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Publication
31515522 | J:301843
First Author: Nan H
Year: 2019
Journal: J Hum Genet
Title: UBAP1 mutations cause juvenile-onset hereditary spastic paraplegias (SPG80) and impair UBAP1 targeting to endosomes.
Volume: 64
Issue: 11
Pages: 1055-1065
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Publication
22405001 | -
First Author: Agromayor M
Year: 2012
Journal: Structure
Title: The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain.
Volume: 20
Issue: 3
Pages: 414-28
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Publication
21757351 | -
First Author: Stefani F
Year: 2011
Journal: Curr Biol
Title: UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting.
Volume: 21
Issue: 14
Pages: 1245-50
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Publication
38402586 | J:346057
First Author: Lu D
Year: 2024
Journal: Cell Rep
Title: ESCRT-I protein UBAP1 controls ventricular expansion and cortical neurogenesis via modulating adherens junctions of radial glial cells.
Volume: 43
Issue: 3
Pages: 113818
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Protein
A0A6I8MWX1
Organism: Mus musculus/domesticus
Length: 243  
Fragment?: true
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Protein
G3UW59
Organism: Mus musculus/domesticus
Length: 384  
Fragment?: false
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Protein
A0A1L1SRH2
Organism: Mus musculus/domesticus
Length: 74  
Fragment?: true
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Protein
Q3TQY7
Organism: Mus musculus/domesticus
Length: 378  
Fragment?: false
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Protein
Q8BH48
Organism: Mus musculus/domesticus
Length: 502  
Fragment?: false
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Protein
F6WHE1
Organism: Mus musculus/domesticus
Length: 141  
Fragment?: true
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Protein Coding Gene
MGP_CAROLIEiJ_G0025911 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0028159 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0028117 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0028080 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0028129 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0027857 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2149543 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0028570 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0027313 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0027829 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0027973 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0027940 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0028081 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0027973 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0028629 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0027032 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0027389 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0024034 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0026859 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
11599797 | J:71312
First Author: Qian J
Year: 2001
Journal: J Cancer Res Clin Oncol
Title: Isolation and characterization of a novel cDNA, UBAP1, derived from the tumor suppressor locus in human chromosome 9p21-22.
Volume: 127
Issue: 10
Pages: 613-8
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Publication
- | J:175295
     
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Ubap1<em1Yta> | MGI:7414300
 
Name: ubiquitin-associated protein 1; endonuclease-mediated mutation 1, Yoshihisa Takiyama
Allele Type: Endonuclease-mediated
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Genotype
Genotype
Symbol: Ubap1/Ubap1<+>
Background: involves: C57BL/6 * C57BL/6N * DBA/2
Zygosity: ht
Has Mutant Allele: true
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DO Term
DOID:0112341 | hereditary spastic paraplegia 80
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Protein Domain
IPR042575 | UBAP1_C
Type: Homologous_superfamily
Description: UBAP1 (ubiquitin associated protein 1) is a ubiquitin-binding ESCRT-I subunit (endosomal sorting complexes required for transport) []. The C-terminal region of UBAP1 is described as a solenoid of overlapping UBAs (SOUBA) which interacts with ubiquitin []. UBAP1-containing ESCRT-I is essential for degradation of antiviral cell-surface proteins.
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Protein
E0CXP6
Organism: Mus musculus/domesticus
Length: 133  
Fragment?: false
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Protein
E0CX23
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: false
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Protein Domain
IPR023340 | UMA
Type: Domain
Description: A key aspect of eukaryotic intracellular trafficking is the sorting of cell-surface proteins into multi-vesicular endosomes or bodies (MVBs), which eventually fuse with the lysosome, where they are degraded by lipases and peptidases. This is the primary mechanism for down-regulation of signaling via transmembrane receptors and removal of misfolded or defective membrane proteins. This process is also utilised by several viruses (e.g. HIV-1) to facilitate budding of their virions from the cell-membrane. Studies in animals and fungi have shown that it depends on an intricate series of interactions, which is initiated via ubiquitination (typically one or more mono-ubiquitinations) of the cytoplasmic tails of membrane proteins by specific E3 ligases. Ubiquitinated membrane proteins are then captured into endosomes by the ESCRT system and prevented from being recycled back to the plasma membrane via the retrograde trafficking system. The ESCRT system also folds the endosomal membranes into invaginations that are concentrated in these ubiquitinated targets and catalyzes their abscission into intra-luminal-vesicles inside the endosome. This largely seals the fate of these membrane proteins as targets for lysosomal degradation. The ESCRT system is comprised of 4 major protein complexes, ESCRT-0 to ESCRT-III, which are successively involved in the above-described steps [].ESCRT-I contains three subunits that are conserved between yeast and animals, namely the inactive E2-ligase protein TSG101/VPS23, VPS28 and VPS37. Additionally, both yeast and metazoan ESCRT-I contain a fourth subunit termed MVB12 (multivesicular body sorting factor of 12 kD); however, the MVB12 subunits from the two lineages do not show significant sequence similarity. The metazoan MVB12 proteins contain two distinct conserved domains that occur independently in various proteins. The C-terminal region of MVB12, which is shared with ubiquitin associated protein-1 (UBAP1), forms the UBAP1-MVB12 associated (UMA) domain. Human UBAP1 is implicated in nasopharyngeal carcinoma risk and fronto-temporal lobar degeneration. The UMA domain is also found in several other poorly characterised proteins, including at leat one orthologous group of proteins conserved in vertebrates prototyped be the human protein LOC390595 and another group conserved across Metazoa typified by human tcag7.903. The UMA domain found in MVB12 and UBAP1 defines a novel adaptor that might recruit diverse targets to ESCRT-I. The different UMA proteins might function as alternative as MVB12-like subunit that recruit different targets via their specific intercation modules (such as MABP) or UBA or the specific extensions) to the ESCRT-I complex [].This entry represents the UMA domain, which contains a conserved proline followed by a hydrophobic residue in the N terminus and a nearly absolutely conserved glutamate at the C terminus. It is predicted to adopt an alpha+beta fold [].
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Protein
Q6KAU4
Organism: Mus musculus/domesticus
Length: 317  
Fragment?: false
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Protein
Q78HU3
Organism: Mus musculus/domesticus
Length: 271  
Fragment?: false
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Protein
Q8BT99
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: false
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Protein
Q8C2W4
Organism: Mus musculus/domesticus
Length: 288  
Fragment?: false
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Publication
20448139 | -
First Author: de Souza RF
Year: 2010
Journal: Bioinformatics
Title: UMA and MABP domains throw light on receptor endocytosis and selection of endosomal cargoes.
Volume: 26
Issue: 12
Pages: 1477-80
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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