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Search results 1 to 96 out of 96 for Ubqln2

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Hits by Category

Type Details Score
Gene
29978 | UBQLN2
Type: gene
Organism: human
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Gene
539529 | UBQLN2
Type: gene
Organism: cattle
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Gene
707967 | UBQLN2
Type: gene
Organism: macaque, rhesus
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Gene
317396 | Ubqln2
Type: gene
Organism: rat
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Gene
491909 | UBQLN2
Type: gene
Organism: dog, domestic
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Gene
743819 | UBQLN2
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:1860283 | Ubqln2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
30333186 | J:267076
First Author: Sharkey LM
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Mutant UBQLN2 promotes toxicity by modulating intrinsic self-assembly.
Volume: 115
Issue: 44
Pages: E10495-E10504
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Publication
27477512 | J:236006
First Author: Hjerpe R
Year: 2016
Journal: Cell
Title: UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.
Volume: 166
Issue: 4
Pages: 935-949
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Publication
27834214 | J:239510
First Author: Le NT
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations.
Volume: 113
Issue: 47
Pages: E7580-E7589
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Publication
32513711 | J:294726
First Author: Wu JJ
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: ALS/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function.
Volume: 117
Issue: 26
Pages: 15230-15241
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Publication
26141599 | J:227429
 
First Author: Zeng L
Year: 2015
Journal: Neurobiol Dis
Title: Differential recruitment of UBQLN2 to nuclear inclusions in the polyglutamine diseases HD and SCA3.
Volume: 82
Pages: 281-288
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Publication
35247097 | J:336757
First Author: Mohan HM
Year: 2022
Journal: Cell Mol Life Sci
Title: RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control.
Volume: 79
Issue: 3
Pages: 176
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Publication
32653673 | J:299301
 
First Author: Sharkey LM
Year: 2020
Journal: Neurobiol Dis
Title: Modeling UBQLN2-mediated neurodegenerative disease in mice: Shared and divergent properties of wild type and mutant UBQLN2 in phase separation, subcellular localization, altered proteostasis pathways, and selective cytotoxicity.
Volume: 143
Pages: 105016
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Publication
36609661 | J:334796
First Author: Sandoval-Pistorius SS
Year: 2023
Journal: Sci Rep
Title: Ubiquilin-2 regulates pathological alpha-synuclein.
Volume: 13
Issue: 1
Pages: 293
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Publication
30377984 | J:329603
First Author: Picher-Martel V
Year: 2019
Journal: Mol Neurobiol
Title: Neuronal Expression of UBQLN2P497H Exacerbates TDP-43 Pathology in TDP-43G348C Mice through Interaction with Ubiquitin.
Volume: 56
Issue: 7
Pages: 4680-4696
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Publication
32681165 | J:295993
First Author: Gerson JE
Year: 2020
Journal: Hum Mol Genet
Title: Ubiquilin-2 differentially regulates polyglutamine disease proteins.
Volume: 29
Issue: 15
Pages: 2596-2610
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Protein Coding Gene
MGP_CAROLIEiJ_G0033511 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0036195 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0036171 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0036097 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0036162 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0035870 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1860283 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0036687 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0035161 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0035847 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0036005 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0035939 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0036096 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0035975 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0036722 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0034855 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0035296 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0032050 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0034680 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
 
Probe: MGI:5502917
Assay Type: RNA in situ
Annotation Date: 2013-08-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691021
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:5502916
Age: embryonic day 13.5
Note: Expression was detected in dorsal telencephalon. Ubiquitous, higher in progenitors.
Specimen Label: Supp. Table 1
Detected: true
Specimen Num: 1
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Publication
10983987 | J:64191
First Author: Kleijnen MF
Year: 2000
Journal: Mol Cell
Title: The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome.
Volume: 6
Issue: 2
Pages: 409-19
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Publication
24549040 | J:206933
First Author: Farg MA
Year: 2014
Journal: Hum Mol Genet
Title: C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking.
Volume: 23
Issue: 13
Pages: 3579-95
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Publication
10549293 | J:62988
First Author: Wu AL
Year: 1999
Journal: Mol Cell
Title: Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane.
Volume: 4
Issue: 4
Pages: 619-25
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Publication
23774650 | J:310933
 
First Author: Rutherford NJ
Year: 2013
Journal: Brain Res
Title: Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions.
Volume: 1524
Pages: 62-73
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Publication
15328020 | J:93141
First Author: Mattar P
Year: 2004
Journal: Dev Biol
Title: A screen for downstream effectors of Neurogenin2 in the embryonic neocortex.
Volume: 273
Issue: 2
Pages: 373-89
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Publication
16107646 | J:100324
First Author: Bulfone A
Year: 2005
Journal: J Neurosci
Title: Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes.
Volume: 25
Issue: 33
Pages: 7586-600
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Publication
- | J:345476
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2023
Title: TreeGrafter-generated GO annotations
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Tg(Thy1-UBQLN2)356Mont | MGI:5829042
Name: transgene insertion 356, Mervyn Monteiro
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
33028421 | J:329654
First Author: Wang S
Year: 2020
Journal: Acta Neuropathol Commun
Title: Overexpression of UBQLN1 reduces neuropathology in the P497S UBQLN2 mouse model of ALS/FTD.
Volume: 8
Issue: 1
Pages: 164
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Allele
Tg(Thy1-UBQLN2*P497S)3Mont | MGI:5829037
Name: transgene insertion 3, Mervyn Monteiro
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Thy1-UBQLN2*P506T)6Mont | MGI:5896606
Name: transgene insertion 6, Mervyn Monteiro
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Genotype
Genotype
Symbol: Tg(Thy1-UBQLN2*P506T)6Mont/?
Background: involves: C3H * C57BL/6 * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Interaction Experiment
Hjerpe R (2016)
Description: UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.
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Genotype
Genotype
Symbol: Tg(Thy1-UBQLN2*P497S)3Mont/?
Background: involves: C3H * C57BL/6 * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Interaction Experiment
Wu JJ (2020)
Description: ALS/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function.
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Interaction Experiment
Mohan HM (2022)
Description: RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control.
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Transgene
MGI:5829049 | Tg(Thy1-UBQLN2*P497S)3Mont
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:5896607 | Tg(Thy1-UBQLN2*P506T)6Mont
Type: transgene
Organism: mouse, laboratory
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DO Term
DOID:0060206 | amyotrophic lateral sclerosis type 15
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Publication
21857683 | -
First Author: Deng HX
Year: 2011
Journal: Nature
Title: Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia.
Volume: 477
Issue: 7363
Pages: 211-5
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Publication
22560112 | -
First Author: Daoud H
Year: 2012
Journal: Neurobiol Aging
Title: UBQLN2 mutations are rare in French and French-Canadian amyotrophic lateral sclerosis.
Volume: 33
Issue: 9
Pages: 2230.e1-2230.e5
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Publication
22892309 | -
First Author: Synofzik M
Year: 2012
Journal: Neurobiol Aging
Title: Screening in ALS and FTD patients reveals 3 novel UBQLN2 mutations outside the PXX domain and a pure FTD phenotype.
Volume: 33
Issue: 12
Pages: 2949.e13-7
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Allele
Tg(Prnp-UBQLN2)WT-hiHlp | MGI:6784070
Name: transgene insertion WT-hi, Henry L Paulson
Allele Type: Transgenic
Attribute String: Epitope tag, Humanized sequence, Inserted expressed sequence
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Allele
Tg(Prnp-UBQLN2)WT-lowHlp | MGI:6784047
Name: transgene insertion WT-low, Henry L Paulson
Allele Type: Transgenic
Attribute String: Epitope tag, Humanized sequence, Inserted expressed sequence
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Allele
Tg(Prnp-UBQLN2*P506T)#Hlp | MGI:6784048
Name: transgene insertion, Henry L Paulson
Allele Type: Transgenic
Attribute String: Epitope tag, Humanized sequence, Inserted expressed sequence
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Genotype
Genotype
Symbol: Tg(Prnp-UBQLN2)WT-hiHlp/?
Background: involves: C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Prnp-UBQLN2)WT-lowHlp/?
Background: involves: C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Prnp-UBQLN2*P506T)#Hlp/?
Background: involves: C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
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Strain
MGI:5829053 | B6.Cg-Tg(Thy1-UBQLN2)356Mont/J
Attribute String: transgenic, mutant strain, congenic
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Strain
MGI:6455403 | B6;C3-Tg(Thy1-UBQLN2*P506T)6Mont/J
Attribute String: mutant stock, transgenic
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Genotype
Genotype
Symbol: Tg(Thy1-UBQLN2)356Mont/?
Background: involves: C57BL/6J * SJL
Zygosity: ot
Has Mutant Allele: true
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Strain
MGI:5829050 | B6.Cg-Tg(Thy1-UBQLN2*P497S)3Mont/J
Attribute String: congenic, mutant strain, transgenic
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Publication
25398946 | J:219220
First Author: Osaka M
Year: 2015
Journal: Hum Mol Genet
Title: Evidence of a link between ubiquilin 2 and optineurin in amyotrophic lateral sclerosis.
Volume: 24
Issue: 6
Pages: 1617-29
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Publication
25246588 | J:216459
First Author: Gorrie GH
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Dendritic spinopathy in transgenic mice expressing ALS/dementia-linked mutant UBQLN2.
Volume: 111
Issue: 40
Pages: 14524-9
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Publication
25193032 | J:253702
First Author: Ajroud-Driss S
Year: 2015
Journal: Biochim Biophys Acta
Title: Sporadic and hereditary amyotrophic lateral sclerosis (ALS).
Volume: 1852
Issue: 4
Pages: 679-84
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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